[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100655260":3},{"organization":4,"outcomesModule":7,"designInfo":37,"detailedDescription":16,"studyPopulation":16,"armGroups":43,"interventions":59,"overallOfficials":16,"centralContacts":68,"locations":74,"responsibleParty":1155,"collaborators":1157,"id":1160,"slug":1161,"hasResults":1162,"nctId":1163,"briefTitle":1164,"officialTitle":1165,"acronym":16,"eligibilityCriteria":1166,"healthyVolunteers":1162,"sex":1167,"minAge":1168,"maxAge":16,"enrollmentInfo":1169,"targetDuration":16,"studyType":1172,"phases":1173,"briefSummary":1175,"conditions":1176,"keywords":1178,"overallStatus":907,"whyStopped":16,"lastUpdateSubmitDate":1184,"lastUpdatePostDateStruct":1185,"startDateStruct":1188,"completionDateStruct":1190,"leadSponsor":1192,"locationsCount":1193},{"fullName":5,"class":6},"Vividion Therapeutics, Inc.","INDUSTRY",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":16},[9],{"measure":10,"description":11,"timeFrame":12},"Landmark progression-free survival (PFS) rate at 6 months, as assessed by the investigator","Defined as the proportion of participants who are alive and free from disease progression as per RECIST v1.1","From start of study treatment until end of follow-up (up to approximately 36 months)",[14,18,21,24,26,28,30,32,35],{"measure":15,"description":16,"timeFrame":17},"Incidence and severity of Adverse Events (AEs) graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events, version 5.0 (NCI CTCAE v5.0)",null,"From start of study treatment up to 30 days following the last dose of study drug (100 days after last administration of pembrolizumab)",{"measure":19,"description":20,"timeFrame":12},"Recommended Phase 2 Dose (RP2D) of VVD-133214 in combination with pembrolizumab","The RP2D will be based on incidence, severity and frequency of adverse events, anti-tumor activity, PK\u002FPD, and assessment of disease biomarkers for two doses of VVD-133214 combined with the standard of care (SoC) dose of pembrolizumab",{"measure":22,"description":16,"timeFrame":23},"Maximum plasma concentration observed (Cmax) following single and multiple doses of VVD-133214","Predose and multiple timepoints post-dose, up to approximately 36 months",{"measure":25,"description":16,"timeFrame":23},"Time of maximum plasma concentration observed (Tmax) following single and multiple doses of VVD-133214",{"measure":27,"description":16,"timeFrame":23},"Area under the plasma concentration-time curve (AUC) following single and multiple doses of VVD-133214",{"measure":29,"description":16,"timeFrame":12},"Overall response rate (ORR) according to RECIST v1.1 as assessed by the Investigator",{"measure":31,"description":16,"timeFrame":12},"Disease control rate (DCR) according to RECIST v1.1 as assessed by the Investigator",{"measure":33,"description":16,"timeFrame":34},"Duration of response (DOR) according to RECIST v1.1 as assessed by the Investigator","From the time of first occurrence of a documented response until the time of documented disease progression or death from any cause, whichever occurs first (up to approximately 36 months)",{"measure":36,"description":16,"timeFrame":34},"Median progression-free survival (mPFS) according to RECIST v1.1 as assessed by the Investigator",{"allocation":38,"interventionModel":39,"interventionModelDescription":16,"primaryPurpose":40,"observationalModel":16,"timePerspective":16,"maskingInfo":41},"RANDOMIZED","SEQUENTIAL","TREATMENT",{"masking":42,"maskingDescription":16,"whoMasked":16},"NONE",[44,51,54],{"label":45,"type":46,"description":47,"interventionNames":48},"VVD-133214 Dose 1 + Pembrolizumab","EXPERIMENTAL","Participants will receive VVD-133214 in combination with pembrolizumab",[49,50],"Drug: VVD-133214","Drug: Pembrolizumab",{"label":52,"type":46,"description":47,"interventionNames":53},"VVD-133214 Dose 2 + Pembrolizumab",[49,50],{"label":55,"type":56,"description":57,"interventionNames":58},"Pembrolizumab","ACTIVE_COMPARATOR","Participants will receive pembrolizumab only (monotherapy)",[50],[60,65],{"type":61,"name":62,"description":63,"armGroupLabels":64,"otherNames":16},"DRUG","VVD-133214","VVD-133214 will be administered orally",[45,52],{"type":61,"name":55,"description":66,"armGroupLabels":67,"otherNames":16},"Pembrolizumab will be administered by intravenous infusion (IV) every three weeks",[55,45,52],[69],{"name":70,"role":71,"phone":72,"phoneExt":16,"email":73},"Bayer Clinical Trials Contact","CONTACT","18888422937","clinical-trials-contact@bayer.com",[75,89,99,108,118,124,127,130,140,150,160,164,176,186,196,205,214,226,236,246,255,265,274,282,288,300,310,320,330,340,350,360,370,380,390,400,406,418,427,436,445,457,467,477,487,497,507,517,529,535,545,551,555,564,575,583,591,602,610,619,628,637,649,659,669,679,688,694,705,715,724,733,739,745,756,767,776,782,791,800,809,818,827,836,845,854,865,874,880,886,895,905,912,918,924,930,938,944,950,954,966,975,984,993,1002,1008,1021,1033,1042,1046,1049,1058,1067,1073,1079,1089,1098,1107,1115,1124,1133,1145],{"facility":76,"status":77,"city":78,"state":79,"zip":80,"country":81,"countryCode":82,"cosmosGeoPoint":83,"geoPoint":88,"contacts":16},"University of Arizona Cancer Center - North Campus","NOT_YET_RECRUITING","Tucson","Arizona","85719","United States","US",{"type":84,"coordinates":85},"Point",[86,87],-110.92648,32.22174,{"lat":87,"lon":86},{"facility":90,"status":77,"city":91,"state":92,"zip":93,"country":81,"countryCode":82,"cosmosGeoPoint":94,"geoPoint":98,"contacts":16},"University