[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100525624":3},{"organization":4,"outcomesModule":7,"designInfo":74,"detailedDescription":81,"studyPopulation":77,"armGroups":82,"interventions":116,"overallOfficials":561,"centralContacts":77,"locations":566,"responsibleParty":2793,"collaborators":77,"id":2795,"slug":2796,"hasResults":2797,"nctId":2798,"briefTitle":2799,"officialTitle":2800,"acronym":77,"eligibilityCriteria":2801,"healthyVolunteers":2797,"sex":2802,"minAge":2803,"maxAge":2804,"enrollmentInfo":2805,"targetDuration":77,"studyType":2808,"phases":2809,"briefSummary":2811,"conditions":2812,"keywords":77,"overallStatus":569,"whyStopped":77,"lastUpdateSubmitDate":2814,"lastUpdatePostDateStruct":2815,"startDateStruct":2818,"completionDateStruct":2820,"leadSponsor":2822,"locationsCount":2823},{"fullName":5,"class":6},"National Cancer Institute (NCI)","NIH",{"primaryOutcomes":8,"secondaryOutcomes":20,"otherOutcomes":47},[9,13,16],{"measure":10,"description":11,"timeFrame":12},"Philadelphia chromosome-positive (Ph+) (BCR::ABL1-rearranged) 3-year event free survival (EFS)","Will be assessed in children, adolescents, and young adults \\\u003C25 years old with newly-diagnosed Ph+ (BCR::ABL1-rearranged) B acute lymphoblastic leukemia (B-ALL) who are treated with a modified Berlin-Frankfurt-Münster (mBFM) chemotherapy backbone that incorporates three cycles of blinatumomab without traditional consolidation chemotherapy in combination with continuous dasatinib. Will be estimated using the Kaplan-Meier method with standard errors of Peto.","Time from enrollment to first event, relapse, second malignancy, or death in complete remission, or last contact for those who are event-free, assessed up to 3 years",{"measure":14,"description":15,"timeFrame":12},"ABL-class Ph-like B-ALL 3-year event free survival (EFS)","Will be assessed in children, adolescents, and young adults \\\u003C25 years old with newly-diagnosed ABL-class Ph-like B-ALL who are treated with a modified BFM chemotherapy backbone that incorporates three cycles of blinatumomab without traditional consolidation chemotherapy in combination with continuous imatinib for those with PDGFRB gene fusions or dasatinib for those without PDGFRB gene fusions. Will be estimated using the Kaplan-Meier method with standard errors of Peto.",{"measure":17,"description":18,"timeFrame":19},"Incidence of adverse events","Will assess the safety and toxicity profile (infections, mucositis, neurotoxicity, cytokine release syndrome, hypogammaglobulinemia, therapy delays \\> 14 days, and treatment-related mortality) for patients with Ph+ or ABL-class Ph-like B-ALL treated on this novel chemo-immunotherapy backbone with continuous tyrosine kinase inhibitor (TKI). Will be assessed by the National Cancer Institute Common Terminology Criteria for Adverse Events version 5.","Up to 3 years",[21,25,28,31,34,37,40,44],{"measure":22,"description":23,"timeFrame":24},"3-year overall survival (OS)","Will be assessed in patients with Ph+ and ABL-class Ph-like B-ALL, respectively. Will be estimated using the Kaplan-Meier method with standard errors of Peto.","Time from enrollment to death from any cause or date of last contact for those who are alive, assessed up to 3 years",{"measure":26,"description":27,"timeFrame":12},"3-year EFS","Will be estimated using the Kaplan-Meier method with standard errors of Peto.",{"measure":29,"description":27,"timeFrame":30},"3-year disease free survival","Time from end of consolidation\u002Fblinatumomab block 2 (TP2) for early responders to first event (relapse, second malignancy, or death in complete remission) or last contact for those who are event-free, assessed up to 3 years",{"measure":32,"description":33,"timeFrame":19},"Cumulative incidence rates of relapse","Will be estimated using Gray's method.",{"measure":35,"description":36,"timeFrame":19},"Treatment related mortality","Will be estimated at the end of therapy.",{"measure":38,"description":39,"timeFrame":24},"OS of patients with ABL-class Ph-like B-ALL","Will be stratified by their underlying ABL-class fusion subtypes.",{"measure":41,"description":42,"timeFrame":43},"Rates of end of Consolidation (EOC)\u002Ftimepoint 2 (TP2) minimal residual disease (MRD) negativity for patients with Ph+ B-ALL","Defined as \\\u003C1x10\\^-4 or \\\u003C0.01% for patients with Ph+ B-ALL.","From EOC to TP2",{"measure":45,"description":46,"timeFrame":43},"Rates of EOC\u002FTP2 MRD negativity for patients with ABL-class Ph-like B-ALL collectively and based on their ABL-class fusion subtypes","Defined as \\\u003C1x10\\^-4 or \\\u003C0.01% for patients with ABL-class Ph-like B-ALL collectively and based on their ABL-class fusion subtypes.",[48,52,55,58,61,64,67,69,71],{"measure":49,"description":50,"timeFrame":51},"Rates of end of induction (EOI)\u002Ftimepoint 1 (TP1) bone marrow MRD negativity with the introduction of dasatinib","Defined as \\\u003C1x10-4 or \\\u003C0.01% with the introduction of the relevant TKI during Induction for patients with Ph+ B-ALL.","From