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0043","Metropolitan Borough of Wirral","North West","CH634JY",{"type":108,"coordinates":721},[722,723],-3.10501,53.37616,{"lat":723,"lon":722},[726],{"name":727,"role":94,"phone":11,"phoneExt":11,"email":11},"Site 0043",{"facility":729,"status":11,"city":730,"state":11,"zip":731,"country":705,"countryCode":706,"cosmosGeoPoint":732,"geoPoint":736,"contacts":737},"Local Institution - 0049","London","EC1A7BE",{"type":108,"coordinates":733},[734,735],-0.12574,51.50853,{"lat":735,"lon":734},[738],{"name":739,"role":94,"phone":11,"phoneExt":11,"email":11},"Site 0049",{"type":741,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR",[743],{"name":744,"class":6},"BioNTech SE","100659878","phase-2-a-study-to-assess-the-safety-and-tolerability-of-pumitamig-based-therapy-administered-before-surgery-in-participants-with-early-stage-non-small-cell-lung-cancer-rosetta-lung-220-100659878",false,"NCT07871214","A Study to Assess The Safety and Tolerability of Pumitamig-Based Therapy Administered Before Surgery in Participants With Early-Stage Non-Small Cell Lung Cancer (ROSETTA Lung-220)","ROSETTA Lung-220: A Phase 2, Open-Label, Multicenter, Multi-Arm Platform Study Evaluating Pumitamig and Other Novel Neoadjuvant Regimens in Participants With Resectable, Early-Stage (IIA to IIIB) Non-Small Cell Lung Cancer","Inclusion Criteria\n\n* Participants must have newly diagnosed, previously untreated participants with histologically confirmed non-small cell lung cancer (NSCLC) (squamous or non-squamous histology); resectable Stage IIA to IIIB (N2) disease (American Joint Committee on Cancer (AJCC) 9th edition).\n* Participants must have an Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1.\n* Participants must have an evaluable programmed death-ligand 1 (PD-L1) expression.\n\nExclusion Criteria\n\n* Participants must not have unresectable disease, N3 nodal involvement, or any evidence of distant metastatic disease (M1) at baseline assessment (suspected or confirmed).\n* Participants must not have active, known autoimmune disease.\n* Participants must not have significant cardiovascular impairment as evidenced by uncontrolled hypertension (despite optimal medical treatment), congestive heart failure, active coronary disease (within 6 months prior to randomization), ventricular arrhythmias or major thrombotic or embolic events.\n* Participants must not have advanced\u002Fclinically significant lung disease (within 6 months prior to randomization) or history of interstitial lung disease (ILD) or pneumonitis requiring treatment with systemic steroids (≥ Grade 2), or who have current or suspected ILD or pneumonitis.\n* Participants must not have significant risk of bleeding or history of major hemorrhagic events (including gastrointestinal (GI) hemorrhage or hemorrhagic stroke).\n* Participants must not have GI or non-GI fistula, GI perforation, or intra-abdominal abscess.\n* Participants must not have prior systemic anticancer therapy, radiotherapy, or investigational therapy for NSCLC or contraindication to curative-intent surgery or study-specified chemotherapy.\n* Other protocol-defined Inclusion\u002FExclusion criteria apply.","ALL","18 Years",{"count":755,"type":756},80,"ESTIMATED","INTERVENTIONAL",[759],"PHASE2","The purpose of this study is to assess the safety, tolerability, and surgical feasibility of preoperative Pumitamig-based therapy and other molecules in resectable, Early-Stage Non-Small Cell Lung Cancer",[762],"Early-Stage Non-Small Cell Lung Cancer",[764],"Participants with Stage IIA to IIIB considered surgical candidates","NOT_YET_RECRUITING","2026-10-07",{"date":768,"type":769},"2026-10-13","ACTUAL",{"date":771,"type":756},"2026-11-30",{"date":773,"type":756},"2028-03-15",{"name":5,"class":6},50]