of Michigan Rogel Cancer Center","Ann Arbor","Michigan","48109",{"type":84,"coordinates":95},[96,97],-83.74088,42.27756,{"lat":97,"lon":96},{"facility":100,"status":77,"city":101,"state":92,"zip":102,"country":81,"countryCode":82,"cosmosGeoPoint":103,"geoPoint":107,"contacts":16},"Brigette Harris Cancer Pavilion at Henry Ford Cancer Center - Detroit","Detroit","48202",{"type":84,"coordinates":104},[105,106],-83.04575,42.33143,{"lat":106,"lon":105},{"facility":109,"status":77,"city":110,"state":111,"zip":112,"country":81,"countryCode":82,"cosmosGeoPoint":113,"geoPoint":117,"contacts":16},"Mary Babb Randolph Cancer Center","Morgantown","West Virginia","26505",{"type":84,"coordinates":114},[115,116],-79.9559,39.62953,{"lat":116,"lon":115},{"facility":119,"status":77,"city":120,"state":120,"zip":121,"country":122,"countryCode":123,"cosmosGeoPoint":16,"geoPoint":16,"contacts":16},"Hospital Italiano de Buenos Aires","Buenos Aires","C1199ABB","Argentina","AR",{"facility":125,"status":77,"city":120,"state":120,"zip":126,"country":122,"countryCode":123,"cosmosGeoPoint":16,"geoPoint":16,"contacts":16},"Centro Medico Fleischer","C1414",{"facility":128,"status":77,"city":120,"state":120,"zip":129,"country":122,"countryCode":123,"cosmosGeoPoint":16,"geoPoint":16,"contacts":16},"Instituto Alexander Fleming","C1426ANZ",{"facility":131,"status":77,"city":132,"state":133,"zip":134,"country":122,"countryCode":123,"cosmosGeoPoint":135,"geoPoint":139,"contacts":16},"Sanatorio Allende | Departamento de Investigación Clínica","Córdoba","Córdoba Province","X5000JHQ",{"type":84,"coordinates":136},[137,138],-64.18853,-31.40648,{"lat":138,"lon":137},{"facility":141,"status":77,"city":142,"state":143,"zip":144,"country":122,"countryCode":123,"cosmosGeoPoint":145,"geoPoint":149,"contacts":16},"Fundación Intecnus","Bariloche","Río Negro Province","RP82 8400",{"type":84,"coordinates":146},[147,148],-71.30822,-41.14557,{"lat":148,"lon":147},{"facility":151,"status":77,"city":152,"state":153,"zip":154,"country":122,"countryCode":123,"cosmosGeoPoint":155,"geoPoint":159,"contacts":16},"Sanatorio Parque - Oncology","Rosario","Santa Fe Province","S2000GAP",{"type":84,"coordinates":156},[157,158],-60.63932,-32.94682,{"lat":158,"lon":157},{"facility":161,"status":77,"city":162,"state":16,"zip":163,"country":122,"countryCode":123,"cosmosGeoPoint":16,"geoPoint":16,"contacts":16},"Investigaciones Oncológicas C Colón","Mar Del Plata, Buenos Aires,","7600",{"facility":165,"status":77,"city":166,"state":167,"zip":168,"country":169,"countryCode":170,"cosmosGeoPoint":171,"geoPoint":175,"contacts":16},"Institut Jules Bordet - Clinique D'Oncology","Brussels","Brussels Capital","1070","Belgium","BE",{"type":84,"coordinates":172},[173,174],4.34878,50.85045,{"lat":174,"lon":173},{"facility":177,"status":77,"city":178,"state":179,"zip":180,"country":169,"countryCode":170,"cosmosGeoPoint":181,"geoPoint":185,"contacts":16},"UZ Leuven - Digestive oncology","Leuven","Flemish Brabant","3000",{"type":84,"coordinates":182},[183,184],4.70093,50.87959,{"lat":184,"lon":183},{"facility":187,"status":77,"city":188,"state":189,"zip":190,"country":169,"countryCode":170,"cosmosGeoPoint":191,"geoPoint":195,"contacts":16},"CHU Helora - Hopital de La Louvière - Site Jolimont - Oncology department","La Louvière","Hainaut","7100",{"type":84,"coordinates":192},[193,194],4.18785,50.48657,{"lat":194,"lon":193},{"facility":197,"status":77,"city":198,"state":16,"zip":199,"country":169,"countryCode":170,"cosmosGeoPoint":200,"geoPoint":204,"contacts":16},"UZ Gent - Digestive Oncology","Ghent","9000",{"type":84,"coordinates":201},[202,203],3.71667,51.05,{"lat":203,"lon":202},{"facility":206,"status":77,"city":207,"state":16,"zip":208,"country":169,"countryCode":170,"cosmosGeoPoint":209,"geoPoint":213,"contacts":16},"AZ Delta - Digestive oncology","Roeselare","8800",{"type":84,"coordinates":210},[211,212],3.12269,50.94653,{"lat":212,"lon":211},{"facility":215,"status":77,"city":216,"state":217,"zip":218,"country":219,"countryCode":220,"cosmosGeoPoint":221,"geoPoint":225,"contacts":16},"Hospital Evangélico de Cachoeiro de Itapemirim","Vitória","Espírito Santo","29047-660","Brazil","BR",{"type":84,"coordinates":222},[223,224],-40.33778,-20.31944,{"lat":224,"lon":223},{"facility":227,"status":77,"city":228,"state":229,"zip":230,"country":219,"countryCode":220,"cosmosGeoPoint":231,"geoPoint":235,"contacts":16},"Hospital Araujo Jorge Associaçao de Combate ao Cancer em Goias","Goiânia","Goiás","74605-070",{"type":84,"coordinates":232},[233,234],-49.25389,-16.67861,{"lat":234,"lon":233},{"facility":237,"status":77,"city":238,"state":239,"zip":240,"country":219,"countryCode":220,"cosmosGeoPoint":241,"geoPoint":245,"contacts":16},"Nucleo de Ensino e Pesquisa do Hospital de Clinicas de Ijuí","Ijuí","Rio Grande do Sul","98700-000",{"type":84,"coordinates":242},[243,244],-53.91472,-28.38778,{"lat":244,"lon":243},{"facility":247,"status":77,"city":248,"state":239,"zip":249,"country":219,"countryCode":220,"cosmosGeoPoint":250,"geoPoint":254,"contacts":16},"Unidade de Pesquisas Clinicas em Oncologia","Pelotas","96020-080",{"type":84,"coordinates":251},[252,253],-52.34101,-31.76997,{"lat":253,"lon":252},{"facility":256,"status":77,"city":257,"state":258,"zip":259,"country":219,"countryCode":220,"cosmosGeoPoint":260,"geoPoint":264,"contacts":16},"NAIC - Instituto do Cancer","Bauru","São