EOI to TP1",{"measure":53,"description":54,"timeFrame":19},"Outcomes of patients with Ph+ and Ph-like ABL-class B-ALL who are removed from protocol therapy due to consolidation failure","Will be collected and described. A secondary analysis will also be conducted, examining the EFS of patients in both arms of the randomization using conventional definition of consolidation failure (EOC\u002FTP2 MRD ≥ 1%).",{"measure":56,"description":57,"timeFrame":19},"Percentage of patients with Ph+ and ABL-class Ph-like B-ALL who continue TKI beyond protocol-prescribed therapy and their outcomes","Will be collected and described.",{"measure":59,"description":60,"timeFrame":19},"Outcomes for patients with Ph+ and ABL-class Ph-like B-ALL who continue TKI beyond protocol-prescribed therapy","EFS will be estimated at 3 years.",{"measure":62,"description":63,"timeFrame":19},"Prognostic significance of MRD by next-generation sequencing (NGS) at end of induction and end of consolidation","Its association with outcomes will be explored.",{"measure":65,"description":66,"timeFrame":19},"Clinical characteristics and outcomes of patients with chronic myeloid leukemia-like biology","Will be summarized using descriptive statistics.",{"measure":68,"description":66,"timeFrame":19},"Immune function of Ph+ and ABL-class Ph-like B-ALL patients",{"measure":70,"description":66,"timeFrame":19},"TKI levels in the plasma and cerebrospinal fluid of children with Ph+ and ABL-class Ph-like B-ALL",{"measure":72,"description":73,"timeFrame":19},"Impact of TKIs and high-dose methotrexate interaction and identify clinical and biologic factors influencing methotrexate clearance","Will be assessed by summarizing frequencies observed of the same.",{"allocation":75,"interventionModel":76,"interventionModelDescription":77,"primaryPurpose":78,"observationalModel":77,"timePerspective":77,"maskingInfo":79},"NON_RANDOMIZED","PARALLEL",null,"TREATMENT",{"masking":80,"maskingDescription":77,"whoMasked":77},"NONE","PRIMARY OBJECTIVES:\n\nI. To estimate the 3-year event free survival (EFS) of children, adolescents, and young adults \\\u003C25 years old with newly-diagnosed Ph+ (BCR::ABL1-rearranged) B- ALL who are treated with a modified Berlin-Frankfurt-Münster (mBFM) chemotherapy backbone that incorporates three cycles of blinatumomab without traditional consolidation chemotherapy in combination with continuous dasatinib.\n\nII. To estimate the 3-year EFS of children, adolescents, and young adults \\\u003C25 years old with newly-diagnosed ABL-class Ph-like B-ALL who are treated with a modified BFM chemotherapy backbone that incorporates three cycles of blinatumomab without traditional consolidation chemotherapy in combination with continuous imatinib for those with PDGFRB gene fusions or dasatinib for those without PDGFRB gene fusions.\n\nIII. To describe the safety and toxicity profile (infections, mucositis, neurotoxicity, cytokine release syndrome, hypogammaglobulinemia, therapy delays \\> 14 days, and treatment-related mortality) for patients with Ph+ or ABL-class Ph-like B-ALL treated on this novel chemo-immunotherapy backbone with continuous tyrosine kinase inhibitor (TKI).\n\nSECONDARY OBJECTIVES:\n\nI. To estimate the 3-year overall survival (OS) of patients with Ph+ and ABL-class Ph-like B-ALL, respectively.\n\nII. To estimate the 3-year EFS, disease-free survival (DFS), cumulative incidence rates (CIR) of relapse, and treatment related mortality (TRM), and OS of patients with ABL-class Ph-like B-ALL stratified by their underlying ABL-class fusion subtypes.\n\nIII. To describe rates of end of consolidation (EOC)\u002Ftimepoint 2 (TP2) minimal residual disease (MRD) negativity defined as \\\u003C1x10-4 or \\\u003C0.01% for patients with Ph+ B-ALL.\n\nIV. To describe rates of EOC\u002FTP2 MRD negativity defined as \\\u003C1x10-4 or \\\u003C0.01% for patients with ABL-class Ph-like B-ALL collectively and based on their ABL-class fusion subtypes.\n\nEXPLORATORY OBJECTIVES:\n\nI. To describe rates of end of induction (EOI)\u002Ftimepoint 1 (TP1) bone marrow MRD negativity defined as \\\u003C1x10-4 or \\\u003C0.01% with the introduction of the relevant TKI during Induction for patients with Ph+ and ABL-class Ph-like B-ALL, respectively.\n\nII. To describe the outcomes of patients with Ph+ and ABL-class Ph-like B-ALL who are removed from protocol therapy due to Consolidation Failure.\n\nIII. To describe the percentage of patients with Ph+ and ABL-class Ph-like B-ALL who continue TKI beyond protocol-prescribed therapy and their outcomes.\n\nIV. To describe the impact of MRD by next-generation sequencing (NGS) at End of Consolidation on outcomes for patients with Ph+ and ABL-class Ph-like B-ALL.\n\nV. To describe the clinical characteristics and outcomes of patients with chronic myeloid leukemia-like biology.\n\nVI. To describe the immune function of patients with Ph+ and ABL-class Ph-like B-ALL pre- and post-blinatumomab plus TKI and correlate with treatment response.