[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636924":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":35,"centralContacts":39,"locations":45,"responsibleParty":132,"collaborators":26,"id":134,"slug":135,"hasResults":136,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":26,"eligibilityCriteria":140,"healthyVolunteers":136,"sex":141,"minAge":142,"maxAge":26,"enrollmentInfo":143,"targetDuration":26,"studyType":146,"phases":147,"briefSummary":149,"conditions":150,"keywords":26,"overallStatus":48,"whyStopped":26,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":161},{"fullName":5,"class":6},"Janssen Research & Development, LLC","INDUSTRY",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm A: R\u002FR Acute Myeloid Leukemia (AML)\u002F High-Risk Myelodysplastic Syndrome (HR MDS)","EXPERIMENTAL","Participants with relapsed\u002Frefractory (R\u002FR) AML\u002FHR-MDS will receive JNJ-95804306 monotherapy (Arm A1) or as an addition to standard of care (SoC) therapy in AML (Arm A2) to determine the putative recommended phase 2 dose (RP2D) in Part 1 (Dose escalation) of the study. In Part 2 (Dose expansion) participants will receive JNJ-95804306 monotherapy (Arm A1) or as an addition to SoC therapy in AML (Arm A2) at the determined RP2D regimen(s). For US sites: Participants with R\u002FR AML\u002FHR-MDS will receive JNJ-95804306 monotherapy to determine the putative RP2D in Part 1 (Dose escalation) of the study. In Part 2 (Dose expansion) participants will receive JNJ-95804306 monotherapy at the determined RP2D regimen(s). AML SoC will not be administered for US sites.",[13,14],"Drug: JNJ-95804306","Drug: AML SoC",{"label":16,"type":10,"description":17,"interventionNames":18},"Arm B: R\u002FR Chronic Lymphocytic Leukemia (CLL)\u002F Small Lymphocytic Lymphoma (SLL) or NHL monotherapy","Participants with R\u002FR CLL\u002FSLL\u002FNHL will receive JNJ-95804306 monotherapy (Arm B1) or as an addition to SoC therapy in R\u002FR CLL\u002FSLL (Arm B2 or B3) to determine the putative RP2D in Part 1 (Dose escalation) of the study. In Part 2 (Dose expansion) participants will receive JNJ-95804306 monotherapy (Arm B1) or as an addition to SoC therapy in R\u002FR CLL\u002FSLL (Arm B2 or B3) at the determined RP2D regimen(s). For US sites: Participants with R\u002FR CLL\u002FSLL\u002FNHL will receive JNJ-95804306 monotherapy to determine the putative RP2D in Part 1 (Dose escalation) of the study. In Part 2 (Dose expansion) participants will receive JNJ-95804306 monotherapy at the determined RP2D regimen(s). CLL\u002FSLL\u002FNHL SoC will not be administered for US sites.",[13,19],"Drug: CLL\u002FSLL SoC",[21,27,31],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","JNJ-95804306","JNJ-95804306 will be administered orally.",[9,16],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"AML SoC","AML SoC will be administered subcutaneously\u002Fintravenously.",[9],{"type":22,"name":32,"description":33,"armGroupLabels":34,"otherNames":26},"CLL\u002FSLL SoC","CLL\u002FSLL SoC will be administered orally\u002F intravenously.",[16],[36],{"name":37,"affiliation":5,"role":38},"Janssen Research & Development, LLC Clinical Trial","STUDY_DIRECTOR",[40],{"name":41,"role":42,"phone":43,"phoneExt":26,"email":44},"Study Contact","CONTACT","844-434-4210","Participate-In-This-Study1@its.jnj.com",[46,60,70,80,89,99,110,121],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":26},"Indiana Blood & Marrow Transplantation","RECRUITING","Indianapolis","Indiana","46237","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-86.15804,39.76838,{"lat":58,"lon":57},{"facility":61,"status":48,"city":62,"state":63,"zip":64,"country":52,"countryCode":53,"cosmosGeoPoint":65,"geoPoint":69,"contacts":26},"Start Midwest","Grand Rapids","Michigan","49546",{"type":55,"coordinates":66},[67,68],-85.66809,42.96336,{"lat":68,"lon":67},{"facility":71,"status":48,"city":72,"state":73,"zip":74,"country":52,"countryCode":53,"cosmosGeoPoint":75,"geoPoint":79,"contacts":26},"Rutgers Cancer Institute of New Jersey","Piscataway","New Jersey","08854",{"type":55,"coordinates":76},[77,78],-74.39904,40.49927,{"lat":78,"lon":77},{"facility":81,"status":48,"city":82,"state":82,"zip":83,"country":52,"countryCode":53,"cosmosGeoPoint":84,"geoPoint":88,"contacts":26},"NYU Langone Health","New York","10016",{"type":55,"coordinates":85},[86,87],-74.00597,40.71427,{"lat":87,"lon":86},{"facility":90,"status":48,"city":91,"state":92,"zip":93,"country":52,"countryCode":53,"cosmosGeoPoint":94,"geoPoint":98,"contacts":26},"Sarah Cannon Cancer Institute","Nashville","Tennessee","37203",{"type":55,"coordinates":95},[96,97],-86.78444,36.16589,{"lat":97,"lon":96},{"facility":100,"status":48,"city":101,"state":26,"zip":102,"country":103,"countryCode":104,"cosmosGeoPoint":105,"geoPoint":109,"contacts":26},"Peter MacCallum Cancer