Paulo","17033-490",{"type":84,"coordinates":261},[262,263],-49.06056,-22.31472,{"lat":263,"lon":262},{"facility":266,"status":77,"city":267,"state":258,"zip":268,"country":219,"countryCode":220,"cosmosGeoPoint":269,"geoPoint":273,"contacts":16},"Fundacao Pio XII - Hospital de Cancer de Barretos","Jaú","14784-400",{"type":84,"coordinates":270},[271,272],-48.55778,-22.29639,{"lat":272,"lon":271},{"facility":275,"status":77,"city":258,"state":258,"zip":276,"country":219,"countryCode":220,"cosmosGeoPoint":277,"geoPoint":281,"contacts":16},"Instituto do Cancer do Estado de Sao Paulo","01246-000",{"type":84,"coordinates":278},[279,280],-46.63611,-23.5475,{"lat":280,"lon":279},{"facility":283,"status":77,"city":258,"state":258,"zip":284,"country":219,"countryCode":220,"cosmosGeoPoint":285,"geoPoint":287,"contacts":16},"Hospital Sirio Libanes - Oncology_Sao Paulo","01308-050",{"type":84,"coordinates":286},[279,280],{"lat":280,"lon":279},{"facility":289,"status":77,"city":290,"state":291,"zip":292,"country":293,"countryCode":294,"cosmosGeoPoint":295,"geoPoint":299,"contacts":16},"The First Affiliated Hospital of Bengbu Medical College","Bengbu","Anhui","233004","China","CN",{"type":84,"coordinates":296},[297,298],117.36083,32.94083,{"lat":298,"lon":297},{"facility":301,"status":77,"city":302,"state":303,"zip":304,"country":293,"countryCode":294,"cosmosGeoPoint":305,"geoPoint":309,"contacts":16},"Beijing Cancer Hospital - Oncology Department","Beijing","Beijing Municipality","100142",{"type":84,"coordinates":306},[307,308],116.39723,39.9075,{"lat":308,"lon":307},{"facility":311,"status":77,"city":312,"state":313,"zip":314,"country":293,"countryCode":294,"cosmosGeoPoint":315,"geoPoint":319,"contacts":16},"Fujian Cancer Hospital","Fuzhou","Fujian","350014",{"type":84,"coordinates":316},[317,318],119.30611,26.06139,{"lat":318,"lon":317},{"facility":321,"status":77,"city":322,"state":323,"zip":324,"country":293,"countryCode":294,"cosmosGeoPoint":325,"geoPoint":329,"contacts":16},"The Sixth Affiliated Hospital, Sun Yat-sen University","Guangzhou","Guangdong","510655",{"type":84,"coordinates":326},[327,328],113.25,23.11667,{"lat":328,"lon":327},{"facility":331,"status":77,"city":332,"state":333,"zip":334,"country":293,"countryCode":294,"cosmosGeoPoint":335,"geoPoint":339,"contacts":16},"Harbin Medical University Cancer Hospital","Harbin","Heilongjiang","150000",{"type":84,"coordinates":336},[337,338],126.65,45.75,{"lat":338,"lon":337},{"facility":341,"status":77,"city":342,"state":343,"zip":344,"country":293,"countryCode":294,"cosmosGeoPoint":345,"geoPoint":349,"contacts":16},"Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology","Wuhan","Hubei","430030",{"type":84,"coordinates":346},[347,348],114.26667,30.58333,{"lat":348,"lon":347},{"facility":351,"status":77,"city":352,"state":353,"zip":354,"country":293,"countryCode":294,"cosmosGeoPoint":355,"geoPoint":359,"contacts":16},"Shandong University - Shandong Cancer Hospital","Jinan","Shandong","250117",{"type":84,"coordinates":356},[357,358],116.99722,36.66833,{"lat":358,"lon":357},{"facility":361,"status":77,"city":362,"state":363,"zip":364,"country":293,"countryCode":294,"cosmosGeoPoint":365,"geoPoint":369,"contacts":16},"Zhongshan Hospital, Fudan University","Shanghai","Shanghai Municipality","200032",{"type":84,"coordinates":366},[367,368],121.45806,31.22222,{"lat":368,"lon":367},{"facility":371,"status":77,"city":372,"state":373,"zip":374,"country":293,"countryCode":294,"cosmosGeoPoint":375,"geoPoint":379,"contacts":16},"West China Hospital Sichuan University","Chengdu","Sichuan","610041",{"type":84,"coordinates":376},[377,378],104.06667,30.66667,{"lat":378,"lon":377},{"facility":381,"status":77,"city":382,"state":383,"zip":384,"country":293,"countryCode":294,"cosmosGeoPoint":385,"geoPoint":389,"contacts":16},"Yunnan Cancer Hospital","Kunming","Yunnan","650118",{"type":84,"coordinates":386},[387,388],102.71833,25.03889,{"lat":388,"lon":387},{"facility":391,"status":77,"city":392,"state":393,"zip":394,"country":293,"countryCode":294,"cosmosGeoPoint":395,"geoPoint":399,"contacts":16},"Sir Run Run Shaw Hospital, Zhejiang Univ. School of Medicine - Oncology Department","Hangzhou","Zhejiang","310016",{"type":84,"coordinates":396},[397,398],120.16142,30.29365,{"lat":398,"lon":397},{"facility":401,"status":77,"city":392,"state":393,"zip":402,"country":293,"countryCode":294,"cosmosGeoPoint":403,"geoPoint":405,"contacts":16},"Zhejiang Cancer Hospital","310022",{"type":84,"coordinates":404},[397,398],{"lat":398,"lon":397},{"facility":407,"status":77,"city":408,"state":409,"zip":410,"country":411,"countryCode":412,"cosmosGeoPoint":413,"geoPoint":417,"contacts":16},"CHU Brest - Hopital La Cavale Blanche - service oncologie medicale","Brest","Brittany Region","29200","France","FR",{"type":84,"coordinates":414},[415,416],-4.48628,48.39029,{"lat":416,"lon":415},{"facility":419,"status":77,"city":420,"state":16,"zip":421,"country":411,"countryCode":412,"cosmosGeoPoint":422,"geoPoint":426,"contacts":16},"CHRU de Besancon - Hopital Jean Minjoz - Medical Oncology","Besançon","25030",{"type":84,"coordinates":423},[424,425],6.01815,47.24878,{"lat":425,"lon":424},{"facility":428,"status":77,"city":429,"state":16,"zip":430,"country":411,"countryCode":412,"cosmosGeoPoint":431,"geoPoint":435,"contacts":16},"Unicancer Dijon - Centre Georges Francois Leclerc - Oncologie medicale","Dijon","21000",{"type":84,"coordinates":432},[433,434],5.01391,47.31344,{"lat":434,"lon":433},{"facility":437,"status":77,"city":438,"state":16,"zip":439,"country":411,"countryCode":412,"cosmosGeoPoint":440,"geoPoint":444,"contacts":16},"Unicancer