[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100462901":3},{"organization":4,"armGroups":7,"interventions":43,"overallOfficials":73,"centralContacts":77,"locations":83,"responsibleParty":546,"collaborators":55,"id":548,"slug":549,"hasResults":550,"nctId":551,"briefTitle":552,"officialTitle":553,"acronym":554,"eligibilityCriteria":555,"healthyVolunteers":550,"sex":556,"minAge":557,"maxAge":55,"enrollmentInfo":558,"targetDuration":55,"studyType":561,"phases":562,"briefSummary":564,"conditions":565,"keywords":55,"overallStatus":111,"whyStopped":55,"lastUpdateSubmitDate":567,"lastUpdatePostDateStruct":568,"startDateStruct":571,"completionDateStruct":573,"leadSponsor":575,"locationsCount":576},{"fullName":5,"class":6},"Eli Lilly and Company","INDUSTRY",[8,14,21,26,30,35,39],{"label":9,"type":10,"description":11,"interventionNames":12},"Phase 1A: LOXO-783 Monotherapy Dose Escalation","EXPERIMENTAL","LOXO-783 administered orally",[13],"Drug: LOXO-783",{"label":15,"type":10,"description":16,"interventionNames":17},"Phase 1B: Part A","LOXO-783 administered orally in combination with fulvestrant intramuscularly, imlunestrant orally, or an aromatase inhibitor orally",[13,18,19,20],"Drug: Fulvestrant","Drug: Imlunestrant","Drug: Anastrozole, Exemestane, or Letrozole",{"label":22,"type":10,"description":23,"interventionNames":24},"Phase 1B: Part B","LOXO-783 orally in combination with abemaciclib and either physician's choice aromatase inhibitor orally, fulvestrant intramuscularly, or imlunestrant orally",[13,18,19,25,20],"Drug: Abemaciclib",{"label":27,"type":10,"description":28,"interventionNames":29},"Phase 1B: Part C","LOXO-783 orally in combination with fulvestrant intramuscularly",[13,18],{"label":31,"type":10,"description":32,"interventionNames":33},"Phase 1B: Part D","LOXO-783 orally in combination with paclitaxel intravenously",[13,34],"Drug: Paclitaxel",{"label":36,"type":10,"description":37,"interventionNames":38},"Phase 1B: Part E","LOXO-783 orally",[13],{"label":40,"type":10,"description":41,"interventionNames":42},"Phase 1B: Part F","Multiple randomized dose levels of LOXO-783 orally with fulvestrant intramuscularly",[13,18],[44,51,56,61,66,69],{"type":45,"name":46,"description":47,"armGroupLabels":48,"otherNames":49},"DRUG","LOXO-783","Oral",[9,15,22,27,31,36,40],[50],"LY3849524",{"type":45,"name":52,"description":53,"armGroupLabels":54,"otherNames":55},"Fulvestrant","Intramuscular",[15,22,27,40],null,{"type":45,"name":57,"description":47,"armGroupLabels":58,"otherNames":59},"Imlunestrant",[15,22],[60],"LY3484356",{"type":45,"name":62,"description":47,"armGroupLabels":63,"otherNames":64},"Abemaciclib",[22],[65],"LY2835219",{"type":45,"name":67,"description":47,"armGroupLabels":68,"otherNames":55},"Anastrozole, Exemestane, or Letrozole",[15,22],{"type":45,"name":70,"description":71,"armGroupLabels":72,"otherNames":55},"Paclitaxel","Intravenous",[31],[74],{"name":75,"affiliation":5,"role":76},"Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC\u002FGMT - 5 hours, EST)","STUDY_DIRECTOR",[78],{"name":79,"role":80,"phone":81,"phoneExt":55,"email":82},"There may be multiple sites in this clinical trial 1-877-CTLILLY (1-877-285-4559) or","CONTACT","13176154559","ClinicalTrials.gov@lilly.com",[84,98,109,119,128,138,148,158,164,173,183,192,200,210,220,226,235,244,255,264,273,284,293,304,313,324,333,342,353,362,371,380,389,400,411,420,429,438,448,458,464,475,481,487,496,502,511,520,526,537],{"facility":85,"status":86,"city":87,"state":88,"zip":89,"country":90,"countryCode":91,"cosmosGeoPoint":92,"geoPoint":97,"contacts":55},"Mayo Clinic of