[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100562102":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":41,"centralContacts":45,"locations":51,"responsibleParty":318,"collaborators":36,"id":320,"slug":321,"hasResults":322,"nctId":323,"briefTitle":324,"officialTitle":325,"acronym":36,"eligibilityCriteria":326,"healthyVolunteers":322,"sex":327,"minAge":328,"maxAge":36,"enrollmentInfo":329,"targetDuration":36,"studyType":332,"phases":333,"briefSummary":335,"conditions":336,"keywords":338,"overallStatus":54,"whyStopped":36,"lastUpdateSubmitDate":344,"lastUpdatePostDateStruct":345,"startDateStruct":348,"completionDateStruct":350,"leadSponsor":352,"locationsCount":353},{"fullName":5,"class":6},"BeOne Medicines","INDUSTRY",[8,14,17,21,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Phase 1a: Part A: Monotherapy Dose Escalation with Intravenous Administration","EXPERIMENTAL","Sequential cohorts of increasing dose levels of BG-T187 will be evaluated as monotherapy.",[13],"Drug: Drug: BG-T187",{"label":15,"type":10,"description":11,"interventionNames":16},"Phase 1a: Part B: Monotherapy Dose Escalation with Subcutaneous Administration",[13],{"label":18,"type":10,"description":19,"interventionNames":20},"Phase 1a Part C: Safety Expansion","BG-T187 dose levels that have been determined to be safe and tolerable in Part B will be investigated.",[13],{"label":22,"type":10,"description":23,"interventionNames":24},"Phase 1b: Monotherapy Dose Expansion with Subcutaneous Administration","Participants will receive BG-T187 monotherapy at the recommended dose(s) for expansion (RDFE) determined in Phase 1a.",[13],{"label":26,"type":10,"description":27,"interventionNames":28},"Phase 1b: Combination Therapy: BG-T187 + Other Therapeutic Agents","Participants will receive BG-T187 in combination with Other Therapeutic Agents.",[13,29],"Drug: Other Therapeutic 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Oncology","Madison","Wisconsin","53708-8056",{"type":61,"coordinates":92},[93,94],-89.40123,43.07305,{"lat":94,"lon":93},{"facility":97,"status":54,"city":98,"state":99,"zip":100,"country":101,"countryCode":102,"cosmosGeoPoint":103,"geoPoint":107,"contacts":36},"Blacktown Cancer and Haematology Centre","Blacktown","New South Wales","NSW 2148","Australia","AU",{"type":61,"coordinates":104},[105,106],150.91667,-33.76667,{"lat":106,"lon":105},{"facility":109,"status":54,"city":110,"state":99,"zip":111,"country":101,"countryCode":102,"cosmosGeoPoint":112,"geoPoint":116,"contacts":36},"Macquarie University","North Ryde","NSW 2109",{"type":61,"coordinates":113},[114,115],151.12436,-33.79677,{"lat":115,"lon":114},{"facility":118,"status":54,"city":119,"state":120,"zip":121,"country":101,"countryCode":102,"cosmosGeoPoint":122,"geoPoint":126,"contacts":36},"Cabrini Hospital Malvern","Malvern","Victoria","VIC 3144",{"type":61,"coordinates":123},[124,125],145.02811,-37.86259,{"lat":125,"lon":124},{"facility":128,"status":54,"city":129,"state":130,"zip":131,"country":101,"countryCode":102,"cosmosGeoPoint":132,"geoPoint":136,"contacts":36},"Linear Clinical Research","Nedlands","Western Australia","WA 6009",{"type":61,"coordinates":133},[134,135],115.8073,-31.98184,{"lat":135,"lon":134},{"facility":138,"status":54,"city":139,"state":140,"zip":141,"country":142,"countryCode":143,"cosmosGeoPoint":144,"geoPoint":148,"contacts":36},"Cancer Hospital Chinese Academy of Medical Sciences","Beijing","Beijing Municipality","100021","China","CN",{"type":61,"coordinates":145},[146,147],116.39723,39.9075,{"lat":147,"lon":146},{"facility":150,"status":54,"city":151,"state":152,"zip":153,"country":142,"countryCode":143,"cosmosGeoPoint":154,"geoPoint":158,"contacts":36},"Chongqing