[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100604874":3},{"organization":4,"outcomesModule":7,"designInfo":42,"detailedDescription":41,"studyPopulation":41,"armGroups":48,"interventions":77,"overallOfficials":90,"centralContacts":94,"locations":100,"responsibleParty":1212,"collaborators":41,"id":1214,"slug":1215,"hasResults":1216,"nctId":1217,"briefTitle":1218,"officialTitle":1219,"acronym":41,"eligibilityCriteria":1220,"healthyVolunteers":1216,"sex":1221,"minAge":1222,"maxAge":41,"enrollmentInfo":1223,"targetDuration":41,"studyType":1226,"phases":1227,"briefSummary":1230,"conditions":1231,"keywords":1234,"overallStatus":103,"whyStopped":41,"lastUpdateSubmitDate":1238,"lastUpdatePostDateStruct":1239,"startDateStruct":1242,"completionDateStruct":1244,"leadSponsor":1246,"locationsCount":1247},{"fullName":5,"class":6},"AbbVie","INDUSTRY",{"primaryOutcomes":8,"secondaryOutcomes":16,"otherOutcomes":41},[9,13],{"measure":10,"description":11,"timeFrame":12},"Phase 2: Objective Response (OR) Assessed by the Blinded Independent Central Review (BICR)","OR is defined as participants achieving a best overall response of confirmed complete response (CR) or confirmed partial response (PR) per the BICR based on Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1.","Up to Approximately 69 Months",{"measure":14,"description":15,"timeFrame":12},"Phase 3: Progression-Free Survival (PFS) as assessed by the BICR","PFS is defined as the time from randomization to the first occurrence of radiographic progression based on RECIST version 1.1 as determined by the BICR or death from any cause, whichever occurs earlier.",[17,20,22,25,28,31,35,38],{"measure":18,"description":19,"timeFrame":12},"Phase 2 and 3: Overall Survival (OS)","OS is defined as the time from randomization to the event of death from any cause.",{"measure":21,"description":15,"timeFrame":12},"Phase 2: PFS as assessed by the BICR",{"measure":23,"description":24,"timeFrame":12},"Phase 2 and 3: Duration of Response (DoR) as Assessed by the BICR per RECIST v1.1","DoR is defined as the time from the first response (CR or PR) to Progressive Disease (PD) or death (whichever occurs first) amongst confirmed responders.",{"measure":26,"description":27,"timeFrame":12},"Phase 2 and 3: Disease Control (DC) as Assessed by the BICR per RECIST v1.1","DC is defined as best overall response of confirmed CR or confirmed PR, or stable disease (SD) based on RECIST, version 1.1.",{"measure":29,"description":30,"timeFrame":12},"Phase 3: OR Assessed by the BICR","OR is defined as participants achieving a best overall response of confirmed CR or confirmed PR per the BICR based on RECIST version 1.1.",{"measure":32,"description":33,"timeFrame":34},"Phase 3: Percentage of Participants with Change from Baseline in Physical Functioning as Measured by the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire (EORTC QLQ-C30)","Health-related quality-of-life and symptoms will be assessed with the EORTC QLQ-C30, version 3.0. The EORTC QLQ-C30 is a 30-item patient-reported questionnaire composed of both multi-item and single scales including 5 functional scales (physical, role, emotional, social, and cognitive), 3 symptom scales (fatigue, nausea and vomiting, and pain), a global health status (GHS)\u002FQoL scale, and 6 single items (dyspnea, insomnia, appetite loss, constipation, diarrhea, and financial difficulties). Participants rate items on a 4 point scale ranging from 1 to 4 (1 = Not at All, 2 = A Little, 