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A documented diagnosis of B-cell Non- Hodgkin Lymphoma (NHL) per 2016 World Health Organization criteria and disease requiring treatment:\n\n   1. Follicular lymphoma (FL), Grades 1 through 3B\n   2. Marginal zone lymphoma (MZL)\n   3. Mantle cell lymphoma (MCL)\n   4. Diffuse large B-cell lymphoma (DLBCL)\n   5. Other B-cell NHL\n2. Measurable disease.\n3. Received at least 2 prior lines of systemic therapies and not eligible to receive additional standard of care therapies.\n4. An Eastern Cooperative Oncology Group Performance Status (ECOG PS) ≤ 2 at screening.\n5. Adequate organ function within 3 days of the first dose of study intervention.\n6. A negative blood pregnancy test within 7 days prior to first dose of study intervention (for women of childbearing potential).\n\nExclusion Criteria:\n\n1. Receiving an investigational product or participating in any other type of medical research judged not to be compatible with this study.\n2. Grade \\> 1 neuropathy\n3. History of interstitial lung disease (ILD)\u002Fpneumonitis requiring treatment or any evidence of active ILD\u002Fpneumonitis.\n4. Use of:\n\n   1. Chemotherapy, radiotherapy, small molecule, investigational, and biologic agents (including CD79b-directed agents) within 28 days (or at least 5 half-lives, whichever is shorter), prior to the first dose of the study intervention.\n   2. Any live or live-attenuated vaccine within 28 days before the first dose of the study intervention.\n5. Ongoing clinically relevant toxicity from prior anticancer therapy that has not resolved to Grade ≤ 2 (neutropenia) or Grade ≤ 1 (thrombocytopenia or nonhematologic toxicities), with the exception of alopecia.","ALL","18 Years",{"count":336,"type":337},140,"ESTIMATED","INTERVENTIONAL",[340],"PHASE1","This study is to assess safety, tolerability, pharmacokinetics (PK), pharmacodynamic (PD), and preliminary efficacy of ARC-02.",[343],"B-cell Non Hodgkin Lymphoma",[345,346,347,348,349,350,351,352,353,354,355,356,357,358,359,360,361,30],"Non-Hodgkin's Lymphomas","Diffuse Large B-Cell Lymphoma","Mantle Cell Lymphoma","Follicular Lymphoma","Marginal Zone Lymphoma","Waldenstroms Macroglobulinemia","Germinal Center B-cell","Activated B-Cell","NHL","DLBCL","MCL","FL","MZL","WM","GCB","ABC","Cancer","2026-07-27",{"date":364,"type":365},"2026-07-28","ACTUAL",{"date":367,"type":365},"2026-06-22",{"date":369,"type":337},"2030-12",{"name":5,"class":6},29]