Scottsdale","NOT_YET_RECRUITING","Scottsdale","Arizona","85259","United States","US",{"type":93,"coordinates":94},"Point",[95,96],-111.89903,33.50921,{"lat":96,"lon":95},{"facility":99,"status":100,"city":101,"state":102,"zip":103,"country":90,"countryCode":91,"cosmosGeoPoint":104,"geoPoint":108,"contacts":55},"UCLA Medical Center","COMPLETED","Los Angeles","California","90095",{"type":93,"coordinates":105},[106,107],-118.24368,34.05223,{"lat":107,"lon":106},{"facility":110,"status":111,"city":112,"state":102,"zip":113,"country":90,"countryCode":91,"cosmosGeoPoint":114,"geoPoint":118,"contacts":55},"UCSF Medical Center at Mission Bay","RECRUITING","San Francisco","94158",{"type":93,"coordinates":115},[116,117],-122.41942,37.77493,{"lat":117,"lon":116},{"facility":120,"status":111,"city":121,"state":102,"zip":122,"country":90,"countryCode":91,"cosmosGeoPoint":123,"geoPoint":127,"contacts":55},"Stanford University Hospital","Stanford","94305",{"type":93,"coordinates":124},[125,126],-122.16608,37.42411,{"lat":126,"lon":125},{"facility":129,"status":86,"city":130,"state":131,"zip":132,"country":90,"countryCode":91,"cosmosGeoPoint":133,"geoPoint":137,"contacts":55},"Mayo Clinic","Jacksonville","Florida","32224",{"type":93,"coordinates":134},[135,136],-81.65565,30.33218,{"lat":136,"lon":135},{"facility":139,"status":100,"city":140,"state":141,"zip":142,"country":90,"countryCode":91,"cosmosGeoPoint":143,"geoPoint":147,"contacts":55},"Winship Cancer Center Emory University","Atlanta","Georgia","30322",{"type":93,"coordinates":144},[145,146],-84.38798,33.749,{"lat":146,"lon":145},{"facility":149,"status":100,"city":150,"state":151,"zip":152,"country":90,"countryCode":91,"cosmosGeoPoint":153,"geoPoint":157,"contacts":55},"Massachusetts General Hospital","Boston","Massachusetts","02114",{"type":93,"coordinates":154},[155,156],-71.05977,42.35843,{"lat":156,"lon":155},{"facility":159,"status":86,"city":150,"state":151,"zip":160,"country":90,"countryCode":91,"cosmosGeoPoint":161,"geoPoint":163,"contacts":55},"Dana-Farber Cancer Institute","02215",{"type":93,"coordinates":162},[155,156],{"lat":156,"lon":155},{"facility":129,"status":111,"city":165,"state":166,"zip":167,"country":90,"countryCode":91,"cosmosGeoPoint":168,"geoPoint":172,"contacts":55},"Rochester","Minnesota","55905-0002",{"type":93,"coordinates":169},[170,171],-92.4699,44.02163,{"lat":171,"lon":170},{"facility":174,"status":86,"city":175,"state":176,"zip":177,"country":90,"countryCode":91,"cosmosGeoPoint":178,"geoPoint":182,"contacts":55},"Washington University Medical School","St Louis","Missouri","63110",{"type":93,"coordinates":179},[180,181],-90.19789,38.62727,{"lat":181,"lon":180},{"facility":184,"status":100,"city":185,"state":185,"zip":186,"country":90,"countryCode":91,"cosmosGeoPoint":187,"geoPoint":191,"contacts":55},"Memorial Sloan Kettering Cancer Center","New York","10065",{"type":93,"coordinates":188},[189,190],-74.00597,40.71427,{"lat":190,"lon":189},{"facility":193,"status":86,"city":165,"state":185,"zip":194,"country":90,"countryCode":91,"cosmosGeoPoint":195,"geoPoint":199,"contacts":55},"Wilmot Cancer Institute","14642",{"type":93,"coordinates":196},[197,198],-77.61556,43.15478,{"lat":198,"lon":197},{"facility":201,"status":100,"city":202,"state":203,"zip":204,"country":90,"countryCode":91,"cosmosGeoPoint":205,"geoPoint":209,"contacts":55},"Tennessee Oncology PLLC","Nashville","Tennessee","37203",{"type":93,"coordinates":206},[207,208],-86.78444,36.16589,{"lat":208,"lon":207},{"facility":211,"status":86,"city":212,"state":213,"zip":214,"country":90,"countryCode":91,"cosmosGeoPoint":215,"geoPoint":219,"contacts":55},"Texas