3 = Quite a Bit, and 4 = Very Much).","Up to Week 12",{"measure":36,"description":37,"timeFrame":34},"Phase 3: Percentage of Participants with Change from Baseline in Key Lung Cancer Symptoms as Measured by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Lung Cancer Module 13 (EORTC QLQLC13)","The EORTC QLQ-LC13 is a lung cancer specific module and consists of 13 questions assessing lung cancer-associated symptoms and treatment-related effects, including one multiple-item scale to assess dyspnea and a series of single items assessing coughing, hemoptysis, sore mouth, dysphagia, peripheral neuropathy, alopecia, pain, and pain medication. Each item is assessed on a Likert scale from 1 (not at all) to 4 (very much).",{"measure":39,"description":40,"timeFrame":34},"Phase 3: Percentage of Participants with Change from Baseline in GHS\u002FQoL as measured by the EORTC QLQ-C30","Health-related quality-of-life and symptoms will be assessed with the EORTC QLQ-C30, version 3.0. The EORTC QLQ-C30 is a 30-item patient-reported questionnaire composed of both multi-item and single scales including 5 functional scales (physical, role, emotional, social, and cognitive), 3 symptom scales (fatigue, nausea and vomiting, and pain), a GHS\u002FQoL scale, and 6 single items (dyspnea, insomnia, appetite loss, constipation, diarrhea, and financial difficulties). Participants rate items on a 4 point scale ranging from 1 to 4 (1 = Not at All, 2 = A Little, 3 = Quite a Bit, and 4 = Very Much).",null,{"allocation":43,"interventionModel":44,"interventionModelDescription":41,"primaryPurpose":45,"observationalModel":41,"timePerspective":41,"maskingInfo":46},"RANDOMIZED","SEQUENTIAL","TREATMENT",{"masking":47,"maskingDescription":41,"whoMasked":41},"NONE",[49,55,59,64,68,72],{"label":50,"type":51,"description":52,"interventionNames":53},"Phase 2: Telisotuzumab Adizutecan Dose A","EXPERIMENTAL","Participants will receive telisotuzumab adizutecan dose A, as part of the approximately 69 month study duration.",[54],"Drug: Telisotuzumab Adizutecan",{"label":56,"type":51,"description":57,"interventionNames":58},"Phase 2: Telisotuzumab Adizutecan Dose B","Participants will receive telisotuzumab adizutecan dose B, as part of the approximately 69 month study duration.",[54],{"label":60,"type":51,"description":61,"interventionNames":62},"Phase 2: Telisotuzumab Adizutecan Dose A + Osimertinib","Participants will receive telisotuzumab adizutecan dose A in combination with osimertinib, as part of the approximately 69 month study duration.",[54,63],"Drug: Osimertinib",{"label":65,"type":51,"description":66,"interventionNames":67},"Phase 2: Telisotuzumab Adizutecan Dose B + Osimertinib","Participants will receive telisotuzumab adizutecan dose B in combination with osimertinib, as part of the approximately 69 month study duration.",[54,63],{"label":69,"type":51,"description":70,"interventionNames":71},"Phase 3: Telisotuzumab Adizutecan Recommended Phase 3 Dose","Participants will receive telisotuzumab adizutecan at the recommended phase 3 dose, as part of the approximately 69 month study duration.",[54],{"label":73,"type":51,"description":74,"interventionNames":75},"Phase 3: Stand of Care (SOC)","Participants will receive investigator's choice of SOC, as part of the approximately 69 month study duration.",[76],"Drug: Standard of Care",[78,83,86],{"type":79,"name":80,"description":81,"armGroupLabels":82,"otherNames":41},"DRUG","Telisotuzumab Adizutecan","Intravenous (IV) Infusion",[50,60,56,65,69],{"type":79,"name":84,"description":84,"armGroupLabels":85,"otherNames":41},"Standard of Care",[73],{"type":79,"name":87,"description":88,"armGroupLabels":89,"otherNames":41},"Osimertinib","Oral",[60,65],[91],{"name":92,"affiliation":5,"role":93},"ABBVIE INC.","STUDY_DIRECTOR",[95],{"name":96,"role":97,"phone":98,"phoneExt":41,"email":99},"ABBVIE CALL CENTER","CONTACT","844-663-3742","abbvieclinicaltrials@abbvie.com",[101,119,129,138,147,157,166,175,185,195,205,215,225,235,244,254,263,275,285,295,305,315,324,334,346,358,368,378,388,397,409,421,431,441,451,463,473,483,493,503,515,525,535,545,555,564,576,585,594,604,613,625,635,645,655,665,671,681,690,699,711,716,721,730,742,752,761,770,782,792,802,812,822,834,844,854,863,872,878,890,895,901,911,921,931,942,952,962,968,974,980,992,1002,1010,1019,1025,1034,1043,1052,1063,1072,1078,1087,1096,1102,1108,1117,1128,1137,1146,1152,1158,1167,1173,1182,1191,1203],{"facility":102,"status":103,"city":104,"state":105,"zip":106,"country":107,"countryCode":108,"cosmosGeoPoint":109,"geoPoint":114,"contacts":115},"Highlands Oncology Group - Springdale \u002FID# 277132","RECRUITING","Springdale","Arkansas","72762","United States","US",{"type":110,"coordinates":111},"Point",[112,113],-94.12881,36.18674,{"lat":113,"lon":112},[116],{"name":117,"role":97,"phone":118,"phoneExt":41,"email":41},"Site Coordinator","479-872-8130",{"facility":120,"status":103,"city":121,"state":122,"zip":123,"country":107,"countryCode":108,"cosmosGeoPoint":124,"geoPoint":128,"contacts":41},"City of Hope National Medical Center \u002FID# 277005","Duarte","California","91010",{"type":110,"coordinates":125},[126,127],-117.97729,34.13945,{"lat":127,"lon":126},{"facility":130,"status":103,"city":131,"state":122,"zip":132,"country":107,"countryCode":108,"cosmosGeoPoint":133,"geoPoint":137,"contacts":41},"City of Hope - Orange County Lennar Foundation Cancer Center \u002FID# 277928","Irvine","92618",{"type":110,"coordinates":134},[135,136],-117.82311,33.66946,{"lat":136,"lon":135},{"facility":139,"status":103,"city":140,"state":122,"zip":141,"country":107,"countryCode":108,"cosmosGeoPoint":142,"geoPoint":146,"contacts":41},"UC San Diego Health - Moores Cancer Center \u002FID# 278836","La Jolla","92037",{"type":110,"coordinates":143},[144,145],-117.2742,32.84727,{"lat":145,"lon":144},{"facility":148,"status":103,"city":149,"state":150,"zip":151,"country":107,"countryCode":108,"cosmosGeoPoint":152,"geoPoint":156,"contacts":41},"Cancer Specialists of North Florida \u002FID# 277332","Jacksonville","Florida","32256",{"type":110,"coordinates":153},[154,155],-81.65565,30.33218,{"lat":155,"lon":154},{"facility":158,"status":103,"city":159,"state":150,"zip":160,"country":107,"countryCode":108,"cosmosGeoPoint":161,"geoPoint":165,"contacts":41},"Cancer Care Centers of Brevard- Rockledge \u002FID# 277853","Rockledge","32955",{"type":110,"coordinates":162},[163,164],-80.72533,28.35084,{"lat":164,"lon":163},{"facility":167,"status":103,"city":168,"state":150,"zip":169,"country":107,"countryCode":108,"cosmosGeoPoint":170,"geoPoint":174,"contacts":41},"Moffitt Cancer Center \u002FID# 276785","Tampa","33612",{"type":110,"coordinates":171},[172,173],-82.45843,27.94752,{"lat":173,"lon":172},{"facility":176,"status":103,"city":177,"state":178,"zip":179,"country":107,"countryCode":108,"cosmosGeoPoint":180,"geoPoint":184,"contacts":41},"Parkview Research Center \u002FID# 277651","Fort