[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100564854":3},{"organization":4,"armGroups":7,"interventions":47,"overallOfficials":75,"centralContacts":79,"locations":84,"responsibleParty":556,"collaborators":63,"id":558,"slug":559,"hasResults":560,"nctId":561,"briefTitle":562,"officialTitle":563,"acronym":63,"eligibilityCriteria":564,"healthyVolunteers":560,"sex":565,"minAge":566,"maxAge":63,"enrollmentInfo":567,"targetDuration":63,"studyType":570,"phases":571,"briefSummary":574,"conditions":575,"keywords":580,"overallStatus":87,"whyStopped":63,"lastUpdateSubmitDate":589,"lastUpdatePostDateStruct":590,"startDateStruct":593,"completionDateStruct":595,"leadSponsor":597,"locationsCount":598},{"fullName":5,"class":6},"BeOne Medicines","INDUSTRY",[8,15,19,24,28,33,37,43],{"label":9,"type":10,"description":11,"interventionNames":12},"Substudy 1 Part 1a: Dose Escalation","EXPERIMENTAL","Sequential cohorts of increasing dose level combinations of tacabrutideg and sonrotoclax will be evaluated in participants with selected B-cell malignancies.",[13,14],"Drug: Tacabrutideg","Drug: Sonrotoclax",{"label":16,"type":10,"description":17,"interventionNames":18},"Substudy 1 Part 1b: Safety Expansion","Cohorts of select dose level combinations of tacabrutideg and sonrotoclax will be evaluated in participants with selected B-cell malignancies.",[13,14],{"label":20,"type":10,"description":21,"interventionNames":22},"Substudy 2 Part 1a: Dose Escalation","Sequential cohorts of increasing dose level combinations of tacabrutideg and zanubrutinib will be evaluated in participants with selected B-cell malignancies.",[13,23],"Drug: Zanubrutinib",{"label":25,"type":10,"description":26,"interventionNames":27},"Substudy 2 Part 1b: Safety Expansion","Cohorts of select dose level combinations of tacabrutideg and zanubrutinib will be evaluated in participants with selected B-cell malignancies.",[13,23],{"label":29,"type":10,"description":30,"interventionNames":31},"Substudy 3 Part 1a: Dose Escalation","Sequential cohorts of increasing dose level combinations of tacabrutideg and mosunetuzumab will be evaluated in participants with selected B-cell malignancies.",[13,32],"Drug: Mosunetuzumab",{"label":34,"type":10,"description":35,"interventionNames":36},"Substudy 3 Part 1b: Safety Expansion","Cohorts of select dose level combinations of tacabrutideg and mosunetuzumab will be evaluated in participants with selected B-cell malignancies.",[13,32],{"label":38,"type":10,"description":39,"interventionNames":40},"Substudy 4 Part 1a: Dose Escalation","Sequential cohorts of increasing dose level combinations of tacabrutideg and glofitamab will be evaluated in participants with selected B-cell malignancies. Participants will receive obinutuzumab as pretreatment prior to the start of combination treatment.",[13,41,42],"Drug: Glofitamab","Drug: Obinutuzumab",{"label":44,"type":10,"description":45,"interventionNames":46},"Substudy 4 Part 1b: Safety Expansion","Cohorts of select dose level combinations of tacabrutideg and glofitamab will be evaluated in participants with selected B-cell malignancies.",[13,41,42],[48,55,60,64,68,72],{"type":49,"name":50,"description":51,"armGroupLabels":52,"otherNames":53},"DRUG","Tacabrutideg","Administered