[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636860":3},{"organization":4,"outcomesModule":7,"designInfo":13,"detailedDescription":11,"studyPopulation":11,"armGroups":19,"interventions":26,"overallOfficials":31,"centralContacts":35,"locations":45,"responsibleParty":180,"collaborators":11,"id":182,"slug":183,"hasResults":184,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":11,"eligibilityCriteria":188,"healthyVolunteers":184,"sex":189,"minAge":190,"maxAge":191,"enrollmentInfo":192,"targetDuration":11,"studyType":195,"phases":196,"briefSummary":198,"conditions":199,"keywords":11,"overallStatus":79,"whyStopped":11,"lastUpdateSubmitDate":201,"lastUpdatePostDateStruct":202,"startDateStruct":205,"completionDateStruct":207,"leadSponsor":209,"locationsCount":210},{"fullName":5,"class":6},"Eli Lilly and Company","INDUSTRY",{"primaryOutcomes":8,"secondaryOutcomes":11,"otherOutcomes":11},[9],{"measure":10,"description":11,"timeFrame":12},"Number of Participants with One or More Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration",null,"Baseline Up to Week 96",{"allocation":14,"interventionModel":15,"interventionModelDescription":11,"primaryPurpose":16,"observationalModel":11,"timePerspective":11,"maskingInfo":17},"NA","PARALLEL","BASIC_SCIENCE",{"masking":18,"maskingDescription":11,"whoMasked":11},"NONE",[20],{"label":21,"type":22,"description":23,"interventionNames":24},"LY4256984","EXPERIMENTAL","LY4256984 administered intrathecally (IT)",[25],"Drug: LY4256984",[27],{"type":28,"name":21,"description":29,"armGroupLabels":30,"otherNames":11},"DRUG","Administered IT",[21],[32],{"name":33,"affiliation":5,"role":34},"Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC\u002FGMT - 5 hours, EST)","STUDY_DIRECTOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":11,"email":40},"Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or","CONTACT","1-317-615-4559","LillyTrials@Lilly.com",{"name":42,"role":38,"phone":43,"phoneExt":11,"email":44},"Physicians interested in becoming principal investigators please contact","3176154559","clinical_inquiry_hub@lilly.com",[46,63,77,90,102,116,128,140,154,168],{"facility":47,"status":48,"city":49,"state":11,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"UZ Leuven","NOT_YET_RECRUITING","Leuven","3000","Belgium","BE",{"type":54,"coordinates":55},"Point",[56,57],4.70093,50.87959,{"lat":57,"lon":56},[60],{"name":61,"role":62,"phone":11,"phoneExt":11,"email":11},"Philip Van Damme","PRINCIPAL_INVESTIGATOR",{"facility":64,"status":48,"city":65,"state":11,"zip":66,"country":67,"countryCode":68,"cosmosGeoPoint":69,"geoPoint":73,"contacts":74},"University Hospital - London Health Sciences Centre","London","N6A 5A5","Canada","CA",{"type":54,"coordinates":70},[71,72],-81.23304,42.98339,{"lat":72,"lon":71},[75],{"name":76,"role":62,"phone":11,"phoneExt":11,"email":11},"Christen Shoesmith",{"facility":78,"status":79,"city":80,"state":11,"zip":81,"country":67,"countryCode":68,"cosmosGeoPoint":82,"geoPoint":86,"contacts":87},"McGill University Health Centre","RECRUITING","Montreal","H4A 3J1",{"type":54,"coordinates":83},[84,85],-73.58781,45.50884,{"lat":85,"lon":84},[88],{"name":89,"role":62,"phone":11,"phoneExt":11,"email":11},"Angela Genge",{"facility":91,"status":79,"city":92,"state":11,"zip":93,"country":67,"countryCode":68,"cosmosGeoPoint":94,"geoPoint":98,"contacts":99},"Sunnybrook Research Institute","Toronto","M4N 3M5",{"type":54,"coordinates":95},[96,97],-79.39864,43.70643,{"lat":97,"lon":96},[100],{"name":101,"role":62,"phone":11,"phoneExt":11,"email":11},"Agessandro Abrahao",{"facility":103,"status":48,"city":104,"state":11,"zip":105,"country":106,"countryCode":107,"cosmosGeoPoint":108,"geoPoint":112,"contacts":113},"Universitätsklinikum Schleswig-Holstein","Lübeck","23538","Germany","DE",{"type":54,"coordinates":109},[110,111],10.68729,53.86893,{"lat":111,"lon":110},[114],{"name":115,"role":62,"phone":11,"phoneExt":11,"email":11},"Julian Grosskreutz",{"facility":117,"status":48,"city":118,"state":11,"zip":119,"country":106,"countryCode":107,"cosmosGeoPoint":120,"geoPoint":124,"contacts":125},"Universitätsmedizin