[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100651947":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":25,"responsibleParty":36,"collaborators":25,"id":40,"slug":41,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":25,"eligibilityCriteria":46,"healthyVolunteers":42,"sex":47,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":25,"studyType":53,"phases":54,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":64,"whyStopped":25,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":25},{"fullName":5,"class":6},"Sohag University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group I (Letrozole + Misoprostol)","ACTIVE_COMPARATOR","Group I (Letrozole + Misoprostol): Patients will receive letrozole 2.5 mg orally the dose of letrozole is 4 tab once\u002Fday for 3 consecutive days, followed by vaginal misoprostol",[13],"Drug: · Misoprostol + letrozole",{"label":15,"type":10,"description":16,"interventionNames":17},"Group II (Misoprostol alone","· Group II (Misoprostol alone (: Patients will receive vaginal misoprostol alone using the same dosage schedule without letrozole pretreatment.",[18],"Drug: misoprostol alone",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","· Misoprostol + letrozole","1. to compare the effect of letrozole plus misoprostol versus misoprostol alone for termination of second-trimester pregnancy.\n2. to compare efficacy of letrozole and misoprostol versus misoprostol alone in theraputic abortion (living fetus) versus missed abortion.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"misoprostol alone","1. to compare the effect of letrozole plus misoprostol versus misoprostol alone for termination of second-trimester pregnancy.\n2. to compare efficacy of letrozole and misoprostol versus misoprostol alone in theraputic abortion (living fetus) versus missed abortion",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"ahmed khalifa elsayed, resident","CONTACT","01142626766","AhmedKhalifa.ahmedelsayed@med.sohag.edu.eg",{"type":37,"investigatorFullName":38,"investigatorTitle":39,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Ahmed Khalifa Ahmed Elsayed","Ahmed Khalifa Ahmed","100651947","phase-1-second-trimester-abortion-with-letrozole-and-misoprostol-compared-to-misoprostol-alone-100651947",false,"NCT07767435","Second Trimester Abortion With Letrozole and Misoprostol Compared to Misoprostol Alone","Termination of Second Trimester Abortion With Letrozole and Misoprostol Compared to Misoprostol Alone","Inclusion Criteria:\n\n* Pregnant women aged 18-45 years.\n* Failed pregnancy.\n* Gestational age between 14 and 20weeks, confirmed by ultrasonography on the day of admission.\n* Hemoglobin concentration \\>9 g\u002FdL.\n* Closed cervix.\n* Absence of products of conception in the cervical canal.\n\n  \\- Exclusion Criteria:\n* Previous attempt to terminate the current pregnancy.\n* Molar pregnancy (hydatidiform mole).\n* Pathological uterine lesions including uterine fibroids and congenital uterine malformations.\n* Cardiac disease.\n* Renal disease.\n* Hemorrhagic disorders.\n* Body mass index (BMI) \\>35 kg\u002Fm².\n* Documented hypersensitivity or allergy to letrozole, misoprostol, or any of the study medications.","FEMALE","18 Years","45 Years",{"count":51,"type":52},80,"ESTIMATED","INTERVENTIONAL",[55,56],"PHASE1","PHASE2","Termination of Second trimester Abortion with Letrozole and Misoprostol Compared to Misoprostol Alone",[59,60],"Abortion Induced Complicated","Abortion",[62,63],"medical abortion","induced abortion","NOT_YET_RECRUITING","2026-08-11",{"date":67,"type":68},"2026-08-17","ACTUAL",{"date":70,"type":52},"2026-08-01",{"date":72,"type":52},"2027-06-01",{"name":5,"class":6}]