[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626904":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":38,"centralContacts":42,"locations":52,"responsibleParty":567,"collaborators":33,"id":569,"slug":570,"hasResults":571,"nctId":572,"briefTitle":573,"officialTitle":574,"acronym":33,"eligibilityCriteria":575,"healthyVolunteers":571,"sex":576,"minAge":577,"maxAge":33,"enrollmentInfo":578,"targetDuration":33,"studyType":581,"phases":582,"briefSummary":584,"conditions":585,"keywords":587,"overallStatus":123,"whyStopped":33,"lastUpdateSubmitDate":591,"lastUpdatePostDateStruct":592,"startDateStruct":595,"completionDateStruct":597,"leadSponsor":599,"locationsCount":600},{"fullName":5,"class":6},"Incyte Corporation","INDUSTRY",[8,14,19,23],{"label":9,"type":10,"description":11,"interventionNames":12},"Part 1a: Dose Escalation","EXPERIMENTAL","INCA036978 will be administered at a protocol defined starting regimen as monotherapy to identify the MTD and\u002For RDE(s).",[13],"Drug: INCA036978",{"label":15,"type":10,"description":16,"interventionNames":17},"Part 1b: Dose Escalation","INCA036978 will be administered at a protocol defined starting regimen in combination with a standard disease-directed therapy to identify the MTD and\u002For RDE(s).",[13,18],"Drug: Standard disease-directed therapy",{"label":20,"type":10,"description":21,"interventionNames":22},"Part 2a: Dose Expansion","INCA036978 will be administered as monotherapy at the RDE(s) identified during Part 1",[13],{"label":24,"type":10,"description":25,"interventionNames":26},"Part 2b: Dose Expansion","INCA036978 will be administered in combination with a standard disease-directed therapy at the RDE(s) identified during Part 1.",[13,18],[28,34],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"DRUG","INCA036978","INCA036978 will be administered at protocol defined dose.",[9,15,20,24],null,{"type":29,"name":35,"description":36,"armGroupLabels":37,"otherNames":33},"Standard disease-directed therapy","A standard disease-directed therapy will be administered according to Prescribing Information\u002FSmPC.",[15,24],[39],{"name":40,"affiliation":5,"role":41},"Incyte Medical Monitor","STUDY_DIRECTOR",[43,48],{"name":44,"role":45,"phone":46,"phoneExt":33,"email":47},"Incyte Corporation Call Center (US)","CONTACT","1.855.463.3463","medinfo@incyte.com",{"name":49,"role":45,"phone":50,"phoneExt":33,"email":51},"Incyte Corporation Call Center (ex-US)","+800 00027423","eumedinfo@incyte.com",[53,67,77,86,92,102,112,121,132,142,152,162,171,177,183,193,202,211,221,230,240,250,260,270,282,291,301,311,321,332,341,353,363,374,383,392,403,412,421,430,439,450,459,468,477,483,492,502,509,520,529,538,549,558],{"facility":54,"status":55,"city":56,"state":57,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":33},"University of Alabama At Birmingham","NOT_YET_RECRUITING","Birmingham","Alabama","35233","United States","US",{"type":62,"coordinates":63},"Point",[64,65],-86.80249,33.52066,{"lat":65,"lon":64},{"facility":68,"status":55,"city":69,"state":70,"zip":71,"country":59,"countryCode":60,"cosmosGeoPoint":72,"geoPoint":76,"contacts":33},"City of Hope-Lennar Foundation Cancer Center","Irvine","California","92618",{"type":62,"coordinates":73},[74,75],-117.82311,33.66946,{"lat":75,"lon":74},{"facility":78,"status":55,"city":79,"state":70,"zip":80,"country":59,"countryCode":60,"cosmosGeoPoint":81,"geoPoint":85,"contacts":33},"Usc