Marseille - Institut Paoli-Calmettes - Oncologie medicale","Marseille","13009",{"type":84,"coordinates":441},[442,443],5.38107,43.29695,{"lat":443,"lon":442},{"facility":446,"status":77,"city":447,"state":448,"zip":449,"country":450,"countryCode":451,"cosmosGeoPoint":452,"geoPoint":456,"contacts":16},"Universitätsklinikum Ulm - Klinik für Innere Medizin I","Ulm","Baden-Wurttemberg","89081","Germany","DE",{"type":84,"coordinates":453},[454,455],9.99155,48.39841,{"lat":455,"lon":454},{"facility":458,"status":77,"city":459,"state":460,"zip":461,"country":450,"countryCode":451,"cosmosGeoPoint":462,"geoPoint":466,"contacts":16},"Leopoldina-Krankenhaus der Stadt Schweinfurt GmbH-Medizinische Klinik 2","Schweinfurt","Bavaria","97422",{"type":84,"coordinates":463},[464,465],10.22175,50.04937,{"lat":465,"lon":464},{"facility":468,"status":77,"city":469,"state":470,"zip":471,"country":450,"countryCode":451,"cosmosGeoPoint":472,"geoPoint":476,"contacts":16},"Asklepios Klinik Altona - Onkologie, Hämatologie, Palliativmedizin, Rheumatologie und Pneumologie","Hamburg","Free and Hanseatic City of Hamburg","22763",{"type":84,"coordinates":473},[474,475],9.99302,53.55073,{"lat":475,"lon":474},{"facility":478,"status":77,"city":479,"state":480,"zip":481,"country":450,"countryCode":451,"cosmosGeoPoint":482,"geoPoint":486,"contacts":16},"Krankenhaus Nordwest GmbH - Institut Fuer Klinisch-Onkologische Forschung (IKF)","Frankfurt am Main","Hesse","60488",{"type":84,"coordinates":483},[484,485],8.68417,50.11552,{"lat":485,"lon":484},{"facility":488,"status":77,"city":489,"state":490,"zip":491,"country":450,"countryCode":451,"cosmosGeoPoint":492,"geoPoint":496,"contacts":16},"Klinikum Oldenburg - Klinik für Onkologie und Hämatologie","Oldenburg","Lower Saxony","26133",{"type":84,"coordinates":493},[494,495],8.21479,53.14039,{"lat":495,"lon":494},{"facility":498,"status":77,"city":499,"state":500,"zip":501,"country":450,"countryCode":451,"cosmosGeoPoint":502,"geoPoint":506,"contacts":16},"Universitaetsklinikum Essen - Innere Klinik (Tumorforschung)","Essen","North Rhine-Westphalia","45147",{"type":84,"coordinates":503},[504,505],7.01228,51.45657,{"lat":505,"lon":504},{"facility":508,"status":77,"city":509,"state":510,"zip":511,"country":450,"countryCode":451,"cosmosGeoPoint":512,"geoPoint":516,"contacts":16},"DRK Kliniken Berlin-Köpenick - Darmzentrum","Berlin","State of Berlin","12559",{"type":84,"coordinates":513},[514,515],13.41053,52.52437,{"lat":515,"lon":514},{"facility":518,"status":77,"city":519,"state":520,"zip":521,"country":522,"countryCode":523,"cosmosGeoPoint":524,"geoPoint":528,"contacts":16},"Saint Savvas Oncology Hospital -1st Internal Medicine - Oncology Department","Athens","Attica","115 22","Greece","GR",{"type":84,"coordinates":525},[526,527],23.72784,37.98376,{"lat":527,"lon":526},{"facility":530,"status":77,"city":519,"state":520,"zip":531,"country":522,"countryCode":523,"cosmosGeoPoint":532,"geoPoint":534,"contacts":16},"General Hospital Of Athens Alexandra-Plasma Cell Dyscrasias Unit, Department of Clinical Therapeutics, N.K.U.A","115 28",{"type":84,"coordinates":533},[526,527],{"lat":527,"lon":526},{"facility":536,"status":77,"city":537,"state":538,"zip":539,"country":522,"countryCode":523,"cosmosGeoPoint":540,"geoPoint":544,"contacts":16},"Athens Medical Center S.A.\u002F European Interbalkan Medical Center - 4th Department of Medical Oncology","Pylaia","Thessaloniki","570 01",{"type":84,"coordinates":541},[542,543],22.98613,40.59918,{"lat":543,"lon":542},{"facility":546,"status":77,"city":519,"state":16,"zip":547,"country":522,"countryCode":523,"cosmosGeoPoint":548,"geoPoint":550,"contacts":16},"Laiko General Hospital Of Athens- Oncology Department","11526",{"type":84,"coordinates":549},[526,527],{"lat":527,"lon":526},{"facility":552,"status":77,"city":553,"state":16,"zip":554,"country":522,"countryCode":523,"cosmosGeoPoint":16,"geoPoint":16,"contacts":16},"Metropolitan General Hospital -Oncologic Clinical Trials and Research Clinic","Cholargos\u002F Athens","155 62",{"facility":556,"status":77,"city":557,"state":16,"zip":558,"country":522,"countryCode":523,"cosmosGeoPoint":559,"geoPoint":563,"contacts":16},"General University Hospital Of Patras- Division of Oncology, Department of Medicine","Pátrai","265 04",{"type":84,"coordinates":560},[561,562],21.73508,38.2462,{"lat":562,"lon":561},{"facility":565,"status":77,"city":566,"state":567,"zip":568,"country":566,"countryCode":569,"cosmosGeoPoint":570,"geoPoint":574,"contacts":16},"Queen Mary Hospital","Hong Kong","Hong Kong SAR","00000","HK",{"type":84,"coordinates":571},[572,573],114.17469,22.27832,{"lat":573,"lon":572},{"facility":576,"status":77,"city":577,"state":577,"zip":568,"country":566,"countryCode":569,"cosmosGeoPoint":578,"geoPoint":582,"contacts":16},"Hong Kong United Oncology Centre","Kowloon",{"type":84,"coordinates":579},[580,581],114.18333,22.31667,{"lat":581,"lon":580},{"facility":584,"status":77,"city":585,"state":586,"zip":568,"country":566,"countryCode":569,"cosmosGeoPoint":587,"geoPoint":590,"contacts":16},"Prince of Wales Hospital","Shatin","New Territories",{"type":84,"coordinates":588},[580,589],22.38333,{"lat":589,"lon":580},{"facility":592,"status":77,"city":593,"state":593,"zip":594,"country":595,"countryCode":596,"cosmosGeoPoint":597,"geoPoint":601,"contacts":16},"ASST Grande Ospedale