[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646898":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":52,"collaborators":21,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":21,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":21,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":78,"whyStopped":21,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Chiesi Farmaceutici S.p.A.","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Fixed Sequence Treatment","EXPERIMENTAL","CHF10196 - Pantoprazole - Pantoprazole with CHF10196",[13,14],"Drug: CHF10196","Drug: Pantoprazole",[16,22],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"DRUG","CHF10196","Treatment Period 1:\n\nCHF10196 single dose administration on Day1;\n\nTreatment Period 2:\n\nCHF10196 single dose administration after pantoprazole single dose administration on Day13",[9],null,{"type":17,"name":23,"description":24,"armGroupLabels":25,"otherNames":21},"Pantoprazole","Treatment Period 2:\n\nPantoprazole single dose administration from Day8 to Day13",[9],[27],{"name":28,"affiliation":29,"role":30},"Benjamen Monaghan","Fortrea Clinical Research Unit (CRU)","PRINCIPAL_INVESTIGATOR",[32],{"name":33,"role":34,"phone":35,"phoneExt":21,"email":36},"Chiesi Clinical trial Info","CONTACT","+390521279715","clinicaltrials_info@chiesi.com",[38],{"facility":39,"status":21,"city":40,"state":21,"zip":21,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Fortrea Clinical Research Unit (CRU) Limited","Leeds","United Kingdom","UK",{"type":44,"coordinates":45},"Point",[46,47],-1.54785,53.79648,{"lat":47,"lon":46},[50],{"name":51,"role":34,"phone":21,"phoneExt":21,"email":21},"Firas Almezedi",{"type":53,"investigatorFullName":21,"investigatorTitle":21,"investigatorAffiliation":21,"oldNameTitle":21,"oldOrganization":21},"SPONSOR","100646898","phase-1-a-study-to-compare-how-chf10196-florensocatib-is-absorbed-into-the-blood-when-given-alone-and-with-a-drug-that-reduces-stomach-acid-in-healthy-male-participants-100646898",false,"NCT07683793","A Study to Compare How CHF10196 (Florensocatib) is Absorbed Into the Blood When Given Alone and With a Drug That Reduces Stomach Acid in Healthy Male Participants","An Open-label, Fixed-sequence, Non-randomised, Drug-drug Interaction Study to Evaluate the Effect of Pantoprazole (Proton Pump Inhibitor) on the Pharmacokinetics of CHF10196 in Healthy Male Participants.","Key Inclusion Criteria:\n\n* BMI (body mass index) between 18.0 and 30.0 kg\u002Fm²\n* Weight between 45 and 100 kg\n* Non-smokers or ex-smokers (\\\u003C5 pack-years)\n* Clinically healthy based on medical history and examination\n* Normal vital signs\n* Normal ECG\n* Willingness to comply with contraception requirements\n\nKey Exclusion Criteria:\n\n* Recent participation in another clinical study\n* Significant medical conditions\n* Abnormal laboratory values\n* Positive HIV or hepatitis tests\n* Recent infection or COVID-19\n* Drug or alcohol abuse\n* Use of prohibited medications\n* Gastrointestinal surgery affecting absorption\n* Hypersensitivity to study drugs",true,"MALE","18 Years","55 Years",{"count":66,"type":67},18,"ESTIMATED","INTERVENTIONAL",[70],"PHASE1","This Phase 1 study evaluates the effect of pantoprazole (a proton pump inhibitor) on the pharmacokinetics (PK) of CHF10196 (Florensocatib) in healthy male participants. Participants receive CHF10196 alone and in combination with pantoprazole to assess potential drug-drug interaction (DDI) effects on systemic exposure.",[73],"Healthy Volunteers",[75,18,76,77],"pharmacokinetics","DDI","Dipeptidyl Peptidase 1 (DPP1) inhibitor","NOT_YET_RECRUITING","2026-07-02",{"date":81,"type":82},"2026-07-06","ACTUAL",{"date":84,"type":67},"2026-10-14",{"date":86,"type":67},"2026-12-09",{"name":5,"class":6},1]