[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652149":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":49,"centralContacts":53,"locations":61,"responsibleParty":75,"collaborators":77,"id":81,"slug":82,"hasResults":83,"nctId":84,"briefTitle":85,"officialTitle":85,"acronym":35,"eligibilityCriteria":86,"healthyVolunteers":83,"sex":87,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":35,"studyType":93,"phases":94,"briefSummary":96,"conditions":97,"keywords":35,"overallStatus":99,"whyStopped":35,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Yale University","OTHER",[8,14,20,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Nicotine","ACTIVE_COMPARATOR","These test days will evaluate two nicotine doses (0.05 mg\u002Fpulse and 0.1 mg\u002Fpulse)",[13],"Drug: Nicotine 0.05 mg\u002Fpulse and 0.1 mg\u002Fpulse",{"label":15,"type":16,"description":17,"interventionNames":18},"saline","PLACEBO_COMPARATOR","Saline (sugar water)",[19],"Drug: Saline Placebo (0.5mL injection)",{"label":21,"type":10,"description":22,"interventionNames":23},"sucrolose","participants practice using the e-cigarette and sample the sweet (sucralose) and control (unsweetened) flavors",[24],"Dietary Supplement: sucralose",{"label":26,"type":16,"description":22,"interventionNames":27},"unsweetened flavor",[28],"Dietary Supplement: Sugar syrup (Placebo)",[30,36,40,45],{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"DRUG","Nicotine 0.05 mg\u002Fpulse and 0.1 mg\u002Fpulse","Nicotine will be used and compared to saline given by IV push by study physician",[9],null,{"type":31,"name":37,"description":38,"armGroupLabels":39,"otherNames":35},"Saline Placebo (0.5mL injection)","Saline will be used compared to the low dose of Nicotine given by IV push by study physician",[15],{"type":41,"name":42,"description":43,"armGroupLabels":44,"otherNames":35},"DIETARY_SUPPLEMENT","sucralose","sweet flavor (sucralose) compared to unsweetened flavor",[21],{"type":41,"name":46,"description":47,"armGroupLabels":48,"otherNames":35},"Sugar syrup (Placebo)","Unsweetened flavor compared to the sweetened flavor sucralose.",[26],[50],{"name":51,"affiliation":5,"role":52},"Mehmet Sofuoglu, M.D., Ph.D.","PRINCIPAL_INVESTIGATOR",[54,58],{"name":51,"role":55,"phone":56,"phoneExt":35,"email":57},"CONTACT","203-932-5711","Mehmet.Sofuoglu@yale.edu",{"name":59,"role":55,"phone":60,"phoneExt":35,"email":35},"Stacy A Minnix, B.S.","203--932-5711",[62],{"facility":63,"status":35,"city":64,"state":65,"zip":66,"country":67,"countryCode":68,"cosmosGeoPoint":69,"geoPoint":74,"contacts":35},"VA Hospital","West Haven","Connecticut","06516","United States","US",{"type":70,"coordinates":71},"Point",[72,73],-72.94705,41.27065,{"lat":73,"lon":72},{"type":76,"investigatorFullName":35,"investigatorTitle":35,"investigatorAffiliation":35,"oldNameTitle":35,"oldOrganization":35},"SPONSOR",[78],{"name":79,"class":80},"National Institute on Drug Abuse (NIDA)","NIH","100652149","phase-1-impact-of-sweeteners-on-the-addictive-threshold-of-nicotine-100652149",false,"NCT07771725","Impact of Sweeteners on the Addictive Threshold of Nicotine","Inclusion Criteria:\n\n* Smoking at least for one year and more frequently than once a week, smoking status confirmed with a semi-quantitative urine nicotine test. Smokers will be stratified by level of dependence, assessed with the FTND 29 low or no dependence ≤3 and moderate or high dependence ≥ 4.\n* In good health as verified by medical history, screening examination, and screening laboratory tests.\n* For women, report using acceptable birth control methods.\n\nExclusion Criteria:\n\n* History of major medical or psychiatric disorders that the physician investigator deems as contraindicated for the participant to be in the study;\n* regular current use of certain psychotropic medications (such as mood stabilizers, antipsychotics, or anxiolytics being prescribed to treat bipolar disorder, psychosis or anxiety spectrum disorders, respectively);\n* current untreated alcohol or substance use disorder for any other recreational or prescription drugs other than nicotine;\n* for women, pregnant as determined by pregnancy screening, or breastfeeding; and 5) seeking (or undergoing) treatment for tobacco dependence or smoking.","ALL","21 Years","59 Years",{"count":91,"type":92},36,"ESTIMATED","INTERVENTIONAL",[95],"PHASE1","To determine if sucralose, an artificial sweetener, modulates nicotine threshold doses for discrimination, subjective-rewarding effects, and reinforcement in smokers with varying levels of dependence.",[98],"Smoking ( Cigarette)","NOT_YET_RECRUITING","2026-08-13",{"date":102,"type":103},"2026-08-18","ACTUAL",{"date":105,"type":92},"2026-09-01",{"date":107,"type":92},"2029-12-31",{"name":5,"class":6},1]