\n\nVII. To describe the TKI levels in the plasma and cerebrospinal fluid of children with Ph+ and ABL-class Ph-like B-ALL over the treatment course and correlate with outcome VIII. To describe the impact of TKIs and high-dose methotrexate interaction and identify clinical and biologic factors influencing methotrexate clearance.\n\nOUTLINE:\n\nSTRATUM I (PH+ B-ALL PATIENTS):\n\nINDUCTION PART I: Patients receive induction chemotherapy on days 1-14 as per standard of care (SOC).\n\nINDUCTION PART II: Patients receive dasatinib PO once daily (QD) on days 15-29, daunorubicin intravenously (IV) over 15 minutes on days 15 and 22, prednisolone or prednisone PO twice daily (BID) on days 15-28, vincristine IV on days 15 and 22, methotrexate intrathecally (IT) on days 15, 22, and 29, and cytarabine IT on days 18 and 25 if central nervous system (CNS)-3 at study entry.\n\nBLINATUMOMAB BLOCK I: Patients receive dexamethasone PO or intravenously (IV) on day 1, blinatumomab IV on days 1-28, dasatinib PO on days 1-35, and methotrexate IT on days 1 and 15 over 5 weeks on study. Patients may undergo radiation therapy in 12 QD fractions.\n\nBLINATUMOMAB BLOCK II: Patients receive dexamethasone PO or IV on day 1, blinatumomab IV on days 1-28, dasatinib PO on days 1-35, and methotrexate IT on days 1 and 15 over 5 weeks on study.\n\nINTERIM MAINTENANCE I: Patients receive dasatinib PO QD until the end of interim maintenance I, mercaptopurine PO QD on days 1-56, vincristine IV on days 8, 22, 36, and 50, methotrexate IT on days 8 and 36, high-dose methotrexate IV over 24 hours on days 8, 22, 36 and 50, and leucovorin PO or IV on days 10, 11, 24, 25, 38, 39, 52 and 53 over 9 weeks on study.\n\nBLINATUMOMAB BLOCK III: Patients receive blinatumomab IV on days 1-28, dasatinib PO QD on days 1-35, and methotrexate IT on day 1 over 5 weeks on study.\n\nDELAYED INTENSIFICATION PART I: Patients receive dasatinib PO QD on days 1-28, methotrexate IT on day 1, dexamethasone PO or IV on days 1-7 and 15-21, doxorubicin IV over 15 minutes on days 1, 8, and 15, vincristine IV on days 1, 8, and 15, and pegaspargase IV or calaspargase pegol IV over 1-2 hours on day 4 over 4 weeks on study.\n\nDELAYED INTENSIFICATION PART II: Patients receive dasatinib PO QD on day 29 until the end of delayed intensification part II, cyclophosphamide IV over 60 minutes on day 29, cytarabine IV over 30 minutes on days 29-32 and 36-39, methotrexate IT on days 29 and 36, thioguanine PO on days 29-42, pegaspargase IV or calaspargase pegol on day 43 and vincristine IV on days 43 and 50 over 5 weeks on study.\n\nINTERIM MAINTENANCE PART II: Patients receive dasatinib PO QD on day 1 until the end of interim maintenance part II, methotrexate IV on days 1, 11, 21, 31, and 41, vincristine IV on 1, 11, 21, 31, and 41, methotrexate IT on days 1 and 31, and pegaspargase IV or calaspargase pegol IV over 1-2 hours on days 2, 22 or 23 over 8 weeks on study.\n\nMAINTENANCE CYCLES I-II: Patients receive dasatinib PO QD on days 1-84, methotrexate IT on days 1 and 29, dexamethasone PO BID or IV on days 1-5, 29-33, and 57-61, mercaptopurine PO on days 1-84, vincristine IV on days 1, 29 and 57, and methotrexate PO on days 8, 15, 22, 29, 36, 43, 50, 57, 64, 71, and 78 on study.\n\nMAINTENANCE CYCLES III AND SUBSEQUENT CYCLES: Patients receive dasatinib PO QD on days 1-84, methotrexate IT on day 1, dexamethasone PO BID or IV on days 1-5, 29-33, and 57-61, mercaptopurine PO on days 1-84, vincristine IV on days 1, 29 and 57, and methotrexate PO on days 8, 15, 22, 29, 36, 43, 50, 57, 64, 71, and 78 on study. Cycles repeat every 12 weeks for 2 years from the start of Induction therapy in the absence of disease progression or unacceptable toxicity.\n\nSTRATUM II (PDGFRB ABL-CLASS FUSIONS):\n\nBLINATUMOMAB BLOCK I: Patients receive dexamethasone PO or IV on day 1, blinatumomab IV on days 1-28, imatinib PO on days 1-35, and methotrexate IT on days 1 and 15 over 5 weeks on study. Patients may undergo radiation therapy in 12 QD fractions.\n\nBLINATUMOMAB BLOCK II: Patients receive dexamethasone PO or IV on day 1, blinatumomab IV on days 1-28, imatinib PO on days 1-35, and methotrexate IT on days 1 and 15 over 5 weeks on study.\n\nINTERIM MAINTENANCE I: Patients receive imatinib PO QD until the end of interim maintenance I, mercaptopurine PO QD on days 1-56, vincristine IV on days 8, 22, 36, and 50, methotrexate IT on days 8 and 36, high-dose methotrexate IV over 24 hours on days 8, 22, 36 and 50, and leucovorin PO or IV on days 10, 11, 24, 25, 38, 39, 52 and 53 over 9 weeks on study.\n\nBLINATUMOMAB BLOCK III: Patients receive blinatumomab IV on days 1-28, imatinib PO QD on days 1-35, and methotrexate IT on day 1 over 5 weeks on study.\n\nDELAYED INTENSIFICATION PART I: Patients receive imatinib PO QD on days 1-28, methotrexate IT on day 1, dexamethasone PO or IV on days 1-7 and 15-21, doxorubicin IV over 15 minutes on days 1, 8, and 15, vincristine IV on days 1, 8, and 15, and pegaspargase IV or calaspargase pegol IV over 1-2 hours on day 4 over 9 weeks on study.