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1001)","Barcelona","08035",{"type":83,"coordinates":665},[666,667],2.15899,41.38879,{"lat":667,"lon":666},[670],{"name":90,"role":70,"phone":671,"phoneExt":52,"email":52},"+34932746000",{"facility":673,"status":76,"city":674,"state":52,"zip":675,"country":637,"countryCode":638,"cosmosGeoPoint":676,"geoPoint":680,"contacts":681},"Hospital Universitario Gregorio Maranon ( Site 1003)","Madrid","28007",{"type":83,"coordinates":677},[678,679],-3.70256,40.4165,{"lat":679,"lon":678},[682],{"name":90,"role":70,"phone":683,"phoneExt":52,"email":52},"917996984",{"facility":685,"status":76,"city":686,"state":687,"zip":688,"country":689,"countryCode":690,"cosmosGeoPoint":52,"geoPoint":52,"contacts":691},"Faculty of Medicine Siriraj Hospital ( Site 3000)","Bangkoknoi","Bangkok","10700","Thailand","TH",[692],{"name":90,"role":70,"phone":693,"phoneExt":52,"email":52},"+6624194488",{"facility":695,"status":76,"city":696,"state":687,"zip":697,"country":689,"countryCode":690,"cosmosGeoPoint":698,"geoPoint":702,"contacts":703},"Bangkok Metropolitan Administration Medical College and Vajira Hospital ( Site 3002)","Dusit","10300",{"type":83,"coordinates":699},[700,701],100.51958,13.77706,{"lat":701,"lon":700},[704],{"name":90,"role":70,"phone":705,"phoneExt":52,"email":52},"+6622443000",{"facility":707,"status":76,"city":708,"state":709,"zip":710,"country":689,"countryCode":690,"cosmosGeoPoint":711,"geoPoint":715,"contacts":716},"Songklanagarind hospital ( Site 3001)","Hat Yai","Changwat Songkhla","90110",{"type":83,"coordinates":712},[713,714],100.47668,7.00836,{"lat":714,"lon":713},[717],{"name":90,"role":70,"phone":718,"phoneExt":52,"email":52},"+6674451469",{"type":720,"investigatorFullName":52,"investigatorTitle":52,"investigatorAffiliation":52,"oldNameTitle":52,"oldOrganization":52},"SPONSOR",[722],{"name":723,"class":6},"Daiichi Sankyo","100610439","phase-1-a-clinical-study-of-gocatamig-mk-6070-and-infinatamab-deruxtecan-mk-2400-in-people-with-small-cell-lung-cancer-mk-6070-003-100610439",false,"NCT07227597","A Clinical Study of Gocatamig (MK-6070) and Infinatamab Deruxtecan (MK-2400) in People With Small Cell Lung Cancer (MK-6070-003)","A Phase 1b\u002F2 Open-label Study Evaluating Different MK-6070 and Ifinatamab Deruxtecan (MK-2400)-Based Regimens in First-line Extensive Stage Small Cell Lung Cancer","Inclusion Criteria:\n\nThe main inclusion criteria include but are not limited to the following:\n\n* Has a histologically or cytologically confirmed diagnosis of extensive-stage small cell lung cancer (ES-SCLC)\n* For participants receiving gocatamig + ifinatamab deruxtecan (I-DXd) in maintenance only:\n\n  * Completed 3 to 4 cycles of platinum + etoposide chemotherapy with concurrent approved anti-programmed cell death 1\u002FLigand 1 (anti PD-1\u002FL1) as first line (1L) treatment of ES-SCLC within 6 weeks prior to enrollment\n  * No radiological disease progression per Response Evaluation Criteria In Solid Tumors version 1.1 (RECIST 1.1)\n  * No other prior systemic ES-SCLC therapy allowed\n  * Rechallenge therapy counts as an additional line and leads to exclusion\n* For participants receiving gocatamig + I-DXd in induction and maintenance, or gocatamig + I-DXd in induction followed by gocatamig + atezolizumab in maintenance, or carboplatin + etoposide + atezolizumab in induction followed by atezolizumab in maintenance: No prior systemic ES-SCLC treatment allowed\n* Applicable to all participants: prior limited-stage small cell lung cancer (SCLC) is allowed if \\> 6 months have passed since the end of previous therapy and progression\n* Must be able to provide a pretreatment archival tumor tissue sample or newly obtained core, incisional, or excisional biopsy of a tumor lesion not previously irradiated\n* Measurable disease by RECIST 1.1 as assessed by the local site investigator\u002Fradiology. Lesions situated in a previously irradiated area are considered measurable if growth has been shown in such lesions since the completion of