[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651171":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":31,"centralContacts":35,"locations":44,"responsibleParty":84,"collaborators":11,"id":87,"slug":88,"hasResults":89,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":11,"eligibilityCriteria":93,"healthyVolunteers":89,"sex":94,"minAge":95,"maxAge":96,"enrollmentInfo":97,"targetDuration":11,"studyType":100,"phases":101,"briefSummary":103,"conditions":104,"keywords":106,"overallStatus":110,"whyStopped":11,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":120},{"fullName":5,"class":6},"The University of Texas Health Science Center, Houston","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Photodynamic Therapy","EXPERIMENTAL",null,[13,14,15],"Drug: ALA 10% gel","Device: PDT","Drug: Urea",[17,22,27],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":11},"DRUG","ALA 10% gel","ALA 10% gel will be applied under occlusion for 3 hours before PDT",[9],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":11},"DEVICE","PDT","Participants will have illumination on the affected nail with RhodoLED® XL 635 nm red light at 37 J\u002Fcm² at 5 inches for 13.5 minutes.",[9],{"type":18,"name":28,"description":29,"armGroupLabels":30,"otherNames":11},"Urea","Participants will have 20% urea applied to affected nail daily for 2 weeks before start of treatment",[9],[32],{"name":33,"affiliation":5,"role":34},"Stephen Tyring, MD, PhD, MBA","PRINCIPAL_INVESTIGATOR",[36,40],{"name":33,"role":37,"phone":38,"phoneExt":11,"email":39},"CONTACT","(281) 333-3376","Stephen.K.Tyring@uth.tmc.edu",{"name":41,"role":37,"phone":42,"phoneExt":11,"email":43},"Luke Moore","(817) 795-7546","luke.c.moore@uth.tmc.edu",[45,61,73],{"facility":46,"status":11,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Arlington Center for Dermatology","Arlington","Texas","76011","United States","US",{"type":53,"coordinates":54},"Point",[55,56],-97.10807,32.73569,{"lat":56,"lon":55},[59],{"name":60,"role":37,"phone":42,"phoneExt":11,"email":43},"Luke Moore, MBTS, BS",{"facility":62,"status":11,"city":63,"state":48,"zip":64,"country":50,"countryCode":51,"cosmosGeoPoint":65,"geoPoint":69,"contacts":70},"Houston Skin","Houston","77004",{"type":53,"coordinates":66},[67,68],-95.36327,29.76328,{"lat":68,"lon":67},[71,72],{"name":33,"role":37,"phone":38,"phoneExt":11,"email":39},{"name":41,"role":37,"phone":42,"phoneExt":11,"email":43},{"facility":62,"status":11,"city":74,"state":48,"zip":75,"country":50,"countryCode":51,"cosmosGeoPoint":76,"geoPoint":80,"contacts":81},"Webster","77598",{"type":53,"coordinates":77},[78,79],-95.11826,29.53773,{"lat":79,"lon":78},[82,83],{"name":33,"role":37,"phone":38,"phoneExt":11,"email":39},{"name":41,"role":37,"phone":42,"phoneExt":11,"email":43},{"type":34,"investigatorFullName":85,"investigatorTitle":86,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Stephen K Tyring","Adjunct Professor","100651171","phase-1-photodynamic-therapy-for-onychomycosis-100651171",false,"NCT07756671","Photodynamic Therapy For Onychomycosis","Photodynamic Therapy For Onychomycosis: An Open Label Study","Inclusion Criteria:\n\n* Clinical and mycological diagnosis \\[by potassium hydroxide (KOH) stain\\] of onychomycosis\n\nExclusion Criteria:\n\n* Known or suspected allergies or sensitivities to any components of any of the study drugs\n* Patients with coagulation disorders\n* Known or suspected claustrophobia\n* Pregnancy during the treatment period\n* Medically unable to consent\n* Employees of the clinics\n* Prisoners","ALL","18 Years","100 Years",{"count":98,"type":99},5,"ESTIMATED","INTERVENTIONAL",[102],"PHASE1","The purpose of this study is clinical and mycological clearance of onychomycosis using photodynamic therapy (PDT) with aminolevulinic acid (ALA) 10% gel at 6 months, 3 months, 9 months and 12 months",[105],"Onychomycosis of Toenail",[107,108,109],"toenail fungus","photodynamic therapy (PDT)","aminolevulinic acid (ALA)","NOT_YET_RECRUITING","2026-08-06",{"date":113,"type":114},"2026-08-11","ACTUAL",{"date":116,"type":99},"2026-08-10",{"date":118,"type":99},"2027-12-31",{"name":5,"class":6},3]