Oncology-Baylor Charles A. Sammons Cancer Center","Dallas","Texas","75246",{"type":93,"coordinates":216},[217,218],-96.80667,32.78306,{"lat":218,"lon":217},{"facility":221,"status":111,"city":212,"state":213,"zip":222,"country":90,"countryCode":91,"cosmosGeoPoint":223,"geoPoint":225,"contacts":55},"UT Southwestern Medical Center","75390-8884",{"type":93,"coordinates":224},[217,218],{"lat":218,"lon":217},{"facility":227,"status":86,"city":228,"state":213,"zip":229,"country":90,"countryCode":91,"cosmosGeoPoint":230,"geoPoint":234,"contacts":55},"University of Texas MD Anderson Cancer Center","Houston","77030",{"type":93,"coordinates":231},[232,233],-95.36327,29.76328,{"lat":233,"lon":232},{"facility":236,"status":86,"city":237,"state":213,"zip":238,"country":90,"countryCode":91,"cosmosGeoPoint":239,"geoPoint":243,"contacts":55},"South Texas Accelerated Research Therapeutics (START)","San Antonio","78229",{"type":93,"coordinates":240},[241,242],-98.49363,29.42412,{"lat":242,"lon":241},{"facility":245,"status":86,"city":246,"state":55,"zip":247,"country":248,"countryCode":249,"cosmosGeoPoint":250,"geoPoint":254,"contacts":55},"Cancer Research SA","Adelaide","5000","Australia","AU",{"type":93,"coordinates":251},[252,253],138.59863,-34.92866,{"lat":253,"lon":252},{"facility":256,"status":86,"city":257,"state":55,"zip":258,"country":248,"countryCode":249,"cosmosGeoPoint":259,"geoPoint":263,"contacts":55},"Peter Maccallum Cancer Institute Erb","East Melbourne","3002",{"type":93,"coordinates":260},[261,262],144.9879,-37.81667,{"lat":262,"lon":261},{"facility":265,"status":86,"city":266,"state":55,"zip":267,"country":248,"countryCode":249,"cosmosGeoPoint":268,"geoPoint":272,"contacts":55},"St Vincent's Hospital","Sydney","2010",{"type":93,"coordinates":269},[270,271],151.20732,-33.86785,{"lat":271,"lon":270},{"facility":274,"status":86,"city":275,"state":55,"zip":276,"country":277,"countryCode":278,"cosmosGeoPoint":279,"geoPoint":283,"contacts":55},"Institut Jules Bordet","Anderlecht","1070","Belgium","BE",{"type":93,"coordinates":280},[281,282],4.31454,50.83619,{"lat":282,"lon":281},{"facility":285,"status":86,"city":286,"state":55,"zip":287,"country":277,"countryCode":278,"cosmosGeoPoint":288,"geoPoint":292,"contacts":55},"Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg","Leuven","3000",{"type":93,"coordinates":289},[290,291],4.70093,50.87959,{"lat":291,"lon":290},{"facility":294,"status":111,"city":295,"state":55,"zip":296,"country":297,"countryCode":298,"cosmosGeoPoint":299,"geoPoint":303,"contacts":55},"Princess Margaret Hospital (Hong Kong)","Toronto","M5G 2M9","Canada","CA",{"type":93,"coordinates":300},[301,302],-79.39864,43.70643,{"lat":302,"lon":301},{"facility":305,"status":111,"city":306,"state":55,"zip":307,"country":297,"countryCode":298,"cosmosGeoPoint":308,"geoPoint":312,"contacts":55},"BC Cancer Vancouver","Vancouver","V5Z4E6",{"type":93,"coordinates":309},[310,311],-123.11934,49.24966,{"lat":311,"lon":310},{"facility":314,"status":86,"city":315,"state":55,"zip":316,"country":317,"countryCode":318,"cosmosGeoPoint":319,"geoPoint":323,"contacts":55},"Beijing Cancer hospital","Beijing","100036","China","CN",{"type":93,"coordinates":320},[321,322],116.39723,39.9075,{"lat":322,"lon":321},{"facility":325,"status":111,"city":326,"state":55,"zip":327,"country":317,"countryCode":318,"cosmosGeoPoint":328,"geoPoint":332,"contacts":55},"The Third Hospital of Nanchang","Nanchang","330009",{"type":93,"coordinates":329},[330,331],115.85306,28.68396,{"lat":331,"lon":330},{"facility":334,"status":111,"city":335,"state":55,"zip":336,"country":317,"countryCode":318,"cosmosGeoPoint":337,"geoPoint":341,"contacts":55},"Fudan