\n\nDELAYED INTENSIFICATION PART II: Patients receive imatinib PO QD on day 29 until the end of Delayed Intensification part II, cyclophosphamide IV over 30-60 minutes on day 29, cytarabine IV over 30 minutes on days 29-32 and 36-39, methotrexate IT on days 29 and 36, thioguanine PO on days 29-42, and pegaspargase IV or calaspargase pegol IV on day 43, and vincristine IV on days 43 and 50 over 5 weeks on study.\n\nINTERIM MAINTENANCE II: Patients receive imatinib PO QD until the end of interim maintenance II, methotrexate IV and vincristine IV on days 1, 11, 21, 31 and 41, methotrexate IT on days 1 and 31, and pegaspargase IV or calaspargase pegol IV over 1-2 hours on days 2, 22 or 23 over 8 weeks on study.\n\nMAINTENANCE CYCLES I-II: Patients receive imatinib PO QD on days 1-84, methotrexate IT on days 1 and 29, dexamethasone PO BID or IV on days 1-5, 29-33, and 57-61, mercaptopurine PO on days 1-84, vincristine IV on days 1, 29 and 57, and methotrexate PO on days 8, 15, 22, 29, 36, 43, 50, 57, 64, 71, and 78 on study.\n\nMAINTENANCE CYCLES III AND SUBSEQUENT CYCLES: Patients receive imatinib PO QD on days 1-84, methotrexate IT on day 1, dexamethasone PO BID or IV on days 1-5, 29-33, and 57-61, mercaptopurine PO on days 1-84, vincristine IV on days 1, 29 and 57, and methotrexate PO on days 8, 15, 22, 29, 36, 43, 50, 57, 64, 71, and 78 on study. Cycles repeat every 12 weeks for 2 years from the start of Induction therapy in the absence of disease progression or unacceptable toxicity.\n\nSTRATUM III (NON-PDGFRB ABL-CLASS FUSIONS):\n\nBLINATUMOMAB BLOCK I: Patients receive dexamethasone PO or IV on day 1, blinatumomab IV on days 1-28, dasatinib PO on days 1-35, and methotrexate IT on days 1 and 15 over 5 weeks on study. Patients may undergo radiation therapy in 12 QD fractions.\n\nBLINATUMOMAB BLOCK II: Patients receive dexamethasone PO or IV on day 1, blinatumomab IV on days 1-28, dasatinib PO on days 1-35, and methotrexate IT on days 1 and 15 over 5 weeks on study.\n\nINTERIM MAINTENANCE I: Patients receive dasatinib PO QD until the end of interim maintenance I, mercaptopurine PO QD on days 1-56, vincristine IV on days 8, 22, 36, and 50, methotrexate IT on days 8 and 36, high-dose methotrexate IV over 24 hours on days 8, 22, 36 and 50, and leucovorin PO or IV on days 10, 11, 24, 25, 38, 39, 52 and 53 over 9 weeks on study.\n\nBLINATUMOMAB BLOCK III: Patients receive blinatumomab IV on days 1-28, dasatinib PO on days 1-35, and methotrexate IT on day 1 over 5 weeks on study.\n\nDELAYED INTENSIFICATION PART I: Patients receive dasatinib PO QD on days 1-28, methotrexate IT on day 1, dexamethasone PO or IV on days 1-7 and 15-21, doxorubicin IV over 15 minutes on days 1, 8, and 15, vincristine IV on days 1, 8, and 15, and pegaspargase IV or calaspargase pegol IV over 1-2 hours on day 4 over 4 weeks on study.\n\nDELAYED INTENSIFICATION PART II: Patients receive dasatinib PO QD and methotrexate IT on day 29 until the end of Delayed Intensification part II, cyclophosphamide IV over 30-60 minutes on day 29, cytarabine IV over 30 minutes on days 29-32 and 36-39, methotrexate IT on days 29 and 36, thioguanine PO on days 29-42, pegaspargase IV or calaspargase pegol on day 43 and vincristine IV on days 43 and 50 over 5 weeks on study.\n\nINTERIM MAINTENANCE II: Patients receive dasatinib PO QD until the end of interim maintenance II, methotrexate IV and vincristine IV on days 1, 11, 21, 31 and 41, methotrexate IT on days 1 and 31, and pegaspargase IV or calaspargase pegol IV over 1-2 hours on days 2, 22 or 23 over 8 weeks on study.\n\nMAINTENANCE CYCLES I-II: Patients receive dasatinib PO QD on days 1-84, methotrexate IT on days 1 and 29, dexamethasone PO BID or IV on days 1-5, 29-33, and 57-61, mercaptopurine PO on days 1-84, vincristine IV on days 1, 29 and 57, and methotrexate PO on days 8, 15, 22, 29, 36, 43, 50, 57, 64, 71, and 78 on study.\n\nMAINTENANCE CYCLES III AND SUBSEQUENT CYCLES: Patients receive dasatinib PO QD on days 1-84, methotrexate IT on day 1, dexamethasone PO BID or IV on days 1-5, 29-33, and 57-61, mercaptopurine PO on days 1-84, vincristine IV on days 1, 29 and 57, and methotrexate PO on days 8, 15, 22, 29, 36, 43, 50, 57, 64, 71, and 78 on study. Cycles repeat every 12 weeks for 2 years from the start of Induction therapy in the absence of disease progression or unacceptable toxicity.