orally",[9,16,20,25,29,34,38,44],[54],"BGB-16673",{"type":49,"name":56,"description":51,"armGroupLabels":57,"otherNames":58},"Sonrotoclax",[9,16],[59],"BGB-11417",{"type":49,"name":61,"description":51,"armGroupLabels":62,"otherNames":63},"Zanubrutinib",[20,25],null,{"type":49,"name":65,"description":66,"armGroupLabels":67,"otherNames":63},"Mosunetuzumab","Administered subcutaneously",[29,34],{"type":49,"name":69,"description":70,"armGroupLabels":71,"otherNames":63},"Glofitamab","Administered intravenously",[38,44],{"type":49,"name":73,"description":70,"armGroupLabels":74,"otherNames":63},"Obinutuzumab",[38,44],[76],{"name":77,"affiliation":5,"role":78},"Study Director","STUDY_DIRECTOR",[80],{"name":77,"role":81,"phone":82,"phoneExt":63,"email":83},"CONTACT","1.877.828.5568","clinicaltrials@beonemed.com",[85,99,109,119,128,138,148,158,168,177,183,189,195,203,213,223,233,243,252,264,274,284,293,299,309,320,329,338,347,359,369,379,389,398,409,418,427,436,445,456,465,474,483,492,503,509,520,529,538,547],{"facility":86,"status":87,"city":88,"state":89,"zip":90,"country":91,"countryCode":92,"cosmosGeoPoint":93,"geoPoint":98,"contacts":63},"Mayo Clinic Phoenix","RECRUITING","Phoenix","Arizona","85054-4502","United States","US",{"type":94,"coordinates":95},"Point",[96,97],-112.07404,33.44838,{"lat":97,"lon":96},{"facility":100,"status":87,"city":101,"state":102,"zip":103,"country":91,"countryCode":92,"cosmosGeoPoint":104,"geoPoint":108,"contacts":63},"University of Southern California Norris Comprehensive","Los Angeles","California","90033",{"type":94,"coordinates":105},[106,107],-118.24368,34.05223,{"lat":107,"lon":106},{"facility":110,"status":87,"city":111,"state":112,"zip":113,"country":91,"countryCode":92,"cosmosGeoPoint":114,"geoPoint":118,"contacts":63},"Mayo Clinic Jacksonville","Jacksonville","Florida","32224-1865",{"type":94,"coordinates":115},[116,117],-81.65565,30.33218,{"lat":117,"lon":116},{"facility":120,"status":87,"city":121,"state":112,"zip":122,"country":91,"countryCode":92,"cosmosGeoPoint":123,"geoPoint":127,"contacts":63},"Moffitt Cancer Center","Tampa","33612-9496",{"type":94,"coordinates":124},[125,126],-82.45843,27.94752,{"lat":126,"lon":125},{"facility":129,"status":87,"city":130,"state":131,"zip":132,"country":91,"countryCode":92,"cosmosGeoPoint":133,"geoPoint":137,"contacts":63},"The University of Kansas Cancer Center","Westwood","Kansas","66205-2003",{"type":94,"coordinates":134},[135,136],-94.6169,39.04056,{"lat":136,"lon":135},{"facility":139,"status":87,"city":140,"state":141,"zip":142,"country":91,"countryCode":92,"cosmosGeoPoint":143,"geoPoint":147,"contacts":63},"Mayo Clinic Rochester","Rochester","Minnesota","55905-0001",{"type":94,"coordinates":144},[145,146],-92.4699,44.02163,{"lat":146,"lon":145},{"facility":149,"status":87,"city":150,"state":151,"zip":152,"country":91,"countryCode":92,"cosmosGeoPoint":153,"geoPoint":157,"contacts":63},"Washington University School of Medicine","St Louis","Missouri","63110-1010",{"type":94,"coordinates":154},[155,156],-90.19789,38.62727,{"lat":156,"lon":155},{"facility":159,"status":87,"city":160,"state":161,"zip":162,"country":91,"countryCode":92,"cosmosGeoPoint":163,"geoPoint":167,"contacts":63},"Summit Medical Group","Florham Park","New Jersey","07932-1049",{"type":94,"coordinates":164},[165,166],-74.38821,40.78788,{"lat":166,"lon":165},{"facility":169,"status":87,"city":170,"state":170,"zip":171,"country":91,"countryCode":92,"cosmosGeoPoint":172,"geoPoint":176,"contacts":63},"Icahn School of Medicine At Mount Sinai","New