[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100503520":3},{"organization":4,"armGroups":7,"interventions":57,"overallOfficials":63,"centralContacts":84,"locations":94,"responsibleParty":453,"collaborators":63,"id":455,"slug":456,"hasResults":457,"nctId":458,"briefTitle":459,"officialTitle":460,"acronym":63,"eligibilityCriteria":461,"healthyVolunteers":457,"sex":462,"minAge":463,"maxAge":63,"enrollmentInfo":464,"targetDuration":63,"studyType":467,"phases":468,"briefSummary":470,"conditions":471,"keywords":475,"overallStatus":97,"whyStopped":63,"lastUpdateSubmitDate":476,"lastUpdatePostDateStruct":477,"startDateStruct":480,"completionDateStruct":482,"leadSponsor":484,"locationsCount":485},{"fullName":5,"class":6},"Incyte Corporation","INDUSTRY",[8,14,17,22,27,32,37,42,45,48,51,54],{"label":9,"type":10,"description":11,"interventionNames":12},"Part 1a - Dose Escalation Monotherapy","EXPERIMENTAL","INCA33890 will be administered at the protocol-defined dose based on cohort assignment.",[13],"Drug: INCA33890",{"label":15,"type":10,"description":11,"interventionNames":16},"Part 1b-Dose Expansion Monotherapy",[13],{"label":18,"type":10,"description":19,"interventionNames":20},"Part 2a - Dose Escalation Combination Therapy - Group 1","INCA33890 will be administered in combination with bevacizumab at the protocol-defined dose based on cohort assignment.",[13,21],"Drug: bevacizumab",{"label":23,"type":10,"description":24,"interventionNames":25},"Part 2a - Dose Escalation Combination Therapy - Group 2","INCA33890 will be administered in combination with bevacizumab and FOLFIRI at the protocol-defined dose based on cohort assignment.",[13,21,26],"Drug: FOLFIRI",{"label":28,"type":10,"description":29,"interventionNames":30},"Part 2a - Dose Escalation Combination Therapy - Group 3","INCA33890 will be administered in combination with bevacizumab and FOLFOX at the protocol-defined dose based on cohort assignment.",[13,21,31],"Drug: FOLFOX",{"label":33,"type":10,"description":34,"interventionNames":35},"Part 2a - Dose Escalation Combination Therapy - Group 4","INCA33890 will be administered in combination with cetuximab at the protocol-defined dose based on cohort assignment.",[13,36],"Drug: Cetuximab",{"label":38,"type":10,"description":39,"interventionNames":40},"Part 2a - Dose Escalation Combination Therapy - Group 5","INCA33890 will be administered in combination with ADG126 at the protocol-defined dose based on cohort assignment.",[13,41],"Drug: ADG126",{"label":43,"type":10,"description":19,"interventionNames":44},"Part 2b - Dose Expansion Combination Therapy - Group 1",[13,21],{"label":46,"type":10,"description":24,"interventionNames":47},"Part 2b - Dose Expansion Combination Therapy - Group 2",[13,21,26],{"label":49,"type":10,"description":29,"interventionNames":50},"Part 2b - Dose Expansion Combination Therapy - Group 3",[13,21,31],{"label":52,"type":10,"description":34,"interventionNames":53},"Part 2b - Dose Expansion Combination Therapy - Group 4",[13,36],{"label":55,"type":10,"description":39,"interventionNames":56},"Part 2b - Dose Expansion Combination Therapy - Group 5",[13,41],[58,64,68,72,76,80],{"type":59,"name":60,"description":61,"armGroupLabels":62,"otherNames":63},"DRUG","INCA33890","INCA33890 will be administered at protocol defined dose.",[9,15,18,23,28,33,38,43,46,49,52,55],null,{"type":59,"name":65,"description":66,"armGroupLabels":67,"otherNames":63},"bevacizumab","Bevacizumab will be administered at protocol defined dose.",[18,23,28,43,46,49],{"type":59,"name":69,"description":70,"armGroupLabels":71,"otherNames":63},"FOLFIRI","FOLFIRI will be administered at protocol defined dose.",[23,46],{"type":59,"name":73,"description":74,"armGroupLabels":75,"otherNames":63},"FOLFOX","FOLFOX will be