\n\nAll patients undergo echocardiography (ECHO) or multigated acquisition scan (MUGA) during screening. Patients also undergo blood and cerebrospinal fluid (CSF) sample collection and bone marrow biopsy throughout the study and as clinically indicated on study.",[83,106,113],{"label":84,"type":85,"description":86,"interventionNames":87},"Stratum I (Ph+ ALL)","EXPERIMENTAL","See detailed description",[88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105],"Procedure: Biospecimen Collection","Biological: Blinatumomab","Procedure: Bone Marrow Biopsy","Drug: Calaspargase Pegol","Drug: Cyclophosphamide","Drug: Cytarabine","Drug: Dasatinib","Drug: Daunorubicin","Drug: Doxorubicin","Procedure: Echocardiography Test","Drug: Leucovorin","Drug: Mercaptopurine","Drug: Methotrexate","Procedure: Multigated Acquisition Scan","Drug: Pegaspargase","Drug: Prednisolone","Drug: Prednisone","Drug: Vincristine",{"label":107,"type":85,"description":108,"interventionNames":109},"Stratum II (PDGFRB ABL-Class fusions)","See detailed description.",[88,89,90,91,92,93,95,96,97,110,98,99,100,101,102,103,104,111,112,105],"Drug: Imatinib","Radiation: Radiation Therapy","Drug: Thioguanine",{"label":114,"type":85,"description":108,"interventionNames":115},"Stratum III (non-PDGFRB ABL-Class fusions)",[88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,111,112,105],[117,127,145,152,163,209,246,257,267,275,282,286,292,331,372,390,404,461,507,525,553],{"type":118,"name":119,"description":120,"armGroupLabels":121,"otherNames":122},"PROCEDURE","Biospecimen Collection","Undergo blood and CSF sample collection",[84,107,114],[123,124,125,126],"Biological Sample Collection","Biospecimen Collected","Sample Collection","Specimen Collection",{"type":128,"name":129,"description":130,"armGroupLabels":131,"otherNames":132},"BIOLOGICAL","Blinatumomab","Receive IV",[84,107,114],[133,134,135,136,137,138,139,140,141,142,143,144],"AMG 103","AMG-103","AMG103","Anti-CD19 x Anti-CD3 Bispecific Monoclonal Antibody","Anti-CD19\u002FAnti-CD3 Recombinant Bispecific Monoclonal Antibody MT103","Blincyto","MEDI 538","MEDI-538","MEDI538","MT 103","MT-103","MT103",{"type":118,"name":146,"description":147,"armGroupLabels":148,"otherNames":149},"Bone Marrow Biopsy","Undergo bone marrow biopsy",[84,107,114],[150,151],"Biopsy of Bone Marrow","Biopsy, Bone Marrow",{"type":153,"name":154,"description":130,"armGroupLabels":155,"otherNames":156},"DRUG","Calaspargase Pegol",[84,107,114],[157,158,159,160,161,162],"Asparaginase (Escherichia coli Isoenzyme II), Conjugate with alpha-(((2,5-Dioxo-1-pyrrolidinyl)oxy)carbonyl)-omega-methoxypoly(oxy-1,2-ethanediyl)","Asparlas","Calaspargase Pegol-mknl","EZN-2285","SC-PEG E. Coli L-Asparaginase","Succinimidyl Carbonate Monomethoxypolyethylene Glycol E. coli L-Asparaginase",{"type":153,"name":164,"description":130,"armGroupLabels":165,"otherNames":166},"Cyclophosphamide",[84,107,114],[167,168,169,170,171,172,173,174,175,176,177,178,179,180,181,182,183,184,185,186,187,188,189,190,191,192,193,194,195,196,197,198,199,200,201,202,203,204,205,206,207,208],"(-)-Cyclophosphamide","2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate","Asta B 518","B 518","B-518","B518","Carloxan","Ciclofosfamida","Ciclofosfamide","Cicloxal","Clafen","Claphene","CP monohydrate","CTX","CYCLO-cell","Cycloblastin","Cycloblastine","Cyclophospham","Cyclophosphamid monohydrate","Cyclophosphamide Monohydrate","Cyclophosphamidum","Cyclophosphan","Cyclophosphane","Cyclophosphanum","Cyclostin","Cyclostine","Cytophosphan","Cytophosphane","Cytoxan","Fosfaseron","Frindovyx","Genoxal","Genuxal","Ledoxina","Mitoxan","Neosar","Revimmune","Syklofosfamid","WR 138719","WR- 138719","WR-138719","WR138719",{"type":153,"name":210,"description":211,"armGroupLabels":212,"otherNames":213},"Cytarabine","Receive IV or subcutaneously",[84,107,114],[214,215,216,217,218,219,220,221,222,223,224,225,226,227,228,229,230,231,232,233,234,235,236,237,238,239,240,241,242,243,244,245],".beta.-Cytosine arabinoside","1-.beta.-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone","1-.beta.-D-Arabinofuranosylcytosine","1-Beta-D-arabinofuranosyl-4-amino-2(1H)pyrimidinone","1-Beta-D-arabinofuranosylcytosine","1.beta.-D-Arabinofuranosylcytosine","2(1H)-Pyrimidinone, 4-Amino-1-beta-D-arabinofuranosyl-","2(1H)-Pyrimidinone, 4-amino-1.beta.-D-arabinofuranosyl-","Alexan","Ara-C","ARA-cell","Arabine","Arabinofuranosylcytosine","Arabinosylcytosine","Aracytidine","Aracytin","Aracytine","Beta-Cytosine Arabinoside","CHX-3311","Cytarabinum","Cytarbel","Cytosar","Cytosine Arabinoside","Cytosine-.beta.-arabinoside","Cytosine-beta-arabinoside","Erpalfa","Starasid","Tarabine PFS","U 19920","U-19920","Udicil","WR-28453",{"type":153,"name":247,"description":248,"armGroupLabels":249,"otherNames":250},"Dasatinib","Receive PO",[84,114],[251,252,253,254,255,256],"BMS 354825","BMS-354825","BMS354825","Dasatinib Hydrate","Dasatinib Monohydrate","Sprycel",{"type":153,"name":258,"description":130,"armGroupLabels":259,"otherNames":260},"Daunorubicin",[84,107,114],[261,262,263,264,265,266],"Daunomycin","Daunorrubicina","DNR","Leukaemomycin C","Rubidomycin","Rubomycin C",{"type":153,"name":268,"description":130,"armGroupLabels":269,"otherNames":270},"Doxorubicin",[84,107,114],[271,272,273,274],"Adriablastin","Hydroxydaunomycin","Hydroxyl Daunorubicin","Hydroxyldaunorubicin",{"type":118,"name":276,"description":277,"armGroupLabels":278,"otherNames":279},"Echocardiography Test","Undergo ECHO",[84,107,114],[280,281],"EC","Echocardiography",{"type":153,"name":283,"description":284,"armGroupLabels":285,"otherNames":77},"Imatinib","Given 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Harker-Murray",{"facility":2598,"status":569,"city":2599,"state":2600,"zip":2601,"country":2602,"countryCode":2603,"cosmosGeoPoint":77,"geoPoint":77,"contacts":2604},"John