York","10029-6504",{"type":94,"coordinates":173},[174,175],-74.00597,40.71427,{"lat":175,"lon":174},{"facility":178,"status":87,"city":170,"state":170,"zip":179,"country":91,"countryCode":92,"cosmosGeoPoint":180,"geoPoint":182,"contacts":63},"Columbia University Medical Center","10032",{"type":94,"coordinates":181},[174,175],{"lat":175,"lon":174},{"facility":184,"status":87,"city":170,"state":170,"zip":185,"country":91,"countryCode":92,"cosmosGeoPoint":186,"geoPoint":188,"contacts":63},"Weill Cornell Medical College Newyork Presbyterian Hospital","10065-4870",{"type":94,"coordinates":187},[174,175],{"lat":175,"lon":174},{"facility":190,"status":87,"city":170,"state":170,"zip":191,"country":91,"countryCode":92,"cosmosGeoPoint":192,"geoPoint":194,"contacts":63},"Memorial Sloan Kettering Cancer Center Mskcc","10065-6800",{"type":94,"coordinates":193},[174,175],{"lat":175,"lon":174},{"facility":196,"status":87,"city":140,"state":170,"zip":197,"country":91,"countryCode":92,"cosmosGeoPoint":198,"geoPoint":202,"contacts":63},"University of Rochester","14642-0001",{"type":94,"coordinates":199},[200,201],-77.61556,43.15478,{"lat":201,"lon":200},{"facility":204,"status":87,"city":205,"state":206,"zip":207,"country":91,"countryCode":92,"cosmosGeoPoint":208,"geoPoint":212,"contacts":63},"Fox Chase Cancer Center","Philadelphia","Pennsylvania","19111-2434",{"type":94,"coordinates":209},[210,211],-75.16362,39.95238,{"lat":211,"lon":210},{"facility":214,"status":87,"city":215,"state":216,"zip":217,"country":91,"countryCode":92,"cosmosGeoPoint":218,"geoPoint":222,"contacts":63},"The University of Texas Md Anderson Cancer Center","Houston","Texas","77030-4009",{"type":94,"coordinates":219},[220,221],-95.36327,29.76328,{"lat":221,"lon":220},{"facility":224,"status":87,"city":225,"state":226,"zip":227,"country":91,"countryCode":92,"cosmosGeoPoint":228,"geoPoint":232,"contacts":63},"Huntsman Cancer Institute","Salt Lake City","Utah","84112-5550",{"type":94,"coordinates":229},[230,231],-111.89105,40.76078,{"lat":231,"lon":230},{"facility":234,"status":87,"city":235,"state":236,"zip":237,"country":91,"countryCode":92,"cosmosGeoPoint":238,"geoPoint":242,"contacts":63},"University of Wisconsin","Madison","Wisconsin","53792-0001",{"type":94,"coordinates":239},[240,241],-89.40123,43.07305,{"lat":241,"lon":240},{"facility":244,"status":87,"city":245,"state":236,"zip":246,"country":91,"countryCode":92,"cosmosGeoPoint":247,"geoPoint":251,"contacts":63},"Medical College of Wisconsin","Milwaukee","53226-3522",{"type":94,"coordinates":248},[249,250],-87.90647,43.0389,{"lat":250,"lon":249},{"facility":253,"status":87,"city":254,"state":255,"zip":256,"country":257,"countryCode":258,"cosmosGeoPoint":259,"geoPoint":263,"contacts":63},"St George Hospital","Kogarah","New South Wales","NSW 2217","Australia","AU",{"type":94,"coordinates":260},[261,262],151.13564,-33.9681,{"lat":262,"lon":261},{"facility":265,"status":87,"city":266,"state":267,"zip":268,"country":257,"countryCode":258,"cosmosGeoPoint":269,"geoPoint":273,"contacts":63},"Mater Cancer Care Centre","South Brisbane","Queensland","QLD 4101",{"type":94,"coordinates":270},[271,272],153.02049,-27.48034,{"lat":272,"lon":271},{"facility":275,"status":87,"city":276,"state":277,"zip":278,"country":257,"countryCode":258,"cosmosGeoPoint":279,"geoPoint":283,"contacts":63},"Monash Health","Clayton","Victoria","VIC 