[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651411":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":11,"centralContacts":11,"locations":11,"responsibleParty":20,"collaborators":11,"id":24,"slug":25,"hasResults":26,"nctId":27,"briefTitle":28,"officialTitle":29,"acronym":11,"eligibilityCriteria":30,"healthyVolunteers":31,"sex":32,"minAge":33,"maxAge":34,"enrollmentInfo":35,"targetDuration":11,"studyType":38,"phases":39,"briefSummary":41,"conditions":42,"keywords":11,"overallStatus":44,"whyStopped":11,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":11},{"fullName":5,"class":6},"Al-Azhar University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Fractional CO₂ laser","ACTIVE_COMPARATOR",null,[13],"Drug: Topical metformin",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":11},"DRUG","Topical metformin","applied to one half of the neck only",[9],{"type":21,"investigatorFullName":22,"investigatorTitle":23,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Ahmed Hamdan Abdellah","Ahmed Hamdan","100651411","phase-1-efficacy-and-safety-of-fractional-carbon-dioxide-laser-plus-topical-metformin-in-treatment-of-acanthosis-nigricans-100651411",false,"NCT07760181","Efficacy and Safety Of Fractional Carbon Dioxide Laser Plus Topical Metformin In Treatment Of Acanthosis Nigricans","Efficacy and Safety Of Fractional Carbon Dioxide Laser Plus Topical Metformin In Treatment Of Acanthosis Nigricans: A Comparative Study","Inclusion Criteria:\n\n* \\- male or female patients aged 18-50 years\n* clinically \\& dermoscopy diagnosed acanthosis nigricans involving the neck\n* skin types iii-v\n* stable systemic condition for at least 3 months\n* willingness to comply with study protocol and follow-up\n\nExclusion Criteria:\n\n* \\- pregnancy or lactation\n* malignancy-associated acanthosis nigricans\n* active skin infection or inflammatory dermatosis at the treatment site\n* history of keloid or hypertrophic scar formation\n* photosensitivity disorders\n* use of topical or systemic treatment for acanthosis nigricans within the last 4 weeks\n* previous laser treatment to the neck within the last 6 months",true,"ALL","18 Years","50 Years",{"count":36,"type":37},34,"ESTIMATED","INTERVENTIONAL",[40],"PHASE1","evaluate and compare the clinical Efficacy \\& Safety Of Fractional Carbon Dioxide (Co₂) Laser Plus Topical Metformin In Treatment Of Acanthosis Nigricans.",[43],"Acanthosis Nigricans","NOT_YET_RECRUITING","2026-08-07",{"date":47,"type":48},"2026-08-12","ACTUAL",{"date":50,"type":37},"2026-08-10",{"date":52,"type":37},"2027-09-10",{"name":5,"class":6}]