Hunter Children's Hospital","Hunter Regional Mail Centre","New South Wales","2310","Australia","AU",[2605,2607],{"name":583,"role":584,"phone":2606,"phoneExt":77,"email":77},"(02) 4985 5180",{"name":2608,"role":565,"phone":77,"phoneExt":77,"email":77},"Kristy McCarthy",{"facility":2610,"status":569,"city":2611,"state":2612,"zip":2613,"country":2602,"countryCode":2603,"cosmosGeoPoint":2614,"geoPoint":2618,"contacts":2619},"Queensland Children's Hospital","South Brisbane","Queensland","4101",{"type":576,"coordinates":2615},[2616,2617],153.02049,-27.48034,{"lat":2617,"lon":2616},[2620,2622],{"name":583,"role":584,"phone":2621,"phoneExt":77,"email":77},"61 7 3068 1111",{"name":2623,"role":565,"phone":77,"phoneExt":77,"email":77},"Christopher J. Fraser",{"facility":2625,"status":569,"city":2626,"state":2627,"zip":2628,"country":2602,"countryCode":2603,"cosmosGeoPoint":2629,"geoPoint":2633,"contacts":2634},"Royal Children's Hospital","Parkville","Victoria","3052",{"type":576,"coordinates":2630},[2631,2632],144.95,-37.78333,{"lat":2632,"lon":2631},[2635,2638],{"name":583,"role":584,"phone":2636,"phoneExt":77,"email":2637},"61 3 9345 5656","Jordan.Hansford@rch.org.au",{"name":2639,"role":565,"phone":77,"phoneExt":77,"email":77},"Stacie S. Wang",{"facility":2641,"status":569,"city":2642,"state":2643,"zip":2644,"country":2602,"countryCode":2603,"cosmosGeoPoint":2645,"geoPoint":2649,"contacts":2650},"Perth Children's Hospital","Perth","Western Australia","6009",{"type":576,"coordinates":2646},[2647,2648],115.8614,-31.95224,{"lat":2648,"lon":2647},[2651,2652],{"name":583,"role":584,"phone":77,"phoneExt":77,"email":999},{"name":2653,"role":565,"phone":77,"phoneExt":77,"email":77},"Michelle Ng",{"facility":2655,"status":2656,"city":2657,"state":2658,"zip":2659,"country":2660,"countryCode":2661,"cosmosGeoPoint":2662,"geoPoint":2666,"contacts":77},"Alberta Children's Hospital","SUSPENDED","Calgary","Alberta","T3B 6A8","Canada","CA",{"type":576,"coordinates":2663},[2664,2665],-114.08529,51.05011,{"lat":2665,"lon":2664},{"facility":2668,"status":569,"city":2669,"state":2658,"zip":2670,"country":2660,"countryCode":2661,"cosmosGeoPoint":2671,"geoPoint":2675,"contacts":2676},"University of Alberta Hospital","Edmonton","T6G 2B7",{"type":576,"coordinates":2672},[2673,2674],-113.46871,53.55014,{"lat":2674,"lon":2673},[2677,2680],{"name":583,"role":584,"phone":2678,"phoneExt":77,"email":2679},"780-407-8798","pedsoncologyresearch@ahs.ca",{"name":2681,"role":565,"phone":77,"phoneExt":77,"email":77},"Sarah J. McKillop",{"facility":2683,"status":2656,"city":2684,"state":2685,"zip":2686,"country":2660,"countryCode":2661,"cosmosGeoPoint":2687,"geoPoint":2691,"contacts":77},"British Columbia Children's Hospital","Vancouver","British Columbia","V6H 3V4",{"type":576,"coordinates":2688},[2689,2690],-123.11934,49.24966,{"lat":2690,"lon":2689},{"facility":2693,"status":569,"city":2694,"state":2695,"zip":2696,"country":2660,"countryCode":2661,"cosmosGeoPoint":2697,"geoPoint":2701,"contacts":2702},"CancerCare Manitoba","Winnipeg","Manitoba","R3E 0V9",{"type":576,"coordinates":2698},[2699,2700],-97.14704,49.8844,{"lat":2700,"lon":2699},[2703,2706],{"name":583,"role":584,"phone":2704,"phoneExt":77,"email":2705},"866-561-1026","ctu_web@cancercare.mb.ca",{"name":2707,"role":565,"phone":77,"phoneExt":77,"email":77},"Stephanie M. Villeneuve",{"facility":2709,"status":2656,"city":2710,"state":2711,"zip":2712,"country":2660,"countryCode":2661,"cosmosGeoPoint":2713,"geoPoint":2717,"contacts":77},"IWK Health Centre","Halifax","Nova Scotia","B3K 6R8",{"type":576,"coordinates":2714},[2715,2716],-63.57688,44.64269,{"lat":2716,"lon":2715},{"facility":2719,"status":2656,"city":2720,"state":2721,"zip":2722,"country":2660,"countryCode":2661,"cosmosGeoPoint":2723,"geoPoint":2727,"contacts":77},"McMaster Children's Hospital at Hamilton Health Sciences","Hamilton","Ontario","L8N 3Z5",{"type":576,"coordinates":2724},[2725,2726],-79.84963,43.25011,{"lat":2726,"lon":2725},{"facility":2729,"status":569,"city":2730,"state":2721,"zip":2731,"country":2660,"countryCode":2661,"cosmosGeoPoint":2732,"geoPoint":2736,"contacts":2737},"Hospital for Sick Children","Toronto","M5G 1X8",{"type":576,"coordinates":2733},[2734,2735],-79.39864,43.70643,{"lat":2735,"lon":2734},[2738,2741],{"name":583,"role":584,"phone":2739,"phoneExt":77,"email":2740},"416-813-7654","ask.CRS@sickkids.ca",{"name":2742,"role":565,"phone":77,"phoneExt":77,"email":77},"Sumit Gupta",{"facility":2744,"status":2656,"city":2745,"state":2746,"zip":2747,"country":2660,"countryCode":2661,"cosmosGeoPoint":2748,"geoPoint":2752,"contacts":77},"The Montreal Children's Hospital of the MUHC","Montreal","Quebec","H3H 1P3",{"type":576,"coordinates":2749},[2750,2751],-73.58781,45.50884,{"lat":2751,"lon":2750},{"facility":2754,"status":2656,"city":2745,"state":2746,"zip":2755,"country":2660,"countryCode":2661,"cosmosGeoPoint":2756,"geoPoint":2758,"contacts":77},"Centre Hospitalier Universitaire