Centre","Melbourne","3000","Australia","AU",{"type":55,"coordinates":106},[107,108],144.96332,-37.814,{"lat":108,"lon":107},{"facility":111,"status":48,"city":112,"state":26,"zip":113,"country":114,"countryCode":115,"cosmosGeoPoint":116,"geoPoint":120,"contacts":26},"UZ Antwerpen","Edegem","2650","Belgium","BE",{"type":55,"coordinates":117},[118,119],4.44504,51.15662,{"lat":119,"lon":118},{"facility":122,"status":48,"city":123,"state":26,"zip":124,"country":125,"countryCode":126,"cosmosGeoPoint":127,"geoPoint":131,"contacts":26},"The Christie Nhs Foundation Trust","Manchester","M20 4BX","United Kingdom","UK",{"type":55,"coordinates":128},[129,130],-2.23743,53.48095,{"lat":130,"lon":129},{"type":133,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100636924","phase-1-a-study-of-jnj-95804306-for-relapsed-or-refractory-hematological-malignancies-100636924",false,"NCT07572006","A Study of JNJ-95804306 for Relapsed or Refractory Hematological Malignancies","A Phase 1, First-in-human, Dose Escalation Study of JNJ-95804306 for Relapsed or Refractory Hematological Malignancies","Inclusion criteria:\n\nFor Arm A:\n\n* Have a diagnosis of: Acute myeloid leukemia (AML) per International Consensus Classification (ICC) 2022 or myelodysplastic syndromes (MDS) per world health organization (WHO) 2022 classified as moderate high, high, or very high-risk per the molecular international prognostic scoring system (IPSSM). All participants must have relapsed or refractory disease and have exhausted or are ineligible for standard therapeutic options\n* Body weight greater than or equal to (\\>=) 40 kilograms (kg)\n* Eastern cooperative oncology group (ECOG) performance status of 0 to 2\n\nFor Arm B:\n\n* All participants must have relapsed or refractory disease with no other approved therapies available that would be more appropriate in the investigator's judgement. Have a diagnosis of either: Chronic lymphocytic leukemia (CLL)\u002FSmall lymphocytic lymphoma (SLL) meeting 2018 International workshop on chronic lymphocytic leukemia (iwCLL) National cancer institute (NCI) working group guidelines (Hallek 2018) that meet the following criteria:\n\n  a. Participants must have received at least 2 prior lines of therapy; b. Have clinically measurable disease\n* Body weight \\>= 40 kg\n* ECOG performance status of 0 to 2\n* Must sign an Informed consent form (ICF)\n* For US sites: Have a diagnosis of CLL\u002FSLL that meets iwCLL, NCI Working Group Guidelines which is relapsed or refractory and requires treatment with no other approved therapies available that would be more appropriate in the investigator's judgement. a. Participants must have received at least 2 prior lines of therapy\n\nExclusion criteria:\n\nFor Arm A:\n\n* Has acute promyelocytic leukemia according to world health organization (WHO) 2022 criteria or known active central nervous system (CNS) involvement of AML\u002FMDS, unless in specific cohort (s) per study evaluation team (SET) decision\n* Need for supplemental oxygen use to maintain adequate oxygenation\n* Have evidence of uncontrolled systemic viral, bacterial, or fungal infection. Antimicrobial prophylaxis is permitted\n* For US sites: Has acute promyelocytic leukemia according to WHO 2022 criteria or known active CNS involvement of AML\u002FMDS\n\nFor Arm B:\n\n* Need for supplemental oxygen use to maintain adequate oxygenation\n* Have evidence of uncontrolled systemic viral, bacterial, or fungal infection requiring initiation of parenteral treatment as medical intervention\n* Developed Richter's transformation or prolymphocytic leukemia\n* Known active CNS or leptomeningeal involvement of CLL\u002FSLL\u002FNon-Hodgkin lymphoma (NHL)","ALL","18 Years",{"count":144,"type":145},360,"ESTIMATED","INTERVENTIONAL",[148],"PHASE1","The purpose of Part 1 (Dose Escalation) of the study is to assess how safe and tolerable JNJ-95804306 is and to find out the most suitable dose (recommended phase 2 dose \\[RP2D\\]) of JNJ-95804306. The purpose of Part 2 (Dose Expansion) is to further assess the safety of JNJ-95804306 and determine the anti-tumor activity alone and\u002For when administered in addition to standard of care (SoC) therapy at the putative RP2D(s) regimens in participants with hematological malignancies (cancer that begins in blood-forming tissue, such as the bone marrow, or in the cells of the immune system). For US sites: The purpose of Part 1 (Dose Escalation) of the study is to assess how safe and tolerable JNJ-95804306 is and to find out the most suitable dose (recommended phase 2 dose \\[RP2D\\]) of JNJ-95804306. The purpose of Part 2 (Dose Expansion) is to further assess the safety of JNJ-95804306 and determine the anti-tumor activity alone at the putative RP2D(s) regimens in participants with hematological malignancies (cancer that begins in blood-forming tissue, such as the bone marrow, or in the cells of the immune system).",[151],"Hematologic Neoplasms","2026-07-20",{"date":154,"type":155},"2026-07-22","ACTUAL",{"date":157,"type":155},"2026-05-13",{"date":159,"type":145},"2032-09-24",{"name":5,"class":6},8]