Wayne","Indiana","46845",{"type":110,"coordinates":181},[182,183],-85.12886,41.1306,{"lat":183,"lon":182},{"facility":186,"status":103,"city":187,"state":188,"zip":189,"country":107,"countryCode":108,"cosmosGeoPoint":190,"geoPoint":194,"contacts":41},"HealthPartners Cancer Research Center \u002FID# 277339","Saint Louis Park","Minnesota","55426",{"type":110,"coordinates":191},[192,193],-93.34801,44.9483,{"lat":193,"lon":192},{"facility":196,"status":103,"city":197,"state":198,"zip":199,"country":107,"countryCode":108,"cosmosGeoPoint":200,"geoPoint":204,"contacts":41},"Nho - Revive Research Institute \u002FID# 277569","Lincoln","Nebraska","68506",{"type":110,"coordinates":201},[202,203],-96.66696,40.8,{"lat":203,"lon":202},{"facility":206,"status":103,"city":207,"state":208,"zip":209,"country":107,"countryCode":108,"cosmosGeoPoint":210,"geoPoint":214,"contacts":41},"Dartmouth-Hitchcock Medical Center \u002FID# 277673","Lebanon","New Hampshire","03756",{"type":110,"coordinates":211},[212,213],-72.25176,43.64229,{"lat":213,"lon":212},{"facility":216,"status":103,"city":217,"state":218,"zip":219,"country":107,"countryCode":108,"cosmosGeoPoint":220,"geoPoint":224,"contacts":41},"Astera Cancer Care \u002FID# 277570","East Brunswick","New Jersey","08816-4096",{"type":110,"coordinates":221},[222,223],-74.41598,40.42788,{"lat":223,"lon":222},{"facility":226,"status":103,"city":227,"state":228,"zip":229,"country":107,"countryCode":108,"cosmosGeoPoint":230,"geoPoint":234,"contacts":41},"Tennessee Cancer Specialists - Knoxville - Old Weisgarber Road \u002FID# 277891","Knoxville","Tennessee","37909",{"type":110,"coordinates":231},[232,233],-83.92074,35.96064,{"lat":233,"lon":232},{"facility":236,"status":103,"city":237,"state":228,"zip":238,"country":107,"countryCode":108,"cosmosGeoPoint":239,"geoPoint":243,"contacts":41},"SCRI Oncology Partners \u002FID# 276959","Nashville","37203",{"type":110,"coordinates":240},[241,242],-86.78444,36.16589,{"lat":242,"lon":241},{"facility":245,"status":103,"city":246,"state":247,"zip":248,"country":107,"countryCode":108,"cosmosGeoPoint":249,"geoPoint":253,"contacts":41},"Fred Hutchinson Cancer Center. \u002FID# 277939","Seattle","Washington","98109-4405",{"type":110,"coordinates":250},[251,252],-122.33207,47.60621,{"lat":252,"lon":251},{"facility":255,"status":103,"city":256,"state":247,"zip":257,"country":107,"countryCode":108,"cosmosGeoPoint":258,"geoPoint":262,"contacts":41},"Northwest Cancer Specialists - Vancouver \u002FID# 277855","Vancouver","98684",{"type":110,"coordinates":259},[260,261],-122.66149,45.63873,{"lat":261,"lon":260},{"facility":264,"status":103,"city":265,"state":266,"zip":267,"country":268,"countryCode":269,"cosmosGeoPoint":270,"geoPoint":274,"contacts":41},"Canberra Hospital \u002FID# 277166","Garran","Australian Capital Territory","2605","Australia","AU",{"type":110,"coordinates":271},[272,273],149.10846,-35.34206,{"lat":273,"lon":272},{"facility":276,"status":103,"city":277,"state":278,"zip":279,"country":268,"countryCode":269,"cosmosGeoPoint":280,"geoPoint":284,"contacts":41},"St George Hospital - Kogarah \u002FID# 277168","Kogarah","New South Wales","2217",{"type":110,"coordinates":281},[282,283],151.13564,-33.9681,{"lat":283,"lon":282},{"facility":286,"status":103,"city":287,"state":288,"zip":289,"country":268,"countryCode":269,"cosmosGeoPoint":290,"geoPoint":294,"contacts":41},"Mater Misericordiae \u002FID# 276985","South