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5PT",{"type":51,"coordinates":698},[691,692],{"lat":692,"lon":691},{"facility":701,"status":44,"city":685,"state":26,"zip":702,"country":687,"countryCode":688,"cosmosGeoPoint":703,"geoPoint":705,"contacts":26},"Hammersmith Hospital - Imperial College Healthcare Nhs Trust","W12 0HS",{"type":51,"coordinates":704},[691,692],{"lat":692,"lon":691},{"facility":707,"status":44,"city":708,"state":26,"zip":709,"country":687,"countryCode":688,"cosmosGeoPoint":26,"geoPoint":26,"contacts":26},"The Christie Nhs Foundation Trust","Manchester Greater","M204BX",{"type":711,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[713,716],{"name":714,"class":715},"ENGOT Foundation","UNKNOWN",{"name":717,"class":718},"GOG Foundation","NETWORK","100594759","phase-2-a-study-of-incb123667-in-participants-with-platinum-resistant-ovarian-cancer-with-cyclin-e1-overexpression-100594759",false,"NCT07023627","A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression","A Phase 2, Single-Arm Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression (MAESTRA 1)","MAESTRA 1","Inclusion Criteria:\n\n* Histological diagnosis of a high-grade serous epithelial ovarian, fallopian tube, or primary peritoneal cancer.\n* Have platinum-resistant disease:\n\n  * Participants who have only had 1 line of platinum-based therapy must have received at least 4 cycles of a platinum-containing regimen.\n  * Participants who have received 2 to 4 lines of platinum-based therapy must have progressed on or within 6 months after the last dose of platinum.\n* Willingness to undergo a pretreatment biopsy. Note: Tissue from a fresh pretreatment biopsy is preferred, however an archival sample is acceptable as long as the sample is no older than 5 years.\n* Received at least 1 and no more than 4 prior lines of systemic therapy following the initial diagnosis, after which single-agent therapy is considered an appropriate next therapeutic option.\n* Must have received bevacizumab unless there was a contraindication for its use.\n* If the tumor tests positive for FRα, participants must have received mirvetuximab soravtansine unless there is an exception for its use on medical grounds.\n\nExclusion Criteria:\n\n* Have endometrioid, clear cell, mucinous, or sarcomatous histology, mixed tumors containing any of these histologies, or low-grade\u002Fborderline ovarian cancer.\n* Have primary platinum-refractory disease: either did not respond (CR or PR) to first-line platinum-containing therapy or progressed on or within 3 months after the last dose of the first line platinum-containing therapy.\n* The tumor tests positive for FRα but the participant has not received mirvetuximab soravtansine for any reason other than medical contraindication.\n* Clinically significant or uncontrolled cardiac disease within 6 months before the first dose of study drug.\n* Known active CNS metastases and\u002For carcinomatous meningitis.\n* Known additional malignancy that is progressing or requires active treatment.\n\nOther protocol-defined Inclusion\u002FExclusion Criteria may apply.","FEMALE","18 Years","99 Years",{"count":731,"type":732},160,"ESTIMATED","INTERVENTIONAL",[735],"PHASE2","This study will evaluate the safety and efficacy of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer (PROC) With Cyclin E1 Overexpression.",[738],"Ovarian Cancer",[23],"2026-08-04",{"date":742,"type":743},"2026-08-06","ACTUAL",{"date":745,"type":743},"2025-11-12",{"date":747,"type":732},"2027-10-24",{"name":5,"class":6},74]