[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100596852":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":37,"locations":47,"responsibleParty":71,"collaborators":31,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":75,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":31,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":94,"overallStatus":49,"whyStopped":31,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"VA Office of Research and Development","FED",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Deep rTMS","ACTIVE_COMPARATOR","The first group will receive 10 Hz DTMS (standard TMS) with a protocol of 3 seconds on, 15 seconds off, and a total of 1800 pulses\u002Fsession, lasting 18 minutes, targeting the bilateral insula and lateral prefrontal cortex.",[13],"Device: Transcranial Magnetic Stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"Precision TMS","EXPERIMENTAL","The other group will receive 10 Hz personalized-image-guided and Efield-modeling dose rTMS (precision TMS) with a protocol of 5 seconds on, 10 seconds off, and a total of 3000 pulses\u002Fsession, lasting 15 minutes, targeting the left dorsolateral prefrontal cortex (DLPFC).",[19],"Device: Personalized-image-guided and E-field-modeling dose rTMS (precision TMS)",[21,27],{"type":22,"name":23,"description":11,"armGroupLabels":24,"otherNames":25},"DEVICE","Transcranial Magnetic Stimulation",[9],[26],"Deep TMS, Standard rTMS",{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Personalized-image-guided and E-field-modeling dose rTMS (precision TMS)","With a protocol of 5 seconds on, 10 seconds off, and a total of 3000 pulses\u002Fsession, lasting 15 minutes, targeting the left DLPFC.",[15],null,[33],{"name":34,"affiliation":35,"role":36},"Xingbao Li, MD MS","Ralph H. Johnson VA Medical Center, Charleston, SC","PRINCIPAL_INVESTIGATOR",[38,43],{"name":34,"role":39,"phone":40,"phoneExt":41,"email":42},"CONTACT","(843) 577-5011","205853","xingbao.li@va.gov",{"name":44,"role":39,"phone":45,"phoneExt":31,"email":46},"Aimee L Mcrae-Clark, PharmD","(843) 792-5216","Aimee.McRae-Clark@va.gov",[48],{"facility":35,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"RECRUITING","Charleston","South Carolina","29401-5703","United States","US",{"type":56,"coordinates":57},"Point",[58,59],-79.93275,32.77632,{"lat":59,"lon":58},[62,66,70],{"name":63,"role":39,"phone":64,"phoneExt":31,"email":65},"R. Amanda C LaRue, PhD","(843) 789-6707","Rutha.Larue@va.gov",{"name":67,"role":39,"phone":68,"phoneExt":31,"email":69},"Sarah A Jackson, BA MA","(843) 789-6700","sarah.jackson@va.gov",{"name":34,"role":36,"phone":31,"phoneExt":31,"email":31},{"type":72,"investigatorFullName":31,"investigatorTitle":31,"investigatorAffiliation":31,"oldNameTitle":31,"oldOrganization":31},"SPONSOR","100596852","personalized-brain-stimulation-to-help-veterans-quit-smoking-100596852",false,"NCT07050862","Personalized Brain Stimulation to Help Veterans Quit Smoking","Circuity-guided Repetitive Transcranial Magnetic Stimulation (rTMS) for Tobacco Use in Veterans: A Comparison of Insula-rTMS and Prefrontal-rTMS","VICTOR","Inclusion Criteria:\n\n* Veteran\n* Individuals who smoke 10 or more cigarettes per day and have a CO level \\> 10 ppm indicative of recent smoking\n* Those who have not received substance abuse treatment within the previous 30 days\n* Those who have been stable on psychotropic medications for at least three months\n* For females, those who test non-pregnant and use adequate birth control\n* Those who are willing to provide informed consent\n* Those who can comply with protocol requirements and likely complete all study procedures\n* Those who are motivated to quit smoking (based on responses of \"very likely\" or \"somewhat likely\" in the motivation questionnaire\n\nExclusion Criteria:\n\n* Current moderate to severe substance use of any psychoactive substances other than nicotine or caffeine, as defined by DSM-V criteria\n* Contraindications to MRI (e.g., metal in the skull, orbital or intracranial cavity, or claustrophobia)\n* Contraindications to rTMS (history of a seizure or epilepsy)\n* A history of autoimmune, endocrine, viral, or vascular disorders affecting the brain\n* History or MRI evidence of neurological disorder that would lead to local or diffuse brain lesions or significant physical impairment\n* Unstable cardiac disease, uncontrolled hypertension, severe renal or liver insufficiency, or sleep apnea\n* Major Axis I disorders diagnosed according to DSM-V criteria, such as bipolar affective disorder, schizophrenia, dementia, or major depression\n\n  * Regarding the Veteran population, the investigators will enroll smokers who have PTSD\n* Current use of other forms of nicotine delivery, such as nicotine patches or electronic cigarettes\n* Currently prescribed bupropion and\u002For varenicline","ALL","18 Years","70 Years",{"count":85,"type":86},56,"ESTIMATED","INTERVENTIONAL",[89],"NA","Cigarette smoking is a significant public health concern for Veterans. Encouraging smoking cessation continues to be a top priority for the Veterans' Administration as Veterans who use tobacco experience negative health effects, including cancer, heart disease, and mental disorders. Despite the efficacy of current evidence-based pharmacotherapies and psychotherapies for smoking cessation, alternative treatments are critically needed. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive form of brain stimulation, US FDA-approved for smoking cessation. In this protocol, the investigators propose comparing the two rTMS protocols (standard TMS vs. precision TMS) to find a better treatment parameter for smoking cessation in Veterans. Identifying an efficacious rTMS protocol would benefit Veterans who want to quit smoking.",[92,93],"Tabacco Use Disorder","rTMS",[95,96,23,97],"Tabacco use disorder","Veterans","Smoking Cessation","2026-07-31",{"date":100,"type":101},"2026-08-04","ACTUAL",{"date":103,"type":101},"2026-07-01",{"date":105,"type":86},"2030-08-31",{"name":5,"class":6},1]