[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100586796":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":35,"centralContacts":36,"locations":45,"responsibleParty":435,"collaborators":35,"id":437,"slug":438,"hasResults":439,"nctId":440,"briefTitle":441,"officialTitle":442,"acronym":35,"eligibilityCriteria":443,"healthyVolunteers":439,"sex":444,"minAge":445,"maxAge":446,"enrollmentInfo":447,"targetDuration":35,"studyType":450,"phases":451,"briefSummary":453,"conditions":454,"keywords":457,"overallStatus":48,"whyStopped":35,"lastUpdateSubmitDate":461,"lastUpdatePostDateStruct":462,"startDateStruct":465,"completionDateStruct":467,"leadSponsor":469,"locationsCount":470},{"fullName":5,"class":6},"GlaxoSmithKline","INDUSTRY",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Efimosfermin (Dose 1)","EXPERIMENTAL","Participants will receive efimosfermin (Dose 1) once every 4 weeks (Q4W).",[13],"Drug: Efimosfermin",{"label":15,"type":10,"description":16,"interventionNames":17},"Efimosfermin (Dose 2)","Participants will receive efimosfermin (Dose 2) Q4W.",[13],{"label":19,"type":20,"description":21,"interventionNames":22},"Placebo","PLACEBO_COMPARATOR","Participants will receive placebo Q4W.",[23],"Drug: Placebo",[25,32],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","Efimosfermin","Efimosfermin will be administered as a subcutaneous injection.",[9,15],[31],"BOS-580",{"type":26,"name":19,"description":33,"armGroupLabels":34,"otherNames":35},"Placebo will be administered as a subcutaneous injection.",[19],null,[37,42],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},"US GSK Clinical Trials Call Center","CONTACT","877-379-3718","GSKClinicalSupportHD@gsk.com",{"name":43,"role":39,"phone":44,"phoneExt":35,"email":41},"EU GSK Clinical Trials Call Center","+44 (0) 20 89904466",[46,68,81,94,108,121,134,147,160,174,187,201,215,229,242,256,269,283,293,302,315,328,341,350,360,372,385,398,408,421],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"GSK Investigational Site","RECRUITING","Chandler","Arizona","85224","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-111.84125,33.30616,{"lat":58,"lon":57},[61,62,65],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},"EU GSK Clinical Trials Call Centre","+44 (0) 20 8990 4466",{"name":66,"role":67,"phone":35,"phoneExt":35,"email":35},"Anita Kohli","PRINCIPAL_INVESTIGATOR",{"facility":47,"status":48,"city":69,"state":50,"zip":70,"country":52,"countryCode":53,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"Mesa","85381",{"type":55,"coordinates":72},[73,74],-111.82264,33.42227,{"lat":74,"lon":73},[77,78,79],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":80,"role":67,"phone":35,"phoneExt":35,"email":35},"Ann Moore",{"facility":47,"status":48,"city":82,"state":50,"zip":83,"country":52,"countryCode":53,"cosmosGeoPoint":84,"geoPoint":88,"contacts":89},"Tucson","85712",{"type":55,"coordinates":85},[86,87],-110.92648,32.22174,{"lat":87,"lon":86},[90,91,92],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":93,"role":67,"phone":35,"phoneExt":35,"email":35},"Aimee Bachelier",{"facility":47,"status":48,"city":95,"state":96,"zip":97,"country":52,"countryCode":53,"cosmosGeoPoint":98,"geoPoint":102,"contacts":103},"Fresno","California","93720",{"type":55,"coordinates":99},[100,101],-119.77237,36.74773,{"lat":101,"lon":100},[104,105,106],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":107,"role":67,"phone":35,"phoneExt":35,"email":35},"Muhammad Sheikh",{"facility":47,"status":48,"city":109,"state":96,"zip":110,"country":52,"countryCode":53,"cosmosGeoPoint":111,"geoPoint":115,"contacts":116},"Lancaster","93534",{"type":55,"coordinates":112},[113,114],-118.13674,34.69804,{"lat":114,"lon":113},[117,118,119],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":120,"role":67,"phone":35,"phoneExt":35,"email":35},"Jatinder