Norris Comprehensive Cancer Center","Los Angeles","90033",{"type":62,"coordinates":82},[83,84],-118.24368,34.05223,{"lat":84,"lon":83},{"facility":87,"status":55,"city":79,"state":70,"zip":88,"country":59,"countryCode":60,"cosmosGeoPoint":89,"geoPoint":91,"contacts":33},"UCLA Medical Hematology & Oncology","90095",{"type":62,"coordinates":90},[83,84],{"lat":84,"lon":83},{"facility":93,"status":55,"city":94,"state":95,"zip":96,"country":59,"countryCode":60,"cosmosGeoPoint":97,"geoPoint":101,"contacts":33},"Yale Cancer Center","New Haven","Connecticut","06510",{"type":62,"coordinates":98},[99,100],-72.92816,41.30815,{"lat":100,"lon":99},{"facility":103,"status":55,"city":104,"state":105,"zip":106,"country":59,"countryCode":60,"cosmosGeoPoint":107,"geoPoint":111,"contacts":33},"University of Miami","Miami","Florida","33136",{"type":62,"coordinates":108},[109,110],-80.19366,25.77427,{"lat":110,"lon":109},{"facility":113,"status":55,"city":114,"state":105,"zip":115,"country":59,"countryCode":60,"cosmosGeoPoint":116,"geoPoint":120,"contacts":33},"Moffitt Cancer Center","Tampa","33612",{"type":62,"coordinates":117},[118,119],-82.45843,27.94752,{"lat":119,"lon":118},{"facility":122,"status":123,"city":124,"state":125,"zip":126,"country":59,"countryCode":60,"cosmosGeoPoint":127,"geoPoint":131,"contacts":33},"Winship Cancer Institute of Emory University","RECRUITING","Atlanta","Georgia","30322",{"type":62,"coordinates":128},[129,130],-84.38798,33.749,{"lat":130,"lon":129},{"facility":133,"status":55,"city":134,"state":135,"zip":136,"country":59,"countryCode":60,"cosmosGeoPoint":137,"geoPoint":141,"contacts":33},"John Hopkins Hospital","Baltimore","Maryland","21287",{"type":62,"coordinates":138},[139,140],-76.61219,39.29038,{"lat":140,"lon":139},{"facility":143,"status":55,"city":144,"state":145,"zip":146,"country":59,"countryCode":60,"cosmosGeoPoint":147,"geoPoint":151,"contacts":33},"Massachusetts General Hospital","Boston","Massachusetts","02114",{"type":62,"coordinates":148},[149,150],-71.05977,42.35843,{"lat":150,"lon":149},{"facility":153,"status":55,"city":154,"state":155,"zip":156,"country":59,"countryCode":60,"cosmosGeoPoint":157,"geoPoint":161,"contacts":33},"Washington University School of Medicine","St Louis","Missouri","63108",{"type":62,"coordinates":158},[159,160],-90.19789,38.62727,{"lat":160,"lon":159},{"facility":163,"status":55,"city":164,"state":164,"zip":165,"country":59,"countryCode":60,"cosmosGeoPoint":166,"geoPoint":170,"contacts":33},"Memorial Sloan Kettering Cancer Center","New York","10021",{"type":62,"coordinates":167},[168,169],-74.00597,40.71427,{"lat":169,"lon":168},{"facility":172,"status":55,"city":164,"state":164,"zip":173,"country":59,"countryCode":60,"cosmosGeoPoint":174,"geoPoint":176,"contacts":33},"Mount Sinai School of Medicine","10029",{"type":62,"coordinates":175},[168,169],{"lat":169,"lon":168},{"facility":178,"status":55,"city":164,"state":164,"zip":179,"country":59,"countryCode":60,"cosmosGeoPoint":180,"geoPoint":182,"contacts":33},"Weill Cornell Medicine","10065",{"type":62,"coordinates":181},[168,169],{"lat":169,"lon":168},{"facility":184,"status":55,"city":185,"state":186,"zip":187,"country":59,"countryCode":60,"cosmosGeoPoint":188,"geoPoint":192,"contacts":33},"University of North Carolina At Chapel Hill","Chapel Hill","North