[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100614942":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":60,"centralContacts":64,"locations":70,"responsibleParty":403,"collaborators":405,"id":408,"slug":409,"hasResults":410,"nctId":411,"briefTitle":412,"officialTitle":413,"acronym":32,"eligibilityCriteria":414,"healthyVolunteers":410,"sex":415,"minAge":416,"maxAge":32,"enrollmentInfo":417,"targetDuration":32,"studyType":420,"phases":421,"briefSummary":424,"conditions":425,"keywords":32,"overallStatus":73,"whyStopped":32,"lastUpdateSubmitDate":427,"lastUpdatePostDateStruct":428,"startDateStruct":431,"completionDateStruct":433,"leadSponsor":435,"locationsCount":436},{"fullName":5,"class":6},"Merck Sharp & Dohme LLC","INDUSTRY",[8,16,21],{"label":9,"type":10,"description":11,"interventionNames":12},"MK-1084 + Patritumab deruxtecan (HER3-DXd)","EXPERIMENTAL","Participants will receive MK-1084 and HER3-DXd until discontinuation due to toxicity, adverse event (AE) or at the discretion of an investigator.",[13,14,15],"Drug: MK-1084","Biological: Patritumab deruxtecan","Drug: Rescue Medications",{"label":17,"type":10,"description":18,"interventionNames":19},"MK-1084 + Sacituzumab tirumotecan (Sac-TMT)","Participants will receive MK-1084 and sac-TMT until discontinuation due to toxicity, AE or at the discretion of an investigator.",[13,20,15],"Biological: Sacituzumab tirumotecan",{"label":22,"type":10,"description":23,"interventionNames":24},"MK-1084 + Cetuximab","Participants will receive MK-1084 and cetuximab until discontinuation due to toxicity, AE or at the discretion of an investigator. Per amendment 3, the MK-1084 + Cetuximab arm was discontinued.",[13,25],"Biological: Cetuximab",[27,33,42,50,56],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"DRUG","MK-1084","Oral administration",[22,9,17],null,{"type":34,"name":35,"description":36,"armGroupLabels":37,"otherNames":38},"BIOLOGICAL","Patritumab deruxtecan","IV infusion",[9],[39,40,41],"HER3-DXd","MK-1022","U3-1402",{"type":34,"name":43,"description":44,"armGroupLabels":45,"otherNames":46},"Sacituzumab tirumotecan","IV Infusion",[17],[47,48,49],"Sac-TMT","MK-2870","SKB264",{"type":34,"name":51,"description":44,"armGroupLabels":52,"otherNames":53},"Cetuximab",[22],[54,55],"C225","Erbitux",{"type":28,"name":57,"description":58,"armGroupLabels":59,"otherNames":32},"Rescue Medications","Participants receive rescue medication at the investigator's discretion for prevention of nausea and vomiting, per approved product label. Recommended rescue medications are histamine-1 (H1) receptor antagonist, histamine-2 (H2) receptor antagonist, acetaminophen or equivalent, dexamethasone or equivalent infusion, or steroid mouthwash (dexamethasone or equivalent), 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist, neurokinin 1 (NK-1) receptor antagonist and corticosteroid.",[9,17],[61],{"name":62,"affiliation":5,"role":63},"Medical Director","STUDY_DIRECTOR",[65],{"name":66,"role":67,"phone":68,"phoneExt":32,"email":69},"Toll Free Number","CONTACT","1-888-577-8839","Trialsites@msd.com",[71,89,102,115,123,138,151,163,174,189,198,207,222,237,252,261,269,282,293,304,318,330,342,357,370,380,391],{"facility":72,"status":73,"city":74,"state":75,"zip":76,"country":77,"countryCode":78,"cosmosGeoPoint":79,"geoPoint":84,"contacts":85},"Clermont Oncology Center ( Site 0041)","RECRUITING","Clermont","Florida","34711","United States","US",{"type":80,"coordinates":81},"Point",[82,83],-81.77285,28.54944,{"lat":83,"lon":82},[86],{"name":87,"role":67,"phone":88,"phoneExt":32,"email":32},"Study Coordinator","386-538-3169",{"facility":90,"status":73,"city":91,"state":92,"zip":93,"country":77,"countryCode":78,"cosmosGeoPoint":94,"geoPoint":98,"contacts":99},"University of Illinois Hospital & Health Sciences System ( Site 0044)","Chicago","Illinois","60612",{"type":80,"coordinates":95},[96,97],-87.65005,41.85003,{"lat":97,"lon":96},[100],{"name":87,"role":67,"phone":101,"phoneExt":32,"email":32},"312-996-9272",{"facility":103,"status":73,"city":104,"state":105,"zip":106,"country":77,"countryCode":78,"cosmosGeoPoint":107,"geoPoint":111,"contacts":112},"Providence Portland Medical Center ( Site 0043)","Portland","Oregon","97213",{"type":80,"coordinates":108},[109,110],-122.67621,45.52345,{"lat":110,"lon":109},[113],{"name":87,"role":67,"phone":114,"phoneExt":32,"email":32},"503-215-1979",{"facility":116,"status":73,"city":104,"state":105,"zip":117,"country":77,"countryCode":78,"cosmosGeoPoint":118,"geoPoint":120,"contacts":121},"Providence Oncology and Hematology Care Clinic - 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Korea",{"type":80,"coordinates":363},[364,365],126.9784,37.566,{"lat":365,"lon":364},[368],{"name":87,"role":67,"phone":369,"phoneExt":32,"email":32},"+82222280880",{"facility":371,"status":73,"city":372,"state":373,"zip":374,"country":375,"countryCode":376,"cosmosGeoPoint":32,"geoPoint":32,"contacts":377},"Institut