Sainte-Justine","H3T 1C5",{"type":576,"coordinates":2757},[2750,2751],{"lat":2751,"lon":2750},{"facility":2760,"status":2656,"city":2761,"state":2746,"zip":2762,"country":2660,"countryCode":2661,"cosmosGeoPoint":2763,"geoPoint":2767,"contacts":77},"Centre Hospitalier Universitaire de Sherbrooke-Fleurimont","Sherbrooke","J1H 5N4",{"type":576,"coordinates":2764},[2765,2766],-71.89908,45.40008,{"lat":2766,"lon":2765},{"facility":2769,"status":2656,"city":2770,"state":77,"zip":2771,"country":2660,"countryCode":2661,"cosmosGeoPoint":2772,"geoPoint":2776,"contacts":77},"CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)","Québec","G1V 4G2",{"type":576,"coordinates":2773},[2774,2775],-71.21454,46.81228,{"lat":2775,"lon":2774},{"facility":2778,"status":569,"city":2779,"state":77,"zip":2780,"country":2781,"countryCode":2782,"cosmosGeoPoint":2783,"geoPoint":2787,"contacts":2788},"University Pediatric Hospital","San Juan","00926","Puerto Rico","PR",{"type":576,"coordinates":2784},[2785,2786],-66.10572,18.46633,{"lat":2786,"lon":2785},[2789,2791],{"name":583,"role":584,"phone":2790,"phoneExt":77,"email":77},"787-474-0333",{"name":2792,"role":565,"phone":77,"phoneExt":77,"email":77},"Maria E. Echevarria",{"type":2794,"investigatorFullName":77,"investigatorTitle":77,"investigatorAffiliation":77,"oldNameTitle":77,"oldOrganization":77},"SPONSOR","100525624","phase-2-a-study-testing-the-combination-of-dasatinib-or-imatinib-to-chemotherapy-treatment-with-blinatumomab-for-children-adolescents-and-young-adults-with-philadelphia-chromosome-positive-ph-or-abl-class-philadelphia-chromosome-like-ph-like-b-cell-acute-lymphoblastic-leukemia-b-all-100525624",false,"NCT06124157","A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)","An International Phase 2 Study of Chemotherapy and Tyrosine Kinase Inhibitors With Blinatumomab in Patients With Newly-Diagnosed Philadelphia Chromosome-Positive or ABL-Class Philadelphia Chromosome-Like B-Cell Acute Lymphoblastic Leukemia","Inclusion Criteria:\n\n* Patients must be \\> 365 days and \\\u003C 18 years (for AIEOP-BFM), \\> 365 days and \\\u003C 22 years (for Children's Oncology Group \\[COG\\]) and \\> 365 days and \\\u003C 46 years (for ALLTogether sites) at the time of enrollment\n* Newly-diagnosed Ph+ or ABL-class Ph-like B-ALL. Leukemic blasts must express CD19. ABL-class fusions are defined as rearrangements involving the following genes predicted to be sensitive to imatinib and\u002For dasatinib: ABL1, ABL2, CSF1R, and PDGFRB\n* Evidence of BCR::ABL1 should be documented by a clinically-validated assay prior to study entry on day 15 from the first dose of vinCRIStine during Induction therapy. ABL-class Ph-like B-ALL gene rearrangements should be documented by a clinically-validated assay and enrolled on study by day 1 of Blinatumomab Block 1. Accepted methods of detection include fluorescence in situ hybridization (FISH) using break-apart of colocalization signal probes, singleplex or multiplex reverse-transcription polymerase chain reaction (RT-PCR), whole-transcriptome or panel-based ribonucleic acid (RNA) sequencing (e.g., Hematologic Cancer Fusion Analysis, TruSight RNA Pan-Cancer Panel or equivalent). Confirmation of 5' fusion partner genes is not required for study enrollment\n* Patients with Ph+ B-ALL must have previously started Induction therapy, which includes vinCRIStine, a corticosteroid, pegaspargase or calaspargase pegol, with or without anthracycline, and\u002For other standard cytotoxic chemotherapy\n* Patients with Ph+ B-ALL have not received more than 14 days of systemic Induction therapy beginning with the first Induction dose of vinCRIStine\n* Patients with ABL-class Ph-like B-ALL must have previously completed 4 or 5 weeks of multiagent Induction chemotherapy (Induction 1A)\n* Patients may have started either imatinib or dasatinib prior to study entry but should have received no more than 14 days of TKI for Ph+ B-ALL or no more than 35 days of TKI for ABL-class Ph-like B-ALL\n* Patients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of ≤ 2 or Karnofsky and Lansky performance scores ≥ 50%. Use Karnofsky for patients \\> 16 years of age and Lansky for patients ≤ 16 years of age\n* For pediatric patients (age 1-17 years): a glomerular filtration rate (GFR) ≥ 50 mL\u002Fmin\u002F1.73 m\\^2, as determined by one of the following methods (must be performed within 7 days prior to enrollment unless otherwise indicated):\n\n  * Estimated GFR (eGFR) ≥ 50 mL\u002Fmin\u002F1.73 m2\n  * Measured GFR ≥ 50 mL\u002Fmin\u002F1.73 m\\^2 (any age). If measured GFR is used, it must be performed using direct measurement with a nuclear blood sampling method or small molecule clearance method (iothalamate or other molecule per institutional standard\n* For adult patients (age 18 years or older): Creatinine clearance ≥ 30 mL\u002Fmin, as estimated by the Cockcroft and Gault formula. The creatinine value used in the calculation must have been obtained within 28 days prior to registration. Estimated creatinine clearance is based