Carolina","27514",{"type":62,"coordinates":189},[190,191],-79.05584,35.9132,{"lat":191,"lon":190},{"facility":194,"status":55,"city":195,"state":186,"zip":196,"country":59,"countryCode":60,"cosmosGeoPoint":197,"geoPoint":201,"contacts":33},"Levine Cancer Institute","Charlotte","28204",{"type":62,"coordinates":198},[199,200],-80.84313,35.22709,{"lat":200,"lon":199},{"facility":203,"status":55,"city":204,"state":186,"zip":205,"country":59,"countryCode":60,"cosmosGeoPoint":206,"geoPoint":210,"contacts":33},"Duke University Medical Center, Department of Hematologic Malignancies and Cellular Therapy","Durham","27705",{"type":62,"coordinates":207},[208,209],-78.89862,35.99403,{"lat":209,"lon":208},{"facility":212,"status":55,"city":213,"state":214,"zip":215,"country":59,"countryCode":60,"cosmosGeoPoint":216,"geoPoint":220,"contacts":33},"Cleveland Clinic","Cleveland","Ohio","44195",{"type":62,"coordinates":217},[218,219],-81.69541,41.4995,{"lat":219,"lon":218},{"facility":222,"status":123,"city":223,"state":214,"zip":224,"country":59,"countryCode":60,"cosmosGeoPoint":225,"geoPoint":229,"contacts":33},"Ohio State University","Columbus","43210",{"type":62,"coordinates":226},[227,228],-82.99879,39.96118,{"lat":228,"lon":227},{"facility":231,"status":123,"city":232,"state":233,"zip":234,"country":59,"countryCode":60,"cosmosGeoPoint":235,"geoPoint":239,"contacts":33},"Tristar Bmt\u002FTcto","Nashville","Tennessee","37203",{"type":62,"coordinates":236},[237,238],-86.78444,36.16589,{"lat":238,"lon":237},{"facility":241,"status":55,"city":242,"state":243,"zip":244,"country":59,"countryCode":60,"cosmosGeoPoint":245,"geoPoint":249,"contacts":33},"University of Texas M. D. Anderson Cancer Center","Houston","Texas","77030",{"type":62,"coordinates":246},[247,248],-95.36327,29.76328,{"lat":248,"lon":247},{"facility":251,"status":55,"city":252,"state":253,"zip":254,"country":59,"countryCode":60,"cosmosGeoPoint":255,"geoPoint":259,"contacts":33},"Huntsman Cancer Institute","Salt Lake City","Utah","84112",{"type":62,"coordinates":256},[257,258],-111.89105,40.76078,{"lat":258,"lon":257},{"facility":261,"status":55,"city":262,"state":263,"zip":264,"country":59,"countryCode":60,"cosmosGeoPoint":265,"geoPoint":269,"contacts":33},"Medical College of Wisconsin","Milwaukee","Wisconsin","53226",{"type":62,"coordinates":266},[267,268],-87.90647,43.0389,{"lat":268,"lon":267},{"facility":271,"status":123,"city":272,"state":273,"zip":274,"country":275,"countryCode":276,"cosmosGeoPoint":277,"geoPoint":281,"contacts":33},"Concord General Repatriation Hospital","Concord","New South Wales","02139","Australia","AU",{"type":62,"coordinates":278},[279,280],151.10381,-33.84722,{"lat":280,"lon":279},{"facility":283,"status":123,"city":284,"state":273,"zip":285,"country":275,"countryCode":276,"cosmosGeoPoint":286,"geoPoint":290,"contacts":33},"Royal North Shore Hospital","St Leonards","02065",{"type":62,"coordinates":287},[288,289],151.19836,-33.82344,{"lat":289,"lon":288},{"facility":292,"status":123,"city":293,"state":294,"zip":295,"country":275,"countryCode":276,"cosmosGeoPoint":296,"geoPoint":300,"contacts":33},"Icon Cancer Centre","Auchenflower","Queensland","04066",{"type":62,"coordinates":297},[298,299],152.99213,-27.47443,{"lat":299,"lon":298},{"facility":302,"status":123,"city":303,"state":304,"zip":305,"country":275,"countryCode":276,"cosmosGeoPoint":306,"geoPoint":310,"contacts":33},"Epworth