[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100655905":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":13,"studyPopulation":13,"armGroups":23,"interventions":41,"overallOfficials":55,"centralContacts":59,"locations":68,"responsibleParty":85,"collaborators":13,"id":88,"slug":89,"hasResults":90,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":94,"eligibilityCriteria":95,"healthyVolunteers":96,"sex":97,"minAge":98,"maxAge":99,"enrollmentInfo":100,"targetDuration":13,"studyType":103,"phases":104,"briefSummary":106,"conditions":107,"keywords":110,"overallStatus":70,"whyStopped":13,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":123},{"fullName":5,"class":6},"Colorado State University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Gastrointestinal Symptom Rating Scale","The Gastrointestinal Symptom Rating Scale (GSRS) is a widely used tool for measuring gastrointestinal symptoms across five domains. The GSRS is scored between \"No discomfort\" and \"Very severe discomfort\"","4 weeks",null,{"allocation":15,"interventionModel":16,"interventionModelDescription":13,"primaryPurpose":17,"observationalModel":13,"timePerspective":13,"maskingInfo":18},"RANDOMIZED","CROSSOVER","SUPPORTIVE_CARE",{"masking":19,"maskingDescription":13,"whoMasked":20},"DOUBLE",[21,22],"PARTICIPANT","INVESTIGATOR",[24,30,35],{"label":25,"type":26,"description":27,"interventionNames":28},"MuniPhage","EXPERIMENTAL","1 x 10E6 Plaque Forming Units (PFU) of bacteriophage strains PBH34, CAH57, BFX121, and DNK95 that have been designed to target specific pro-inflammatory E. coli strains in the gut.",[29],"Dietary Supplement: Bacteriophages - MuniPhage",{"label":31,"type":26,"description":32,"interventionNames":33},"RenuPhage","Dietary supplement containing 1 x 10E6 PFU of phage strains LG91, BD117, CD007, and PD23 designed to target S. aureus in the gut which may also reduce S. aureus load on the skin.",[34],"Dietary Supplement: Bacteriophages - RenuPhage",{"label":36,"type":37,"description":38,"interventionNames":39},"Placebo","PLACEBO_COMPARATOR","Rice maltodextrin",[40],"Other: Placebo",[42,48,53],{"type":43,"name":44,"description":45,"armGroupLabels":46,"otherNames":47},"DIETARY_SUPPLEMENT","Bacteriophages - MuniPhage","1 x 106 Plaque Forming Units (PFU) of bacteriophage strains PBH34, CAH57, BFX121, and DNK95",[25],[25],{"type":43,"name":49,"description":50,"armGroupLabels":51,"otherNames":52},"Bacteriophages - RenuPhage","1 x 106 PFU of phage strains LG91, BD117, CD007, and PD23",[31],[31],{"type":6,"name":36,"description":38,"armGroupLabels":54,"otherNames":13},[36],[56],{"name":57,"affiliation":5,"role":58},"Tiffany Weir, PhD","PRINCIPAL_INVESTIGATOR",[60,64],{"name":57,"role":61,"phone":62,"phoneExt":13,"email":63},"CONTACT","970-215-7571","tiffany.weir@colostate.edu",{"name":65,"role":61,"phone":66,"phoneExt":13,"email":67},"Jenny Whittington, MS","970-310-6843","ijwhitt@rams.colostate.edu",[69],{"facility":5,"status":70,"city":71,"state":72,"zip":73,"country":74,"countryCode":75,"cosmosGeoPoint":76,"geoPoint":81,"contacts":82},"RECRUITING","Fort Collins","Colorado","80523","United States","US",{"type":77,"coordinates":78},"Point",[79,80],-105.08442,40.58526,{"lat":80,"lon":79},[83,84],{"name":57,"role":61,"phone":62,"phoneExt":13,"email":63},{"name":57,"role":58,"phone":13,"phoneExt":13,"email":13},{"type":58,"investigatorFullName":86,"investigatorTitle":87,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"Tiffany Weir","Professor","100655905","phage-based-control-and-limitation-of-pathobionts-for-microbiome-equilibrium-and-resilience-100655905",false,"NCT07816809","Phage-based Control and Limitation of Pathobionts for Microbiome Equilibrium and Resilience","Phage-CLEAR: Phage-based Control and Limitation of Pathobionts for Microbiome Equilibrium and Resilience","Phage-CLEAR","Inclusion Criteria:\n\n* Between 18-75 years old\n* BMI \\\u003C30\n* Experiencing mild-moderate gastrointestinal distress\u002F abdominal pain, bloating, constipation, and\u002For diarrhea\n\nExclusion Criteria:\n\n* Younger than 18 years old or greater than 75 years old\n* BMI \\>29.9\n* Antibiotic use in the past 2 months\n* Use of statins, metformin, prescription NSAIDs, and MAO inhibitors, or other medications that could interfere with study outcomes, as determined by the study PI\n* Current diagnosis of cancer, liver or kidney disease, gastrointestinal diseases, or cardiometabolic disease (diabetes, cardiovascular disease)\n* Individuals with allergies to capsule ingredients\n* Pregnant or breastfeeding individuals\n* Excess alcohol consumption (≥4 drinks on any given occasion and\u002For ≥8 drinks\u002Fweek for women, and ≥5 drinks on any given occasion and\u002For ≥15 drinks\u002Fweek for men)\n* Use of dietary supplements that contain probiotics or phages\n* Actively trying to lose weight\n* Participation in other research studies that would interfere with study endpoints or compliance\n* Unable or unwilling to consume capsules, provide stool or blood samples, track bowel movements and symptoms, and attend scheduled clinic visits",true,"ALL","18 Years","75 Years",{"count":101,"type":102},40,"ESTIMATED","INTERVENTIONAL",[105],"NA","Bacteriophages are viruses that can selectively infect specific species and strains of bacteria. Some bacterial species in the human gut have been negatively associated with gut health and skin health. This study is designed to measure the efficacy of two different bacteriophage-based treatments for 4 weeks to improve gut and skin health. These treatments are bacteriophage that target specific strains of Escherichia coli and Staphylococcus Aureus.",[108,109],"Gastrointestinal Symptoms","Skin Quality",[111,112,113],"Gut Health","Skin Health","Bacteriophage","2026-10-05",{"date":116,"type":117},"2026-10-08","ACTUAL",{"date":119,"type":102},"2026-09-14",{"date":121,"type":102},"2028-01",{"name":5,"class":6},1]