[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651193":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":10,"centralContacts":36,"locations":44,"responsibleParty":61,"collaborators":10,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":67,"sex":73,"minAge":74,"maxAge":10,"enrollmentInfo":75,"targetDuration":10,"studyType":78,"phases":10,"briefSummary":79,"conditions":80,"keywords":10,"overallStatus":47,"whyStopped":10,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"First Affiliated Hospital Xi'an Jiaotong University","OTHER",[8,14,18,23],{"label":9,"type":10,"description":11,"interventionNames":12},"Cohort 1 Atrial Fibrillation Group",null,"Participants in cohort 1 diagnosed with atrial fibrillation based on Holter monitoring. Peripheral blood samples will be analyzed using untargeted lipidomic profiling.",[13],"Other: Peripheral blood untargeted lipidomic profiling",{"label":15,"type":10,"description":16,"interventionNames":17},"Cohort 1 Control Group","Control participants in cohort 1 with other cardiovascular diseases and no documented atrial fibrillation. Peripheral blood samples will be analyzed using untargeted lipidomic profiling.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Cohort 2 Atrial Fibrillation Group","Participants in cohort 2 diagnosed with atrial fibrillation based on Holter monitoring. Peripheral blood samples will be analyzed using targeted ceramide assays.",[22],"Other: Peripheral blood targeted ceramide assay",{"label":24,"type":10,"description":25,"interventionNames":26},"Cohort 2 Control Group","Control participants in cohort 2 with other cardiovascular diseases and no documented atrial fibrillation. Peripheral blood samples will be analyzed using targeted ceramide assays.",[22],[28,32],{"type":6,"name":29,"description":30,"armGroupLabels":31,"otherNames":10},"Peripheral blood untargeted lipidomic profiling","Peripheral blood samples from cohort 1 will be analyzed using untargeted lipidomic profiling. No treatment or therapeutic intervention will be assigned by the investigators.",[9,15],{"type":6,"name":33,"description":34,"armGroupLabels":35,"otherNames":10},"Peripheral blood targeted ceramide assay","Peripheral blood samples from cohort 2 will be analyzed using targeted ceramide assays. No treatment or therapeutic intervention will be assigned by the investigators.",[19,24],[37,42],{"name":38,"role":39,"phone":40,"phoneExt":10,"email":41},"Weiyan Zhang","CONTACT","0086-13571200428","zwhy19324@gmail.com",{"name":38,"role":39,"phone":40,"phoneExt":10,"email":43},"3093887704@qq.com",[45],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"First Affiliated Hospital of Xian JiaotongUniversity","RECRUITING","Xi'an","Shaanxi","710061","China","CN",{"type":54,"coordinates":55},"Point",[56,57],108.92861,34.25833,{"lat":57,"lon":56},[60],{"name":38,"role":39,"phone":40,"phoneExt":10,"email":41},{"type":62,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","She JianQing","First Affiliated Hospital Xian Jiaotong University","100651193","peripheral-blood-lipidomic-and-ceramide-profiles-in-atrial-fibrillation-100651193",false,"NCT07757282","Peripheral Blood Lipidomic and Ceramide Profiles in Atrial Fibrillation","Association of Peripheral Blood Lipidomic and Ceramide Profiles With Atrial Fibrillation: A Prospective Multi-Cohort Observational Study","LIPID-AF","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Participants who are able to provide informed consent.\n* Participants diagnosed with atrial fibrillation based on Holter monitoring, or control participants with other cardiovascular diseases and no documented atrial fibrillation.\n* Participants with available peripheral blood samples for untargeted lipidomic profiling or targeted ceramide analysis.\n\nExclusion Criteria:\n\n* Inability or unwillingness to provide informed consent.\n* Missing key clinical information.\n* Missing or poor-quality peripheral blood samples unsuitable for lipidomic or targeted ceramide analysis.\n* Participants considered unsuitable for this study by the investigators.","ALL","18 Years",{"count":76,"type":77},200,"ESTIMATED","OBSERVATIONAL","This prospective multi-cohort observational study evaluates the association between peripheral blood lipidomic and ceramide profiles and atrial fibrillation. The study hypothesis is that peripheral blood lipidomic features and ceramide-related profiles are associated with the presence of atrial fibrillation. Participants with atrial fibrillation and control participants with other cardiovascular diseases will be prospectively enrolled. Peripheral blood samples will be analyzed using untargeted lipidomic profiling in one cohort and targeted ceramide assays in another cohort.",[81],"Atrial Fibrillation (AF)","2026-08-07",{"date":84,"type":85},"2026-08-11","ACTUAL",{"date":87,"type":85},"2017-06-15",{"date":89,"type":77},"2027-02",{"name":5,"class":6},1]