3168",{"type":94,"coordinates":280},[281,282],145.11667,-37.91667,{"lat":282,"lon":281},{"facility":285,"status":87,"city":286,"state":277,"zip":287,"country":257,"countryCode":258,"cosmosGeoPoint":288,"geoPoint":292,"contacts":63},"Peter Maccallum Cancer Centre","Melbourne","VIC 3000",{"type":94,"coordinates":289},[290,291],144.96332,-37.814,{"lat":291,"lon":290},{"facility":294,"status":87,"city":286,"state":277,"zip":295,"country":257,"countryCode":258,"cosmosGeoPoint":296,"geoPoint":298,"contacts":63},"The Alfred Hospital","VIC 3004",{"type":94,"coordinates":297},[290,291],{"lat":291,"lon":290},{"facility":300,"status":87,"city":301,"state":302,"zip":303,"country":257,"countryCode":258,"cosmosGeoPoint":304,"geoPoint":308,"contacts":63},"Linear Clinical Research","Nedlands","Western Australia","WA 6009",{"type":94,"coordinates":305},[306,307],115.8073,-31.98184,{"lat":307,"lon":306},{"facility":310,"status":87,"city":311,"state":63,"zip":312,"country":313,"countryCode":314,"cosmosGeoPoint":315,"geoPoint":319,"contacts":63},"Hospital Sirio Libanes Brasilia","Brasília","70200-730","Brazil","BR",{"type":94,"coordinates":316},[317,318],-47.92972,-15.77972,{"lat":318,"lon":317},{"facility":321,"status":87,"city":322,"state":63,"zip":323,"country":313,"countryCode":314,"cosmosGeoPoint":324,"geoPoint":328,"contacts":63},"Ensino E Terapia de Inovacao Clinica Amo Etica","Salvador","41950-640",{"type":94,"coordinates":325},[326,327],-38.49096,-12.97563,{"lat":327,"lon":326},{"facility":330,"status":87,"city":331,"state":63,"zip":332,"country":313,"countryCode":314,"cosmosGeoPoint":333,"geoPoint":337,"contacts":63},"Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto","São José do Rio Preto","15090-000",{"type":94,"coordinates":334},[335,336],-49.37944,-20.81972,{"lat":336,"lon":335},{"facility":339,"status":87,"city":340,"state":63,"zip":341,"country":313,"countryCode":314,"cosmosGeoPoint":342,"geoPoint":346,"contacts":63},"Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein","São Paulo","05652-900",{"type":94,"coordinates":343},[344,345],-46.63611,-23.5475,{"lat":345,"lon":344},{"facility":348,"status":87,"city":349,"state":350,"zip":351,"country":352,"countryCode":353,"cosmosGeoPoint":354,"geoPoint":358,"contacts":63},"Fujian Medical University Union Hospital","Fuzhou","Fujian","350001","China","CN",{"type":94,"coordinates":355},[356,357],119.30611,26.06139,{"lat":357,"lon":356},{"facility":360,"status":87,"city":361,"state":362,"zip":363,"country":352,"countryCode":353,"cosmosGeoPoint":364,"geoPoint":368,"contacts":63},"Sun Yat Sen University Cancer Center","Guangzhou","Guangdong","510060",{"type":94,"coordinates":365},[366,367],113.25,23.11667,{"lat":367,"lon":366},{"facility":370,"status":87,"city":371,"state":372,"zip":373,"country":352,"countryCode":353,"cosmosGeoPoint":374,"geoPoint":378,"contacts":63},"The First Affiliated Hospital of Soochow University","Suzhou","Jiangsu","215006",{"type":94,"coordinates":375},[376,377],120.59538,31.30408,{"lat":377,"lon":376},{"facility":380,"status":87,"city":381,"state":382,"zip":383,"country":352,"countryCode":353,"cosmosGeoPoint":384,"geoPoint":388,"contacts":63},"The First Affiliated Hospital, Zhejiang University School of Medicinechengzhan","Hangzhou","Zhejiang","310002",{"type":94,"coordinates":385},[386,387],120.16142,30.29365,{"lat":387,"lon":386},{"facility":390,"status":87,"city":391,"state":382,"zip":392,"country":352,"countryCode":353,"cosmosGeoPoint":393,"geoPoint":397,"contacts":63},"The First Affiliated Hospital