administered at protocol defined dose.",[28,49],{"type":59,"name":77,"description":78,"armGroupLabels":79,"otherNames":63},"Cetuximab","Cetuximab will be administered at protocol defined dose.",[33,52],{"type":59,"name":81,"description":82,"armGroupLabels":83,"otherNames":63},"ADG126","ADG126 will be administered at protocol defined dose.",[38,55],[85,90],{"name":86,"role":87,"phone":88,"phoneExt":63,"email":89},"Incyte Corporation Call Center (US)","CONTACT","1.855.463.3463","medinfo@incyte.com",{"name":91,"role":87,"phone":92,"phoneExt":63,"email":93},"Incyte Corporation Call Center (ex-US)","+800 00027423","eumedinfo@incyte.com",[95,109,115,125,135,145,155,163,173,183,193,202,214,220,229,240,249,258,267,278,287,298,307,316,327,336,342,353,359,368,374,380,391,400,409,420,429,435,444],{"facility":96,"status":97,"city":98,"state":99,"zip":100,"country":101,"countryCode":102,"cosmosGeoPoint":103,"geoPoint":108,"contacts":63},"The Angeles Clinic and Research Institute","RECRUITING","Los Angeles","California","90025","United States","US",{"type":104,"coordinates":105},"Point",[106,107],-118.24368,34.05223,{"lat":107,"lon":106},{"facility":110,"status":97,"city":98,"state":99,"zip":111,"country":101,"countryCode":102,"cosmosGeoPoint":112,"geoPoint":114,"contacts":63},"Valkyrie Clinical Trials","90067",{"type":104,"coordinates":113},[106,107],{"lat":107,"lon":106},{"facility":116,"status":97,"city":117,"state":118,"zip":119,"country":101,"countryCode":102,"cosmosGeoPoint":120,"geoPoint":124,"contacts":63},"Dana Farber Cancer Institute","Boston","Massachusetts","02215",{"type":104,"coordinates":121},[122,123],-71.05977,42.35843,{"lat":123,"lon":122},{"facility":126,"status":97,"city":127,"state":128,"zip":129,"country":101,"countryCode":102,"cosmosGeoPoint":130,"geoPoint":134,"contacts":63},"Cancer and Hematology Centers of Western Michigan-Start Midwest","Grand Rapids","Michigan","49546",{"type":104,"coordinates":131},[132,133],-85.66809,42.96336,{"lat":133,"lon":132},{"facility":136,"status":97,"city":137,"state":138,"zip":139,"country":101,"countryCode":102,"cosmosGeoPoint":140,"geoPoint":144,"contacts":63},"Hackensack University Medical Center","Hackensack","New Jersey","07601",{"type":104,"coordinates":141},[142,143],-74.04347,40.88593,{"lat":143,"lon":142},{"facility":146,"status":97,"city":147,"state":148,"zip":149,"country":101,"countryCode":102,"cosmosGeoPoint":150,"geoPoint":154,"contacts":63},"Nyu Langone Health - Long Island Hospital","Mineola","New York","11501",{"type":104,"coordinates":151},[152,153],-73.64068,40.74927,{"lat":153,"lon":152},{"facility":156,"status":97,"city":148,"state":148,"zip":157,"country":101,"countryCode":102,"cosmosGeoPoint":158,"geoPoint":162,"contacts":63},"Laura and Isaac Perlmutter Cancer Center","10016",{"type":104,"coordinates":159},[160,161],-74.00597,40.71427,{"lat":161,"lon":160},{"facility":164,"status":97,"city":165,"state":166,"zip":167,"country":101,"countryCode":102,"cosmosGeoPoint":168,"geoPoint":172,"contacts":63},"University of Pennsylvania","Philadelphia","Pennsylvania","19104",{"type":104,"coordinates":169},[170,171],-75.16362,39.95238,{"lat":171,"lon":170},{"facility":174,"status":97,"city":175,"state":176,"zip":177,"country":101,"countryCode":102,"cosmosGeoPoint":178,"geoPoint":182,"contacts":63},"Lifespan Cancer Research Institute","Providence","Rhode Island","02903",{"type":104,"coordinates":179},[180,181],-71.41283,41.82399,{"lat":181,"lon":180},{"facility":184,"status":97,"city":185,"state":186,"zip":187,"country":101,"countryCode":102,"cosmosGeoPoint":188,"geoPoint":192,"contacts":63},"University of Texas Md Anderson Cancer