[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100653428":3},{"organization":4,"outcomesModule":7,"designInfo":24,"detailedDescription":11,"studyPopulation":11,"armGroups":33,"interventions":56,"overallOfficials":79,"centralContacts":83,"locations":92,"responsibleParty":325,"collaborators":11,"id":327,"slug":328,"hasResults":329,"nctId":330,"briefTitle":331,"officialTitle":332,"acronym":11,"eligibilityCriteria":333,"healthyVolunteers":334,"sex":335,"minAge":336,"maxAge":337,"enrollmentInfo":338,"targetDuration":11,"studyType":341,"phases":342,"briefSummary":344,"conditions":345,"keywords":11,"overallStatus":350,"whyStopped":11,"lastUpdateSubmitDate":351,"lastUpdatePostDateStruct":352,"startDateStruct":355,"completionDateStruct":357,"leadSponsor":359,"locationsCount":360},{"fullName":5,"class":6},"Eli Lilly and Company","INDUSTRY",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":11},[9],{"measure":10,"description":11,"timeFrame":12},"Number of Participants with One or More Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration",null,"Baseline up to 25 Weeks",[14,17,20,22],{"measure":15,"description":11,"timeFrame":16},"Pharmacokinetics (PK): Maximum Concentration (Cmax) of LY4405094 in Healthy Participants","Baseline through Study Completion (Week 13)",{"measure":18,"description":11,"timeFrame":19},"PK: Area Under the Concentration Versus Time Curve (AUC) of LY4405094 in Participants with Alzheimer's Disease (AD)","Baseline through Study Completion (25 Weeks)",{"measure":21,"description":11,"timeFrame":16},"Change from Baseline of Cerebrospinal Fluid (CSF) Concentration of LY4405094 in Healthy Participants",{"measure":23,"description":11,"timeFrame":19},"Change from Baseline of Amyloid Plaque levels as Assessed by Amyloid Positron Emission Tomography (PET) in Participants with AD",{"allocation":25,"interventionModel":26,"interventionModelDescription":11,"primaryPurpose":27,"observationalModel":11,"timePerspective":11,"maskingInfo":28},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":29,"maskingDescription":11,"whoMasked":30},"DOUBLE",[31,32],"PARTICIPANT","INVESTIGATOR",[34,40,46,52],{"label":35,"type":36,"description":37,"interventionNames":38},"LY4405094 Part A: Single-Ascending Dose (SAD)","EXPERIMENTAL","LY4405094 administered intravenously (IV) or subcutaneously (SC) in healthy volunteers.",[39],"Drug: LY4405094",{"label":41,"type":42,"description":43,"interventionNames":44},"Placebo Part A","PLACEBO_COMPARATOR","Placebo administered IV or SC in healthy volunteers.",[45],"Drug: Placebo",{"label":47,"type":36,"description":48,"interventionNames":49},"LY4405094 Part B: Multiple Ascending Dose (MAD)","LY4405094 administered IV to participants with AD. Florbetapir F 18 or Florbetaben F 18 will be administered IV during amyloid positron emission tomography (PET) scan.",[39,50,51],"Other: Florbetapir F18","Other: Florbetaben F 18",{"label":53,"type":42,"description":54,"interventionNames":55},"Placebo Part B","Placebo administered IV to participants with AD. Florbetapir F 18 or Florbetaben F 18 will be administered IV during amyloid positron emission tomography (PET) scan.",[45,50,51],[57,62,65,69,72,76],{"type":58,"name":59,"description":60,"armGroupLabels":61,"otherNames":11},"DRUG","LY4405094","Administered intravenously (IV)",[35,47],{"type":58,"name":59,"description":63,"armGroupLabels":64,"otherNames":11},"Administered Subcutaneously (SC)",[35],{"type":58,"name":66,"description":67,"armGroupLabels":68,"otherNames":11},"Placebo","Administered IV",[41,53],{"type":58,"name":66,"description":70,"armGroupLabels":71,"otherNames":11},"Administered SC",[41],{"type":73,"name":74,"description":67,"armGroupLabels":75,"otherNames":11},"OTHER","Florbetapir F18",[47,53],{"type":73,"name":77,"description":67,"armGroupLabels":78,"otherNames":11},"Florbetaben F 18",[47,53],[80],{"name":81,"affiliation":5,"role":82},"Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC\u002FGMT - 5 hours, EST)","STUDY_DIRECTOR",[84,89],{"name":85,"role":86,"phone":87,"phoneExt":11,"email":88},"Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or","CONTACT","1-317-615-4559","LillyTrials@Lilly.com",{"name":90,"role":86,"phone":11,"phoneExt":11,"email":91},"Physicians interested in becoming principal investigators please contact","clinical_inquiry_hub@lilly.com",[93,112,126,140,155,169,183,197,211,225,239,252,267,282,296,312],{"facility":94,"status":11,"city":95,"state":96,"zip":97,"country":98,"countryCode":99,"cosmosGeoPoint":100,"geoPoint":105,"contacts":106},"CenExel ACT","Anaheim","California","92801","United States","US",{"type":101,"coordinates":102},"Point",[103,104],-117.9145,33.83529,{"lat":104,"lon":103},[107,109],{"name":11,"role":86,"phone":108,"phoneExt":11,"email":11},"714-774-7777",{"name":110,"role":111,"phone":11,"phoneExt":11,"email":11},"Amina Haggag","PRINCIPAL_INVESTIGATOR",{"facility":113,"status":11,"city":114,"state":96,"zip":115,"country":98,"countryCode":99,"cosmosGeoPoint":116,"geoPoint":120,"contacts":121},"Irvine Clinical Research","Irvine","92614",{"type":101,"coordinates":117},[118,119],-117.82311,33.66946,{"lat":119,"lon":118},[122,124],{"name":11,"role":86,"phone":123,"phoneExt":11,"email":11},"949-753-1663",{"name":125,"role":111,"phone":11,"phoneExt":11,"email":11},"Elly Lee",{"facility":127,"status":11,"city":128,"state":96,"zip":129,"country":98,"countryCode":99,"cosmosGeoPoint":130,"geoPoint":134,"contacts":135},"Collaborative Neuroscience Network - CNS","Los Alamitos","90720",{"type":101,"coordinates":131},[132,133],-118.07256,33.80307,{"lat":133,"lon":132},[136,138],{"name":11,"role":86,"phone":137,"phoneExt":11,"email":11},"714-799-7799",{"name":139,"role":111,"phone":11,"phoneExt":11,"email":11},"Steven Reynolds",{"facility":141,"status":11,"city":142,"state":143,"zip":144,"country":98,"countryCode":99,"cosmosGeoPoint":145,"geoPoint":149,"contacts":150},"Fortrea Clinical Research Unit","Daytona Beach","Florida","32117",{"type":101,"coordinates":146},[147,148],-81.02283,29.21081,{"lat":148,"lon":147},[151,153],{"name":11,"role":86,"phone":152,"phoneExt":11,"email":11},"386-366-6400",{"name":154,"role":111,"phone":11,"phoneExt":11,"email":11},"Chiamaka Iheme",{"facility":156,"status":11,"city":157,"state":143,"zip":158,"country":98,"countryCode":99,"cosmosGeoPoint":159,"geoPoint":163,"contacts":164},"K2 Medical Research - The Villages","Lady Lake","32159",{"type":101,"coordinates":160},[161,162],-81.92286,28.91749,{"lat":162,"lon":161},[165,167],{"name":11,"role":86,"phone":166,"phoneExt":11,"email":11},"321-278-5590",{"name":168,"role":111,"phone":11,"phoneExt":11,"email":11},"Craig