Pruthi",{"facility":47,"status":48,"city":122,"state":96,"zip":123,"country":52,"countryCode":53,"cosmosGeoPoint":124,"geoPoint":128,"contacts":129},"Pasadena","91105",{"type":55,"coordinates":125},[126,127],-118.14452,34.14778,{"lat":127,"lon":126},[130,131,132],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":133,"role":67,"phone":35,"phoneExt":35,"email":35},"Edward Mena",{"facility":47,"status":48,"city":135,"state":96,"zip":136,"country":52,"countryCode":53,"cosmosGeoPoint":137,"geoPoint":141,"contacts":142},"Rialto","92377",{"type":55,"coordinates":138},[139,140],-117.37032,34.1064,{"lat":140,"lon":139},[143,144,145],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":146,"role":67,"phone":35,"phoneExt":35,"email":35},"Zeid Kayali",{"facility":47,"status":48,"city":148,"state":96,"zip":149,"country":52,"countryCode":53,"cosmosGeoPoint":150,"geoPoint":154,"contacts":155},"Santa Maria","93458",{"type":55,"coordinates":151},[152,153],-120.43572,34.95303,{"lat":153,"lon":152},[156,157,158],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":159,"role":67,"phone":35,"phoneExt":35,"email":35},"Keval Shah",{"facility":47,"status":48,"city":161,"state":162,"zip":163,"country":52,"countryCode":53,"cosmosGeoPoint":164,"geoPoint":168,"contacts":169},"Miami","Florida","33156",{"type":55,"coordinates":165},[166,167],-80.19366,25.77427,{"lat":167,"lon":166},[170,171,172],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":173,"role":67,"phone":35,"phoneExt":35,"email":35},"Lazaro M Garcia",{"facility":47,"status":48,"city":175,"state":162,"zip":176,"country":52,"countryCode":53,"cosmosGeoPoint":177,"geoPoint":181,"contacts":182},"Viera","32940",{"type":55,"coordinates":178},[179,180],-80.737,28.24696,{"lat":180,"lon":179},[183,184,185],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":186,"role":67,"phone":35,"phoneExt":35,"email":35},"Rosemary Laird",{"facility":47,"status":48,"city":188,"state":189,"zip":190,"country":52,"countryCode":53,"cosmosGeoPoint":191,"geoPoint":195,"contacts":196},"Marietta","Georgia","30060",{"type":55,"coordinates":192},[193,194],-84.54993,33.9526,{"lat":194,"lon":193},[197,198,199],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":200,"role":67,"phone":35,"phoneExt":35,"email":35},"Aasim Sheikh",{"facility":47,"status":48,"city":202,"state":203,"zip":204,"country":52,"countryCode":53,"cosmosGeoPoint":205,"geoPoint":209,"contacts":210},"Baltimore","Maryland","21202",{"type":55,"coordinates":206},[207,208],-76.61219,39.29038,{"lat":208,"lon":207},[211,212,213],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":214,"role":67,"phone":35,"phoneExt":35,"email":35},"Paul Thuluvath",{"facility":47,"status":48,"city":216,"state":217,"zip":218,"country":52,"countryCode":53,"cosmosGeoPoint":219,"geoPoint":223,"contacts":224},"Kansas City","Missouri","64131",{"type":55,"coordinates":220},[221,222],-94.57857,39.09973,{"lat":222,"lon":221},[225,226,227],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":228,"role":67,"phone":35,"phoneExt":35,"email":35},"Bradley Freilich",{"facility":47,"status":48,"city":230,"state":230,"zip":231,"country":52,"countryCode":53,"cosmosGeoPoint":232,"geoPoint":236,"contacts":237},"New York","10029",{"type":55,"coordinates":233},[234,235],-74.00597,40.71427,{"lat":235,"lon":234},[238,239,240],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":241,"role":67,"phone":35,"phoneExt":35,"email":35},"Frances Lee",{"facility":47,"status":48,"city":243,"state":244,"zip":245,"country":52,"countryCode":53,"cosmosGeoPoint":246,"geoPoint":250,"contacts":251},"Fayetteville","North Carolina","28304",{"type":55,"coordinates":247},[248,249],-78.87836,35.05266,{"lat":249,"lon":248},[252,253,254],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":255,"role":67,"phone":35,"phoneExt":35,"email":35},"John