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I Politecni La Fe","Valencia","46026",{"type":72,"coordinates":440},[441,442],-0.37966,39.47391,{"lat":442,"lon":441},{"facility":445,"status":65,"city":446,"state":33,"zip":447,"country":448,"countryCode":33,"cosmosGeoPoint":449,"geoPoint":453,"contacts":33},"Marmara University Pendik Training Hospital","Istanbul","34899","Turkey (Türkiye)",{"type":72,"coordinates":450},[451,452],28.94966,41.01384,{"lat":452,"lon":451},{"facility":455,"status":65,"city":456,"state":33,"zip":457,"country":448,"countryCode":33,"cosmosGeoPoint":458,"geoPoint":462,"contacts":33},"Sakarya University Training and Research Hospital","Sakarya","54100",{"type":72,"coordinates":459},[460,461],32.07583,39.50333,{"lat":461,"lon":460},{"facility":464,"status":65,"city":465,"state":33,"zip":466,"country":467,"countryCode":468,"cosmosGeoPoint":469,"geoPoint":473,"contacts":33},"University College London Hospitals","London","NW1 2BU","United Kingdom","UK",{"type":72,"coordinates":470},[471,472],-0.12574,51.50853,{"lat":472,"lon":471},{"type":475,"investigatorFullName":33,"investigatorTitle":33,"investigatorAffiliation":33,"oldNameTitle":33,"oldOrganization":33},"SPONSOR","100567416","phase-2-a-study-of-jnj-90301900-in-combination-with-chemoradiation-followed-by-consolidation-immunotherapy-for-non-small-cell-lung-cancer-nsclc-100567416",false,"NCT06667908","A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)","A Phase 2, Randomized, Open-Label, Active-Controlled Study of JNJ-90301900 in Combination With Chemoradiation Followed by Durvalumab in Locally Advanced and Unresectable Stage III NSCLC","CONVERGE","Inclusion Criteria:\n\n* Must be a candidate for standard of care (SOC) treatment of non small cell lung cancer (NSCLC) by concurrent platinum-based doublet chemotherapy with radiation therapy (cCRT) followed by consolidation durvalumab treatment as determined by the investigator and per local guidelines at screening\n* Have a medical history of pathologically (histologically or cytologically) proven diagnosis of NSCLC within 3 months prior to enrollment\u002Frandomization\n* Have locally advanced unresectable stage III NSCLC according to the eighth edition lung cancer stage classification\n* Have at least 1 target lesion (primary lung lesion or involved lymph node\\[s\\]) per RECIST version 1.1 that is amenable to intratumoral and\u002For intranodal injection and intensity modulated radiation therapy (IMRT) as determined by the investigator at screening\n* Have an eastern cooperative oncology group (ECOG) performance status of 0 to 1\n\nExclusion Criteria:\n\n* Medical history of: (a) Primary immunodeficiency (b) Organ transplant that requires therapeutic immunosuppression\n* Any of the following within 3 months prior to enrollment\u002Frandomization: severe or unstable angina, myocardial infarction, clinically significant ventricular arrhythmias or heart failure New York heart association functional classification class III to IV\n* Another concurrent or prior primary malignancy within the last 36 months at informed consent\n* Known allergies, hypersensitivity, or intolerance to any ingredients of JNJ-90301900 crystalline solution, platinum-based doublet chemotherapy (ChT), or durvalumab\n* History of coagulation disorders, including: (a) Active bleeding diathesis or requirement for therapeutic anticoagulation or antiplatelet that cannot be interrupted or altered for JNJ-90301900 injection procedures, (b) Major thromboembolic events (for example, pulmonary embolism, cerebrovascular accident) within 3 months of enrollment or randomization","ALL","18 Years",{"count":487,"type":488},130,"ESTIMATED","INTERVENTIONAL",[491],"PHASE2","The purpose of this study is to determine whether JNJ-90301900 added to concurrent platinum-based doublet chemotherapy with radiation therapy (cCRT) followed by consolidation immunotherapy (cIT) can improve objective response rate (ORR; that is percentage of participants whose best response is complete response or partial response during the study) in participants with locally advanced and unresectable stage III non-small cell lung cancer.",[494],"Carcinoma, Non-Small-Cell Lung","2026-07-02",{"date":497,"type":498},"2026-07-06","ACTUAL",{"date":500,"type":498},"2024-12-06",{"date":502,"type":488},"2028-12-31",{"name":5,"class":6},43]