[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651191":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":33,"centralContacts":34,"locations":43,"responsibleParty":58,"collaborators":33,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":33,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":33,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":33,"overallStatus":80,"whyStopped":33,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Zhejiang Kanova Biopharmaceutical Co., LTD","INDUSTRY",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Cohort 1","ACTIVE_COMPARATOR","Cohort 1 will receive 300 mg XKH001 Injection or XKH001 Placebo Injection",[13,14],"Drug: XKH001 Injection","Drug: XKH001 Placebo Injection",{"label":16,"type":10,"description":17,"interventionNames":18},"Cohort 2","Cohort 2 will receive 600 mg XKH001 Injection or XKH001 Placebo Injection",[13,14],[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","XKH001 Injection","XKH001, developed by Zhejiang Kanova Biopharmaceutical Co., Ltd., is a recombinant anti-IL-25 humanized IgG1 monoclonal antibody (mAb) composed of two identical light chains and two identical heavy chains linked by disulfide bonds. Each light chain consists of 215 amino acids, and each heavy chain consists of 455 amino acids, for a total of 1340 amino acids.",[9,16],[26],"XKH001",{"type":21,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"XKH001 Placebo Injection","Placebo；",[9,16],[32],"Placebo",null,[35,40],{"name":36,"role":37,"phone":38,"phoneExt":33,"email":39},"Jiangguo You","CONTACT","010-82176552","jianguo.you@kanovabiopharma.com",{"name":41,"role":37,"phone":38,"phoneExt":33,"email":42},"Yaxin Li","yaxin.li@kanovabiopharma.com",[44],{"facility":45,"status":33,"city":46,"state":33,"zip":33,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Q-Pharm Pty Limited (also known as Nucleus Network Brisbane)","Melbourne","Australia","AU",{"type":50,"coordinates":51},"Point",[52,53],144.96332,-37.814,{"lat":53,"lon":52},[56],{"name":57,"role":37,"phone":38,"phoneExt":33,"email":39},"Jian guo You",{"type":59,"investigatorFullName":33,"investigatorTitle":33,"investigatorAffiliation":33,"oldNameTitle":33,"oldOrganization":33},"SPONSOR","100651191","phase-1-bridging-study-of-xkh001-in-healthy-adult-caucasian-participants-100651191",false,"NCT07757659","Bridging Study of XKH001 in Healthy Adult Caucasian Participants","A Phase Id, Randomised, Double-Blind, Placebo-Controlled, Multiple-Dose Bridging Study To Evaluate The Pharmacokinetics, Safety, Tolerability, and Immunogenicity of XKH001 in Healthy Adult Caucasian Participants","Inclusion Criteria:\n\n1. Healthy participants who voluntarily provide written informed consent and can comply with all study procedures according to the protocol.\n2. Male or female participants of Caucasian ethnicity(both biological parents and all four grandparents of Caucasian origin), 18-65 years of age (inclusive).\n3. Body mass index (BMI) between 18.0-32.0 kg\u002Fm² (inclusive).\n4. Vital signs, physical examination, clinical laboratory tests, and 12-lead electrocardiogram (ECG) within normal limits or considered not clinically significant by the investigator, with QTcF ≤450 ms.\n5. No use of prescription or over-the-counter medications within 4 weeks prior to first dosing.\n6. Participants must meet the sex- and reproductive-status-specific contraception and gamete-donation requirements specified in Appendix 2. Where contraception is required, the participant must agree to use the protocol-specified established effective contraception from the time of signing the informed consent form until 7 months after the last dose of study drug.\n\nExclusion Criteria:\n\n1. Pregnant or breastfeeding women.\n2. Any clinically significant disease within 5 years that could affect participation (gastrointestinal, renal, hepatic, pulmonary, neurology, Haematology, endocrine, oncology, metabolic, psychiatric, or cerebrovascular).\n3. History of autoimmune disease, known hereditary immunodeficiency, or recurrent infections suggesting immunodeficiency.\n4. Active infection requiring hospitalisation or IV antibiotics within 3 months, or clinically symptomatic bacterial, viral, or fungal infection within 4 weeks prior to first dosing.\n5. Active or latent tuberculosis infection.\n6. HBsAg positive, HCV antibody positive, syphilis antibody positive, or HIV antigen\u002Fantibody positive.\n7. Live or attenuated vaccine within 4 weeks prior to dosing or planned during trial.\n8. Participation in any clinical trial within 3 months or 5 half-lives of the investigational drug (whichever is longer) prior to dosing.\n9. History of allergy to the investigational drug, any formulation component, or protein-based drugs.\n10. Alcohol consumption \\>14 units\u002Fweek within 6 weeks prior to screening, or alcohol-containing products within 1 day before dosing (1 unit = 8 g or 10 mL of pure alcohol).\n11. Drug abuse or illicit substance use within 5 years, or positive urine drug screen(A positive cotinine result alone is not exclusionary).\n12. Smoking history (\\>5 cigarettes\u002Fday) within 3 months prior to screening.\n13. Blood donation or loss \\>450 mL within 8 weeks, or \\>200 mL blood donation or \\>300 mL blood loss within 1 month.\n14. Unsuitable venous access or intolerance of venipuncture.\n15. Prior exposure to any anti-IL-25 therapeutic agent, including XKH001 or any other investigational or approved therapeutic agent targeting IL-25.\n16. Any other reason deemed unsuitable by the investigator.",true,"ALL","18 Years","65 Years",{"count":72,"type":73},2,"ESTIMATED","INTERVENTIONAL",[76],"PHASE1","This is a Phase Id, randomised, double-blind, placebo-controlled, multiple-dose, bridging study conducted at a single Phase I clinical research unit in Australia. The study is designed to evaluate the pharmacokinetics, safety, tolerability, and immunogenicity of XKH001 following repeated subcutaneous administration in healthy adult Caucasian participants, and to provide an ethnic-bridging pharmacokinetic comparison with the prior Phase I dataset in Chinese participants, required for XKH001's global development programme.",[79],"Healthy Adult","NOT_YET_RECRUITING","2026-08-05",{"date":83,"type":84},"2026-08-11","ACTUAL",{"date":86,"type":73},"2026-08-01",{"date":88,"type":73},"2027-08-01",{"name":5,"class":6},1]