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Southwestern Medical Center \u002FID# 276053","Dallas","75235",{"type":40,"coordinates":162},[163,164],-96.80667,32.78306,{"lat":164,"lon":163},{"facility":167,"status":33,"city":168,"state":150,"zip":169,"country":37,"countryCode":38,"cosmosGeoPoint":170,"geoPoint":174,"contacts":19},"The University of Texas MD Anderson Cancer Center \u002FID# 275663","Houston","77030",{"type":40,"coordinates":171},[172,173],-95.36327,29.76328,{"lat":173,"lon":172},{"facility":176,"status":33,"city":177,"state":150,"zip":178,"country":37,"countryCode":38,"cosmosGeoPoint":179,"geoPoint":183,"contacts":19},"South Texas Accelerated Research Therapeutics \u002FID# 276608","San Antonio","78229",{"type":40,"coordinates":180},[181,182],-98.49363,29.42412,{"lat":182,"lon":181},{"facility":185,"status":33,"city":186,"state":187,"zip":188,"country":37,"countryCode":38,"cosmosGeoPoint":189,"geoPoint":193,"contacts":19},"Start Mountain Region \u002FID# 276607","West Valley City","Utah","84119",{"type":40,"coordinates":190},[191,192],-112.00105,40.69161,{"lat":192,"lon":191},{"facility":195,"status":33,"city":196,"state":197,"zip":198,"country":37,"countryCode":38,"cosmosGeoPoint":199,"geoPoint":203,"contacts":19},"Virginia Cancer Specialists - 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Pamplona \u002FID# 275503","Pamplona","Navarre","31008","Spain","ES",{"type":40,"coordinates":344},[345,346],-1.64323,42.81687,{"lat":346,"lon":345},{"facility":349,"status":33,"city":350,"state":19,"zip":351,"country":341,"countryCode":342,"cosmosGeoPoint":352,"geoPoint":356,"contacts":19},"Hospital Universitario Vall de Hebron \u002FID# 275499","Barcelona","08035",{"type":40,"coordinates":353},[354,355],2.15899,41.38879,{"lat":355,"lon":354},{"facility":358,"status":33,"city":359,"state":19,"zip":360,"country":341,"countryCode":342,"cosmosGeoPoint":361,"geoPoint":365,"contacts":19},"Hospital General Universitario Gregorio Maranon \u002FID# 275498","Madrid","28007",{"type":40,"coordinates":362},[363,364],-3.70256,40.4165,{"lat":364,"lon":363},{"facility":367,"status":33,"city":359,"state":19,"zip":368,"country":341,"countryCode":342,"cosmosGeoPoint":369,"geoPoint":371,"contacts":19},"Hospital Universitario 12 de Octubre \u002FID# 275496","28041",{"type":40,"coordinates":370},[363,364],{"lat":364,"lon":363},{"facility":373,"status":33,"city":374,"state":19,"zip":375,"country":341,"countryCode":342,"cosmosGeoPoint":376,"geoPoint":380,"contacts":19},"Hospital Clinico Universitario de Valencia \u002FID# 275501","Valencia","46010",{"type":40,"coordinates":377},[378,379],-0.37966,39.47391,{"lat":379,"lon":378},{"type":382,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100608060","phase-2-a-study-to-assess-adverse-events-and-change-in-disease-activity-in-participants-12-years-of-age-or-older-with-locally-advanced-or-metastatic-solid-tumors-that-harbor-met-amplification-receiving-intravenously-infused-telisotuzumab-adizutecan-100608060",false,"NCT07196644","A Study to Assess Adverse Events and Change in Disease Activity in Participants 12 Years of Age or Older With Locally Advanced or Metastatic Solid Tumors That Harbor MET Amplification Receiving Intravenously Infused Telisotuzumab Adizutecan","A Phase 2 Study to Evaluate the Safety and Efficacy of Telisotuzumab Adizutecan for the Treatment of Subjects With Locally Advanced or Metastatic Solid Tumors That Harbor MET Amplification","Inclusion Criteria:\n\n* Locally advanced\u002Fmetastatic solid tumors with documented MET amplification via Local next generation sequencing (NGS) or Central NGS via FoundationOne Companion Diagnostic (F1CDx).\n* Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 1\n* Measurable disease at baseline per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 or Response Assessment in Neuro-Oncology (RANO) 2.0 criteria as appropriate to tumor type.\n* Received prior systemic therapy appropriate for their tumor type and stage of disease and who have no satisfactory alternative therapy for advanced solid tumors that would be expected to provide a substantial survival benefit for their tumor type.\n* If participant has central nervous system (CNS) metastasis, these should be clinically asymptomatic or radiologically stable (i.e., without evidence of progression after definitive treatment).\n\nExclusion Criteria:\n\n* Current, historical, or suspected (non-infectious) interstitial lung disease (ILD)\u002Fpneumonitis that required steroids.\n* Any major, life-threatening conditions and life expectancy should be at least 12 weeks.","ALL","12 Years",{"count":393,"type":394},100,"ESTIMATED","INTERVENTIONAL",[397],"PHASE2","Cancer is a condition where cells in a specific part of body grow and reproduce uncontrollably. The purpose of this study is to assess adverse events and change in disease activity of telisotuzumab adizutecan.\n\nTelisotuzumab adizutecan is an investigational drug being developed for the treatment of locally advanced or metastatic solid tumors that harbor MET amplification. This study will have 1 arm where participants will receive telisotuzumab adizutecan. Approximately 100 participants 12 years of age or older. with solid tumors harboring MET amplification will be enrolled in the study in up to 50 sites around the world.\n\nParticipants will receive intravenous (IV) telisotuzumab adizutecan, as part of the 61.5 month study duration.\n\nThere may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at an approved institution (hospital or clinic). The effect of the treatment will be frequently checked by medical assessments, blood tests, questionnaires and side effects.",[400],"Solid Tumors Harboring MET Amplification",[402,9],"Solid Tumors harboring MET Amplification","2026-08-13",{"date":405,"type":406},"2026-08-14","ACTUAL",{"date":408,"type":406},"2025-12-01",{"date":410,"type":394},"2030-12",{"name":5,"class":6},38]