on body weight\n* Direct bilirubin \\\u003C 2.0 mg\u002FdL (34.2 micromoles\u002FL) (must be performed within 7 days prior to enrollment unless otherwise indicated)\n* Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 10 x upper limit of normal (ULN) (must be performed within 7 days prior to enrollment unless otherwise indicated)\n* \\* Shortening fraction of ≥ 27% by echocardiogram (must be obtained within 21 days prior to enrollment and start of protocol therapy \\[repeat if necessary\\]) OR\n\n  * Left Ventricular Ejection fraction of ≥ 50% by radionuclide angiogram or echocardiogram (must be obtained within 21 days prior to enrollment and start of protocol therapy \\[repeat if necessary\\]) AND\n  * Corrected QT Interval, QTc \\\u003C 480mSec (must be obtained within 21 days prior to enrollment and start of protocol therapy \\[repeat if necessary\\])\n\n    * Note: Repeat echocardiogram and electrocardiogram are not required if they were performed at or after initial ALL diagnosis before study enrollment\n\nExclusion Criteria:\n\n* Known history of chronic myeloid leukemia (CML)\n* ABL-class Ph-like B-ALL who are CNS2 or CNS3 at end of Induction phase\n* ALL developing after a previous cancer treated with cytotoxic chemotherapy\n* Active, uncontrolled infection or active systemic illness that requires ongoing vasopressor support or mechanical ventilation\n* Down syndrome (trisomy 21)\n* Pregnancy and breast feeding\n\n  * Female patients who are pregnant since fetal toxicities and teratogenic effects have been noted for several of the study drugs. A negative pregnancy test is required for female patients of childbearing potential within 7 days prior to enrollment\n  * Lactating females who plan to breastfeed their infants\n  * Sexually active male and female patients of reproductive potential who have not agreed to use an effective contraception method for the duration of treatment according to protocol\n\n    * NOTE: Patients who could become pregnant or could father a child must use effective contraception during protocol treatment and for 30 days after the last dose of dasatinib or 14 days after the last dose of imatinib dose or per institutional standard of care for multiagent chemotherapy, whichever is longer\n* Prior treatment with TKIs before study entry with the exception of imatinib or dasatinib\n* Patients with congenital long QT syndrome, history of ventricular arrhythmias, or heart block\n* Patients with known Charcot-Marie-Tooth disease\n* Patients with significant central nervous system pathology that would preclude treatment with blinatumomab, including history of severe neurologic disorder or autoimmune disease with central nervous system (CNS) involvement\n\n  * Note: Patients with a history of seizures that are well controlled on stable doses of anti-epileptic drugs are eligible. Patients with a history of cerebrovascular ischemia\u002Fhemorrhage with residual deficits are not eligible. Patients with a history of cerebrovascular ischemia\u002Fhemorrhage remain eligible provided all neurologic deficits have resolved\n* HIV-infected patients are eligible if on effective anti-retroviral therapy that does not interact with planned study agents and with undetectable viral load within 6 months of treatment\n* All patients and\u002For their parents or legal guardians must sign a written informed consent\n* All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met","ALL","366 Days","46 Years",{"count":2806,"type":2807},222,"ESTIMATED","INTERVENTIONAL",[2810],"PHASE2","This pilot trial assesses the effect of the combination of blinatumomab with dasatinib or imatinib and standard chemotherapy for treating patients with Philadelphia chromosome positive (Ph+) or ABL-class Philadelphia chromosome-like (Ph-like) B-Cell acute lymphoblastic leukemia (B-ALL). Blinatumomab is a bispecific antibody that binds to two different proteins-one on the surface of cancer cells and one on the surface of cells in the immune system. An antibody is a protein made by the immune system to help fight infections and other harmful processes\u002Fcells\u002Fmolecules. Blinatumomab may bind to the cancer cell and a T cell (which plays a key role in the immune system's fighting response) at the same time. Blinatumomab may strengthen the immune system's ability to fight cancer cells by activating the body's own immune cells to destroy the tumor. Dasatinib and imatinib are in a class of medications called tyrosine kinase inhibitors. They work by blocking the action of an abnormal protein that signals cancer cells to multiply, which may help keep cancer cells from growing. Giving blinatumomab and dasatinib or imatinib in combination with standard chemotherapy may work better in treating patients with Ph+ or Ph-like ABL-class B-ALL than dasatinib or imatinib with chemotherapy.",[2813],"B Acute Lymphoblastic Leukemia","2026-09-16",{"date":2816,"type":2817},"2026-09-17","ACTUAL",{"date":2819,"type":2817},"2025-05-30",{"date":2821,"type":2807},"2030-12-01",{"name":5,"class":6},157]