[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100605360":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":49,"centralContacts":53,"locations":58,"responsibleParty":75,"collaborators":77,"id":81,"slug":82,"hasResults":83,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":36,"eligibilityCriteria":87,"healthyVolunteers":88,"sex":89,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":36,"studyType":95,"phases":96,"briefSummary":98,"conditions":99,"keywords":36,"overallStatus":61,"whyStopped":36,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Northwestern University","OTHER",[8,14,20,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Personalized TBS-EEG over the prefrontal cortex","EXPERIMENTAL","Theta burst stimulation (TBS) will be administrated with a figure-8 coil over the left dorsolateral prefrontal cortex (DLPFC) at the pulse intensity of up to 120% of the individualized resting motor threshold (rMT). Stimulation will be conducted at rest. The TBS parameters will be individualized to the prefrontal EEG activity (theta-gamma coupling) and delivered in synchrony with the prefrontal theta activity (phase). The approach\u002Favoidance test and resting-state EEG recordings will be administered before and after the stimulation.",[13],"Device: TBS-EEG",{"label":15,"type":16,"description":17,"interventionNames":18},"Personalized TBS-EEG over the head vertex","ACTIVE_COMPARATOR","Theta burst stimulation (TBS) will be administrated with a figure-8 coil over the postcentral gyrus (- a brain area with minimal functional relevance to the task) at the pulse intensity of up to 120% of the individualized resting motor threshold (rMT). Stimulation will be conducted at rest. The TBS parameters will be individualized to the prefrontal EEG activity (theta-gamma coupling) and delivered in synchrony with the prefrontal theta activity (phase). The approach\u002Favoidance test and resting-state EEG recordings will be administered before and after the stimulation.",[19],"Device: TBS-EEG \u002F Spatial Control",{"label":21,"type":16,"description":22,"interventionNames":23},"Conventional TBS over the prefrontal cortex","Theta burst stimulation (TBS) will be administrated with a figure-8 coil over the left dorsolateral prefrontal cortex (DLPFC) at the pulse intensity of up to 120% of the individualized resting motor threshold (rMT). Stimulation will be conducted at rest The TBS parameters will be randomized within the normative range of theta-gamma coupling (biomarker in the main experimental arm) and delivered in open-loop (irrespective of the EEG activity). The approach\u002Favoidance test and resting-state EEG recordings will be administered before and after the stimulation.",[24],"Device: TBS \u002F Temporal Control",{"label":26,"type":16,"description":27,"interventionNames":28},"Lower intensity personalized TBS-EEG","Theta burst stimulation (TBS) will be administrated with a figure-8 coil over the left dorsolateral prefrontal cortex (DLPFC) at the sub-threshold pulse intensity of up to 80% of the individualized resting motor threshold (rMT). Stimulation will be conducted at rest. The TBS parameters will be individualized to the prefrontal EEG activity (theta-gamma coupling) and delivered in synchrony with the prefrontal theta activity (phase). The approach\u002Favoidance test and resting-state EEG recordings will be administered before and after the stimulation.",[29],"Device: TBS-EEG \u002F Dose Control",[31,37,41,45],{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"DEVICE","TBS-EEG","Theta-burst stimulation (TBS) over the left dorsolateral prefrontal cortex (DLPFC) synchronized with the ongoing electroencephalographic (EEG) oscillations in the theta (3-7 Hz) range at a suprathreshold pulse intensity (up to 120% rMT).",[9],null,{"type":32,"name":38,"description":39,"armGroupLabels":40,"otherNames":36},"TBS-EEG \u002F Spatial Control","Theta-burst stimulation (TBS) over the postcentral gyrus, synchronized with the ongoing electroencephalographic (EEG) oscillations in the theta (3-7 Hz) range at a suprathreshold pulse intensity (up to 120% rMT).",[15],{"type":32,"name":42,"description":43,"armGroupLabels":44,"otherNames":36},"TBS \u002F Temporal Control","Theta-burst stimulation (TBS) over the left dorsolateral prefrontal cortex (DLPFC) at a suprathreshold pulse intensity (up to 120% rMT).",[21],{"type":32,"name":46,"description":47,"armGroupLabels":48,"otherNames":36},"TBS-EEG \u002F Dose Control","Theta-burst stimulation (TBS) similar to the \"TBS-EEG\" condition but at a subthreshold pulse intensity (up to 80% rMT).",[26],[50],{"name":51,"affiliation":5,"role":52},"Ivan Alekseichuk, PhD","PRINCIPAL_INVESTIGATOR",[54],{"name":51,"role":55,"phone":56,"phoneExt":36,"email":57},"CONTACT","312-503-3196","neuromodlab@northwestern.edu",[59],{"facility":60,"status":61,"city":62,"state":63,"zip":64,"country":65,"countryCode":66,"cosmosGeoPoint":67,"geoPoint":72,"contacts":73},"Northwestern University Feinberg School of Medicine","RECRUITING","Chicago","Illinois","60611","United States","US",{"type":68,"coordinates":69},"Point",[70,71],-87.65005,41.85003,{"lat":71,"lon":70},[74],{"name":51,"role":55,"phone":56,"phoneExt":36,"email":57},{"type":76,"investigatorFullName":36,"investigatorTitle":36,"investigatorAffiliation":36,"oldNameTitle":36,"oldOrganization":36},"SPONSOR",[78],{"name":79,"class":80},"National Institute of Mental Health (NIMH)","NIH","100605360","personalized-theta-burst-stimulation-for-long-lasting-changes-in-approachavoidance-behavior-100605360",false,"NCT07161505","Personalized Theta-burst Stimulation for Long-lasting Changes in Approach\u002FAvoidance Behavior","The Efficiency of Personalized Theta-burst Stimulation for Inducing Long-lasting Changes in DLPFC","Inclusion Criteria:\n\n1. Participants must be legal adults between the ages of 18 to 65;\n2. Able and willing to complete study procedures and tasks.\n\nExclusion Criteria:\n\n1. History or evidence of chronic neurological or mental disorder;\n2. Chronic condition that requires pharmacological treatment over the course of study participation;\n3. Pregnancy or breastfeeding;\n4. History or evidence of alcohol or drug addiction;\n5. Contraindications for transcranial magnetic stimulation (history of seizures, metallic or electric implant in the head\u002Fneck area);\n6. Contraindications for magnetic resonance imaging at 3 Tesla (non-compatible implants, metallic foreign bodies, insulin pump, pacemaker).",true,"ALL","18 Years","65 Years",{"count":93,"type":94},26,"ESTIMATED","INTERVENTIONAL",[97],"NA","This study will assess the long-lasting effects of personalized theta burst stimulation (TBS), a repetitive form of transcranial magnetic stimulation (TMS), over the left prefrontal cortex on the approach\u002Favoidance behavior. TBS will be personalized based on the prefrontal theta rhythm captured with electroencephalography (EEG). The main questions it aims to answer are: 1. does a single session of personalized TBS synchronized with the individual theta rhythm over the left prefrontal cortex results in the outlasting changes in the individual behavior? 2. Does TBS results in the brain rhythms' changes as measured using resting-state EEG?",[100],"Approach\u002FAvoidance Behavior","2026-08-14",{"date":103,"type":104},"2026-08-18","ACTUAL",{"date":106,"type":104},"2025-07-31",{"date":108,"type":94},"2027-02-28",{"name":5,"class":6},1]