Metropolitano Niguarda - Oncologia Falck","Milan","20162","Italy","IT",{"type":84,"coordinates":598},[599,600],9.18951,45.46427,{"lat":600,"lon":599},{"facility":603,"status":77,"city":593,"state":16,"zip":604,"country":595,"countryCode":596,"cosmosGeoPoint":605,"geoPoint":609,"contacts":16},"Istituto Europeo di Oncologia s.r.l - Sviluppo di nuovi farmaci per Terapie Innovative","20141",{"type":84,"coordinates":606},[607,608],12.59836,42.78235,{"lat":608,"lon":607},{"facility":611,"status":77,"city":612,"state":16,"zip":613,"country":595,"countryCode":596,"cosmosGeoPoint":614,"geoPoint":618,"contacts":16},"A.O.U. Universita' Degli Studi Della Campania Luigi Vanvitelli - Oncoematologia","Naples","80131",{"type":84,"coordinates":615},[616,617],14.26811,40.85216,{"lat":617,"lon":616},{"facility":620,"status":77,"city":621,"state":16,"zip":622,"country":595,"countryCode":596,"cosmosGeoPoint":623,"geoPoint":627,"contacts":16},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOC Oncologia Medica","Roma","00168",{"type":84,"coordinates":624},[625,626],11.10642,44.99364,{"lat":626,"lon":625},{"facility":629,"status":77,"city":630,"state":16,"zip":631,"country":595,"countryCode":596,"cosmosGeoPoint":632,"geoPoint":636,"contacts":16},"Humanitas Mirasole S.p.A. - Oncologia Medica ed Ematologia","Rozzano","20089",{"type":84,"coordinates":633},[634,635],9.1559,45.38193,{"lat":635,"lon":634},{"facility":638,"status":77,"city":639,"state":640,"zip":641,"country":642,"countryCode":643,"cosmosGeoPoint":644,"geoPoint":648,"contacts":16},"Sunway Medical Centre Penang - Department of Clinical Oncology","Perai","Pulau Pinang","13700","Malaysia","MY",{"type":84,"coordinates":645},[646,647],100.38333,5.38333,{"lat":647,"lon":646},{"facility":650,"status":77,"city":651,"state":652,"zip":653,"country":642,"countryCode":643,"cosmosGeoPoint":654,"geoPoint":658,"contacts":16},"Hospital Wanita Dan Kanak Kanak Sabah - Oncology and Radiotherapy","Kota Kinabalu","Sabah","88996",{"type":84,"coordinates":655},[656,657],116.0724,5.9749,{"lat":657,"lon":656},{"facility":660,"status":77,"city":661,"state":662,"zip":663,"country":642,"countryCode":643,"cosmosGeoPoint":664,"geoPoint":668,"contacts":16},"Hospital Umum Sarawak (Sarawak General Hospital) SGH","Kuching","Sarawak","93586",{"type":84,"coordinates":665},[666,667],110.33333,1.55,{"lat":667,"lon":666},{"facility":670,"status":77,"city":671,"state":672,"zip":673,"country":642,"countryCode":643,"cosmosGeoPoint":674,"geoPoint":678,"contacts":16},"Sunway Medical Centre - Medical Oncology","Subang Jaya","Selangor","47500",{"type":84,"coordinates":675},[676,677],101.58062,3.04384,{"lat":677,"lon":676},{"facility":680,"status":77,"city":681,"state":16,"zip":682,"country":642,"countryCode":643,"cosmosGeoPoint":683,"geoPoint":687,"contacts":16},"Universiti Malaya Medical Centre - Clinical Oncology Department","Kuala Lumpur","59100",{"type":84,"coordinates":684},[685,686],101.68653,3.1412,{"lat":686,"lon":685},{"facility":689,"status":77,"city":681,"state":16,"zip":690,"country":642,"countryCode":643,"cosmosGeoPoint":691,"geoPoint":693,"contacts":16},"Cengild G.I. Medical Centre - Curie Oncology KL","59200",{"type":84,"coordinates":692},[685,686],{"lat":686,"lon":685},{"facility":695,"status":77,"city":696,"state":696,"zip":697,"country":698,"countryCode":699,"cosmosGeoPoint":700,"geoPoint":704,"contacts":16},"Instituto Nacional de Cancerología","Mexico City","14080","Mexico","MX",{"type":84,"coordinates":701},[702,703],-99.12766,19.42847,{"lat":703,"lon":702},{"facility":706,"status":77,"city":707,"state":708,"zip":709,"country":698,"countryCode":699,"cosmosGeoPoint":710,"geoPoint":714,"contacts":16},"Hospital Zambrano Hellion","Monterrey","Nuevo León","66278",{"type":84,"coordinates":711},[712,713],-100.31721,25.68435,{"lat":713,"lon":712},{"facility":716,"status":77,"city":717,"state":16,"zip":718,"country":698,"countryCode":699,"cosmosGeoPoint":719,"geoPoint":723,"contacts":16},"Grupo Medico ASSET S.C","Benito Juárez","03100",{"type":84,"coordinates":720},[721,722],-99.1564,19.3727,{"lat":722,"lon":721},{"facility":725,"status":77,"city":726,"state":16,"zip":727,"country":698,"countryCode":699,"cosmosGeoPoint":728,"geoPoint":732,"contacts":16},"Renati Innovation SAPI de CV","Guadalajara","44680",{"type":84,"coordinates":729},[730,731],-103.34749,20.67738,{"lat":731,"lon":730},{"facility":734,"status":77,"city":696,"state":16,"zip":735,"country":698,"countryCode":699,"cosmosGeoPoint":736,"geoPoint":738,"contacts":16},"Oncare Viaducto Nápoles","3810",{"type":84,"coordinates":737},[702,703],{"lat":703,"lon":702},{"facility":740,"status":77,"city":707,"state":16,"zip":741,"country":698,"countryCode":699,"cosmosGeoPoint":742,"geoPoint":744,"contacts":16},"Hospital Universitrio Dr. José Eleuterio González. Servicio de Oncologia","64460",{"type":84,"coordinates":743},[712,713],{"lat":713,"lon":712},{"facility":746,"status":77,"city":747,"state":16,"zip":748,"country":749,"countryCode":750,"cosmosGeoPoint":751,"geoPoint":755,"contacts":16},"HagaZiekenhuis - Oncologie Interne Geneeskunde","The Hague","2545 AA","Netherlands","NL",{"type":84,"coordinates":752},[753,754],4.29861,52.07667,{"lat":754,"lon":753},{"facility":757,"status":77,"city":758,"state":16,"zip":759,"country":760,"countryCode":761,"cosmosGeoPoint":762,"geoPoint":766,"contacts":16},"Białostockie Centrum Onkologii im. M. Skłodowskiej-Curie w Białymstoku Oddział Onkologii