radiation\n\nExclusion Criteria:\n\nThe main exclusion criteria include but are not limited to the following:\n\n* Has pleural effusion, pericardial effusion, or ascites requiring recurrent drainage procedures\n* Has any history of interstitial lung disease (ILD)\u002Fpneumonitis irrespective of steroid use, current ILD, ILD that cannot be ruled out by imaging at screening, or suspected ILD\n* Has clinically severe pulmonary compromise resulting from intercurrent pulmonary illnesses\n* Has history of clinically significant intracranial bleeding or spinal cord bleeding\n* Has active neurologic paraneoplastic syndrome\n* Has history of coronary\u002Fperipheral artery bypass graft and\u002For any coronary\u002Fperipheral angioplasty or clinically significant cardiovascular disease such as myocardial infarction, symptomatic congestive heart failure (CHF), and\u002For uncontrolled cardiac arrhythmia within 6 months before the first dose of study intervention\n* Has other uncontrolled or significant protocol specified cardiovascular disease\n* Has history of arterial thrombosis within 6 months before the first dose of study intervention\n* Has chronic liver disease\n* Has history of allogeneic tissue\u002Fsolid organ transplant\n* Has history of leptomeningeal disease\n* Is infected with human immunodeficiency virus (HIV) and has a history of Kaposi's sarcoma and\u002For Multicentric Castleman's Disease\n* Has received prior therapy with an anti-programmed cell death protein 1 (anti-PD-1), anti-programmed cell death ligand 1 (anti-PD-L1), or anti-programmed cell death ligand 2 (anti-PD-L2) agent or with an agent directed to another stimulatory or coinhibitory T-cell receptor\n* Has received prior radiotherapy within 2 weeks of start of study intervention, or has radiation-related toxicities, requiring corticosteroids\n* Has known additional malignancy that is progressing or has required active treatment within the past 3 years\n* Has active autoimmune disease that has required systemic treatment in the past 2 years except replacement therapy\n* Has known active central nervous system (CNS) metastases and\u002For carcinomatous meningitis\n* Has major surgery within 4 weeks or minor surgery within 2 weeks of allocation\u002Frandomization (or first dose), or is anticipated to require a major surgical procedure during the study","ALL","18 Years",{"count":734,"type":735},170,"ESTIMATED","INTERVENTIONAL",[738,739],"PHASE1","PHASE2","Researchers are looking for new ways to treat extensive-stage small cell lung cancer (ES-SCLC). ES-SCLC is a type of lung cancer that has spread throughout the lung, to the other lung, or to other parts of the body.\n\nA standard (usual) treatment for ES-SCLC uses both chemotherapy and immunotherapy.\n\n* Chemotherapy is a treatment that works to destroy cancer cells or stop them from growing.\n* Immunotherapy is a treatment that helps the immune system fight cancer.\n\nGocatamig and I-DXd (short for ifinatamab deruxtecan) are study medicines. Researchers want to know if giving gocatamig and I-DXd together can treat ES-SCLC. Researchers will also look at giving the study medicines with standard treatment. Gocatamig is a T-cell engager therapy. I-DXd is an antibody drug conjugate.\n\n* T-cell engager therapy is a certain type of immunotherapy that uses T-cells to find and destroy cancer cells.\n* A T-cell is a type of white blood cell, which are cells that help the body fight infection.\n* An antibody drug conjugate (ADC) is a treatment that attaches to a protein on cancer cells and delivers treatment to destroy those cells.\n\nThe goals of this study are to learn:\n\n* About the safety of combining gocatamig and I-DXd and if people tolerate them together\n* If people who receive gocatamig and I-DXd have ES-SCLC respond, which means the cancer gets smaller or goes away",[742],"Small Cell Lung Cancer Extensive Stage","2026-08-20",{"date":745,"type":746},"2026-08-21","ACTUAL",{"date":748,"type":746},"2026-01-29",{"date":750,"type":735},"2030-12-30",{"name":5,"class":6},52]