of Wenzhou Medical University","Wenzhou","325000",{"type":94,"coordinates":394},[395,396],120.66682,27.99942,{"lat":396,"lon":395},{"facility":399,"status":87,"city":400,"state":63,"zip":401,"country":402,"countryCode":403,"cosmosGeoPoint":404,"geoPoint":408,"contacts":63},"Universitatsklinikum Carl Gustav Carus An Der Technischen Universitat Dresden","Dresden","01307","Germany","DE",{"type":94,"coordinates":405},[406,407],13.73832,51.05089,{"lat":407,"lon":406},{"facility":410,"status":87,"city":411,"state":63,"zip":412,"country":402,"countryCode":403,"cosmosGeoPoint":413,"geoPoint":417,"contacts":63},"Universitatsklinikum Jena Klinik Fur Innere Medizin Ii","Jena","07747",{"type":94,"coordinates":414},[415,416],11.5899,50.92878,{"lat":416,"lon":415},{"facility":419,"status":87,"city":420,"state":63,"zip":421,"country":402,"countryCode":403,"cosmosGeoPoint":422,"geoPoint":426,"contacts":63},"Universitatsklinikum Schleswig Holstein Campus Kiel","Kiel","24105",{"type":94,"coordinates":423},[424,425],10.13489,54.32133,{"lat":425,"lon":424},{"facility":428,"status":87,"city":429,"state":63,"zip":430,"country":402,"countryCode":403,"cosmosGeoPoint":431,"geoPoint":435,"contacts":63},"Medizinische Universitaetsklinik","Tübingen","72076",{"type":94,"coordinates":432},[433,434],9.05222,48.52266,{"lat":434,"lon":433},{"facility":437,"status":87,"city":438,"state":63,"zip":439,"country":402,"countryCode":403,"cosmosGeoPoint":440,"geoPoint":444,"contacts":63},"Universitaetsklinikum Ulm","Ulm","89081",{"type":94,"coordinates":441},[442,443],9.99155,48.39841,{"lat":443,"lon":442},{"facility":446,"status":87,"city":447,"state":63,"zip":448,"country":449,"countryCode":450,"cosmosGeoPoint":451,"geoPoint":455,"contacts":63},"Azienda Ospedaliera Universitaria Policlinico Santorsola Malpighi","Bologna","40138","Italy","IT",{"type":94,"coordinates":452},[453,454],11.33875,44.49381,{"lat":454,"lon":453},{"facility":457,"status":87,"city":458,"state":63,"zip":459,"country":449,"countryCode":450,"cosmosGeoPoint":460,"geoPoint":464,"contacts":63},"Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda","Milan","20162",{"type":94,"coordinates":461},[462,463],12.59836,42.78235,{"lat":463,"lon":462},{"facility":466,"status":87,"city":467,"state":63,"zip":468,"country":449,"countryCode":450,"cosmosGeoPoint":469,"geoPoint":473,"contacts":63},"Istituto Nazionale Tumori Fondazione G Pascale","Naples","80131",{"type":94,"coordinates":470},[471,472],14.26811,40.85216,{"lat":472,"lon":471},{"facility":475,"status":87,"city":476,"state":63,"zip":477,"country":449,"countryCode":450,"cosmosGeoPoint":478,"geoPoint":482,"contacts":63},"Istituto Clinico Humanitas","Rozzano","20089",{"type":94,"coordinates":479},[480,481],9.1559,45.38193,{"lat":481,"lon":480},{"facility":484,"status":87,"city":485,"state":63,"zip":486,"country":449,"countryCode":450,"cosmosGeoPoint":487,"geoPoint":491,"contacts":63},"Centroricerche Cliniche Di Verona Srl","Verona","37134",{"type":94,"coordinates":488},[489,490],10.9938,45.43854,{"lat":490,"lon":489},{"facility":493,"status":87,"city":494,"state":63,"zip":495,"country":496,"countryCode":497,"cosmosGeoPoint":498,"geoPoint":502,"contacts":63},"North Shore Hospital","Auckland","0622","New Zealand","NZ",{"type":94,"coordinates":499},[500,501],174.76349,-36.84853,{"lat":501,"lon":500},{"facility":504,"status":87,"city":494,"state":63,"zip":505,"country":496,"countryCode":497,"cosmosGeoPoint":506,"geoPoint":508,"contacts":63},"Auckland