Klinicznej","Bialystok","15-027","Poland","PL",{"type":84,"coordinates":763},[764,765],23.16433,53.13333,{"lat":765,"lon":764},{"facility":768,"status":77,"city":769,"state":16,"zip":770,"country":760,"countryCode":761,"cosmosGeoPoint":771,"geoPoint":775,"contacts":16},"Pratia McM Kraków","Krakow","30-727",{"type":84,"coordinates":772},[773,774],19.93658,50.06143,{"lat":774,"lon":773},{"facility":777,"status":77,"city":769,"state":16,"zip":778,"country":760,"countryCode":761,"cosmosGeoPoint":779,"geoPoint":781,"contacts":16},"Comarch Healthcare SA Centrum Medyczne iMed24","31-864",{"type":84,"coordinates":780},[773,774],{"lat":774,"lon":773},{"facility":783,"status":77,"city":784,"state":16,"zip":785,"country":760,"countryCode":761,"cosmosGeoPoint":786,"geoPoint":790,"contacts":16},"Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Łodzi","Lodz","93-513",{"type":84,"coordinates":787},[788,789],19.47395,51.77058,{"lat":789,"lon":788},{"facility":792,"status":77,"city":793,"state":16,"zip":794,"country":760,"countryCode":761,"cosmosGeoPoint":795,"geoPoint":799,"contacts":16},"Opolskie Centrum Onkologii","Opole","45-061",{"type":84,"coordinates":796},[797,798],17.92604,50.67119,{"lat":798,"lon":797},{"facility":801,"status":77,"city":802,"state":16,"zip":803,"country":760,"countryCode":761,"cosmosGeoPoint":804,"geoPoint":808,"contacts":16},"Europejskie Centrum Zdrowia Otwock, Szpital im. F. Chopina","Otwock","05-400",{"type":84,"coordinates":805},[806,807],21.26129,52.10577,{"lat":807,"lon":806},{"facility":810,"status":77,"city":811,"state":16,"zip":812,"country":760,"countryCode":761,"cosmosGeoPoint":813,"geoPoint":817,"contacts":16},"Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu Oddział Onkologiczny z Pododdziałem Dziennej Chemioterapii","Przemyśl","37-700",{"type":84,"coordinates":814},[815,816],22.76728,49.78498,{"lat":816,"lon":815},{"facility":819,"status":77,"city":820,"state":16,"zip":821,"country":760,"countryCode":761,"cosmosGeoPoint":822,"geoPoint":826,"contacts":16},"Mazowiecki Szpital Wojewódzki Siedleckie Centrum Onkologii Oddział Onkologii Klinicznej i Radioterapii","Siedlce","08-110",{"type":84,"coordinates":823},[824,825],22.29006,52.16772,{"lat":825,"lon":824},{"facility":828,"status":77,"city":829,"state":16,"zip":830,"country":760,"countryCode":761,"cosmosGeoPoint":831,"geoPoint":835,"contacts":16},"Centrum Medyczne Pratia Poznan","Skorzewo","60-185",{"type":84,"coordinates":832},[833,834],17.97006,54.16909,{"lat":834,"lon":833},{"facility":837,"status":77,"city":838,"state":16,"zip":839,"country":760,"countryCode":761,"cosmosGeoPoint":840,"geoPoint":844,"contacts":16},"Narodowy Instytut Onkologii im. Marii Skłodowskiej Curie Państwowy Instytut Badawczy- Oddział Warszawa Wawelska","Warsaw","02-034",{"type":84,"coordinates":841},[842,843],21.01178,52.22977,{"lat":843,"lon":842},{"facility":846,"status":77,"city":847,"state":16,"zip":848,"country":760,"countryCode":761,"cosmosGeoPoint":849,"geoPoint":853,"contacts":16},"Pratia Wroclaw","Wroclaw","50-417",{"type":84,"coordinates":850},[851,852],17.03006,51.10286,{"lat":852,"lon":851},{"facility":855,"status":77,"city":856,"state":16,"zip":857,"country":858,"countryCode":859,"cosmosGeoPoint":860,"geoPoint":864,"contacts":16},"Unidade Local de Saúde de Coimbra, E.P.E. - Hospitais da Universidade de Coimbra - Serviço de Oncologia","Coimbra","3004-561","Portugal","PT",{"type":84,"coordinates":861},[862,863],-8.41996,40.20686,{"lat":863,"lon":862},{"facility":866,"status":77,"city":867,"state":16,"zip":868,"country":858,"countryCode":859,"cosmosGeoPoint":869,"geoPoint":873,"contacts":16},"Instituto Português de Oncologia de Lisboa Francisco Gentil, E.P.E. - Serviço de Oncologia Médica","Lisbon","1099-023",{"type":84,"coordinates":870},[871,872],-9.1498,38.72509,{"lat":872,"lon":871},{"facility":875,"status":77,"city":867,"state":16,"zip":876,"country":858,"countryCode":859,"cosmosGeoPoint":877,"geoPoint":879,"contacts":16},"Unidade Local de Saúde de São José, E.P.E - Hospital de Santo António dos Capuchos - Serviço de Oncologia Médica","1169-050",{"type":84,"coordinates":878},[871,872],{"lat":872,"lon":871},{"facility":881,"status":77,"city":867,"state":16,"zip":882,"country":858,"countryCode":859,"cosmosGeoPoint":883,"geoPoint":885,"contacts":16},"START Research Portugal - ULSS Maria - Unidade de Ensaios de Fase I Start Lisbon","1649-035",{"type":84,"coordinates":884},[871,872],{"lat":872,"lon":871},{"facility":887,"status":77,"city":888,"state":16,"zip":889,"country":858,"countryCode":859,"cosmosGeoPoint":890,"geoPoint":894,"contacts":16},"Instituto Português de Oncologia do Porto Francisco Gentil, E.P.E. - Serviço de Oncologia Médica","Porto","4200-072",{"type":84,"coordinates":891},[892,893],-8.61097,41.1485,{"lat":893,"lon":892},{"facility":896,"status":77,"city":897,"state":16,"zip":898,"country":897,"countryCode":899,"cosmosGeoPoint":900,"geoPoint":904,"contacts":16},"National University Cancer Institute (NCIS)","Singapore","119074","SG",{"type":84,"coordinates":901},[902,903],103.85007,1.28967,{"lat":903,"lon":902},{"facility":906,"status":907,"city":897,"state":16,"zip":908,"country":897,"countryCode":899,"cosmosGeoPoint":909,"geoPoint":911,"contacts":16},"National Cancer Center Singapore - Oncology Department","RECRUITING","168583",{"type":84,"coordinates":910},[902,903],{"lat":903,"lon":902},{"facility":913,"status":77,"city":897,"state":16,"zip":914,"country":897,"countryCode":899,"cosmosGeoPoint":915,"geoPoint":917,"contacts":16},"OncoCare