Brisbane","Queensland","4101",{"type":110,"coordinates":291},[292,293],153.02049,-27.48034,{"lat":293,"lon":292},{"facility":296,"status":103,"city":297,"state":298,"zip":299,"country":268,"countryCode":269,"cosmosGeoPoint":300,"geoPoint":304,"contacts":41},"Icon Cancer Centre Hobart \u002FID# 277549","Hobart","Tasmania","7000",{"type":110,"coordinates":301},[302,303],147.32941,-42.87936,{"lat":303,"lon":302},{"facility":306,"status":103,"city":307,"state":308,"zip":309,"country":268,"countryCode":269,"cosmosGeoPoint":310,"geoPoint":314,"contacts":41},"St Vincent's Hospital Melbourne \u002FID# 277002","Fitzroy","Victoria","03065",{"type":110,"coordinates":311},[312,313],144.97833,-37.79839,{"lat":313,"lon":312},{"facility":316,"status":103,"city":317,"state":308,"zip":318,"country":268,"countryCode":269,"cosmosGeoPoint":319,"geoPoint":323,"contacts":41},"Sunshine Hospital \u002FID# 276894","St Albans","3021",{"type":110,"coordinates":320},[321,322],144.80049,-37.74496,{"lat":322,"lon":321},{"facility":325,"status":103,"city":326,"state":327,"zip":328,"country":268,"countryCode":269,"cosmosGeoPoint":329,"geoPoint":333,"contacts":41},"One Clinical Research - Nedlands \u002FID# 277598","Nedlands","Western Australia","6009",{"type":110,"coordinates":330},[331,332],115.8073,-31.98184,{"lat":332,"lon":331},{"facility":335,"status":103,"city":336,"state":337,"zip":338,"country":339,"countryCode":340,"cosmosGeoPoint":341,"geoPoint":345,"contacts":41},"Klinik Floridsdorf \u002FID# 276679","Vienna","State of Vienna","1210","Austria","AT",{"type":110,"coordinates":342},[343,344],16.37208,48.20849,{"lat":344,"lon":343},{"facility":347,"status":103,"city":348,"state":349,"zip":350,"country":351,"countryCode":352,"cosmosGeoPoint":353,"geoPoint":357,"contacts":41},"Institut Jules Bordet \u002FID# 277283","Anderlecht","Brussels Capital","1070","Belgium","BE",{"type":110,"coordinates":354},[355,356],4.31454,50.83619,{"lat":356,"lon":355},{"facility":359,"status":103,"city":360,"state":361,"zip":362,"country":351,"countryCode":352,"cosmosGeoPoint":363,"geoPoint":367,"contacts":41},"Grand Hopital de Charleroi - Les Viviers \u002FID# 277282","Charleroi","Hainaut","6280",{"type":110,"coordinates":364},[365,366],4.44448,50.41136,{"lat":366,"lon":365},{"facility":369,"status":103,"city":370,"state":371,"zip":372,"country":351,"countryCode":352,"cosmosGeoPoint":373,"geoPoint":377,"contacts":41},"Jessa Ziekenhuis - 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277155","28041",{"type":110,"coordinates":1023},[1016,1017],{"lat":1017,"lon":1016},{"facility":1026,"status":103,"city":1027,"state":41,"zip":1028,"country":985,"countryCode":986,"cosmosGeoPoint":1029,"geoPoint":1033,"contacts":41},"Hospital Universitario Virgen de la Victoria \u002FID# 277159","Málaga","29010",{"type":110,"coordinates":1030},[1031,1032],-4.42034,36.72016,{"lat":1032,"lon":1031},{"facility":1035,"status":103,"city":1036,"state":41,"zip":1037,"country":985,"countryCode":986,"cosmosGeoPoint":1038,"geoPoint":1042,"contacts":41},"Hospital Clinico Universitario de Valencia \u002FID# 277147","Valencia","46010",{"type":110,"coordinates":1039},[1040,1041],-0.37966,39.47391,{"lat":1041,"lon":1040},{"facility":1044,"status":103,"city":1045,"state":41,"zip":1046,"country":985,"countryCode":986,"cosmosGeoPoint":1047,"geoPoint":1051,"contacts":41},"Hospital Clinico Universitario Lozano Blesa \u002FID# 277154","Zaragoza","50009",{"type":110,"coordinates":1048},[1049,1050],-0.87734,41.65606,{"lat":1050,"lon":1049},{"facility":1053,"status":103,"city":1054,"state":41,"zip":1055,"country":1056,"countryCode":1057,"cosmosGeoPoint":1058,"geoPoint":1062,"contacts":41},"Changhua