University Shanghai Cancer Center","Shanghai","200032",{"type":93,"coordinates":338},[339,340],121.45806,31.22222,{"lat":340,"lon":339},{"facility":343,"status":111,"city":344,"state":55,"zip":345,"country":346,"countryCode":347,"cosmosGeoPoint":348,"geoPoint":352,"contacts":55},"Centre Leon Berard","Lyon","69373","France","FR",{"type":93,"coordinates":349},[350,351],4.84789,45.74906,{"lat":351,"lon":350},{"facility":354,"status":86,"city":355,"state":55,"zip":356,"country":346,"countryCode":347,"cosmosGeoPoint":357,"geoPoint":361,"contacts":55},"Institut Curie","Paris","75248",{"type":93,"coordinates":358},[359,360],2.3488,48.85341,{"lat":360,"lon":359},{"facility":363,"status":111,"city":364,"state":55,"zip":365,"country":346,"countryCode":347,"cosmosGeoPoint":366,"geoPoint":370,"contacts":55},"Institut de Cancérologie de l'Ouest","Saint-Herblain","44805",{"type":93,"coordinates":367},[368,369],-1.651,47.21154,{"lat":369,"lon":368},{"facility":372,"status":111,"city":373,"state":55,"zip":374,"country":346,"countryCode":347,"cosmosGeoPoint":375,"geoPoint":379,"contacts":55},"ICANS_Institut de Cancerologie Strasbourg Europe","Strasbourg","67033",{"type":93,"coordinates":376},[377,378],7.74553,48.58392,{"lat":378,"lon":377},{"facility":381,"status":86,"city":382,"state":55,"zip":383,"country":346,"countryCode":347,"cosmosGeoPoint":384,"geoPoint":388,"contacts":55},"Gustave Roussy","Villejuif","94805",{"type":93,"coordinates":385},[386,387],2.35992,48.7939,{"lat":387,"lon":386},{"facility":390,"status":86,"city":391,"state":55,"zip":392,"country":393,"countryCode":394,"cosmosGeoPoint":395,"geoPoint":399,"contacts":55},"Universitätsklinikum Erlangen","Erlangen","91054","Germany","DE",{"type":93,"coordinates":396},[397,398],11.00783,49.59099,{"lat":398,"lon":397},{"facility":401,"status":111,"city":402,"state":55,"zip":403,"country":404,"countryCode":405,"cosmosGeoPoint":406,"geoPoint":410,"contacts":55},"National Cancer Center Hospital","Chūōku","104-0045","Japan","JP",{"type":93,"coordinates":407},[408,409],130.67068,33.63867,{"lat":409,"lon":408},{"facility":412,"status":111,"city":413,"state":55,"zip":414,"country":404,"countryCode":405,"cosmosGeoPoint":415,"geoPoint":419,"contacts":55},"The Cancer Institute Hospital of JFCR","Kōtō City","135-8550",{"type":93,"coordinates":416},[417,418],130.74537,32.77856,{"lat":418,"lon":417},{"facility":421,"status":86,"city":422,"state":55,"zip":423,"country":404,"countryCode":405,"cosmosGeoPoint":424,"geoPoint":428,"contacts":55},"Kyoto University Hospital","Kyoto","606-8507",{"type":93,"coordinates":425},[426,427],135.75385,35.02107,{"lat":427,"lon":426},{"facility":430,"status":111,"city":431,"state":55,"zip":432,"country":404,"countryCode":405,"cosmosGeoPoint":433,"geoPoint":437,"contacts":55},"Aichi Cancer Center Hospital","Nagoya","464-8681",{"type":93,"coordinates":434},[435,436],136.90641,35.18147,{"lat":436,"lon":435},{"facility":439,"status":86,"city":440,"state":55,"zip":441,"country":440,"countryCode":442,"cosmosGeoPoint":443,"geoPoint":447,"contacts":55},"National Cancer Centre Singapore","Singapore","169610","SG",{"type":93,"coordinates":444},[445,446],103.85007,1.28967,{"lat":446,"lon":445},{"facility":449,"status":86,"city":450,"state":55,"zip":451,"country":452,"countryCode":55,"cosmosGeoPoint":453,"geoPoint":457,"contacts":55},"Samsung Medical Center","Seoul","06351","South