[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100610343":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":42,"centralContacts":46,"locations":51,"responsibleParty":270,"collaborators":34,"id":272,"slug":273,"hasResults":274,"nctId":275,"briefTitle":276,"officialTitle":277,"acronym":34,"eligibilityCriteria":278,"healthyVolunteers":274,"sex":279,"minAge":280,"maxAge":34,"enrollmentInfo":281,"targetDuration":34,"studyType":284,"phases":285,"briefSummary":287,"conditions":288,"keywords":290,"overallStatus":54,"whyStopped":34,"lastUpdateSubmitDate":295,"lastUpdatePostDateStruct":296,"startDateStruct":299,"completionDateStruct":301,"leadSponsor":303,"locationsCount":304},{"fullName":5,"class":6},"BeOne Medicines","INDUSTRY",[8,14,20,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Phase 1a, Part A: Dose Escalation, BG-75098 Monotherapy","EXPERIMENTAL","Sequential cohorts of increasing dose levels of BG-75098 will be evaluated as monotherapy.",[13],"Drug: BG-75098",{"label":15,"type":10,"description":16,"interventionNames":17},"Phase 1a, Part B: Dose Escalation, BG-75098 Combination","Sequential cohorts of increasing dose levels of BG-75098 will be evaluated in combination with BGB-43395 and fulvestrant.",[13,18,19],"Drug: BGB-43395","Drug: Fulvestrant",{"label":21,"type":10,"description":22,"interventionNames":23},"Phase 1b, Cohort 1: Dose Expansion, BG-75098 Combination","Participants will receive BG-75098 at the recommended dose level from Phase 1a in combination with BGB-43395 and fulvestrant.",[13,18,19],{"label":25,"type":10,"description":26,"interventionNames":27},"Phase 1b, Cohort 2: Dose Expansion, BG-75098 Monotherapy","Participants will receive BG-75098 as monotherapy at the recommended dose level from Phase 1a.",[13],[29,35,38],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"DRUG","BG-75098","Administered orally.",[9,15,21,25],null,{"type":30,"name":36,"description":32,"armGroupLabels":37,"otherNames":34},"BGB-43395",[15,21],{"type":30,"name":39,"description":40,"armGroupLabels":41,"otherNames":34},"Fulvestrant","Administered by intramuscular injection.",[15,21],[43],{"name":44,"affiliation":5,"role":45},"Study Director","STUDY_DIRECTOR",[47],{"name":44,"role":48,"phone":49,"phoneExt":34,"email":50},"CONTACT","8778285568","clinicaltrials@beonemed.com",[52,66,76,86,96,106,112,122,134,143,153,163,172,182,194,204,214,224,230,240,250,259],{"facility":53,"status":54,"city":55,"state":56,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":34},"University of Alabama At Birmingham Hospital","RECRUITING","Birmingham","Alabama","35294-0004","United States","US",{"type":61,"coordinates":62},"Point",[63,64],-86.80249,33.52066,{"lat":64,"lon":63},{"facility":67,"status":54,"city":68,"state":69,"zip":70,"country":58,"countryCode":59,"cosmosGeoPoint":71,"geoPoint":75,"contacts":34},"Yale Cancer Center","New Haven","Connecticut","06510",{"type":61,"coordinates":72},[73,74],-72.92816,41.30815,{"lat":74,"lon":73},{"facility":77,"status":54,"city":78,"state":79,"zip":80,"country":58,"countryCode":59,"cosmosGeoPoint":81,"geoPoint":85,"contacts":34},"Sidney Kimmel Comprehensive Cancer At Johns Hopkins","Baltimore","Maryland","21287",{"type":61,"coordinates":82},[83,84],-76.61219,39.29038,{"lat":84,"lon":83},{"facility":87,"status":54,"city":88,"state":89,"zip":90,"country":58,"countryCode":59,"cosmosGeoPoint":91,"geoPoint":95,"contacts":34},"Massachusetts General Hospital","Boston","Massachusetts","02114",{"type":61,"coordinates":92},[93,94],-71.05977,42.35843,{"lat":94,"lon":93},{"facility":97,"status":54,"city":98,"state":99,"zip":100,"country":58,"countryCode":59,"cosmosGeoPoint":101,"geoPoint":105,"contacts":34},"The University of Texas Md Anderson Cancer Center","Houston","Texas","77030-4009",{"type":61,"coordinates":102},[103,104],-95.36327,29.76328,{"lat":104,"lon":103},{"facility":107,"status":54,"city":98,"state":99,"zip":108,"country":58,"countryCode":59,"cosmosGeoPoint":109,"geoPoint":111,"contacts":34},"Next