Center","Houston","Texas","77030",{"type":104,"coordinates":189},[190,191],-95.36327,29.76328,{"lat":191,"lon":190},{"facility":194,"status":97,"city":195,"state":186,"zip":196,"country":101,"countryCode":102,"cosmosGeoPoint":197,"geoPoint":201,"contacts":63},"South Texas Accelerated Research Therapeutics","San Antonio","78229",{"type":104,"coordinates":198},[199,200],-98.49363,29.42412,{"lat":200,"lon":199},{"facility":203,"status":204,"city":205,"state":63,"zip":206,"country":207,"countryCode":208,"cosmosGeoPoint":209,"geoPoint":213,"contacts":63},"Cancer Hospital Chinese Academy of Medical Sciences","NOT_YET_RECRUITING","Beijing","100021","China","CN",{"type":104,"coordinates":210},[211,212],116.39723,39.9075,{"lat":212,"lon":211},{"facility":215,"status":204,"city":205,"state":63,"zip":216,"country":207,"countryCode":208,"cosmosGeoPoint":217,"geoPoint":219,"contacts":63},"Peking University People'S Hospital","100044",{"type":104,"coordinates":218},[211,212],{"lat":212,"lon":211},{"facility":221,"status":204,"city":222,"state":63,"zip":223,"country":207,"countryCode":208,"cosmosGeoPoint":224,"geoPoint":228,"contacts":63},"The First Affiliated Hospital, Zhejiang University School of Medicine (Fahzu)","Hangzhou","310003",{"type":104,"coordinates":225},[226,227],120.16142,30.29365,{"lat":227,"lon":226},{"facility":230,"status":97,"city":231,"state":63,"zip":232,"country":233,"countryCode":234,"cosmosGeoPoint":235,"geoPoint":239,"contacts":63},"Rigshospitalet Uni of Hospital of Copenhagen","Copenhagen","02100","Denmark","DK",{"type":104,"coordinates":236},[237,238],12.56553,55.67594,{"lat":238,"lon":237},{"facility":241,"status":97,"city":242,"state":63,"zip":243,"country":233,"countryCode":234,"cosmosGeoPoint":244,"geoPoint":248,"contacts":63},"Herlev Og Gentofte Hospital","Herlev","02730",{"type":104,"coordinates":245},[246,247],12.43998,55.72366,{"lat":247,"lon":246},{"facility":250,"status":97,"city":251,"state":63,"zip":252,"country":233,"countryCode":234,"cosmosGeoPoint":253,"geoPoint":257,"contacts":63},"Odense University Hospital","Odense C","05000",{"type":104,"coordinates":254},[255,256],10.39538,55.40841,{"lat":256,"lon":255},{"facility":259,"status":97,"city":260,"state":63,"zip":261,"country":233,"countryCode":234,"cosmosGeoPoint":262,"geoPoint":266,"contacts":63},"Vejle Hospital","Vejle","07100",{"type":104,"coordinates":263},[264,265],9.5357,55.70927,{"lat":265,"lon":264},{"facility":268,"status":97,"city":269,"state":63,"zip":270,"country":271,"countryCode":272,"cosmosGeoPoint":273,"geoPoint":277,"contacts":63},"Centre Leon Berard","Lyon","69373","France","FR",{"type":104,"coordinates":274},[275,276],4.84789,45.74906,{"lat":276,"lon":275},{"facility":279,"status":97,"city":280,"state":63,"zip":281,"country":271,"countryCode":272,"cosmosGeoPoint":282,"geoPoint":286,"contacts":63},"Institut Gustave Roussy","Villejuif","94805",{"type":104,"coordinates":283},[284,285],2.35992,48.7939,{"lat":285,"lon":284},{"facility":288,"status":97,"city":289,"state":63,"zip":290,"country":291,"countryCode":292,"cosmosGeoPoint":293,"geoPoint":297,"contacts":63},"Fondazione Irccs Istituto Nazionale Dei Tumori","Milan","20133","Italy","IT",{"type":104,"coordinates":294},[295,296],12.59836,42.78235,{"lat":296,"lon":295},{"facility":299,"status":97,"city":300,"state":63,"zip":301,"country":291,"countryCode":292,"cosmosGeoPoint":302,"geoPoint":306,"contacts":63},"Irccs Istituto Clinico Humanitas","Rozzano","20089",{"type":104,"coordinates":303},[304,305],9.1559,45.38193,{"lat":305,"lon":304},{"facility":308,"status":97,"city":309,"state":63,"zip":310,"country":291,"countryCode":292,"cosmosGeoPoint":311,"geoPoint":315,"contacts":63},"Centro Ricerche Cliniche Di Verona","Verona","37134",{"type":104,"coordinates":312},[313,314],10.9938,45.43854,{"lat":314,"lon":313},{"facility":317,"status":97,"city":318,"state":63,"zip":319,"country":320,"countryCode":321,"cosmosGeoPoint":322,"geoPoint":326,"contacts":63},"Kansai