[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650538":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":18,"locations":24,"responsibleParty":42,"collaborators":10,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":10,"eligibilityCriteria":50,"healthyVolunteers":46,"sex":51,"minAge":52,"maxAge":10,"enrollmentInfo":53,"targetDuration":10,"studyType":56,"phases":10,"briefSummary":57,"conditions":58,"keywords":10,"overallStatus":27,"whyStopped":10,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":69},{"fullName":5,"class":6},"China National Center for Cardiovascular Diseases","OTHER_GOV",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Determination of GFR trajectories after cardiovascular surgery or contrast agent exposure",null,"Perform GFR testing on patients who are scheduled for cardiovascular surgery or who are going to receive contrast agents to determine the GFR trajectory after the cardiovascular surgery or the contrast agent exposure.",{"label":13,"type":10,"description":14,"interventionNames":10},"The determination of the GFR trajectory for CSA-AKI or CA-AKI","Perform GFR testing on patients with AKI related to cardiovascular surgery or contrast agents to determine their trajectory",{"label":16,"type":10,"description":17,"interventionNames":10},"Perioperative changes in GFR for the early prediction and diagnosis of CSA-AKI","Incorporate adult patients who meet the inclusion and exclusion criteria and are scheduled for cardiovascular surgery, and monitor their perioperative changes in GFR through GFR testing to achieve early prediction and diagnosis of CSA-AKI.",[19],{"name":20,"role":21,"phone":22,"phoneExt":10,"email":23},"Jianfang Cai","CONTACT","+86 15801601007","caijfbj@126.com",[25],{"facility":26,"status":27,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Center for Cardiovascular Diseases","RECRUITING","Beijing","Beijing Municipality","100037","China","CN",{"type":34,"coordinates":35},"Point",[36,37],116.39723,39.9075,{"lat":37,"lon":36},[40],{"name":41,"role":21,"phone":22,"phoneExt":10,"email":23},"Jianfan Cai",{"type":43,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100650538","perioperative-transcutaneous-fluorescence-detection-of-gfr-trajectory-for-the-early-prediction-and-diagnosis-of-csa-aki-100650538",false,"NCT07749417","Perioperative Transcutaneous Fluorescence Detection of GFR Trajectory for the Early Prediction and Diagnosis of CSA-AKI.","Establishment and Validation of an Early Warning Model for Acute Kidney Injury During the Perioperative Period of Cardiovascular Diseases.","Inclusion Criteria:\n\n1. Age ≥ 18 years old;\n2. Specific inclusion criteria for the cohort:\n\n   * GFR trajectory characterization after cardiovascular surgery or Iodine contrast agent exposure: Patients scheduled for elective cardiovascular surgery or interventional cardiovascular surgery or CTA; ② GFR trajectory characterization of AKI: Patients with confirmed CSA-AKI or contrast-associated acute kidney injury (CA-AKI).\n\nExclusion Criteria:\n\n1. Received renal replacement therapy before surgery or before contrast imaging, including kidney transplantation and regular dialysis;\n2. Serum creatinine \\> 353 μmol\u002FL before surgery or before contrast imaging;\n3. Patients with AKI who did not recover before surgery or before contrast imaging;\n4. Patients with malignant tumors.","ALL","18 Years",{"count":54,"type":55},436,"ESTIMATED","OBSERVATIONAL","brief summary：The goal of this observational study is to evaluate the value of perioperative transcutaneous fluorescence glomerular filtration rate (GFR) monitoring for the early prediction and diagnosis of cardiac surgery-associated acute kidney injury (CSA-AKI) and contrast-associated acute kidney injury(CA-AKI) in adult patients. The main questions it aims to answer are: Can perioperative GFR or peri-contast trajectories measured by a transcutaneous fluorescence monitoring system predict the development of CSA-AKI or CA-AKI before conventional diagnostic criteria are met? What changes in perioperative or peri-contast GFR trajectories are associated with the occurrence and severity of CSA-AKI or CA-AKI? Participants scheduled for cardiovascular surgery or contast-enhanced CT scan or PCI will undergo continuous perioperative transcutaneous GFR monitoring following intravenous administration of a fluorescent tracer. Clinical characteristics, perioperative or peri-contast hemodynamic data, laboratory measurements, imaging findings, and postoperative or post-contast outcomes will be collected to evaluate the predictive and diagnostic performance of perioperative or peri-contrast GFR trajectories for CSA-AKI or PC-AKI.",[59],"Acute Kidney Injury","2026-08-03",{"date":62,"type":63},"2026-08-06","ACTUAL",{"date":65,"type":63},"2026-07-17",{"date":67,"type":55},"2029-07",{"name":5,"class":6},1]