Houston","77054",{"type":61,"coordinates":110},[103,104],{"lat":104,"lon":103},{"facility":113,"status":54,"city":114,"state":115,"zip":116,"country":58,"countryCode":59,"cosmosGeoPoint":117,"geoPoint":121,"contacts":34},"Medical College of Wisconsin","Milwaukee","Wisconsin","53226-3522",{"type":61,"coordinates":118},[119,120],-87.90647,43.0389,{"lat":120,"lon":119},{"facility":123,"status":54,"city":124,"state":125,"zip":126,"country":127,"countryCode":128,"cosmosGeoPoint":129,"geoPoint":133,"contacts":34},"Blacktown Cancer and Haematology Centre","Blacktown","New South Wales","NSW 2148","Australia","AU",{"type":61,"coordinates":130},[131,132],150.91667,-33.76667,{"lat":132,"lon":131},{"facility":135,"status":54,"city":136,"state":125,"zip":137,"country":127,"countryCode":128,"cosmosGeoPoint":138,"geoPoint":142,"contacts":34},"Genesiscare St Leonards","St Leonards","NSW 2065",{"type":61,"coordinates":139},[140,141],151.19836,-33.82344,{"lat":141,"lon":140},{"facility":144,"status":54,"city":145,"state":146,"zip":147,"country":127,"countryCode":128,"cosmosGeoPoint":148,"geoPoint":152,"contacts":34},"Icon Cancer Centre Wesley","Auchenflower","Queensland","QLD 4066",{"type":61,"coordinates":149},[150,151],152.99213,-27.47443,{"lat":151,"lon":150},{"facility":154,"status":54,"city":155,"state":156,"zip":157,"country":127,"countryCode":128,"cosmosGeoPoint":158,"geoPoint":162,"contacts":34},"Cabrini Hospital Malvern","Malvern","Victoria","VIC 3144",{"type":61,"coordinates":159},[160,161],145.02811,-37.86259,{"lat":161,"lon":160},{"facility":164,"status":54,"city":165,"state":156,"zip":166,"country":127,"countryCode":128,"cosmosGeoPoint":167,"geoPoint":171,"contacts":34},"Peter Maccallum Cancer Centre","Melbourne","VIC 3000",{"type":61,"coordinates":168},[169,170],144.96332,-37.814,{"lat":170,"lon":169},{"facility":173,"status":54,"city":174,"state":175,"zip":176,"country":127,"countryCode":128,"cosmosGeoPoint":177,"geoPoint":181,"contacts":34},"One Clinical Research","Nedlands","Western Australia","WA 6009",{"type":61,"coordinates":178},[179,180],115.8073,-31.98184,{"lat":180,"lon":179},{"facility":183,"status":54,"city":184,"state":185,"zip":186,"country":187,"countryCode":188,"cosmosGeoPoint":189,"geoPoint":193,"contacts":34},"Cancer Hospital Chinese Academy of Medical Sciences","Beijing","Beijing Municipality","100021","China","CN",{"type":61,"coordinates":190},[191,192],116.39723,39.9075,{"lat":192,"lon":191},{"facility":195,"status":54,"city":196,"state":197,"zip":198,"country":187,"countryCode":188,"cosmosGeoPoint":199,"geoPoint":203,"contacts":34},"Sun Yat Sen Memorial Hospital, Sun Yat Sen University (South)","Guangzhou","Guangdong","510245",{"type":61,"coordinates":200},[201,202],113.25,23.11667,{"lat":202,"lon":201},{"facility":205,"status":54,"city":206,"state":207,"zip":208,"country":187,"countryCode":188,"cosmosGeoPoint":209,"geoPoint":213,"contacts":34},"Harbin Medical University Cancer Hospital","Harbin","Heilongjiang","150000",{"type":61,"coordinates":210},[211,212],126.65,45.75,{"lat":212,"lon":211},{"facility":215,"status":54,"city":216,"state":217,"zip":218,"country":187,"countryCode":188,"cosmosGeoPoint":219,"geoPoint":223,"contacts":34},"Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology","Wuhan","Hubei","430030",{"type":61,"coordinates":220},[221,222],114.26667,30.58333,{"lat":222,"lon":221},{"facility":225,"status":54,"city":216,"state":217,"zip":226,"country":187,"countryCode":188,"cosmosGeoPoint":227,"geoPoint":229,"contacts":34},"Union Hospital Tongji Medical College Huazhong University of Science and Technologyjinyinhu Branch","430048",{"type":61,"coordinates":228},[221,222],{"lat":222,"lon":221},{"facility":231,"status":54,"city":232,"state":233,"zip":234,"country":187,"countryCode":188,"cosmosGeoPoint":235,"geoPoint":239,"contacts":34},"Jiangsu Province