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Left ventricular ejection fraction (LVEF) \\\u003C50%.\n* Has severe, uncontrolled or active CV disorders, serious or poorly controlled hypertension, clinically significant bleeding symptoms or serious arteriovenous thromboembolic events\n* Participants with evidence of current ILD\u002Fnon-infectious pneumonitis OR a prior history of ILD\u002Fnon-infectious pneumonitis requiring high-dose glucocorticoids OR suspected ILD\u002Fnon-infectious pneumonitis that cannot be ruled out by imaging.\n* Has a history of autoimmune disease that has required systemic treatments in the 2 years prior to screening. Participants with prior history of autoimmune disease must be discussed with the medical monitor. Replacement therapy is not considered a form of systemic therapy (e.g., thyroid hormone for autoimmune thyroiditis or insulin is not exclusionary).\n* Has any history of prior allogenic or autologous bone marrow transplant or other solid organ transplant.\n* Has received prior anticancer therapy within 28 days of the first dose of study intervention or having to continue these medications during the study.","ALL","18 Years",{"count":1048,"type":1049},845,"ESTIMATED","INTERVENTIONAL",[1052],"PHASE1","The goal of this study is to assess the safety, tolerability, clinical activity and pharmacokinetics of Risvutatug rezetecan (Ris-Rez), also known as GSK5764227. The study will also see how the levels of Ris-Rez will change over time at different dose amounts when administered alone and in combination with other medicines like carboplatin, cisplatin, atezolizumab, pembrolizumab, durvalumab, bevacizumab, cetuximab, tarlatamab, dostarlimab",[1055],"Neoplasms",[1057,1058,1055,1059,1060,112],"Solid Tumors","GSK5764227","EMBOLD PanTumor-101","Risvutatug rezetecan","2026-05-20",{"date":1063,"type":1064},"2026-05-22","ACTUAL",{"date":1066,"type":1064},"2024-09-30",{"date":1068,"type":1049},"2029-06-08",{"name":5,"class":6},67]