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This study will focus on tumor types which are know to highly or moderately express this protein.\n\nResearchers will evaluate the side effects caused by treatment, levels of CRB-601 in the blood, and the effect on the participant cancer. This will help researchers understand the right dose of CRB-601 to use for treatment and whether it is an effective treatment to combine with standard of care treatments such as immunotherapy. It will also help the researchers understand whether combining CRB-601 with standard-of-care immunotherapy and immune-priming radiotherapy is a safe and effective approach to treat cancer.\n\nParticipants in the study will receive CRB-601 via an infusion every two weeks either alone or in combination with immunotherapy.\n\nThere will be assessments to check on the participants general health status (including blood tests) and adverse effects. Participants will also receive regular CT or MRI scans to evaluate the effect of CRB-601 on their cancer. Participants will continue to visit the clinic every two weeks while they are receiving benefit from treatment. If their cancer progresses, participants will be asked to continue to be followed-up by the researchers to understand long-term outcomes, even if they receive other treatments.",[397],"Solid Tumor","2025-05-29",{"date":400,"type":401},"2025-06-03","ACTUAL",{"date":403,"type":401},"2024-12-04",{"date":405,"type":390},"2026-12-01",{"name":5,"class":6},26]