[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100647276":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":39,"centralContacts":43,"locations":53,"responsibleParty":72,"collaborators":31,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":31,"eligibilityCriteria":82,"healthyVolunteers":78,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":31,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":56,"whyStopped":31,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"Misr University for Science and Technology","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"phosphoric acid 37% and aluminium oxid 50 microns","ACTIVE_COMPARATOR","Microabrasion technique could be considered as the first treatment option when trying to improve the esthetics of teeth that present with mild or moderate intrinsic stains as it is a simple, safe, atraumatic, minimally invasive single visit procedure with high success rate",[13],"Drug: phosphoric acid 37% and aluminium oxid 50 microns",{"label":15,"type":10,"description":16,"interventionNames":17},"Opalustre™","a mixture of 37% phosphoric acid gel in extra fine grain pumice or 18% hydrochloric acid in pumice or 6.6% and 10% hydrochloric acid with silica carbide particles, with rubber cup in slow rotating motion to the areas of discoloration or white opacities. Another advantage of microabrasion technique is that it leaves the treated enamel surface as highly polished which minimizes the cariogenic bacteria colonization and render it more resistant to demineralization",[18],"Drug: Opalustre",{"label":20,"type":21,"description":22,"interventionNames":23},"Antivet","EXPERIMENTAL","The Antivet Kit solution is specially formulated to eliminate stains on the enamel surface caused by dental fluorosis or any other external factor.The tooth's surface is exposed to an acid solution by ionization by the fluoride absorbed in the apatite crystals (stains). This reaction allows for the fluoride ions to separate from the fluoride ions in the apatite crystals, forming soluble salts that are easily removed from the tooth enamel surface. Once the stains are removed, a calcium hydroxide solution is applied to neutralize the residual acidic solution left on the tooth surface. Lastly, the tooth is rinsed with water.Acid Base (Antivet): It is hydrofluoric acid at a 21% concentration stabilized by an organic tricarboxylic acid, with a controlled pH of \\\u003C3, necessary to react with the fluoride ions to form soluble salts. The organic and inorganic ions are extracted from within the fluorapatite crystals through this ionization process which essentially allows the enamel surface to be",[24],"Drug: (Antivet, MDC DENTAL, Zapopan Jalisco México)",[26,32,36],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DRUG","(Antivet, MDC DENTAL, Zapopan Jalisco México)","specially formulated to eliminate stains on the enamel surface caused by dental fluorosis or any other external factor.The tooth's surface is exposed to an acid solution by ionization by the fluoride absorbed in the apatite crystals (stains). This reaction allows for the fluoride ions to separate from the fluoride ions in the apatite crystals, forming soluble salts that are easily removed from the tooth enamel surface. Once the stains are removed, a calcium hydroxide solution is applied to neutralize the residual acidic solution left on the tooth surface. Lastly, the tooth is rinsed with water.Acid Base (Antivet): It is hydrofluoric acid at a 21% concentration stabilized by an organic tricarboxylic acid, with a controlled pH of \\\u003C3, necessary to react with the fluoride ions to form soluble salts. The organic and inorganic ions are extracted from within the fluorapatite crystals through this ionization process which essentially allows the enamel surface to be cleansed without damaging it",[20],null,{"type":27,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"Opalustre","technique involves employing a mixture 6.6% hydrochloric acid with silica carbide particles, with rubber cup in slow rotating motion to the areas of discoloration or white opacities for 60 seconds. The teeth will be rinsed with water between slurry applications. Depending on the stain reduction, microabrasion will be repeated up to six times during the same appointment to achieve the desired result.\n\n.",[15],{"type":27,"name":9,"description":37,"armGroupLabels":38,"otherNames":31},"● Equal quantities from phosphoric acid 37% and aluminium oxid 50 microns will be mixed, thick mix will be applied on the affected tooth\u002Fteeth and will be rubbed with a rubber cup in a low-speed contra-angle handpiece for 60 seconds of each application. Every patient will be received the entire microabrasion treatment in a single appointment with a maximum of 6 applications.",[9],[40],{"name":41,"affiliation":5,"role":42},"Esraa Esmeail Hussien EEH Elhaddad, PHD","STUDY_DIRECTOR",[44,49],{"name":45,"role":46,"phone":47,"phoneExt":31,"email":48},"Esraa Esmeail Hussien EEH Lecturer, phd holder","CONTACT","0201111103836","dr.esraaism@gmail.com",{"name":50,"role":46,"phone":51,"phoneExt":31,"email":52},"Dina Fayez Diab DFD Lecturer, phd holder","+201146633390","Dina.Fayez.Diab@gmail.com",[54],{"facility":55,"status":56,"city":57,"state":58,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":68},"Egyptian Russian University","RECRUITING","Badr","Cairo Governorate","11829","Egypt","EG",{"type":63,"coordinates":64},"Point",[65,66],31.715,30.136,{"lat":66,"lon":65},[69],{"name":70,"role":46,"phone":71,"phoneExt":31,"email":48},"Esraa Esmeail Hussien EEH LECTURER, phd holder","+201111103836",{"type":73,"investigatorFullName":74,"investigatorTitle":75,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"PRINCIPAL_INVESTIGATOR","Esraa Esmeail Hussien","Lecturer at Misr university for science and technology","100647276","phase-1-clinical-efficacy-of-antivet-versus-phosphoric-acid-and-hydrochloric-acid-in-microabrasion-100647276",false,"NCT07709286","Clinical Efficacy of Antivet Versus Phosphoric Acid and Hydrochloric Acid in Microabrasion","Clinical Efficacy of Antivet Versus Phosphoric Acid and Hydrochloric Acid in Microabrasion Technique for Treatment of Stained Teeth: Randomized Clinical Trial","1. Eligibility Criteria of participants:\n\n   Inclusion Criteria:\n   * Patients with moderate to mild stained teeth.\n   * 16-50 years.\n   * Males or Females.\n   * Co-operative patients approving to participate in the study.\n\n   Exclusion Criteria:\n   * High caries index with poor oral hygiene.\n   * Severe medical complications.\n   * Pregnancy.\n   * Xerostomia.\n   * Lack of compliance.\n   * Smokers\n2. Eligibility Criteria of teeth:\n\nInclusion Criteria of teeth:\n\n* Anterior teeth.\n* Mild to moderate intrinsic or extrinsic stains.\n* Vital and non-sensitive anterior teeth.\n\nExclusion criteria of the teeth:\n\n* pitted enamel.\n* carious teeth.\n* Deep lesions.\n* Severe periodontal problems.\n* Previous treatment for the stained teeth","ALL","16 Years","50 Years",{"count":87,"type":88},60,"ESTIMATED","INTERVENTIONAL",[91],"PHASE1","This clinical trial will be conducted to assess the clinical efficacy of using Antivet cleaning enamel solution or hydrochloric acid and phosphoric acid in microabrasion technique for mild to moderate intrinsic stained teeth.",[94],"Teeth Staining",[96,97,98],"tooth discoloration","microabrasion","antivet","2026-07-14",{"date":101,"type":102},"2026-07-16","ACTUAL",{"date":104,"type":102},"2026-01-10",{"date":106,"type":88},"2026-10-01",{"name":5,"class":6},1]