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A participant with FSHD1 and a BMI outside this range may be allowed into the study at the discretion of the principal investigator.\n* Must have eligible lower extremity muscle for biopsy as determined from MRI by a central reader\n* A 12-lead electrocardiogram at screening with no abnormalities that may compromise participant's safety in the study\n* Participants of childbearing potential and their partners must use highly effective contraception during the study and for at least 9 months following the end of study or last dose of study medication, whichever is later. Males must not donate sperm during the study from Day 1 until at least 9 months following the end of study or last dose of study medication, whichever is later.\n\nKey Exclusion Criteria:\n\n* Human immunodeficiency virus (HIV) infection as shown by presence of anti-HIV antibody (seropositive) at screening\n* Seropositive for hepatitis B or hepatitis C at screening\n* Uncontrolled hypertension\n* Severe cardiovascular disease\n* History of thrombolic events\n* Platelet count less that the lower limit of normal at screening\n* History or presence of: a hypercoagulable state, nephrotic range proteinuria, antiphospholipid antibody syndrome, myeloproliferative disease, inability to ambulate, use of hormone-based contraceptives.\n* Any contraindication to muscle biopsy or MRI\n\nNote: additional inclusion\u002Fexclusion criteria may apply per protocol","ALL","16 Years","70 Years",{"count":222,"type":223},60,"ESTIMATED","INTERVENTIONAL",[226,227],"PHASE1","PHASE2","The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics of SRP-1001 in participants with facioscapulohumeral muscular dystrophy Type 1 (FSHD1). 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