Català d'Oncologia - L'Hospitalet ( Site 0090)","Hospitalet","Barcelona","08908","Spain","ES",[378],{"name":87,"role":67,"phone":379,"phoneExt":32,"email":32},"0034932607744",{"facility":381,"status":73,"city":373,"state":32,"zip":382,"country":375,"countryCode":376,"cosmosGeoPoint":383,"geoPoint":387,"contacts":388},"Hospital Clinic de Barcelona ( Site 0092)","08036",{"type":80,"coordinates":384},[385,386],2.15899,41.38879,{"lat":386,"lon":385},[389],{"name":87,"role":67,"phone":390,"phoneExt":32,"email":32},"34 932275402",{"facility":392,"status":73,"city":393,"state":32,"zip":394,"country":375,"countryCode":376,"cosmosGeoPoint":395,"geoPoint":399,"contacts":400},"Hospital Universitario Virgen Macarena ( Site 0093)","Seville","41009",{"type":80,"coordinates":396},[397,398],-5.97317,37.38283,{"lat":398,"lon":397},[401],{"name":87,"role":67,"phone":402,"phoneExt":32,"email":32},"+34 671560092",{"type":404,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR",[406],{"name":407,"class":6},"Daiichi Sankyo","100614942","phase-1-a-clinical-study-of-mk-1084-with-other-treatments-for-non-small-cell-lung-cancer-mk-3475-01f-100614942",false,"NCT07286149","A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer (MK-3475-01F)","KEYMAKER-U01 Substudy 01F: A Phase 1b\u002F2 Umbrella Study With Rolling Arms of Investigational Agents for Previously Treated Participants With Advanced or Metastatic Nonsquamous Non-small Cell Lung Cancer (NSCLC) With KRAS G12C Mutations","Inclusion Criteria:\n\nThe main inclusion criteria include but are not limited to the following:\n\n* Has histologically or cytologically confirmed diagnosis of advanced or metastatic non-squamous non-small cell lung cancer (NSCLC)\n* Has tumor tissue or circulating tumor deoxyribonucleic acid (ctDNA) that demonstrates the presence of Kirsten rat sarcoma viral oncogene (KRAS) mutation of glycine to cysteine at codon 12 (G12C) mutations\n* Has documented disease progression after receiving 1-2 prior lines of programmed cell death protein 1 (PD-1)\u002Fprogrammed death-ligand 1 (PD-L1) therapy and platinum-based chemotherapy\n* Has provided tumor tissue for biomarker analysis from an archival sample or a newly obtained core or excisional biopsy of a tumor lesion not previously irradiated\n* Participants with human immunodeficiency virus (HIV) infection must have well-controlled HIV on antiretroviral therapy (ART) per protocol\n\nExclusion Criteria:\n\nThe main exclusion criteria include but are not limited to the following:\n\n* Has a diagnosis of small cell lung cancer or, for mixed tumors, presence of small cell elements\n* Has clinically severe pulmonary compromise resulting from intercurrent pulmonary illnesses\n* Has known active central nervous system (CNS) metastases and\u002For carcinomatous meningitis\n* Has active inflammatory bowel disease requiring immunosuppressive medication or previous history of inflammatory bowel disease\n* Has evidence of any leptomeningeal disease\n* Has uncontrolled or significant cardiovascular disorder or cerebrovascular disease prior to allocation\u002Frandomization\n* Has one or more of the following ophthalmological conditions: a) Clinically significant corneal disease b) history of documented severe dry eye syndrome, severe Meibomian gland disease and\u002For blepharitis\n* HIV-infected participants with a history of Kaposi's sarcoma and\u002For Multicentric Castleman's Disease\n* Has received a live or live-attenuated vaccine within 30 days before the first dose of study intervention\n* Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior to the first dose of study intervention\n* Has known additional malignancy that is progressing or has required active treatment within the past 3 years\n* Has any history of interstitial lung disease (ILD)\u002Fpneumonitis irrespective of steroid use or current ILD, or suspected ILD\n* Has an active infection requiring systemic therapy\n* Has not adequately recovered from major surgery or has ongoing surgical complications","ALL","18 Years",{"count":418,"type":419},140,"ESTIMATED","INTERVENTIONAL",[422,423],"PHASE1","PHASE2","Researchers want to learn if MK-1084, the study medicine, can treat advanced or metastatic non-squamous NSCLC. MK-1084 is a targeted therapy, which is a treatment that works to control how specific types of cancer cells grow and spread. The goals of this study are to learn:\n\n* About the safety of MK-1084 and if people tolerate it when taken with other treatments\n* How many people have the cancer respond (get smaller or go away) to the treatments",[426],"Lung Neoplasm Malignant","2026-08-04",{"date":429,"type":430},"2026-08-06","ACTUAL",{"date":432,"type":430},"2026-04-30",{"date":434,"type":419},"2032-04-13",{"name":5,"class":6},27]