Cancer Centre | Gleneagles Medical Centre","258499",{"type":84,"coordinates":916},[902,903],{"lat":903,"lon":902},{"facility":919,"status":77,"city":897,"state":16,"zip":920,"country":897,"countryCode":899,"cosmosGeoPoint":921,"geoPoint":923,"contacts":16},"Curie Oncology | Farrer","329563",{"type":84,"coordinates":922},[902,903],{"lat":903,"lon":902},{"facility":925,"status":77,"city":926,"state":927,"zip":928,"country":929,"countryCode":16,"cosmosGeoPoint":16,"geoPoint":16,"contacts":16},"Seoul National University Hospital | Oncology","Jongno -Gu","Seoul","03080","South Korea",{"facility":931,"status":77,"city":927,"state":927,"zip":932,"country":929,"countryCode":16,"cosmosGeoPoint":933,"geoPoint":937,"contacts":16},"Severance Hospital | Oncology","03722",{"type":84,"coordinates":934},[935,936],126.9784,37.566,{"lat":936,"lon":935},{"facility":939,"status":77,"city":927,"state":927,"zip":940,"country":929,"countryCode":16,"cosmosGeoPoint":941,"geoPoint":943,"contacts":16},"Asan Medical Center | Oncology","05505",{"type":84,"coordinates":942},[935,936],{"lat":936,"lon":935},{"facility":945,"status":77,"city":927,"state":927,"zip":946,"country":929,"countryCode":16,"cosmosGeoPoint":947,"geoPoint":949,"contacts":16},"Samsung Medical Center | Oncology","06351",{"type":84,"coordinates":948},[935,936],{"lat":936,"lon":935},{"facility":951,"status":77,"city":952,"state":16,"zip":953,"country":929,"countryCode":16,"cosmosGeoPoint":16,"geoPoint":16,"contacts":16},"Seoul National University Bundang Hospital | Oncology","Seongnam-si, Gyeonggi-do","13620",{"facility":955,"status":77,"city":956,"state":957,"zip":958,"country":959,"countryCode":960,"cosmosGeoPoint":961,"geoPoint":965,"contacts":16},"Complexo Hospitalario Universitario De Santiago | Oncologia","Santiago de Compostela","A Coruña","15706","Spain","ES",{"type":84,"coordinates":962},[963,964],-8.54569,42.88052,{"lat":964,"lon":963},{"facility":967,"status":77,"city":968,"state":968,"zip":969,"country":959,"countryCode":960,"cosmosGeoPoint":970,"geoPoint":974,"contacts":16},"Hospital Universitari Vall D Hebron | Oncologia","Barcelona","08035",{"type":84,"coordinates":971},[972,973],2.15899,41.38879,{"lat":973,"lon":972},{"facility":976,"status":77,"city":977,"state":977,"zip":978,"country":959,"countryCode":960,"cosmosGeoPoint":979,"geoPoint":983,"contacts":16},"Hospital Universitario Ramon Y Cajal | Oncologia Medica","Madrid","28034",{"type":84,"coordinates":980},[981,982],-3.70256,40.4165,{"lat":982,"lon":981},{"facility":985,"status":77,"city":986,"state":986,"zip":987,"country":959,"countryCode":960,"cosmosGeoPoint":988,"geoPoint":992,"contacts":16},"Hospital Universitario Virgen De La Victoria | Oncologia Medica","Málaga","20910",{"type":84,"coordinates":989},[990,991],-4.42034,36.72016,{"lat":991,"lon":990},{"facility":994,"status":77,"city":995,"state":995,"zip":996,"country":959,"countryCode":960,"cosmosGeoPoint":997,"geoPoint":1001,"contacts":16},"Hospital Clinico Universitario De Valencia | Oncologia","Valencia","46010",{"type":84,"coordinates":998},[999,1000],-0.37966,39.47391,{"lat":1000,"lon":999},{"facility":1003,"status":77,"city":968,"state":16,"zip":1004,"country":959,"countryCode":960,"cosmosGeoPoint":1005,"geoPoint":1007,"contacts":16},"Hospital del Mar | Oncologia","08003",{"type":84,"coordinates":1006},[972,973],{"lat":973,"lon":972},{"facility":1009,"status":1010,"city":1011,"state":1012,"zip":1013,"country":1014,"countryCode":1015,"cosmosGeoPoint":1016,"geoPoint":1020,"contacts":16},"UniversitätsSpital Zürich (USZ) - Klinik für Medizinische Onkologie und Hämatologie","WITHDRAWN","Zurich","Canton of Zurich","8091","Switzerland","CH",{"type":84,"coordinates":1017},[1018,1019],8.55,47.36667,{"lat":1019,"lon":1018},{"facility":1022,"status":77,"city":1023,"state":1024,"zip":1025,"country":1026,"countryCode":1027,"cosmosGeoPoint":1028,"geoPoint":1032,"contacts":16},"Chang Gung Memorial Hospital Kaohsiung","Kaohsiung City","Kaohsiung","803","Taiwan","TW",{"type":84,"coordinates":1029},[1030,1031],120.31333,22.61626,{"lat":1031,"lon":1030},{"facility":1034,"status":77,"city":1035,"state":1035,"zip":1036,"country":1026,"countryCode":1027,"cosmosGeoPoint":1037,"geoPoint":1041,"contacts":16},"National Cheng Kung University Hospital","Tainan","704",{"type":84,"coordinates":1038},[1039,1040],120.21333,22.99083,{"lat":1040,"lon":1039},{"facility":1043,"status":77,"city":1044,"state":1044,"zip":1045,"country":1026,"countryCode":1027,"cosmosGeoPoint":16,"geoPoint":16,"contacts":16},"Chang Gung Memorial Hospital at Linkou","Taipei","10507",{"facility":1047,"status":77,"city":1044,"state":1044,"zip":1048,"country":1026,"countryCode":1027,"cosmosGeoPoint":16,"geoPoint":16,"contacts":16},"Taipei Veterans General Hospital","11217",{"facility":1050,"status":77,"city":1051,"state":16,"zip":1052,"country":1026,"countryCode":1027,"cosmosGeoPoint":1053,"geoPoint":1057,"contacts":16},"Keelung Chang Gung Memorial Hospital - Division of Hematology and Oncology","Keelung","204201",{"type":84,"coordinates":1054},[1055,1056],121.74094,25.13089,{"lat":1056,"lon":1055},{"facility":1059,"status":77,"city":1060,"state":16,"zip":1061,"country":1026,"countryCode":1027,"cosmosGeoPoint":1062,"geoPoint":1066,"contacts":16},"Taichung Veterans General Hospital | Division of Colorectal Surgery","Taichung","407219",{"type":84,"coordinates":1063},[1064,1065],120.6839,24.1469,{"lat":1065,"lon":1064},{"facility":1068,"status":77,"city":1035,"state":16,"zip":1069,"country":1026,"countryCode":1027,"cosmosGeoPoint":1070,"geoPoint":1072,"contacts":16},"Chi