Korea",{"type":93,"coordinates":454},[455,456],126.9784,37.566,{"lat":456,"lon":455},{"facility":459,"status":86,"city":450,"state":55,"zip":460,"country":452,"countryCode":55,"cosmosGeoPoint":461,"geoPoint":463,"contacts":55},"Asan Medical Center","5505",{"type":93,"coordinates":462},[455,456],{"lat":456,"lon":455},{"facility":465,"status":111,"city":466,"state":55,"zip":467,"country":468,"countryCode":469,"cosmosGeoPoint":470,"geoPoint":474,"contacts":55},"Hospital Universitario Quiron Dexeus","Barcelona","08028","Spain","ES",{"type":93,"coordinates":471},[472,473],2.15899,41.38879,{"lat":473,"lon":472},{"facility":476,"status":86,"city":466,"state":55,"zip":477,"country":468,"countryCode":469,"cosmosGeoPoint":478,"geoPoint":480,"contacts":55},"Hospital Universitari Vall d'Hebron","08035",{"type":93,"coordinates":479},[472,473],{"lat":473,"lon":472},{"facility":482,"status":111,"city":466,"state":55,"zip":483,"country":468,"countryCode":469,"cosmosGeoPoint":484,"geoPoint":486,"contacts":55},"Hospital Clinic de Barcelona","08036",{"type":93,"coordinates":485},[472,473],{"lat":473,"lon":472},{"facility":488,"status":111,"city":489,"state":55,"zip":490,"country":468,"countryCode":469,"cosmosGeoPoint":491,"geoPoint":495,"contacts":55},"Hospital General Universitario Gregorio Maranon","Madrid","28007",{"type":93,"coordinates":492},[493,494],-3.70256,40.4165,{"lat":494,"lon":493},{"facility":497,"status":86,"city":489,"state":55,"zip":498,"country":468,"countryCode":469,"cosmosGeoPoint":499,"geoPoint":501,"contacts":55},"Hospital Universitario 12 de Octubre","28041",{"type":93,"coordinates":500},[493,494],{"lat":494,"lon":493},{"facility":503,"status":111,"city":504,"state":55,"zip":505,"country":468,"countryCode":469,"cosmosGeoPoint":506,"geoPoint":510,"contacts":55},"Hospital Quironsalud Madrid","Pozuelo de Alarcón","28223",{"type":93,"coordinates":507},[508,509],-3.81338,40.43293,{"lat":509,"lon":508},{"facility":512,"status":111,"city":513,"state":55,"zip":514,"country":468,"countryCode":469,"cosmosGeoPoint":515,"geoPoint":519,"contacts":55},"Hospital Clinico Universitario de Valencia","Valencia","46010",{"type":93,"coordinates":516},[517,518],-0.37966,39.47391,{"lat":518,"lon":517},{"facility":521,"status":111,"city":513,"state":55,"zip":522,"country":468,"countryCode":469,"cosmosGeoPoint":523,"geoPoint":525,"contacts":55},"Hospital Arnau de Vilanova Valencia","46015",{"type":93,"coordinates":524},[517,518],{"lat":518,"lon":517},{"facility":527,"status":111,"city":528,"state":55,"zip":529,"country":530,"countryCode":531,"cosmosGeoPoint":532,"geoPoint":536,"contacts":55},"Royal Marsden NHS Trust","London","SW3 6JJ","United Kingdom","UK",{"type":93,"coordinates":533},[534,535],-0.12574,51.50853,{"lat":535,"lon":534},{"facility":538,"status":86,"city":539,"state":55,"zip":540,"country":530,"countryCode":531,"cosmosGeoPoint":541,"geoPoint":545,"contacts":55},"Royal Marsden Hospital (Sutton)","Sutton","SM2 5PT",{"type":93,"coordinates":542},[543,544],-0.2,51.35,{"lat":544,"lon":543},{"type":547,"investigatorFullName":55,"investigatorTitle":55,"investigatorAffiliation":55,"oldNameTitle":55,"oldOrganization":55},"SPONSOR","100462901","phase-1-a-study-of-loxo-783-in-patients-with-breast-cancerother-solid-tumors-100462901",false,"NCT05307705","A Study of LOXO-783 in Patients With Breast Cancer\u002FOther Solid Tumors","A Study of LOXO-783 Administered as Monotherapy and in Combination With Anticancer Therapies for Patients With Advanced Breast Cancer and Other Solid Tumors With a PIK3CA H1047R Mutation","PIKASSO-01","Inclusion Criteria:\n\n* Have advanced breast cancer or another solid tumor with the presence of a phosphatidylinositol 3-kinase catalytic subunit alpha (PIK3CA) H1047R mutation (or other Sponsor and safety review committee (SRC)-approved, activating PIK3CA mutations other than H1047R mutation)\n* Have adequate archival tumor tissue sample available or be approved by the Sponsor for enrollment if no tumor sample is available.