Health Care","East Melbourne","Victoria","03002",{"type":62,"coordinates":307},[308,309],144.9879,-37.81667,{"lat":309,"lon":308},{"facility":312,"status":123,"city":313,"state":314,"zip":315,"country":275,"countryCode":276,"cosmosGeoPoint":316,"geoPoint":320,"contacts":33},"Linear Clinical Research","Nedlands","Western Australia","06009",{"type":62,"coordinates":317},[318,319],115.8073,-31.98184,{"lat":319,"lon":318},{"facility":322,"status":55,"city":323,"state":33,"zip":324,"country":325,"countryCode":326,"cosmosGeoPoint":327,"geoPoint":331,"contacts":33},"Centre Hospitalier Universitaire (Chu) de Liege","Liège","04000","Belgium","BE",{"type":62,"coordinates":328},[329,330],5.56749,50.63373,{"lat":330,"lon":329},{"facility":333,"status":55,"city":334,"state":33,"zip":335,"country":325,"countryCode":326,"cosmosGeoPoint":336,"geoPoint":340,"contacts":33},"AZ DELTA","Roeselare","08800",{"type":62,"coordinates":337},[338,339],3.12269,50.94653,{"lat":339,"lon":338},{"facility":342,"status":55,"city":343,"state":344,"zip":345,"country":346,"countryCode":347,"cosmosGeoPoint":348,"geoPoint":352,"contacts":33},"Princess Margaret Cancer Center","Toronto","Ontario","M5G 2M9","Canada","CA",{"type":62,"coordinates":349},[350,351],-79.39864,43.70643,{"lat":351,"lon":350},{"facility":354,"status":55,"city":355,"state":356,"zip":357,"country":346,"countryCode":347,"cosmosGeoPoint":358,"geoPoint":362,"contacts":33},"McGill University Jewish General Hospital","Montreal","Quebec","H3T 1E2",{"type":62,"coordinates":359},[360,361],-73.58781,45.50884,{"lat":361,"lon":360},{"facility":364,"status":55,"city":365,"state":33,"zip":366,"country":367,"countryCode":368,"cosmosGeoPoint":369,"geoPoint":373,"contacts":33},"Institut Bergonie","Bordeaux","33076","France","FR",{"type":62,"coordinates":370},[371,372],-0.58046,44.84124,{"lat":372,"lon":371},{"facility":375,"status":55,"city":376,"state":33,"zip":377,"country":367,"countryCode":368,"cosmosGeoPoint":378,"geoPoint":382,"contacts":33},"Hospital Saint Louis","Paris","75010",{"type":62,"coordinates":379},[380,381],2.3488,48.85341,{"lat":381,"lon":380},{"facility":384,"status":55,"city":385,"state":33,"zip":386,"country":367,"countryCode":368,"cosmosGeoPoint":387,"geoPoint":391,"contacts":33},"Institut Gustave Roussy","Villejuif","94805",{"type":62,"coordinates":388},[389,390],2.35992,48.7939,{"lat":390,"lon":389},{"facility":393,"status":55,"city":394,"state":33,"zip":395,"country":396,"countryCode":397,"cosmosGeoPoint":398,"geoPoint":402,"contacts":33},"University Medical Center Rwth Aachen","Aachen","D-52074","Germany","DE",{"type":62,"coordinates":399},[400,401],6.08342,50.77664,{"lat":401,"lon":400},{"facility":404,"status":55,"city":405,"state":33,"zip":406,"country":396,"countryCode":397,"cosmosGeoPoint":407,"geoPoint":411,"contacts":33},"Charite Universitaetsmedizin Berlin - Campus Charite Mitte","Berlin","10117",{"type":62,"coordinates":408},[409,410],13.41053,52.52437,{"lat":410,"lon":409},{"facility":413,"status":55,"city":414,"state":33,"zip":415,"country":396,"countryCode":397,"cosmosGeoPoint":416,"geoPoint":420,"contacts":33},"Universitatklinikum Freiburg","Freiburg im Breisgau","79106",{"type":62,"coordinates":417},[418,419],7.85222,47.9959,{"lat":419,"lon":418},{"facility":422,"status":55,"city":423,"state":33,"zip":424,"country":396,"countryCode":397,"cosmosGeoPoint":425,"geoPoint":429,"contacts":33},"Universitatsklinikum