Curtis",{"facility":170,"status":11,"city":171,"state":143,"zip":172,"country":98,"countryCode":99,"cosmosGeoPoint":173,"geoPoint":177,"contacts":178},"K2 Medical Research","Maitland","32751",{"type":101,"coordinates":174},[175,176],-81.36312,28.62778,{"lat":176,"lon":175},[179,181],{"name":11,"role":86,"phone":180,"phoneExt":11,"email":11},"407-232-9262",{"name":182,"role":111,"phone":11,"phoneExt":11,"email":11},"Brandon Lenox",{"facility":184,"status":11,"city":185,"state":143,"zip":186,"country":98,"countryCode":99,"cosmosGeoPoint":187,"geoPoint":191,"contacts":192},"Charter Research","Orlando","32803",{"type":101,"coordinates":188},[189,190],-81.37924,28.53834,{"lat":190,"lon":189},[193,195],{"name":11,"role":86,"phone":194,"phoneExt":11,"email":11},"407-337-1000",{"name":196,"role":111,"phone":11,"phoneExt":11,"email":11},"Diana Balsalobre",{"facility":198,"status":11,"city":199,"state":143,"zip":200,"country":98,"countryCode":99,"cosmosGeoPoint":201,"geoPoint":205,"contacts":206},"Progressive Medical Research","Port Orange","32127",{"type":101,"coordinates":202},[203,204],-80.99561,29.13832,{"lat":204,"lon":203},[207,209],{"name":11,"role":86,"phone":208,"phoneExt":11,"email":11},"386-304-7070",{"name":210,"role":111,"phone":11,"phoneExt":11,"email":11},"Alexander White",{"facility":212,"status":11,"city":213,"state":143,"zip":214,"country":98,"countryCode":99,"cosmosGeoPoint":215,"geoPoint":219,"contacts":220},"Alzheimer's Research and Treatment Center","Stuart","34996",{"type":101,"coordinates":216},[217,218],-80.25283,27.19755,{"lat":218,"lon":217},[221,223],{"name":11,"role":86,"phone":222,"phoneExt":11,"email":11},"772-675-0000",{"name":224,"role":111,"phone":11,"phoneExt":11,"email":11},"Adam Falchook",{"facility":226,"status":11,"city":227,"state":143,"zip":228,"country":98,"countryCode":99,"cosmosGeoPoint":229,"geoPoint":233,"contacts":234},"K2 Medical Research - Tampa","Tampa","33634",{"type":101,"coordinates":230},[231,232],-82.45843,27.94752,{"lat":232,"lon":231},[235,237],{"name":11,"role":86,"phone":236,"phoneExt":11,"email":11},"813-800-5252",{"name":238,"role":111,"phone":11,"phoneExt":11,"email":11},"Kelley Wilson",{"facility":184,"status":11,"city":240,"state":143,"zip":241,"country":98,"countryCode":99,"cosmosGeoPoint":242,"geoPoint":246,"contacts":247},"The Villages","32162-2698",{"type":101,"coordinates":243},[244,245],-81.95994,28.93408,{"lat":245,"lon":244},[248,250],{"name":11,"role":86,"phone":249,"phoneExt":11,"email":11},"352-775-1000",{"name":251,"role":111,"phone":11,"phoneExt":11,"email":11},"Jeffrey Norton",{"facility":253,"status":11,"city":254,"state":255,"zip":256,"country":98,"countryCode":99,"cosmosGeoPoint":257,"geoPoint":261,"contacts":262},"Accel Research Sites - NeuroStudies Clinical Research Unit","Decatur","Georgia","30030",{"type":101,"coordinates":258},[259,260],-84.29631,33.77483,{"lat":260,"lon":259},[263,265],{"name":11,"role":86,"phone":264,"phoneExt":11,"email":11},"404-475-0552",{"name":266,"role":111,"phone":11,"phoneExt":11,"email":11},"Marshall Nash",{"facility":268,"status":11,"city":269,"state":270,"zip":271,"country":98,"countryCode":99,"cosmosGeoPoint":272,"geoPoint":276,"contacts":277},"QUEST Research Institute","Farmington