University Cancer Hospital","Chongqing","Chongqing Municipality","400030",{"type":61,"coordinates":155},[156,157],106.55771,29.56026,{"lat":157,"lon":156},{"facility":160,"status":54,"city":161,"state":162,"zip":163,"country":142,"countryCode":143,"cosmosGeoPoint":164,"geoPoint":168,"contacts":36},"Fujian Cancer Hospital","Fuzhou","Fujian","350014",{"type":61,"coordinates":165},[166,167],119.30611,26.06139,{"lat":167,"lon":166},{"facility":170,"status":54,"city":161,"state":162,"zip":171,"country":142,"countryCode":143,"cosmosGeoPoint":172,"geoPoint":174,"contacts":36},"Fujian Medical University Union Hospitalqishan Branch","350108",{"type":61,"coordinates":173},[166,167],{"lat":167,"lon":166},{"facility":176,"status":54,"city":177,"state":178,"zip":179,"country":142,"countryCode":143,"cosmosGeoPoint":180,"geoPoint":184,"contacts":36},"The Sixth Affiliated Hospital, Sun Yat Sen University","Guangzhou","Guangdong","510655",{"type":61,"coordinates":181},[182,183],113.25,23.11667,{"lat":183,"lon":182},{"facility":186,"status":54,"city":187,"state":188,"zip":189,"country":142,"countryCode":143,"cosmosGeoPoint":190,"geoPoint":194,"contacts":36},"Guangxi Medical University Cancer Hospital","Nanning","Guangxi","530021",{"type":61,"coordinates":191},[192,193],108.31667,22.81667,{"lat":193,"lon":192},{"facility":196,"status":54,"city":197,"state":198,"zip":199,"country":142,"countryCode":143,"cosmosGeoPoint":200,"geoPoint":204,"contacts":36},"Harbin Medical University Cancer Hospital","Harbin","Heilongjiang","150000",{"type":61,"coordinates":201},[202,203],126.65,45.75,{"lat":203,"lon":202},{"facility":206,"status":54,"city":207,"state":208,"zip":209,"country":142,"countryCode":143,"cosmosGeoPoint":210,"geoPoint":214,"contacts":36},"Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology","Wuhan","Hubei","430030",{"type":61,"coordinates":211},[212,213],114.26667,30.58333,{"lat":213,"lon":212},{"facility":216,"status":54,"city":207,"state":208,"zip":217,"country":142,"countryCode":143,"cosmosGeoPoint":218,"geoPoint":220,"contacts":36},"Hubei Cancer Hospital","430079",{"type":61,"coordinates":219},[212,213],{"lat":213,"lon":212},{"facility":222,"status":54,"city":223,"state":224,"zip":225,"country":142,"countryCode":143,"cosmosGeoPoint":226,"geoPoint":230,"contacts":36},"Linyi Peoples Hospital","Linyi","Shandong","276000",{"type":61,"coordinates":227},[228,229],118.34278,35.06306,{"lat":229,"lon":228},{"facility":232,"status":54,"city":233,"state":234,"zip":235,"country":142,"countryCode":143,"cosmosGeoPoint":236,"geoPoint":240,"contacts":36},"Affiliated Zhongshan Hospital of Fudan University","Shanghai","Shanghai 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Hospital","Seongnam-si","13620",{"type":61,"coordinates":288},[289,290],127.13778,37.43861,{"lat":290,"lon":289},{"facility":293,"status":54,"city":294,"state":295,"zip":296,"country":282,"countryCode":36,"cosmosGeoPoint":36,"geoPoint":36,"contacts":36},"Samsung Medical Center","GangnamGu","Seoul Teugbyeolsi","06351",{"facility":298,"status":54,"city":299,"state":295,"zip":300,"country":282,"countryCode":36,"cosmosGeoPoint":36,"geoPoint":36,"contacts":36},"The Catholic University of Korea, Seoul St Marys Hospital","SeochoGu","06591",{"facility":302,"status":54,"city":303,"state":295,"zip":304,"country":282,"countryCode":36,"cosmosGeoPoint":36,"geoPoint":36,"contacts":36},"Severance Hospital Yonsei University Health System","SeodaemunGu","03722",{"facility":306,"status":54,"city":307,"state":295,"zip":308,"country":282,"countryCode":36,"cosmosGeoPoint":309,"geoPoint":313,"contacts":36},"Seoul National University