Christian Hospital \u002FID# 277145","Changhua","500","Taiwan","TW",{"type":110,"coordinates":1059},[1060,1061],120.5512,24.0692,{"lat":1061,"lon":1060},{"facility":1064,"status":103,"city":1065,"state":41,"zip":1066,"country":1056,"countryCode":1057,"cosmosGeoPoint":1067,"geoPoint":1071,"contacts":41},"Kaohsiung Medical University Chung-Ho Memorial Hospital \u002FID# 277138","Kaohsiung City","807",{"type":110,"coordinates":1068},[1069,1070],120.31333,22.61626,{"lat":1070,"lon":1069},{"facility":1073,"status":103,"city":1065,"state":41,"zip":1074,"country":1056,"countryCode":1057,"cosmosGeoPoint":1075,"geoPoint":1077,"contacts":41},"Kaohsiung Chang Gung Memorial Hospital \u002FID# 277472","833",{"type":110,"coordinates":1076},[1069,1070],{"lat":1070,"lon":1069},{"facility":1079,"status":103,"city":1080,"state":41,"zip":1081,"country":1056,"countryCode":1057,"cosmosGeoPoint":1082,"geoPoint":1086,"contacts":41},"Taichung Veterans General Hospital \u002FID# 277142","Taichung","407",{"type":110,"coordinates":1083},[1084,1085],120.6839,24.1469,{"lat":1085,"lon":1084},{"facility":1088,"status":103,"city":1089,"state":41,"zip":1090,"country":1056,"countryCode":1057,"cosmosGeoPoint":1091,"geoPoint":1095,"contacts":41},"Mackay Memorial Hospital \u002FID# 277146","Taipei","104",{"type":110,"coordinates":1092},[1093,1094],121.52639,25.05306,{"lat":1094,"lon":1093},{"facility":1097,"status":103,"city":1089,"state":41,"zip":1098,"country":1056,"countryCode":1057,"cosmosGeoPoint":1099,"geoPoint":1101,"contacts":41},"National Taiwan University Cancer Center (Ntucc) \u002FID# 277134","106",{"type":110,"coordinates":1100},[1093,1094],{"lat":1094,"lon":1093},{"facility":1103,"status":103,"city":1089,"state":41,"zip":1104,"country":1056,"countryCode":1057,"cosmosGeoPoint":1105,"geoPoint":1107,"contacts":41},"Taipei Veterans General Hospital \u002FID# 277141","112",{"type":110,"coordinates":1106},[1093,1094],{"lat":1094,"lon":1093},{"facility":1109,"status":103,"city":1110,"state":41,"zip":1111,"country":1056,"countryCode":1057,"cosmosGeoPoint":1112,"geoPoint":1116,"contacts":41},"Linkou Chang Gung Memorial Hospital \u002FID# 277135","Taoyuan City","333",{"type":110,"coordinates":1113},[1114,1115],121.29696,24.99368,{"lat":1115,"lon":1114},{"facility":1118,"status":103,"city":1119,"state":1120,"zip":1121,"country":1122,"countryCode":41,"cosmosGeoPoint":1123,"geoPoint":1127,"contacts":41},"Sakarya Universitesi Tip Fakultesi - Korucuk Kampusu \u002FID# 276962","Adapazarı","Sakarya","54290","Turkey (Türkiye)",{"type":110,"coordinates":1124},[1125,1126],30.40333,40.78056,{"lat":1126,"lon":1125},{"facility":1129,"status":103,"city":1130,"state":41,"zip":1131,"country":1122,"countryCode":41,"cosmosGeoPoint":1132,"geoPoint":1136,"contacts":41},"Adana Sehir Hastanesi \u002FID# 276957","Adana","01370",{"type":110,"coordinates":1133},[1134,1135],35.32531,36.98615,{"lat":1135,"lon":1134},{"facility":1138,"status":103,"city":1139,"state":41,"zip":1140,"country":1122,"countryCode":41,"cosmosGeoPoint":1141,"geoPoint":1145,"contacts":41},"Gazi University Medical Faculty \u002FID# 276943","Ankara","06560",{"type":110,"coordinates":1142},[1143,1144],32.85427,39.91987,{"lat":1144,"lon":1143},{"facility":1147,"status":103,"city":1139,"state":41,"zip":1148,"country":1122,"countryCode":41,"cosmosGeoPoint":1149,"geoPoint":1151,"contacts":41},"Ankara Universitesi Tip Fakultesi Cebeci Hastanesi \u002FID# 