City Hospital","1023",{"type":94,"coordinates":507},[500,501],{"lat":501,"lon":500},{"facility":510,"status":87,"city":511,"state":63,"zip":512,"country":513,"countryCode":514,"cosmosGeoPoint":515,"geoPoint":519,"contacts":63},"Uniwersyteckie Centrum Kliniczne","Gdansk","80-214","Poland","PL",{"type":94,"coordinates":516},[517,518],18.64912,54.35227,{"lat":518,"lon":517},{"facility":521,"status":87,"city":522,"state":63,"zip":523,"country":513,"countryCode":514,"cosmosGeoPoint":524,"geoPoint":528,"contacts":63},"Uniwersytecki Szpital Kliniczny Nr 1 W Lublinie","Lublin","20-081",{"type":94,"coordinates":525},[526,527],22.57009,51.25058,{"lat":527,"lon":526},{"facility":530,"status":87,"city":531,"state":63,"zip":532,"country":513,"countryCode":514,"cosmosGeoPoint":533,"geoPoint":537,"contacts":63},"Szpital Kliniczny Mswia Z Warmisko Mazurskim Centrum Onkologii","Olsztyn","10-228",{"type":94,"coordinates":534},[535,536],20.49272,53.78376,{"lat":536,"lon":535},{"facility":539,"status":87,"city":540,"state":63,"zip":541,"country":513,"countryCode":514,"cosmosGeoPoint":542,"geoPoint":546,"contacts":63},"Szpital Wojewodzki W Opolu Sp Z Oo Oddzia Hematologii I Onkologii Hematologicznej","Opole","45-061",{"type":94,"coordinates":543},[544,545],17.92604,50.67119,{"lat":545,"lon":544},{"facility":548,"status":87,"city":549,"state":63,"zip":550,"country":513,"countryCode":514,"cosmosGeoPoint":551,"geoPoint":555,"contacts":63},"Narodowy Instytut Onkologii Im Marii Sklodowskiej Curie W Warszawie","Warsaw","02-781",{"type":94,"coordinates":552},[553,554],21.01178,52.22977,{"lat":554,"lon":553},{"type":557,"investigatorFullName":63,"investigatorTitle":63,"investigatorAffiliation":63,"oldNameTitle":63,"oldOrganization":63},"SPONSOR","100564854","phase-1-a-study-to-investigate-safety-and-effectiveness-of-bgb-16673-in-combination-with-other-agents-in-participants-with-relapsed-or-refractory-b-cell-malignancies-100564854",false,"NCT06634589","A Study to Investigate Safety and Effectiveness of Tacabrutideg (BGB-16673) in Combination With Other Agents in Participants With Relapsed or Refractory B-Cell Malignancies","A Phase 1b\u002F2, Open-Label, Master Protocol Study of BTK-Degrader BGB-16673 in Combination With Other Agents in Patients With Relapsed or Refractory B-Cell Malignancies","Key Inclusion Criteria:\n\n* Must sign the informed consent form (ICF) and be capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the ICF\n* Confirmed diagnosis of a R\u002FR B-cell malignancy\n* Protocol-defined measurable disease\n* Stable Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 2\n* Adequate organ function\n* Female participants of childbearing potential must be willing to use a highly effective method of birth control and refrain from egg donation for the duration of the study and for ≥ 7 days after the last dose of sonrotoclax, 30 days after the last dose of tacabrutideg or zanubrutinib, 60 days after the last dose of glofitamab, or 90 days after the last dose of mosunetuzumab. A negative urine or serum pregnancy test result must be provided 10-14 days before the first dose of study treatment\n* Nonsterile male participants must be willing to use a highly effective method of birth control and refrain from sperm donation for the duration of the study and for ≥ 7 days after the last dose of sonrotoclax, 30 days after the last dose of