Halle (Saale)","Halle","06120",{"type":62,"coordinates":426},[427,428],11.97947,51.48158,{"lat":428,"lon":427},{"facility":431,"status":55,"city":432,"state":33,"zip":433,"country":396,"countryCode":397,"cosmosGeoPoint":434,"geoPoint":438,"contacts":33},"Universitatsmedizin Der Johannes Gutenberg-Universitat Mainz Iii","Mainz","55131",{"type":62,"coordinates":435},[436,437],8.28008,49.98185,{"lat":437,"lon":436},{"facility":440,"status":55,"city":441,"state":33,"zip":442,"country":443,"countryCode":444,"cosmosGeoPoint":445,"geoPoint":449,"contacts":33},"Aou Policlinico S. Orsola-Malpighi","Bologna","40138","Italy","IT",{"type":62,"coordinates":446},[447,448],11.33875,44.49381,{"lat":448,"lon":447},{"facility":451,"status":55,"city":452,"state":33,"zip":453,"country":443,"countryCode":444,"cosmosGeoPoint":454,"geoPoint":458,"contacts":33},"Fondazione Irccs Ca' Granda - Ospedale Maggiore Policlinico","Milan","20122",{"type":62,"coordinates":455},[456,457],12.59836,42.78235,{"lat":457,"lon":456},{"facility":460,"status":55,"city":461,"state":33,"zip":462,"country":443,"countryCode":444,"cosmosGeoPoint":463,"geoPoint":467,"contacts":33},"A. Gemelli University Hospital, Catholic University of the Sacred Heart","Roma","00168",{"type":62,"coordinates":464},[465,466],11.10642,44.99364,{"lat":466,"lon":465},{"facility":469,"status":55,"city":470,"state":33,"zip":471,"country":443,"countryCode":444,"cosmosGeoPoint":472,"geoPoint":476,"contacts":33},"Azienda Sanitaria Universitaria Friuli Centrale Asu Fc","Udine","33100",{"type":62,"coordinates":473},[474,475],13.23715,46.0693,{"lat":475,"lon":474},{"facility":478,"status":55,"city":479,"state":33,"zip":480,"country":481,"countryCode":482,"cosmosGeoPoint":33,"geoPoint":33,"contacts":33},"National Cancer Center Hospital East","Kashiwa Chiba","277-0882","Japan","JP",{"facility":484,"status":55,"city":485,"state":33,"zip":486,"country":481,"countryCode":482,"cosmosGeoPoint":487,"geoPoint":491,"contacts":33},"Ehime University Hospital","Toon, Ehime","791-0204",{"type":62,"coordinates":488},[489,490],132.89011,33.79427,{"lat":490,"lon":489},{"facility":493,"status":55,"city":494,"state":33,"zip":495,"country":496,"countryCode":33,"cosmosGeoPoint":497,"geoPoint":501,"contacts":33},"Seoul National University Hospital","Jongno-gu, Seoul","03080","South Korea",{"type":62,"coordinates":498},[499,500],126.9784,37.566,{"lat":500,"lon":499},{"facility":503,"status":55,"city":504,"state":33,"zip":505,"country":496,"countryCode":33,"cosmosGeoPoint":506,"geoPoint":508,"contacts":33},"The Catholic University of Korea Seoul St. Mary'S Hospital","Seocho-gu, Seoul","06591",{"type":62,"coordinates":507},[499,500],{"lat":500,"lon":499},{"facility":510,"status":55,"city":511,"state":33,"zip":512,"country":513,"countryCode":514,"cosmosGeoPoint":515,"geoPoint":519,"contacts":33},"Hospital Universitari Germans Trias I Pujol","Badalona","08916","Spain","ES",{"type":62,"coordinates":516},[517,518],2.24741,41.45004,{"lat":518,"lon":517},{"facility":521,"status":55,"city":522,"state":33,"zip":523,"country":513,"countryCode":514,"cosmosGeoPoint":524,"geoPoint":528,"contacts":33},"Hospital Universitario de Gran Canaria Dr. Negrin","Las Palmas de Gran Canaria","35010",{"type":62,"coordinates":525},[526,527],-15.41573,28.10178,{"lat":527,"lon":526},{"facility":530,"status":55,"city":531,"state":33,"zip":532,"country":513,"countryCode":514,"cosmosGeoPoint":533,"geoPoint":537,"contacts":33},"Hospital