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Hospital","Narita","286-8520",{"type":80,"coordinates":664},[665,666],140.31667,35.78333,{"lat":666,"lon":665},[669,670],{"name":11,"role":65,"phone":635,"phoneExt":11,"email":11},{"name":671,"role":90,"phone":11,"phoneExt":11,"email":11},"Tomoya Hoshi",{"facility":673,"status":11,"city":674,"state":11,"zip":675,"country":676,"countryCode":677,"cosmosGeoPoint":678,"geoPoint":682,"contacts":683},"Dorado Medical Complex","Dorado","00646","Puerto Rico","PR",{"type":80,"coordinates":679},[680,681],-66.26767,18.45883,{"lat":681,"lon":680},[684,686],{"name":11,"role":65,"phone":685,"phoneExt":11,"email":11},"787-278-1576",{"name":687,"role":90,"phone":11,"phoneExt":11,"email":11},"Luis Pagan-Cardona",{"facility":689,"status":11,"city":690,"state":11,"zip":691,"country":676,"countryCode":677,"cosmosGeoPoint":692,"geoPoint":696,"contacts":697},"Wellness clinical Research Vega Baja","Vega Baja","00693",{"type":80,"coordinates":693},[694,695],-66.38767,18.44439,{"lat":695,"lon":694},[698,700],{"name":11,"role":65,"phone":699,"phoneExt":11,"email":11},"787-654-9444",{"name":701,"role":90,"phone":11,"phoneExt":11,"email":11},"Gustavo Albizu Angulo",{"type":703,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100653395","phase-2-a-study-of-clazakizumab-ly5724886-in-adults-with-elevated-hscrp-and-at-increased-risk-for-cardiovascular-event-100653395",false,"NCT07783802","A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP and at Increased Risk for Cardiovascular Event","A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Clazakizumab in Reducing hsCRP in Adults With Elevated hsCRP and Established ASCVD or at Increased Risk for ASCVD Events","CLARITY-CRP","Inclusion Criteria:\n\n* hsCRP ≥2 mg\u002FL and ≤15 mg\u002FL at screening\n* At least one of the following chronic conditions:\n\n  * Established atherosclerotic cardiovascular disease (ASCVD)\n  * Obesity (body mass index (BMI) ≥30 kg\u002Fm2)\n  * Type 2 diabetes\n  * Hypertension\n  * Chronic kidney disease Grade 3 or 4\n\nExclusion Criteria:\n\n* Acute cardiovascular event within 60 days prior to screening\n* Acute decompensated heart failure hospitalization within 60 days prior to screening\n* Planned coronary revascularization (percutaneous coronary intervention or coronary artery bypass grafting) or major surgery at the time of randomization\n* New York Heart Association Class III or IV heart failure\n* Uncontrolled hypertension at screening (systolic blood pressure (BP) ≥160 mmHg or diastolic BP ≥100 mmHg)\n* Type 1 diabetes\n* Type 2 diabetes with Hemoglobin A1c ≥9.0% (86 mmol\u002Fmol) at screening\n* Nephrotic syndrome, estimated glomerular filtration rate (eGFR) \\\u003C15 mL\u002Fmin\u002F1.73 m², or history of kidney transplant\n* Dialysis or acute kidney injury within 60 days prior to screening\n* Congenital\u002Fhereditary kidney disease, polycystic kidney disease, lupus nephritis, or antineutrophil cytoplasmic antibody-associated vasculitis\n* Active tuberculosis, untreated latent tuberculosis, or known hepatitis B or hepatitis C infection\n* Serious, opportunistic, chronic, or recurrent infection requiring treatment within 12 weeks prior to screening\n* Significant active autoimmune disease\n* Suspected or confirmed immunocompromised state (e.g., HIV infection)\n* History of peptic ulcer disease or gastrointestinal ulceration within 12 months prior to screening\n* History of diverticular disease, gastrointestinal perforation, or major gastrointestinal surgery\n* Mechanical heart valve prosthesis requiring chronic vitamin K antagonist anticoagulation\n* Use of colchicine within 14 days prior to screening or anticipated need during the study\n* Use of immunosuppressive or immunomodulatory agents, including other biologic anti-IL-6 therapies, within specified windows prior to screening\n* Use of systemic corticosteroids within 14 days prior to screening\n* Chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs)","ALL","18 Years",{"count":715,"type":716},120,"ESTIMATED","INTERVENTIONAL",[719],"PHASE2","The purpose of this study is to measure the change in high-sensitivity C-reactive protein (hsCRP), a marker of inflammation in the body, with clazakizumab compared with placebo in adults who have elevated hsCRP and at increased risk for cardiovascular event.\n\nParticipation in the study will last about 9 months.",[722,723,724,725,726,727],"Atherosclerosis","Cardiovascular Disease","Obesity","Hypertension","Diabetes Mellitus, Type 2","Renal Insufficiency, Chronic",[729,730,731,732,733,734],"Interleukin-6 (IL-6)","IL-6 inhibition","C-reactive protein","Residual inflammatory risk","Cardiovascular risk","Monoclonal antibody","NOT_YET_RECRUITING","2026-08-21",{"date":738,"type":739},"2026-08-25","ACTUAL",{"date":741,"type":716},"2026-09",{"date":743,"type":716},"2027-10",{"name":5,"class":6},47]