Hospital","Seoul","03080",{"type":61,"coordinates":310},[311,312],126.9784,37.566,{"lat":312,"lon":311},{"facility":315,"status":54,"city":316,"state":295,"zip":317,"country":282,"countryCode":36,"cosmosGeoPoint":36,"geoPoint":36,"contacts":36},"Asan Medical Center","SongpaGu","05505",{"type":319,"investigatorFullName":36,"investigatorTitle":36,"investigatorAffiliation":36,"oldNameTitle":36,"oldOrganization":36},"SPONSOR","100562102","phase-1-study-of-bg-t187-alone-and-in-combination-with-other-therapeutic-agents-in-participants-with-advanced-solid-tumors-100562102",false,"NCT06598800","Study of BG-T187 Alone and in Combination With Other Therapeutic Agents in Participants With Advanced Solid Tumors","A Phase 1 Study Investigating the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of BG-T187, an EGFR×MET Trispecific Antibody, Alone and in Combination With Other Therapeutic Agents in Patients With Advanced Solid Tumors","Inclusion Criteria:\n\n1. Able to provide a signed and dated written informed consent prior to any study-specific procedures, sampling, or data collection.\n2. Participants must be ≥ 18 years of age or the legal age of consent in the jurisdiction in which the study is taking place.\n3. Eastern Cooperative Oncology Group (ECOG) Performance Status ≤ 1.\n4. Participants with selected histologically or cytologically confirmed advanced, metastatic, and unresectable solid tumors who have been previously treated, including but not limited to non-small cell lung cancer (NSCLC), colorectal cancer (CRC).\n5. ≥ 1 measurable or nonmeasurable lesion as assessed by RECIST v1.1. for Phase 1a Part A; ≥ 1 measurable lesion per RECIST v1.1. for Phase 1a Part B and Phase 1b.\n6. Adequate organ function.\n\nExclusion Criteria:\n\n1. Prior severe allergic reactions or hypersensitivity to the active ingredient and excipients of BG-T187 or other monoclonal antibodies.\n2. Spinal cord compression, active leptomeningeal disease, or uncontrolled, untreated brain metastasis.\n3. Any malignancy ≤ 3 years before the first dose of study drug(s) except for the specific cancer under investigation in this study and any locally recurring cancer that has been treated with curative intent (eg, resected basal or squamous cell skin cancer, superficial bladder cancer, or carcinoma in situ of the cervix or breast).\n4. History of interstitial lung disease (ILD) or noninfectious pneumonitis requiring steroids or other immune suppressive agents ≤ 2 years before the first dose of the study drug, or with current ILD\u002Fnoninfectious pneumonitis, or where suspected ILD\u002Fnoninfectious pneumonitis cannot be ruled out by imaging during screening.\n5. Uncontrollable pleural effusion, pericardial effusion, or ascites requiring frequent drainage (recurrence ≤14 days after intervention).\n6. Active hepatitis C.\n7. Infection (including tuberculosis infection, or other) requiring systemic (oral or intravenous) antibacterial, antifungal, or antiviral therapy ≤ 14 days before the first dose of study drug(s).\n\nNote: Other protocol defined Inclusion\u002FExclusion criteria may apply.","ALL","18 Years",{"count":330,"type":331},153,"ESTIMATED","INTERVENTIONAL",[334],"PHASE1","This is a first-in-human (FIH), Phase 1a\u002F1b, open-label, multicenter, dose escalation and dose expansion study to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of BG-T187 alone and in combination with other therapeutic agents in participants with advanced solid tumors.",[337],"Advanced Solid Tumor",[339,340,341,342,343],"Advanced Solid Tumors","First-in-human","BG-T187","EGFR","c-MET","2026-08-06",{"date":346,"type":347},"2026-08-07","ACTUAL",{"date":349,"type":347},"2024-10-18",{"date":351,"type":331},"2028-09-30",{"name":5,"class":6},30]