[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100450966":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":20,"studyPopulation":13,"armGroups":21,"interventions":28,"overallOfficials":34,"centralContacts":13,"locations":38,"responsibleParty":57,"collaborators":13,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":13,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":13,"maxAge":13,"enrollmentInfo":67,"targetDuration":13,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":77,"overallStatus":41,"whyStopped":13,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"The Foundation for Orthopaedics and Regenerative Medicine","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Safety (adverse events)","Clinical monitoring of possible adverse events or complications","Four year follow-up",null,{"allocation":15,"interventionModel":16,"interventionModelDescription":13,"primaryPurpose":17,"observationalModel":13,"timePerspective":13,"maskingInfo":18},"NA","SINGLE_GROUP","TREATMENT",{"masking":19,"maskingDescription":13,"whoMasked":13},"NONE","This patient funded trial aims to study the safety and efficacy of cultured allogeneic adult umbilical cord derived mesenchymal stem cell (UC-MSCs) exosomes for the treatment of Trigeminal Neuralgia. Patients will receive an intranasal instillation of UC-MSCs exosomes. The total dose will be approximately 800 billion exosomes split evenly between both nasal cavities via Tian Syringe through 4 CCs of AlloEx. Patients will be evaluated within one month pre treatment and at 1, 6, 12, 24, 36, and 48 months post treatment for safety and efficacy.\n\nFor patients with more severe disease an autologous Effector cells (activated lymphocytes) treatment will be utilized created from the patient's own cells obtained by apheresis.",[22],{"label":23,"type":24,"description":25,"interventionNames":26},"Treatment Group (AlloEx)","EXPERIMENTAL","Intranasal installation of 4 CCs of AlloEx, which is approximately 800 billion exosomes.",[27],"Biological: AlloEx",[29],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":13},"BIOLOGICAL","AlloEx","cultured allogeneic adult umbilical cord derived mesenchymal stem cell exosomes",[23],[35],{"name":36,"affiliation":5,"role":37},"Chadwick Prodromos, MD","PRINCIPAL_INVESTIGATOR",[39],{"facility":40,"status":41,"city":42,"state":13,"zip":13,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Medical Surgical Associates Center","RECRUITING","St John's","Antigua and Barbuda","AG",{"type":46,"coordinates":47},"Point",[48,49],-61.84329,17.12096,{"lat":49,"lon":48},[52],{"name":53,"role":54,"phone":55,"phoneExt":13,"email":56},"Chadwick Prodromos, M.D.","CONTACT","8476996810","care@thepsci.com",{"type":58,"investigatorFullName":13,"investigatorTitle":13,"investigatorAffiliation":13,"oldNameTitle":13,"oldOrganization":13},"SPONSOR","100450966","phase-1-safety-of-cultured-allogeneic-adult-umbilical-cord-stem-cells-exosomes-for-trigeminal-neuralgia-100450966",false,"NCT05152368","Safety of Cultured Allogeneic Adult Umbilical Cord Stem Cells Exosomes for Trigeminal Neuralgia","Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cells Exosomes for the Treatment of Trigeminal Neuralgia","Inclusion Criteria:\n\n* Diagnosis of Trigeminal Neuralgia or Peripheral Neuropathy\n* Understanding and willingness to sign a written informed consent document\n\nExclusion Criteria:\n\n* Active infection\n* Active cancer\n* Chronic multisystem organ failure\n* Pregnancy\n* Clinically significant Abnormalities on pre-treatment laboratory evaluation\n* Medical condition that would (based on the opinion of the investigator) compromise patient's safety.\n* Continued drug abuse\n* Pre-menopausal women not using contraception\n* Previous organ transplant\n* Hypersensitivity to sulfur","ALL",{"count":68,"type":69},20,"ESTIMATED","INTERVENTIONAL",[72],"PHASE1","This trial will study the safety and efficacy of instillation of cultured allogeneic adult umbilical cord derived mesenchymal stem cell exosomes for the treatment of Trigeminal Neuralgia.",[75,76],"Peripheral Neuropathy","Trigeminal Neuralgia",[75,76,78],"stem cell treatment","2025-04-15",{"date":81,"type":82},"2025-04-17","ACTUAL",{"date":84,"type":82},"2022-09-09",{"date":86,"type":69},"2026-01",{"name":5,"class":6},1]