\n* Have stopped all cancer treatment and have recovered from the major side effects\n* Have adequate organ function, as measured by blood tests\n* Have a performance status of 0 or 1 on the Eastern Cooperative Oncology Group (ECOG) scale\n* Patients must have\n\n  * Measurable disease\n\n    \\--- Patients with non-breast tumor types must have at least 1 measurable lesion\n  * Non-measurable bone disease (at least 1 bone lesion in breast cancer patients only)\n* For patients with an estrogen receptor (ER)+ breast cancer diagnosis:\n\n  * If female, must be postmenopausal\n  * If male, must agree to use hormone suppression\n* Phase 1a:\n\n  \\-- Dose escalation and backfill patients:\n  * Advanced solid tumor\n  * Patients may have had up to 5 prior regimens for advanced disease\n* Phase 1b:\n\n  * Part A:\n\n    * ER+\u002Fhuman epidermal growth factor receptor 2 (HER2)- advanced breast cancer\n    * Patients may have had up to 5 prior regimens for advanced disease ---- Prior cyclin dependent kinase (CDK)4\u002F6 inhibitor therapy required\n  * Part B:\n\n    * ER+\u002FHER2- advanced breast cancer\n    * Patients may have had up to 2 prior regimens for advanced disease.\n  * Part C:\n\n    * ER+\u002FHER2- advanced breast cancer\n    * Patients may have had up to 5 prior regimens for advanced disease.\n\n      \\---- Prior CDK4\u002F6 inhibitor therapy required.\n    * Have a diagnosis of diabetes mellitus Type 2\n  * Part D:\n\n    * Advanced breast cancer\n    * Patients may have had up to 5 prior regimens for advanced disease.\n  * Part E:\n\n    * Advanced solid tumor\n    * Patients may have had up to 3 prior regimens for advanced disease advanced disease\n  * Part F:\n\n    * ER+\u002FHER2- advanced breast cancer\n    * Patients may have had up to 5 prior regimens for advanced disease\n\n      * Prior cyclin dependent kinase (CDK)4\u002F6 inhibitor therapy required\n\nExclusion Criteria:\n\n* Medical Conditions\n\n  * Colorectal cancer\n  * Endometrial cancers with specific concurrent oncogenic alterations\n  * A history of known active or suspected\n\n    * Diabetes mellitus Type 1 or\n    * Diabetes mellitus Type 2 requiring antidiabetic medication (Phase 1a and all parts of Phase 1b except Part C).\n    * Serious concomitant systemic disorder\n* Known or suspected history of untreated or uncontrolled central nervous system (CNS) involvement.\n* Active uncontrolled systemic bacterial, viral, fungal, or parasitic infection, or other clinically significant active disease process\n* Prior exposure to phosphatidylinositol 3-kinase\u002Fprotein kinase B\u002Fmammalian target of rapamycin (PI3K\u002FAKT\u002FmTOR) inhibitor(s), except in certain circumstances","ALL","18 Years",{"count":559,"type":560},260,"ESTIMATED","INTERVENTIONAL",[563],"PHASE1","The main purpose of this study is to learn more about the safety, side effects, and effectiveness of LOXO-783. LOXO-783 may be used to treat breast cancer and other solid tumors that have a change in a particular gene (known as the PIK3CA gene). Participation could last up to 36 months (3 years) and possibly longer if the disease does not get worse.",[566],"Breast Cancer","2026-08-06",{"date":569,"type":570},"2026-08-07","ACTUAL",{"date":572,"type":570},"2022-05-11",{"date":574,"type":560},"2026-12",{"name":5,"class":6},50]