Poulos",{"facility":47,"status":48,"city":257,"state":244,"zip":258,"country":52,"countryCode":53,"cosmosGeoPoint":259,"geoPoint":263,"contacts":264},"Wilson","27612",{"type":55,"coordinates":260},[261,262],-77.91554,35.72127,{"lat":262,"lon":261},[265,266,267],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":268,"role":67,"phone":35,"phoneExt":35,"email":35},"Mitchell Mahmoud",{"facility":47,"status":48,"city":270,"state":271,"zip":272,"country":52,"countryCode":53,"cosmosGeoPoint":273,"geoPoint":277,"contacts":278},"Austin","Texas","78745",{"type":55,"coordinates":274},[275,276],-97.74306,30.26715,{"lat":276,"lon":275},[279,280,281],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":282,"role":67,"phone":35,"phoneExt":35,"email":35},"Nomita Kim",{"facility":47,"status":48,"city":270,"state":271,"zip":284,"country":52,"countryCode":53,"cosmosGeoPoint":285,"geoPoint":287,"contacts":288},"78757",{"type":55,"coordinates":286},[275,276],{"lat":276,"lon":275},[289,290,291],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":292,"role":67,"phone":35,"phoneExt":35,"email":35},"Rohit Puskoor",{"facility":47,"status":48,"city":270,"state":271,"zip":284,"country":52,"countryCode":53,"cosmosGeoPoint":294,"geoPoint":296,"contacts":297},{"type":55,"coordinates":295},[275,276],{"lat":276,"lon":275},[298,299,300],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":301,"role":67,"phone":35,"phoneExt":35,"email":35},"Carmen Landaverde",{"facility":47,"status":48,"city":303,"state":271,"zip":304,"country":52,"countryCode":53,"cosmosGeoPoint":305,"geoPoint":309,"contacts":310},"Dallas","75203",{"type":55,"coordinates":306},[307,308],-96.80667,32.78306,{"lat":308,"lon":307},[311,312,313],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":314,"role":67,"phone":35,"phoneExt":35,"email":35},"Parvez Mantry",{"facility":47,"status":48,"city":316,"state":271,"zip":317,"country":52,"countryCode":53,"cosmosGeoPoint":318,"geoPoint":322,"contacts":323},"Georgetown","78626",{"type":55,"coordinates":319},[320,321],-97.67723,30.63269,{"lat":321,"lon":320},[324,325,326],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":327,"role":67,"phone":35,"phoneExt":35,"email":35},"Nirupama Jerome",{"facility":47,"status":48,"city":329,"state":271,"zip":330,"country":52,"countryCode":53,"cosmosGeoPoint":331,"geoPoint":335,"contacts":336},"Houston","77030",{"type":55,"coordinates":332},[333,334],-95.36327,29.76328,{"lat":334,"lon":333},[337,338,339],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":340,"role":67,"phone":35,"phoneExt":35,"email":35},"Prasun Jalal",{"facility":47,"status":48,"city":329,"state":271,"zip":330,"country":52,"countryCode":53,"cosmosGeoPoint":342,"geoPoint":344,"contacts":345},{"type":55,"coordinates":343},[333,334],{"lat":334,"lon":333},[346,347,348],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":349,"role":67,"phone":35,"phoneExt":35,"email":35},"Joseph Galati",{"facility":47,"status":48,"city":329,"state":271,"zip":351,"country":52,"countryCode":53,"cosmosGeoPoint":352,"geoPoint":354,"contacts":355},"77079",{"type":55,"coordinates":353},[333,334],{"lat":334,"lon":333},[356,357,358],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":359,"role":67,"phone":35,"phoneExt":35,"email":35},"David Huang",{"facility":47,"status":48,"city":122,"state":271,"zip":361,"country":52,"countryCode":53,"cosmosGeoPoint":362,"geoPoint":366,"contacts":367},"77505",{"type":55,"coordinates":363},[364,365],-95.2091,29.69106,{"lat":365,"lon":364},[368,369,370],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":371,"role":67,"phone":35,"phoneExt":35,"email":35},"Rukan