tacabrutideg or zanubrutinib, 60 days after the last dose of glofitamab, or 90 days after the last dose of mosunetuzumab\n* Substudies 1, 3, and 4 Inclusion Criterion:\n\n  * Adequate renal function as indicated by estimated glomerular filtration rate (eGFR) of ≥ 50 mL\u002Fmin\n* Substudy 2 Inclusion Criteria:\n\n  * Bruton tyrosine kinase (BTK) inhibitor-naive, or previously received treatment with a covalent BTK inhibitor and discontinued for reasons other than clinical progression\n  * Adequate renal function as indicated by eGFR of ≥ 30 mL\u002Fmin\n\nKey Exclusion Criteria:\n\n* Treatment-naive B-cell malignancies\n* Unable to comply with the requirements of the protocol\n* Active leptomeningeal disease or uncontrolled, untreated brain metastasis\n* Any malignancy ≤ 2 years before first dose of study treatment except for the specific cancer under investigation in this study or any locally recurring cancer that has been treated curatively\n* Autologous stem cell transplant ≤ 3 months prior to screening or chimeric antigen T-cell therapy ≤ 3 months prior to screening\n* Prior invasive fungal infection, except if participant agrees to receive secondary antifungal prophylaxis during the entire treatment period\n* Substudies 1 and 2: Prior allogeneic stem cell transplant with active graft-versus-host disease (GVHD), or requiring immunosuppressive drugs for treatment of GVHD, or who have taken calcineurin inhibitors within 4 weeks prior to consent\n* Participants who have a history of severe allergic reactions or hypersensitivity to the active ingredient and excipients of tacabrutideg, sonrotoclax, zanubrutinib, mosunetuzumab, or glofitamab\n* Substudy 1 Exclusion Criterion:\n\n  * Prior treatment with a B-cell lymphoma-2 (Bcl-2) inhibitor (with exception for participants who relapsed ≥ 24 months after completion of a full course of a prior Bcl-2 inhibitor containing regimen)\n* Substudy 2 Exclusion Criterion:\n\n  * Participants who discontinued prior zanubrutinib treatment due to intolerance\n* Substudies 3 and 4 Exclusion Criteria:\n\n  * Prior exposure to a CD20 x CD3 T-cell engager antibody treatment\n  * All participants with a prior allogeneic stem cell transplant\n  * Participants with known contraindications to azole antifungal agents, including hypersensitivity reactions\n\nNote: Other protocol defined Inclusion\u002FExclusion criteria may apply.","ALL","18 Years",{"count":568,"type":569},80,"ESTIMATED","INTERVENTIONAL",[572,573],"PHASE1","PHASE2","The purpose of this study is to measure the safety, preliminary antitumor activity, pharmacokinetics, and pharmacodynamics with tacabrutideg in combination with other agents in participants with relapsed or refractory (R\u002FR) B-cell malignancies. This study is structured as a master protocol with separate substudies. This study currently includes four substudies, and more substudies may be added as other combination agents are identified.",[576,577,578,579],"B-cell Malignancy","Relapsed Cancer","Refractory Cancer","B-cell Lymphoma",[581,582,583,54,584,585,586,587,65,69,588],"R\u002FR B-Cell Malignancies","relapsed or refractory B-Cell Malignancies","B-Cell malignancy","sonrotoclax","zanubrutinib","B-cell lymphoma","Bruton Tyrosine Kinase (BTK)","tacabrutideg","2026-08-20",{"date":591,"type":592},"2026-08-21","ACTUAL",{"date":594,"type":592},"2024-11-27",{"date":596,"type":569},"2029-12-02",{"name":5,"class":6},50]