Hills","Michigan","48334",{"type":101,"coordinates":273},[274,275],-83.37716,42.48531,{"lat":275,"lon":274},[278,280],{"name":11,"role":86,"phone":279,"phoneExt":11,"email":11},"248-957-8940",{"name":281,"role":111,"phone":11,"phoneExt":11,"email":11},"Aaron Ellenbogen",{"facility":283,"status":11,"city":284,"state":11,"zip":285,"country":286,"countryCode":287,"cosmosGeoPoint":288,"geoPoint":292,"contacts":293},"Xuanwu Hospital Capital Medical University","Beijing","100053","China","CN",{"type":101,"coordinates":289},[290,291],116.39723,39.9075,{"lat":291,"lon":290},[294],{"name":295,"role":111,"phone":11,"phoneExt":11,"email":11},"Cuibai Wei",{"facility":297,"status":11,"city":298,"state":11,"zip":299,"country":300,"countryCode":301,"cosmosGeoPoint":302,"geoPoint":306,"contacts":307},"The University of Tokyo Hospital","Bunkyō City","113-8655","Japan","JP",{"type":101,"coordinates":303},[304,305],139.4217,35.5331,{"lat":305,"lon":304},[308,310],{"name":11,"role":86,"phone":309,"phoneExt":11,"email":11},"81120023812",{"name":311,"role":111,"phone":11,"phoneExt":11,"email":11},"Yoshiki Niimi",{"facility":313,"status":11,"city":314,"state":11,"zip":315,"country":300,"countryCode":301,"cosmosGeoPoint":316,"geoPoint":320,"contacts":321},"National Center for Geriatrics and Gerontology","Ōbu","4748511",{"type":101,"coordinates":317},[318,319],136.94947,35.01756,{"lat":319,"lon":318},[322,323],{"name":11,"role":86,"phone":309,"phoneExt":11,"email":11},{"name":324,"role":111,"phone":11,"phoneExt":11,"email":11},"Keisuke Suzuki",{"type":326,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100653428","phase-1-a-study-of-ly4405094-in-healthy-participants-and-participants-with-alzheimers-disease-100653428",false,"NCT07787182","A Study of LY4405094 in Healthy Participants and Participants With Alzheimer's Disease","A Placebo-Controlled, Single- and Multiple-Ascending Dose, Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LY4405094 in Healthy Participants and Participants With Alzheimer's Disease","Inclusion Criteria:\n\n* Participants must meet eligibility criteria in the ATMP screening protocol before entry into the treatment study.\n\nExclusion Criteria:\n\n* Have known allergies to LY4405094, related compounds (including remternetug), or any components of the formulation, including LY4405094.\n* Have known allergic reactions to adhesive or hydrogels or a family history of adhesive skin allergies.",true,"ALL","18 Years","85 Years",{"count":339,"type":340},68,"ESTIMATED","INTERVENTIONAL",[343],"PHASE1","The purpose of this study is to see how safe LY4405094 is and to see how much and how quickly LY4405094 gets into the bloodstream. For healthy participants, the study also looks at how much LY4405094 gets into the fluid around the brain and lasts up to 13 weeks and will include a 4-day stay in the Clinical Research Unit (CRU). For participants with Alzheimer's Disease, the study will also look at levels of a specific Alzheimer's-related protein in the brain and will last up to 25 weeks and will include a 3-day stay in the CRU.",[346,347,348,349],"Healthy Volunteers","Alzheimer Disease","Amyloid","Plaque, Amyloid","NOT_YET_RECRUITING","2026-09-21",{"date":353,"type":354},"2026-09-22","ACTUAL",{"date":356,"type":340},"2026-09",{"date":358,"type":340},"2028-01",{"name":5,"class":6},16]