[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646253":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":39,"responsibleParty":53,"collaborators":25,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":25,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":25,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":25,"overallStatus":42,"whyStopped":25,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Novo Nordisk A\u002FS","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"NNC6022-0004","EXPERIMENTAL","Participants will receive NNC6022-0004 administered orally as a single ascending dose (SAD), multiple ascending dose (MAD), or under fed\u002Ffasted conditions.",[13],"Drug: NNC6022-0004",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Participants will receive placebo matched to NNC6022-0004 administered orally as a SAD, MAD, or under fed\u002Ffasted conditions.",[19],"Drug: Placebo",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Participants will receive single dose of NNC6022-0004 administered orally in capsule form.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Participants will receive placebo matched to NNC6022-0004 administered orally in capsule form.",[15],[30],{"name":31,"affiliation":5,"role":32},"Clinical Transparency dept. 2834","STUDY_DIRECTOR",[34],{"name":35,"role":36,"phone":37,"phoneExt":25,"email":38},"Novo Nordisk","CONTACT","(+1) 866-867-7178","clinicaltrials@novonordisk.com",[40],{"facility":41,"status":42,"city":43,"state":25,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":25},"ICON - location Groningen","RECRUITING","Groningen","9728 NZ","Netherlands","NL",{"type":48,"coordinates":49},"Point",[50,51],6.56667,53.21917,{"lat":51,"lon":50},{"type":54,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100646253","phase-1-a-study-to-see-how-safe-a-new-medicine-nnc6022-0004-is-in-healthy-people-and-people-living-with-obesity-100646253",false,"NCT07693868","A Study to See How Safe a New Medicine (NNC6022-0004) is in Healthy People and People Living With Obesity","An NNC6022-0004 Single and Multiple Ascending Dose Study Investigating Safety, Tolerability, Pharmacokinetics, Food Effect and Target Engagement in Healthy Adults Including a Single Cohort in Adults Living With Obesity","Inclusion Criteria:\n\n* Male, or female of non-childbearing potential.\n* For Parts A, B, C and D: Age 18-55 years (both inclusive) at the time of signing the informed consent.\n\nFor optional Part E only: Age 18-65 years (both inclusive) at the time of signing the informed consent.\n\n-For Parts A, B, C and D: Body mass index (BMI) between 18.5 to 29.9 kilogram per meter square (kg\u002Fm\\^2) (both inclusive) at screening.\n\nFor optional Part E only: BMI between greater than or equal to (≥) 30.0 to less than or equal to (≤) 45.0 kg\u002Fm\\^2 at screening, or if BMI is between 27.0 and \\\u003C30.0 kg\u002Fm\\^2, waist to height ratio should be greater than (\\>)0.5.\n\n* Body weight: ≥50.0 kilogram (kg) at screening.\n* Considered to be generally healthy based on the medical history, physical examination, and the results of vital signs, electrocardiogram and clinical laboratory tests performed during the screening visit, as judged by the investigator.\n* For optional Part E only: hsCRP ≥2.00 and ≤8.00 milligrams per liter (mg\u002FL) during screening period in 2 separate samples taken ≥4 days apart.\n\nExclusion Criteria:\n\n* Known or suspected hypersensitivity to study intervention(s) or similar products.\n* Any disorder, unwillingness or inability which in the investigator's opinion might jeopardise participant's safety or compliance with the protocol.\n* Any of the below laboratory safety parameters at screening outside normal range, see designated reference range documents for specific values.\n* Alanine Aminotransferase (ALT) \\> Upper limit of normal (ULN).\n* Alkaline Phosphatase (ALP) \\> ULN.\n* Aspartate aminotransferase (AST) \\> ULN.\n* Total Bilirubin (TBL) \\> ULN.\n* Creatinine \\> ULN.\n* International normalized ratio (INR) \\> ULN.\n* Fibrinogen outside normal range of 1.6 - 4.2 grams per liter (g\u002FL).\n* hsCRP \\> 5.00 mg\u002FL (males) and \\> 8.00 mg\u002FL (females)\\*.\n\n  * applicable for Parts A, B, C and D and for optional Part E: hsCRP \\>8.00 mg\u002FL.\n* Use of prescription medicinal products or vaccines within 14 days before screening and\u002For non prescription medicinal products within 7 days before dosing. Exceptions are: Topical medications not reaching systemic circulation; less than once per week of over-the-counter paracetamol, ibuprofen and\u002For acetylsalicylic acid at their labelled doses for mild pain; vitamins at their labelled doses.",true,"ALL","18 Years","65 Years",{"count":67,"type":68},128,"ESTIMATED","INTERVENTIONAL",[71],"PHASE1","This study is being done to look at the efficacy single and multiple ascending dose study investigating safety, tolerability, pharmacokinetics, food effect and target engagement in healthy adults including a single cohort in adults living with obesity. Participants will either get NNC6022-0004, (the treatment being tested) or Placebo (a treatment that has no active medicine in it) and which treatment participants get is decided by chance.",[74,75],"Obesity","Elevated High-sensitivity C-reactive Protein (hsCRP)","2026-08-17",{"date":78,"type":79},"2026-08-19","ACTUAL",{"date":81,"type":79},"2026-07-06",{"date":83,"type":68},"2027-08-01",{"name":5,"class":6},1]