Daccak",{"facility":47,"status":48,"city":373,"state":271,"zip":374,"country":52,"countryCode":53,"cosmosGeoPoint":375,"geoPoint":379,"contacts":380},"Pearland","77584",{"type":55,"coordinates":376},[377,378],-95.28605,29.56357,{"lat":378,"lon":377},[381,382,383],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":384,"role":67,"phone":35,"phoneExt":35,"email":35},"Jignesh Shah",{"facility":47,"status":48,"city":386,"state":271,"zip":387,"country":52,"countryCode":53,"cosmosGeoPoint":388,"geoPoint":392,"contacts":393},"San Antonio","78215",{"type":55,"coordinates":389},[390,391],-98.49363,29.42412,{"lat":391,"lon":390},[394,395,396],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":397,"role":67,"phone":35,"phoneExt":35,"email":35},"Eric Lawitz",{"facility":47,"status":48,"city":386,"state":271,"zip":399,"country":52,"countryCode":53,"cosmosGeoPoint":400,"geoPoint":402,"contacts":403},"78229",{"type":55,"coordinates":401},[390,391],{"lat":391,"lon":390},[404,405,406],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":407,"role":67,"phone":35,"phoneExt":35,"email":35},"Daniel Santillano",{"facility":47,"status":48,"city":409,"state":271,"zip":410,"country":52,"countryCode":53,"cosmosGeoPoint":411,"geoPoint":415,"contacts":416},"Waco","76710",{"type":55,"coordinates":412},[413,414],-97.14667,31.54933,{"lat":414,"lon":413},[417,418,419],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":420,"role":67,"phone":35,"phoneExt":35,"email":35},"Gregg Lucksinger",{"facility":47,"status":48,"city":422,"state":423,"zip":424,"country":52,"countryCode":53,"cosmosGeoPoint":425,"geoPoint":429,"contacts":430},"Richmond","Virginia","23249",{"type":55,"coordinates":426},[427,428],-77.46026,37.55376,{"lat":428,"lon":427},[431,432,433],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"name":63,"role":39,"phone":64,"phoneExt":35,"email":41},{"name":434,"role":67,"phone":35,"phoneExt":35,"email":35},"Michael Fuchs",{"type":436,"investigatorFullName":35,"investigatorTitle":35,"investigatorAffiliation":35,"oldNameTitle":35,"oldOrganization":35},"SPONSOR","100586796","phase-2-a-study-of-efimosfermin-alfa-in-participants-with-biopsy-confirmed-cirrhosis-compensated-due-to-mash-100586796",false,"NCT06920043","A Study of Efimosfermin Alfa in Participants With Biopsy-confirmed Cirrhosis (Compensated) Due to MASH","A Phase 2, Randomized, Double-blinded, Placebo-controlled Study of Efimosfermin Alfa in Participants With Biopsy-confirmed Cirrhosis (Compensated) Due to Metabolic Dysfunction-associated Steatohepatitis (MASH)","Inclusion Criteria:\n\n* Ability to understand and sign a written informed consent form (ICF)\n* Age 18 through 75 years at enrollment\n* History or presence of 2 or more of the 5 components of metabolic syndrome\n* Liver biopsy confirmation of MASH consistent with stage F4 fibrosis\n* Other inclusion criteria may apply.\n\nExclusion Criteria:\n\n* Individuals with chronic liver disease from other causes, or any history or evidence of decompensated liver disease\n* History of type 1 diabetes\n* Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ≥5 × the upper limit of normal (ULN)\n* Other exclusion criteria may apply.","ALL","18 Years","75 Years",{"count":448,"type":449},42,"ESTIMATED","INTERVENTIONAL",[452],"PHASE2","The purpose of this study is to evaluate the safety, tolerability, preliminary efficacy, and pharmacokinetics (PK) of efimosfermin in participants with metabolic dysfunction associated steatohepatitis (MASH) and compensated cirrhosis consistent with stage F4 fibrosis.",[455,456],"Metabolic Dysfunction-Associated Steatohepatitis","Non-alcoholic Fatty Liver Disease",[458,459,460],"Fibroblast growth factor","Stage 4 fibrosis","Compensated Cirrhosis","2026-07-07",{"date":463,"type":464},"2026-07-08","ACTUAL",{"date":466,"type":464},"2025-04-09",{"date":468,"type":449},"2028-07-10",{"name":5,"class":6},30]