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8777",{"type":65,"coordinates":230},[231,232],138.38333,34.98333,{"lat":232,"lon":231},{"facility":235,"status":58,"city":236,"state":31,"zip":237,"country":209,"countryCode":210,"cosmosGeoPoint":238,"geoPoint":242,"contacts":31},"Tokyo Medical University Hospital","Tokyo","160-0023",{"type":65,"coordinates":239},[240,241],139.69171,35.6895,{"lat":241,"lon":240},{"type":244,"investigatorFullName":31,"investigatorTitle":31,"investigatorAffiliation":31,"oldNameTitle":31,"oldOrganization":31},"SPONSOR","100609794","phase-1-a-study-of-jnj-90301900-in-combination-with-chemoradiation-therapy-in-participants-with-locally-advanced-head-and-neck-squamous-cell-carcinoma-100609794",false,"NCT07219212","A Study of JNJ-90301900 in Combination With Chemoradiation Therapy in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma","A Study of JNJ-90301900 in Combination With Concurrent Chemoradiation Therapy in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma","LUMIRAY","Inclusion criteria:\n\n* Pathologically (histologically or cytologically) proven diagnosis of HNSCC of the oral cavity, oropharynx (p16 negative), hypopharynx, or supraglottic larynx\n* Stage III, IVA or IVB according to the 8th Edition of the American Joint Committee on Cancer (AJCC) guidelines\n* A candidate for definitive concurrent chemoradiation therapy treatment as determined by investigator and per local guidelines\n* Participants must have at least 1 target lesion (primary tumor or involved lymph node) per RECIST v.1.1\n* Eastern Cooperative Oncology Group Performance Status (ECOG PS) 0 or 1\n\nExclusion criteria:\n\n* Primary tumor originating in the nasopharynx, paranasal sinuses, salivary glands, thyroid gland, parathyroid gland, skin, or unknown primary site\n* Non-squamous histology\n* Stages 0, I, II, and IVC HNSCC, loco-regionally recurrent HNSCC, or synchronous second primary HNSCC (within 2 months)\n* Ineligible to receive platinum-based chemotherapy\n* Suspected or known allergies, hypersensitivity, or intolerance to JNJ-90301900 or its excipients","ALL","18 Years","74 Years",{"count":257,"type":258},45,"ESTIMATED","INTERVENTIONAL",[261],"PHASE1","This global, open-label, single arm, phase 1b study aims to learn more about whether a treatment called JNJ-90301900 is safe and effective when injected directly into tumors, along with standard chemotherapy and radiation therapy, for participants with head and neck squamous cell cancer (HNSCC; a type of solid tumor that begins in outer tissue layer of the mouth \\& throat).",[264],"Squamous Cell Carcinoma of Head and Neck","2026-07-30",{"date":267,"type":268},"2026-07-31","ACTUAL",{"date":270,"type":268},"2026-01-26",{"date":272,"type":258},"2028-07-14",{"name":5,"class":6},19]