Rostock","Rostock","18147",{"type":54,"coordinates":121},[122,123],12.14049,54.0887,{"lat":123,"lon":122},[126],{"name":127,"role":62,"phone":11,"phoneExt":11,"email":11},"Andreas Hermann",{"facility":129,"status":48,"city":130,"state":11,"zip":131,"country":106,"countryCode":107,"cosmosGeoPoint":132,"geoPoint":136,"contacts":137},"Universitaetsklinikum Ulm","Ulm","89081",{"type":54,"coordinates":133},[134,135],9.99155,48.39841,{"lat":135,"lon":134},[138],{"name":139,"role":62,"phone":11,"phoneExt":11,"email":11},"Jochen Weishaupt",{"facility":141,"status":48,"city":142,"state":11,"zip":143,"country":144,"countryCode":145,"cosmosGeoPoint":146,"geoPoint":150,"contacts":151},"Universitair Medisch Centrum Utrecht","Utrecht","3584 CX","Netherlands","NL",{"type":54,"coordinates":147},[148,149],5.12222,52.09083,{"lat":149,"lon":148},[152],{"name":153,"role":62,"phone":11,"phoneExt":11,"email":11},"Leonard H. Berg",{"facility":155,"status":48,"city":156,"state":11,"zip":157,"country":158,"countryCode":159,"cosmosGeoPoint":160,"geoPoint":164,"contacts":165},"Hospital Universitari de Bellvitge","L'Hospitalet de Llobregat","08907","Spain","ES",{"type":54,"coordinates":161},[162,163],2.10028,41.35967,{"lat":163,"lon":162},[166],{"name":167,"role":62,"phone":11,"phoneExt":11,"email":11},"MONICA POVEDANO PANADES",{"facility":169,"status":48,"city":170,"state":11,"zip":171,"country":158,"countryCode":159,"cosmosGeoPoint":172,"geoPoint":176,"contacts":177},"Hospital Universitari i Politecnic La Fe","Valencia","46026",{"type":54,"coordinates":173},[174,175],-0.37966,39.47391,{"lat":175,"lon":174},[178],{"name":179,"role":62,"phone":11,"phoneExt":11,"email":11},"Juan Vazquez-Costa",{"type":181,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100636860","phase-1-a-substudy-of-ly4256984-in-participants-with-sporadic-amyotrophic-lateral-sclerosis-100636860",false,"NCT07571174","A Substudy of LY4256984 in Participants With Sporadic Amyotrophic Lateral Sclerosis","A Study of Long-Term Safety, Tolerability, and Clinical Outcomes of Intrathecally Administered LY4256984 in Participants With Sporadic Amyotrophic Lateral Sclerosis: A Multicenter, Open-Label, Long-Term Extension of Study J6I-MC-OWAA","Participants must meet eligibility criteria in the \\[L0U-MC-OLMP\\] screening protocol before entry into the treatment study.\n\nInclusion Criteria:\n\n* Have completed the main treatment period\u002Fphase as well as any off-treatment period\u002Fphase of Study OWAA, the parent study for this ISA.\n\nExclusion Criteria:\n\n* The participant has conditions that preclude a lumbar puncture (LP), such as:\n\n  * A history of clinically significant back pain, back pathology, and\u002For back injury (for example, degenerative disease, spinal deformity, or spinal surgery) that may predispose to complications or technical difficulty with LP.\n  * Allergy to local anesthetics, such as lidocaine or its derivatives.\n  * A local infection at the intended site of the LP.\n  * Less than 100 giga per liter \\[(\\\u003C100 GI\u002FL) is equivalent to 100,000 per cubic millimeter (100,000\u002Fmm³)\\] platelets or clinically significant coagulation abnormality or significant active bleeding, or\n  * Currently receiving treatment with an anticoagulant, antiplatelet agent, or other drug that affects coagulation or platelet function. Low dose (according to local medical guidelines) aspirin is permitted.","ALL","18 Years","80 Years",{"count":193,"type":194},32,"ESTIMATED","INTERVENTIONAL",[197],"PHASE1","The main purpose of this study is to assess the long-term safety and tolerability of LY4256984 in participants with Amyotrophic Lateral Sclerosis (ALS). This study is a long-term extension of study J6I-MC-OWAA (NCT07100119) and is part of the OLMP (NCT07571200) master protocol that will last approximately 96 weeks.",[200],"Amyotrophic Lateral Sclerosis","2026-08-21",{"date":203,"type":204},"2026-08-24","ACTUAL",{"date":206,"type":204},"2026-05-14",{"date":208,"type":194},"2029-06",{"name":5,"class":6},10]