Universitario 12 de Octubre","Madrid","28041",{"type":62,"coordinates":534},[535,536],-3.70256,40.4165,{"lat":536,"lon":535},{"facility":539,"status":55,"city":540,"state":33,"zip":541,"country":542,"countryCode":543,"cosmosGeoPoint":544,"geoPoint":548,"contacts":33},"Guy'S Hospital - Guy'S & St Thomas' Nhs Foundation Trust","London","SE1 9RT","United Kingdom","UK",{"type":62,"coordinates":545},[546,547],-0.12574,51.50853,{"lat":547,"lon":546},{"facility":550,"status":55,"city":551,"state":33,"zip":552,"country":542,"countryCode":543,"cosmosGeoPoint":553,"geoPoint":557,"contacts":33},"Nottingham University Hospitals","Nottingham","NG5 1PB",{"type":62,"coordinates":554},[555,556],-1.15047,52.9536,{"lat":556,"lon":555},{"facility":559,"status":55,"city":560,"state":33,"zip":561,"country":542,"countryCode":543,"cosmosGeoPoint":562,"geoPoint":566,"contacts":33},"University of Oxford","Oxford","OX3 7LE",{"type":62,"coordinates":563},[564,565],-1.25596,51.75222,{"lat":565,"lon":564},{"type":568,"investigatorFullName":33,"investigatorTitle":33,"investigatorAffiliation":33,"oldNameTitle":33,"oldOrganization":33},"SPONSOR","100626904","phase-1-study-of-inca036978-in-participants-with-myeloproliferative-neoplasms-100626904",false,"NCT07441694","Study of INCA036978 in Participants With Myeloproliferative Neoplasms","A Phase 1, Open-Label, Multicenter Study of INCA036978 in Participants With Myeloproliferative Neoplasms","Inclusion Criteria:\n\n* Life expectancy \\> 6 months.\n* Willingness to undergo a pretreatment and limited on-study BM biopsies and aspirates (as appropriate to disease).\n* Participants with MF, PV and ET as defined in the protocol.\n\nExclusion Criteria:\n\n* Presence of any hematological malignancy other than MF, PV, or ET.\n* Malignancy within the last 3 years prior to enrollment.\n* Acute or chronic HBV, Active HCV or known HIV or tuberculosis infection.\n* Clinically significant or uncontrolled cardiac disease.\n* Has undergone any prior allogeneic stem-cell transplantation or such transplantation is planned in the next 6 months.\n* Laboratory values outside the Protocol-defined ranges.\n* Prior history of major bleeding or thrombosis within the last 3 months prior to study enrollment.\n* Presence of chronic or current active infectious disease requiring systemic treatment.\n* Treatment with an MPN-directed therapy (approved or investigational) within the per protocol threshold before the administration of study drug.\n* Prior radiation therapy within 28 days before the first dose of study treatment.\n\nOther protocol-defined Inclusion\u002FExclusion Criteria may apply.","ALL","18 Years",{"count":579,"type":580},218,"ESTIMATED","INTERVENTIONAL",[583],"PHASE1","This study will be conducted to determine the safety, tolerability, dose-limiting toxicity (DLT)s, and maximum tolerated dose (MTD) and\u002For recommended dose for expansion (RDE)s of INCA036978 administered as monotherapy and in combination with a standard disease-directed therapy.",[586],"Myeloproliferative Neoplasms",[586,588,589,590],"Myelofibrosis","Essential thrombocythemia","Polycythemia Vera","2026-07-20",{"date":593,"type":594},"2026-07-22","ACTUAL",{"date":596,"type":594},"2026-05-11",{"date":598,"type":580},"2030-05-24",{"name":5,"class":6},54]