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Exceptions: basal cell carcinoma of the skin or localized squamous cell carcinoma of the skin with previously administered curative treatment, in situ cervical cancer, or other cancers that do not require systemic anti-cancer therapies and will not impact life expectancy.\n* Symptomatic or untreated brain metastasis requiring concurrent treatment. For Part 2, Part 3, and Part 4 the following subjects can be enrolled if they have a stable neurologic status for at least 2 weeks prior to the first dose of ZL-1310:\n\n  1. Subjects with untreated and asymptomatic brain metastases.\n  2. Subjects with treated brain metastases that are no longer symptomatic (i.e. without neurologic signs or symptoms), who require no treatment with steriods or anticonvulsants and have recovered from the actue toxic effects of radiotherapy.\n* Subjects with leptomeningeal disease.\n* Treatment with any systemic anti-cancer treatment or other investigational products\u002F device within 3 weeks before first dose of study treatment.\n* Non-palliative radiotherapy within 2 weeks prior to first dose of study treatment or have had a history of radiation pneumonitis.\n* Major surgery within 4 weeks of the first dose of study treatment.\n* Hypersensitivity to any ingredient of the study treatment.\n* Inadequate organ function (as defined in protocol) within 10 days prior to the first dose of study treatment,\n* Participants with a diagnosis of immunodeficiency or receiving chronic systemic steroid therapy or any other form of immunosuppressive therapy within 14 days or 5 half-lives before the first dose of study treatment, whichever is longer.\n* Participants have received a live or live-attenuated vaccine within 30 days of planned start of study therapy.\n* Impaired cardiac function or clinically significant cardiac disease within the last 3 months before administration of the first dose of the study treatment\n* Lung-specific intercurrent clinically significant illnesses and any autoimmune, connective tissue, or inflammatory disorders, including but not limited to pneumonitis.\n* Pregnant or nursing (lactating) women.\n* Participants who have been on concomitant strong CYP3A or CYP2D6 inhibitors within 14 days or 5 half-lives before the first study treatment, whichever is longer.\n* For Part 1C and Part 4 (ZL-1310 in combination with Atezolizumab and Carboplatin), participants who received prior treatment with CD137 agonists or immune checkpoint blockade therapies, anti-PD-1, and anti-PD-L1 therapeutic antibodies.\n* For Part 1B (ZL-1310 in combination with Atezolizumab) and Part 1C (ZL-1310 in combination with Atezolizumab and Carboplatin), participants who received systemic immunostimulatory agents (including but not limited to, IFNs and IL2) within 4 weeks or 5 drug-elimination half-lives, whichever is longer, prior to the initiation of study treatment.","ALL","18 Years",{"count":471,"type":472},339,"ESTIMATED","INTERVENTIONAL",[475],"PHASE1","An open-label, multicenter study of ZL-1310 as a single agent and in combination with Atezolizumab (with and without Carboplatin) to evaluate the safety, efficacy, and pharmacokinetics in subjects with small cell lung cancer",[478],"SCLC","2026-08-19",{"date":481,"type":482},"2026-08-21","ACTUAL",{"date":484,"type":482},"2024-01-23",{"date":486,"type":472},"2027-07-31",{"name":488,"class":6},"Zai Lab (Shanghai) Co., Ltd.",38]