Hospital Longjiang Branch","Nanjing","Jiangsu","210036",{"type":61,"coordinates":236},[237,238],118.77778,32.06167,{"lat":238,"lon":237},{"facility":241,"status":54,"city":242,"state":243,"zip":244,"country":187,"countryCode":188,"cosmosGeoPoint":245,"geoPoint":249,"contacts":34},"Qilu Hospital of Shandong University","Jinan","Shandong","250000",{"type":61,"coordinates":246},[247,248],116.99722,36.66833,{"lat":248,"lon":247},{"facility":251,"status":54,"city":252,"state":243,"zip":253,"country":187,"countryCode":188,"cosmosGeoPoint":254,"geoPoint":258,"contacts":34},"Weifang Peoples Hospital","Weifang","261000",{"type":61,"coordinates":255},[256,257],119.10194,36.71,{"lat":257,"lon":256},{"facility":260,"status":54,"city":261,"state":34,"zip":262,"country":263,"countryCode":264,"cosmosGeoPoint":265,"geoPoint":269,"contacts":34},"Rigshospitalet","Copenhagen","2100","Denmark","DK",{"type":61,"coordinates":266},[267,268],12.56553,55.67594,{"lat":268,"lon":267},{"type":271,"investigatorFullName":34,"investigatorTitle":34,"investigatorAffiliation":34,"oldNameTitle":34,"oldOrganization":34},"SPONSOR","100610343","phase-1-a-study-of-bg-75098-alone-and-in-combination-with-other-agents-in-adults-with-advanced-solid-tumors-100610343",false,"NCT07226349","A Study of BG-75098 Alone and in Combination With Other Agents in Adults With Advanced Solid Tumors","A Phase 1a\u002F1b, Open-Label Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of BG-75098 Alone and in Combination With Other Agents in Patients With Advanced Solid Tumors","Inclusion Criteria:\n\n* Participants must have measurable disease as assessed by RECIST v1.1.\n* Participants must have a stable Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1.\n* Participants must have adequate organ function.\n* Dose Escalation Part A: Participants with histologically or cytologically confirmed advanced, metastatic, or unresectable solid tumors potentially associated with cyclin-dependent kinase 2 (CDK2) dependency. Participants should have received prior treatment with available standard-of-care (SOC) systemic therapies for advanced\u002Fmetastatic disease, or for whom standard therapy is not available or not tolerated.\n* Dose Escalation Part B: Patients with histologically or cytologically confirmed advanced, metastatic, or unresectable solid tumors who have received ≥ 1 prior line of systemic therapy in the metastatic setting.\n* Dose Expansion Cohort 1: Participants with histologically or cytologically confirmed advanced, metastatic, or unresectable CDK4\u002F6 inhibitor-progressed solid tumors.\n* Dose Expansion Cohort 2: Participants with advanced solid tumors. Participants with primary platinum refractory disease are not eligible. Participants should have received ≥ 1 line of platinum-containing chemotherapy and ≤ 4 prior therapeutic regimens in the advanced\u002Fmetastatic setting.\n\nExclusion Criteria:\n\n* For all cohorts: Prior therapy selectively targeting CDK2 inhibition or degradation.\n* For combination cohorts: Prior therapy selectively targeting CDK4. Prior CDK4\u002F6 inhibitor standard of care therapy is permitted and required in local regions where it is approved and available.\n* Participants with active leptomeningeal disease or uncontrolled, untreated brain metastasis.\n\nNOTE: Other protocol defined Inclusion\u002FExclusion criteria may apply.","ALL","18 Years",{"count":282,"type":283},105,"ESTIMATED","INTERVENTIONAL",[286],"PHASE1","The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of BG-75098 alone and in combination with BGB-43395 and fulvestrant in participants with advanced solid tumors.",[289],"Advanced Solid Tumor",[291,292,293,294],"Cyclin-Dependent Kinase 2- Targeted Protein Degrader","CDK2","CDK4","CDK4 inhibitor","2026-08-18",{"date":297,"type":298},"2026-08-19","ACTUAL",{"date":300,"type":298},"2025-12-11",{"date":302,"type":283},"2028-11-01",{"name":5,"class":6},22]