276961","06620",{"type":110,"coordinates":1150},[1143,1144],{"lat":1144,"lon":1143},{"facility":1153,"status":103,"city":1139,"state":41,"zip":1154,"country":1122,"countryCode":41,"cosmosGeoPoint":1155,"geoPoint":1157,"contacts":41},"Liv Hospital Ankara \u002FID# 276950","06680",{"type":110,"coordinates":1156},[1143,1144],{"lat":1144,"lon":1143},{"facility":1159,"status":103,"city":1160,"state":41,"zip":1161,"country":1122,"countryCode":41,"cosmosGeoPoint":1162,"geoPoint":1166,"contacts":41},"Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi \u002FID# 276956","Istanbul","34722",{"type":110,"coordinates":1163},[1164,1165],28.94966,41.01384,{"lat":1165,"lon":1164},{"facility":1168,"status":103,"city":1160,"state":41,"zip":1169,"country":1122,"countryCode":41,"cosmosGeoPoint":1170,"geoPoint":1172,"contacts":41},"Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi \u002FID# 277063","34899",{"type":110,"coordinates":1171},[1164,1165],{"lat":1165,"lon":1164},{"facility":1174,"status":103,"city":1175,"state":41,"zip":1176,"country":1122,"countryCode":41,"cosmosGeoPoint":1177,"geoPoint":1181,"contacts":41},"Necmettin Erbakan Universitesi Meram Tip Fakultesi - Eski Hastane \u002FID# 276946","Konya","42080",{"type":110,"coordinates":1178},[1179,1180],32.48464,37.87135,{"lat":1180,"lon":1179},{"facility":1183,"status":103,"city":1184,"state":41,"zip":1185,"country":1122,"countryCode":41,"cosmosGeoPoint":1186,"geoPoint":1190,"contacts":41},"Samsun Medical Park Hastanesi \u002FID# 277201","Samsun","55200",{"type":110,"coordinates":1187},[1188,1189],36.3361,41.27976,{"lat":1189,"lon":1188},{"facility":1192,"status":103,"city":1193,"state":1194,"zip":1195,"country":1196,"countryCode":1197,"cosmosGeoPoint":1198,"geoPoint":1202,"contacts":41},"St Bartholomews Hospital - Barts Health \u002FID# 277301","London","Greater London","EC1A 7BE","United Kingdom","UK",{"type":110,"coordinates":1199},[1200,1201],-0.12574,51.50853,{"lat":1201,"lon":1200},{"facility":1204,"status":103,"city":1205,"state":41,"zip":1206,"country":1196,"countryCode":1197,"cosmosGeoPoint":1207,"geoPoint":1211,"contacts":41},"The Christie NHS Foundation Trust - Christie Hospital \u002FID# 277304","Manchester","M20 4BX",{"type":110,"coordinates":1208},[1209,1210],-2.23743,53.48095,{"lat":1210,"lon":1209},{"type":1213,"investigatorFullName":41,"investigatorTitle":41,"investigatorAffiliation":41,"oldNameTitle":41,"oldOrganization":41},"SPONSOR","100604874","phase-2-a-study-to-assess-adverse-events-and-change-in-disease-activity-of-intravenous-iv-telisotuzumab-adizutecan-monotherapy-or-in-combination-with-osimertinib-compared-to-standard-of-care-in-adult-participants-with-locally-advanced-or-metastatic-egfr-mutated-non-squamous-non-small-cell-lung-cancer-100604874",false,"NCT07155187","A Study to Assess Adverse Events and Change in Disease Activity of Intravenous (IV) Telisotuzumab Adizutecan, Monotherapy or in Combination With Osimertinib, Compared to Standard of Care in Adult Participants With Locally Advanced or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer","A Phase 2\u002F3 Open Label Randomized Study of Telisotuzumab Adizutecan, Monotherapy or in Combination With Osimertinib, Compared to Standard of Care in Subjects With Locally Advanced or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer After Progression on a Third-Generation EGFR TKI - AndroMETa-Lung-713","Inclusion Criteria:\n\n* Histologically or cytologically confirmed diagnosis of locally advanced or metastatic non-squamous non-small cell lung cancer (NSCLC) with documented EGFR Exon 19 deletion or Exon21 L858R mutation.