[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100591693":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":39,"centralContacts":43,"locations":51,"responsibleParty":133,"collaborators":135,"id":138,"slug":139,"hasResults":140,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":140,"sex":146,"minAge":147,"maxAge":148,"enrollmentInfo":149,"targetDuration":25,"studyType":152,"phases":153,"briefSummary":155,"conditions":156,"keywords":158,"overallStatus":54,"whyStopped":25,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":179},{"fullName":5,"class":6},"Erasca, Inc.","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"ERAS-0015 Monotherapy Dose Optimization.","EXPERIMENTAL","Escalating doses of ERAS-0015 administered orally.",[13],"Drug: 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Patients With Advanced or Metastatic Solid Tumors","A Phase 1 First-in-Human Open-Label Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of ERAS-0015 Monotherapy and in Combination in Patients Advanced Solid Tumors","AURORAS-1","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Willing and able to give written informed consent\n* Pathological documentation of tumor type and mutation prior to the first dose of study drug(s), for applicable cohorts.\n* There is no available standard systemic therapy available for the patient's tumor histology and\u002For molecular biomarker profile; or standard therapy is intolerable, not effective, or not accessible; or patient has refused standard therapy. Does not apply to newly diagnosed Pancreatic Ductal Carcinoma (PDAC) cohort.\n* Able to swallow oral medication\n* Have Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0 or 1\n* Adequate cardiovascular, hematological, liver, and renal function\n* Willing to comply with all protocol-required visits, assessments, and procedures\n\nExclusion Criteria:\n\n* Previous treatment with a RAS inhibitor\n* Is currently receiving another study therapy or has participated in a study of an investigational agent and received study therapy within 4 weeks of the first dose of ERAS-0015\n* Received prior palliative radiation within 14 days of Cycle 1, Day 1\n* Have primary central nervous system (CNS) tumors\n* Prior surgery (e.g., gastric bypass surgery, gastrectomy) or gastrointestinal dysfunction (e.g., Crohn's disease, ulcerative colitis, short gut syndrome) that may affect drug absorption\n* Have any underlying medical condition, psychiatric condition, or social situation that, in the opinion of the Investigator, would compromise study administration as per protocol or compromise the assessment of AEs\n* Are pregnant or breastfeeding or expecting to conceive or father children within the projected duration of the trial","ALL","18 Years","99 Years",{"count":150,"type":151},600,"ESTIMATED","INTERVENTIONAL",[154],"PHASE1","The main purpose of the study is to assess whether the study drug, ERAS-0015, is safe and tolerable when administered to patients with advanced or metastatic solid tumors with certain RAS mutations. ERAS-0015 will be given alone or in combination with other treatments.",[157],"Metastatic Solid Tumors",[159,160,161,162,163,31,32,33,34,164,165,166,167,168,169],"Solid Tumor","Advanced Solid Tumor","solid malignancies","Targeted therapy","Molecular alterations","Metastatic Solid Tumor","Neoplasms","Colorectal Cancer","Non-small cell lung cancer (NSCLC)","Newly diagnosed Pancreatic Ductal Adenocarcinoma","NSCLC patients previously treated with a KRAS G12c inhibitor","2026-07-29",{"date":172,"type":173},"2026-07-31","ACTUAL",{"date":175,"type":173},"2025-06-05",{"date":177,"type":151},"2028-12-01",{"name":5,"class":6},8]