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If in use, the participant must agree to use one single product consistently through Week 16.\n* Use of oral antibiotics is allowed during the study under the following conditions: the dose and regimen must remain stable until Week 16. Allowed oral antibiotics include doxycycline, minocycline, or tetracycline.\n* Female participants of childbearing potential must have a negative pregnancy test\n* Participants of reproductive potential must use a highly effective method of contraception\n\nExclusion Criteria:\n\n* \\> 20 draining tunnel count\n* Active skin disease (bacterial, fungal, viral infection) that, in the opinion of the Investigator, could interfere with assessment of HS or requires treatment with antibiotic(s) also used to treat HS.\n* Has had major surgery, including HS surgery, within 12 weeks prior to Day 1\n* History of alcohol or drug abuse within the past 2 years.\n* A positive urine drug screen at Screening\n* History or evidence of human immunodeficiency virus (HIV), hepatitis B or hepatitis C virus (HCV), or a positive test at Screening\n* History or current diagnosis of active or latent pulmonary or extrapulmonary TB infection or a positive test at Screening\n* History of moderate to severe heart failure or recent (within past 6 months) cerebrovascular accident, myocardial infarction, or coronary stenting.\n* Any history of malignancy (including lymphoma and leukemia) other than a successfully treated and considered cured non-metastatic cutaneous squamous cell carcinoma, basal cell carcinoma or localized carcinoma in situ\n* History of immune deficiency","ALL","18 Years","70 Years",{"count":407,"type":408},150,"ESTIMATED","INTERVENTIONAL",[411],"PHASE2","The main objective of this study is to determine if NAV-240 works more effectively than a dummy treatment (placebo) for participants with moderate-to-severe HS. 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