Medical University Hospital","Hirakata","573-1191","Japan","JP",{"type":104,"coordinates":323},[324,325],135.64914,34.81352,{"lat":325,"lon":324},{"facility":328,"status":97,"city":329,"state":63,"zip":330,"country":320,"countryCode":321,"cosmosGeoPoint":331,"geoPoint":335,"contacts":63},"National Cancer Center Hospital","Tokyo","104-0045",{"type":104,"coordinates":332},[333,334],139.69171,35.6895,{"lat":334,"lon":333},{"facility":337,"status":97,"city":329,"state":63,"zip":338,"country":320,"countryCode":321,"cosmosGeoPoint":339,"geoPoint":341,"contacts":63},"The Cancer Institute Hospital of Jfcr","135-0063",{"type":104,"coordinates":340},[333,334],{"lat":334,"lon":333},{"facility":343,"status":97,"city":344,"state":63,"zip":345,"country":346,"countryCode":347,"cosmosGeoPoint":348,"geoPoint":352,"contacts":63},"Start Barcelona","Barcelona","08023","Spain","ES",{"type":104,"coordinates":349},[350,351],2.15899,41.38879,{"lat":351,"lon":350},{"facility":354,"status":97,"city":344,"state":63,"zip":355,"country":346,"countryCode":347,"cosmosGeoPoint":356,"geoPoint":358,"contacts":63},"Hospital General Universitario Vall D Hebron","08035",{"type":104,"coordinates":357},[350,351],{"lat":351,"lon":350},{"facility":360,"status":97,"city":361,"state":63,"zip":362,"country":346,"countryCode":347,"cosmosGeoPoint":363,"geoPoint":367,"contacts":63},"Fundacion Jimenez Diaz University Hospital","Madrid","28040",{"type":104,"coordinates":364},[365,366],-3.70256,40.4165,{"lat":366,"lon":365},{"facility":369,"status":97,"city":361,"state":63,"zip":370,"country":346,"countryCode":347,"cosmosGeoPoint":371,"geoPoint":373,"contacts":63},"Hospital Universitario 12 de Octubre","28041",{"type":104,"coordinates":372},[365,366],{"lat":366,"lon":365},{"facility":375,"status":97,"city":361,"state":63,"zip":376,"country":346,"countryCode":347,"cosmosGeoPoint":377,"geoPoint":379,"contacts":63},"Centro Integral Oncologico Clara Campal","28050",{"type":104,"coordinates":378},[365,366],{"lat":366,"lon":365},{"facility":381,"status":97,"city":382,"state":63,"zip":383,"country":384,"countryCode":385,"cosmosGeoPoint":386,"geoPoint":390,"contacts":63},"Istituto Oncologico Della Svizzera Italiana","Bellinzona","06500","Switzerland","CH",{"type":104,"coordinates":387},[388,389],9.01703,46.19278,{"lat":389,"lon":388},{"facility":392,"status":97,"city":393,"state":63,"zip":394,"country":384,"countryCode":385,"cosmosGeoPoint":395,"geoPoint":399,"contacts":63},"Centre Hospitalier Universitaire Vaudois (Chuv)","Lausanne","01011",{"type":104,"coordinates":396},[397,398],6.63282,46.516,{"lat":398,"lon":397},{"facility":401,"status":97,"city":402,"state":63,"zip":403,"country":384,"countryCode":385,"cosmosGeoPoint":404,"geoPoint":408,"contacts":63},"Kantonsspital St. Gallen","Sankt Gallen","09007",{"type":104,"coordinates":405},[406,407],9.37477,47.42391,{"lat":407,"lon":406},{"facility":410,"status":97,"city":411,"state":63,"zip":412,"country":413,"countryCode":414,"cosmosGeoPoint":415,"geoPoint":419,"contacts":63},"Cambridge University Hospitals Nhs Foundation Trust","Cambridge","CB2 0QQ","United Kingdom","UK",{"type":104,"coordinates":416},[417,418],0.11667,52.2,{"lat":418,"lon":417},{"facility":421,"status":97,"city":422,"state":63,"zip":423,"country":413,"countryCode":414,"cosmosGeoPoint":424,"geoPoint":428,"contacts":63},"Guys and St Thomas Nhs Foundation Trust","London","SE1 9RT",{"type":104,"coordinates":425},[426,427],-0.12574,51.50853,{"lat":427,"lon":426},{"facility":430,"status":97,"city":422,"state":63,"zip":431,"country":413,"countryCode":414,"cosmosGeoPoint":432,"geoPoint":434,"contacts":63},"Imperial College Healthcare Nhs Trust - Hammersmith Hospital","W12 