\n* Provide recently obtained tumor tissue during Screening for c-Met immunohistochemistry (IHC) testing (and study stratification in Phase 2). If recently obtained tumor tissue is not available, archived tumor tissue is also acceptable.\n* Received one prior third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) therapy in the adjuvant, locally advanced, or metastatic setting, either as monotherapy or in combination with other agents, and experienced documented radiographic disease progression on or after therapy for the most recent regimen administered prior to study entry. Participant who has received prior third-generation EGFR TKI therapy in the adjuvant setting must have progressed while on treatment.\n* Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 1.\n* At least 1 measurable lesion per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1, that has not been previously irradiated.\n\nExclusion Criteria:\n\n* Tumor(s) have adenosquamous or squamous histology or sarcomatoid features.\n* Received more than 1 line of systemic therapy in the locally advanced or metastatic setting.\n* Active\u002Fsymptomatic central nervous system (CNS) metastases. Previously treated brain metastases may be included provided they are radiologically stable.\n* Evidence of active interstitial lung disease (ILD)\u002Fpneumonitis or history of ILD or pneumonitis that required steroids.\n* Have any clinically significant medical conditions or any other reason that the investigator determines would interfere with the participant's participation.","ALL","18 Years",{"count":1224,"type":1225},490,"ESTIMATED","INTERVENTIONAL",[1228,1229],"PHASE2","PHASE3","Non-small cell lung cancer (NSCLC) is a common type of lung cancer where abnormal cells in the lungs grow out of control. The purpose of this study is to assess adverse events and change in disease activity of telisotuzumab adizutecan as a monotherapy or in combination with osimertinib compared to standard of care (SOC).\n\nTelisotuzumab adizutecan is an investigational drug being developed for the treatment of NSCLC. This study will be divided into two stages, in the first stage (phase 2) participants will receive 1 of 2 doses of telisotuzumab adizutecan as a monotherapy or in combination with osimertinib. In the second stage (phase 3) participants will receive the recommended phase 3 dose (RP3D) of telisotuzumab adizutecan, from the previous stage, or SOC. Approximately 490 adult participants with NSCLC will be enrolled in the study in 200 sites around the world.\n\nIn phase 2, participants will receive 1 of 2 intravenous (IV) doses of telisotuzumab adizutecan as a monotherapy or in combination with oral osimertinib. In phase 3, participants will receive the IV RP3D of telisotuzumab adizutecan, or SOC. The study will run for a duration of approximately 69 months.\n\nThere may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at an approved institution (hospital or clinic). The effect of the treatment will be frequently checked by medical assessments, blood tests, questionnaires and side effects.",[1232,1233],"Non-Small Cell Lung Cancer","c-MET",[1232,80,1235,87,84,1236,1237],"ABBV-400","Cancer","AndroMETa-Lung-713","2026-10-01",{"date":1240,"type":1241},"2026-10-05","ACTUAL",{"date":1243,"type":1241},"2025-12-10",{"date":1245,"type":1225},"2030-09",{"name":5,"class":6},117]