[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100654366":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":23,"studyPopulation":13,"armGroups":24,"interventions":34,"overallOfficials":13,"centralContacts":44,"locations":13,"responsibleParty":50,"collaborators":13,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":13,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":13,"studyType":67,"phases":68,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":76,"whyStopped":13,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":82,"leadSponsor":84,"locationsCount":13},{"fullName":5,"class":6},"Kafrelsheikh University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"total intraoperative isoflurane consumption between propofol dexmedetomidine anesthesia and propofol anesthesia alone under entropy-guided anesthesia","Total intraoperative isoflurane consumption\n\nDescription: The total amount of isoflurane consumed during anesthesia will be compared between patients receiving propofol-dexmedetomidine anesthesia and those receiving propofol anesthesia alone under entropy-guided anesthesia. Isoflurane consumption will be assessed from induction of anesthesia until discontinuation of anesthesia and measured as the total volume consumed. (ML\\\\MIN)","Time Frame: From induction of anesthesia until discontinuation of anesthesia; total isoflurane consumption will be recorded at the end of surgery.",null,{"allocation":15,"interventionModel":16,"interventionModelDescription":13,"primaryPurpose":6,"observationalModel":13,"timePerspective":13,"maskingInfo":17},"RANDOMIZED","PARALLEL",{"masking":18,"maskingDescription":13,"whoMasked":19},"TRIPLE",[20,21,22],"PARTICIPANT","CARE_PROVIDER","OUTCOMES_ASSESSOR","This prospective, randomized, double-blind study was conducted to evaluate the effect of dexmedetomidine as an adjunct to propofol-based anesthesia in patients undergoing minimally invasive cardiac valve surgery. Patients were randomly allocated to receive either dexmedetomidine or placebo in addition to standard propofol-based anesthesia. The primary outcome was total propofol consumption during surgery. Secondary outcomes included intraoperative hemodynamic parameters, anesthetic and recovery characteristics, and postoperative outcomes.",[25,30],{"label":26,"type":27,"description":13,"interventionNames":28},"Propofol group (Group P) (control group)","ACTIVE_COMPARATOR",[29],"Drug: Propofol (Astra-Zeneca)",{"label":31,"type":27,"description":13,"interventionNames":32},"Propofol dexmedetomidine group (Group PD)",[33],"Drug: propofol and dexmetomidine",[35,40],{"type":36,"name":37,"description":38,"armGroupLabels":39,"otherNames":13},"DRUG","Propofol (Astra-Zeneca)","Thirty patients will receive a continuous infusion of propofol at a rate of 2 mg\u002Fkg\u002Fh and 50 cc 0.9% sodium chloride solution infused at a rate of 0.4 µg\u002Fkg\u002Fh (used as a placebo).",[26],{"type":36,"name":41,"description":42,"armGroupLabels":43,"otherNames":13},"propofol and dexmetomidine","patients will receive a continuous infusion of propofol at a rate of 2 mg\u002Fkg\u002Fh in addition to dexmedetomidine at a rate of 0.4 µg\u002Fkg\u002Fh.",[31],[45],{"name":46,"role":47,"phone":48,"phoneExt":13,"email":49},"Donia Hany Hany, MD","CONTACT","01014498540","doniahany1788@gmail.com",{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"PRINCIPAL_INVESTIGATOR","Donia Hany Saad","Lecturer of Anesthesiology and Surgical Intensive Care","100654366","phase-1-propofol-dexmedetomine-adjunction-in-balanced-anesthesia-for-minimally-invasive-cardiac-valve-surgery-effect-on-anesthetic-consumption-perioperative-outcomesand-early-recovery-100654366",false,"NCT07798089","Propofol-Dexmedetomine Adjunction in Balanced Anesthesia for Minimally Invasive Cardiac Valve Surgery :Effect on Anesthetic Consumption ,Perioperative Outcomes,and Early Recovery","Propofol-Dexmedetomine Adjunction in Balanced Anesthesia for Minimally Invasive Cardiac Valve Surgery :Effect on Anesthetic Consumption ,Perioperative Outcomes,and Early Recovery : Randomized Controlled Trial","Inclusion Criteria:\n\n1. patients belonging to American Society of Anesthesiologists (ASA) class I or II\n2. patients scheduled for minimally invasive cardiac valve surgery.\n\nExclusion Criteria:\n\n1. patient more than 60 years\n2. patients having neurological\u002Fpsychological disorders,\n3. patient having severe systemic disorders (renal\u002Fhepatic dysfunction and severe respiratory disorder),\n4. patient with history of allergy to the study drugs,\n5. patient with left ventricular ejection fraction \\\u003C 40%,","ALL","25 Years","60 Years",{"count":65,"type":66},60,"ESTIMATED","INTERVENTIONAL",[69,70],"PHASE1","PHASE2","Propofol-Dexmedetomidine Adjunction in Balanced Anesthesia for Minimally Invasive Cardiac Valve Surgery: Effects on Anesthetic Consumption, perioperative outcomes, and Early Recovery",[73],"Balanced Anesthesia for Minimally Invasive Cardiac Valve Surgery",[75],"propofol , Dexmedetomidine ,Minimally Invasive Cardiac Valve Surgery","NOT_YET_RECRUITING","2026-08-29",{"date":79,"type":80},"2026-09-01","ACTUAL",{"date":79,"type":66},{"date":83,"type":66},"2027-01-15",{"name":5,"class":6}]