0HS",{"type":104,"coordinates":433},[426,427],{"lat":427,"lon":426},{"facility":436,"status":97,"city":437,"state":63,"zip":438,"country":413,"countryCode":414,"cosmosGeoPoint":439,"geoPoint":443,"contacts":63},"The Christie Nhs Foundation Trust Uk","Manchester","M20 4BV",{"type":104,"coordinates":440},[441,442],-2.23743,53.48095,{"lat":442,"lon":441},{"facility":445,"status":97,"city":446,"state":63,"zip":447,"country":413,"countryCode":414,"cosmosGeoPoint":448,"geoPoint":452,"contacts":63},"Freeman Hospital Newcastle Upon Tyne Foundation Nhs Trust","Newcastle upon Tyne","NE7 7DN",{"type":104,"coordinates":449},[450,451],-1.61396,54.97328,{"lat":451,"lon":450},{"type":454,"investigatorFullName":63,"investigatorTitle":63,"investigatorAffiliation":63,"oldNameTitle":63,"oldOrganization":63},"SPONSOR","100503520","phase-1-a-study-to-evaluate-the-safety-of-inca33890-in-participants-with-advanced-or-metastatic-solid-tumors-100503520",false,"NCT05836324","A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors","A Phase 1, Open-Label, Multicenter Study of INCA33890 in Participants With Advanced or Metastatic Solid Tumors","Inclusion Criteria:\n\n* ≥18 years old\n* Histologically or cytologically confirmed advanced or metastatic malignancies as defined in the protocol.\n* Part 1: Participants must have experienced disease progression after treatment with, be intolerant to, or be ineligible for, or refused available therapies, including anti-PD-(L)1 or anti-CTLA4 therapy if applicable, that are known to confer clinical benefit. Part 2: depending on cohort, participants may have received or not prior treatment for the malignancy under study.\n* ECOG performance status score of 0 or 1.\n* Willingness to undergo pre- and on-treatment tumor biopsy (core or excisional). Biopsies are mandatory depending on the cohorts.\n* Presence of measurable disease according to RECIST v1.1.\n\nExclusion Criteria:\n\n* Any known additional malignancy that is progressing or requires active treatment, or history of other malignancy within 2 years.\n* Not recovered to ≤ Grade 1 or baseline from residual toxicities of prior therapy.\n* Has active autoimmune disease requiring systemic immunosuppression with corticosteroids.\n* Brain or CNS metastases untreated or that have progressed.\n* History of organ transplant, including allogeneic stem cell transplantation.\n* History of clinically significant or uncontrolled cardiac disease.\n* Active HBV, active HCV, or HIV positive.\n* Is on chronic systemic steroids (\\> 10 mg\u002Fday of prednisone or equivalent).\n* Chronic or current active infectious disease requiring systemic antibiotics, antifungal, or antiviral treatment\n* Participants that have been initiated on or had modifications in anticoagulation therapies within the last 3 months prior to first dose of treatment.\n* Significant concurrent, uncontrolled medical condition, eg:\n\n  * Cardiovascular: Participants with known vasculitis, aneurisms, and other vascular malformations of clinical significance or history of myocarditis.\n  * Gastrointestinal: Any bowel obstruction within 60 days prior to C1D1.\n* Participants with adequate laboratory values within the protocol defined ranges.\n\nOther protocol-defined Inclusion\u002FExclusion Criteria may apply.","ALL","18 Years",{"count":465,"type":466},570,"ESTIMATED","INTERVENTIONAL",[469],"PHASE1","To evaluate the safety, tolerability, and DLTs and determine the MTD and\u002For RDE(s) of INCA33890 in participants with select advanced or metastatic solid tumors.",[472,473,474],"Solid Tumors","Advanced Solid Tumors","Metastatic Solid Tumors",[472,60],"2026-07-21",{"date":478,"type":479},"2026-07-23","ACTUAL",{"date":481,"type":479},"2023-07-24",{"date":483,"type":466},"2029-05-03",{"name":5,"class":6},39]