[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646181":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":11,"centralContacts":20,"locations":29,"responsibleParty":45,"collaborators":11,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":11,"enrollmentInfo":58,"targetDuration":11,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":72,"whyStopped":11,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Herlev Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Rituximab","EXPERIMENTAL",null,[13],"Drug: Rituximab (RTX)",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":11},"DRUG","Rituximab (RTX)","A single ultra-low dose rituximab (100 mg) infusion for patients with immune-related adverse events",[9],[21,26],{"name":22,"role":23,"phone":24,"phoneExt":11,"email":25},"Inge Marie Svane, Professor, MD, PhD","CONTACT","004538683868","inge.marie.svane@regionh.dk",{"name":27,"role":23,"phone":24,"phoneExt":11,"email":28},"Frederikke Strauss Hansen, MD, PhD-student","frederikke.strauss.hansen@regionh.dk",[30],{"facility":31,"status":11,"city":32,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"National Center for Cancer Immune Therapy, Department of Oncology, Herlev Hospital","Herlev","2730","Denmark","DK",{"type":37,"coordinates":38},"Point",[39,40],12.43998,55.72366,{"lat":40,"lon":39},[43,44],{"name":27,"role":23,"phone":24,"phoneExt":11,"email":28},{"name":11,"role":23,"phone":11,"phoneExt":11,"email":28},{"type":46,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"SPONSOR_INVESTIGATOR","Inge Marie Svane","Professor, MD, PhD","100646181","phase-1-rituximab-for-treatment-of-checkpoint-inhibitor-induced-immune-related-adverse-events-100646181",false,"NCT07694414","Rituximab for Treatment of Checkpoint Inhibitor Induced Immune-related Adverse Events","RiTOX","Inclusion Criteria:\n\n* Histologically confirmed malignant melanoma diagnosis\n* Treatment with immune checkpoint inhibitors (anti-PD1, anti-PDL1, anti-LAG3 and\u002For anti-CTLA4) due to melanoma within 3 months\n* Any irAEs grade 2-4 according to CTCAE v. 6.0\n* Negative pregnancy test (serum hCG) in women of childbearing potential\n* Age ≥ 18 years\n* Ability to provide written and oral consent\n* The patient is able to understand and read Danish\n\nExclusion Criteria:\n\n* Any ongoing infectious disease\n* Neutropenia (\\\u003C1.5 x10\\^9\u002FL) and\u002For thrombocytopenia (\\\u003C75 x10\\^9\u002FL)\n* Known hypersensitivity towards the active substance rituximab or any of the excipients\n* History of cardiovascular disease including severe heart failure NYHA grade 3-4, unstable angina pectoris, atrial fibrillation, atrial flutter, and myocardial infarction\n* Any major wounds\n* Low baseline IgG (\\\u003C6 g\u002FL)\n* Positive hepatitis B virus, hepatitis C virus, HIV, or tuberculosis screening\n* Concomitant immunosuppressive medication except prednisolone\n* Concomitant chemotherapy or other antineoplastic therapy (except checkpoint inhibitor therapy) within 30 days prior to inclusion\n* Females of childbearing potential or males of reproductive potential who are not willing to use an effective method of contraception, such as oral, injected, or implanted hormonal methods of contraception, intrauterine device or intrauterine system, condom in combination with occlusive cap (diaphragm or cervical\u002Fvault caps) with spermicidal foam, gel, film, cream or suppository, male sterilization, or true abstinence throughout study and for a minimum of 3 months after study drug therapy.","ALL","18 Years",{"count":59,"type":60},25,"ESTIMATED","INTERVENTIONAL",[63],"PHASE1","The goal of this clinical trial is to investigate the safety of rituximab for management of immune-related adverse events in malignant melanoma patients. The main questions it aims to answer are:\n\n* Is rituximab safe for management of immune-related adverse events in malignant melanoma patients?\n* Does rituximab provide indications of clinical benefit in the management of immune-related adverse events compared with corticosteroid treatment alone?\n\nParticipants will:\n\n* Receive a single dose of 100 mg rituximab IV\n* Have regular follow-up consultations for 6 months following rituximab infusion\n* Follow a simultaneous corticosteroid tapering plan",[66],"Immune-Related Adverse Events",[9,68,69,70,71],"Immunotherapy","Checkpoint inhibitors","Malignant melanoma","Immune-related adverse event","NOT_YET_RECRUITING","2026-07-20",{"date":75,"type":76},"2026-07-22","ACTUAL",{"date":78,"type":60},"2026-08-01",{"date":80,"type":60},"2028-12-01",{"name":47,"class":6},1]