Mei Medical Center, Yongkang Branch","71004",{"type":84,"coordinates":1071},[1039,1040],{"lat":1040,"lon":1039},{"facility":1074,"status":77,"city":1075,"state":1076,"zip":1077,"country":1078,"countryCode":16,"cosmosGeoPoint":16,"geoPoint":16,"contacts":16},"Ankara Bilkent Sehir Hastanesi","Bilkent Çankaya","Ankara","6800","Turkey (Türkiye)",{"facility":1080,"status":77,"city":1081,"state":1082,"zip":1083,"country":1078,"countryCode":16,"cosmosGeoPoint":1084,"geoPoint":1088,"contacts":16},"İstanbul Medeniyet Üniversitesi Göztepe Süleyman Yalçın Şehir Hastanesi","Kadıköy","Istanbul","34722",{"type":84,"coordinates":1085},[1086,1087],28.36417,41.13658,{"lat":1087,"lon":1086},{"facility":1090,"status":77,"city":1091,"state":16,"zip":1092,"country":1078,"countryCode":16,"cosmosGeoPoint":1093,"geoPoint":1097,"contacts":16},"Trakya Univ. Tip Fak.","Edirne","22030",{"type":84,"coordinates":1094},[1095,1096],26.55597,41.67719,{"lat":1096,"lon":1095},{"facility":1099,"status":77,"city":1100,"state":16,"zip":1101,"country":1078,"countryCode":16,"cosmosGeoPoint":1102,"geoPoint":1106,"contacts":16},"Gaziantep Sehir Hastanesi -Medical Oncology Department","Gaziantep","27470",{"type":84,"coordinates":1103},[1104,1105],37.3825,37.05944,{"lat":1105,"lon":1104},{"facility":1108,"status":77,"city":1082,"state":16,"zip":1109,"country":1078,"countryCode":16,"cosmosGeoPoint":1110,"geoPoint":1114,"contacts":16},"Kartal Dr Lutfi Kirdar Sehir Hastanesi- Medical Oncology","34865",{"type":84,"coordinates":1111},[1112,1113],28.94966,41.01384,{"lat":1113,"lon":1112},{"facility":1116,"status":77,"city":1117,"state":16,"zip":1118,"country":1078,"countryCode":16,"cosmosGeoPoint":1119,"geoPoint":1123,"contacts":16},"VM Medical Park Samsun Hospital Medical Oncology Department","Samsun","55200",{"type":84,"coordinates":1120},[1121,1122],36.3361,41.27976,{"lat":1122,"lon":1121},{"facility":1125,"status":77,"city":1126,"state":16,"zip":1127,"country":1078,"countryCode":16,"cosmosGeoPoint":1128,"geoPoint":1132,"contacts":16},"Ankara Etlik Sehir Hastanesi","Yenimahalle","6170",{"type":84,"coordinates":1129},[1130,1131],27.4238,40.22627,{"lat":1131,"lon":1130},{"facility":1134,"status":77,"city":1135,"state":1136,"zip":1137,"country":1138,"countryCode":1139,"cosmosGeoPoint":1140,"geoPoint":1144,"contacts":16},"University College Hospital | Cancer Clinical Trials Unit","London","Greater London","NW1 2PG","United Kingdom","UK",{"type":84,"coordinates":1141},[1142,1143],-0.12574,51.50853,{"lat":1143,"lon":1142},{"facility":1146,"status":77,"city":1147,"state":1148,"zip":1149,"country":1138,"countryCode":1139,"cosmosGeoPoint":1150,"geoPoint":1154,"contacts":16},"University Hospital Coventry | Oncology","Coventry","West Midlands","CV22DX",{"type":84,"coordinates":1151},[1152,1153],-1.51217,52.40656,{"lat":1153,"lon":1152},{"type":1156,"investigatorFullName":16,"investigatorTitle":16,"investigatorAffiliation":16,"oldNameTitle":16,"oldOrganization":16},"SPONSOR",[1158],{"name":1159,"class":6},"Bayer","100655260","phase-2-a-study-to-evaluate-the-efficacy-of-vvd-133214-in-combination-with-pembrolizumab-compared-with-pembrolizumab-alone-in-participants-with-advanced-cancer-of-the-colon-or-rectum-100655260",false,"NCT07811193","A Study to Evaluate the Efficacy of VVD-133214 in Combination With Pembrolizumab Compared With Pembrolizumab Alone in Participants With Advanced Cancer of the Colon or Rectum","A Phase 2, Randomized, Open-label Study of VVD-133214 in COmbination With Pembrolizumab Compared to Pembrolizumab Monotherapy in Participants With Advanced Colorectal Adenocarcinoma (CRC) Harboring Microsatellite Instability (MSI) and\u002For Deficient Mismatch Repair (DMMR)","Inclusion Criteria:\n\n* Eastern Cooperative Oncology Group (ECOG) performance-status score of 0 or 1\n* Have a known microsatellite instability (MSI) and\u002For deficient mismatch repair (dMMR) tumor status confirmed per local standard of care (SoC), and have histologically or cytologically documented advanced (unresectable and\u002For metastatic) colorectal adenocarcinoma (CRC)\n* No prior systemic treatment for metastatic disease and not amenable to curative resection\n* Participants must have documented MSI and\u002For dMMR tumor status determined as part of the routine diagnostic workup in a certified laboratory\n* Availability of formaldehyde-fixed paraffin-embedded (FFPE) archival tumor tissue for submission to Sponsor\u002Fcentral laboratory for retrospective central testing including a copy of a redacted pathology report if available\n* Presence of measurable disease according to RECIST v1.1\n* Adequate hematologic and end-organ function, defined using laboratory results obtained within 14 days prior to first dose of study treatment\n* Females of childbearing potential must have negative serum pregnancy test before starting study treatment\n\nExclusion Criteria:\n\n* Prior systemic treatment for advanced CRC. Participants may have received prior adjuvant chemotherapy as long as disease progression occurred at least 12 months after the last dose of adjuvant treatment\n* Prior treatment with adjuvant immunotherapy (e.g., anti-PD-1, anti-PD-L1, anti-PD-L2 agent, or anti-CTLA-4 agent, or any other antibody or drug specifically targeting T cell co-stimulation or immune checkpoint pathways, including prior therapy with anti-tumor vaccines or other immuno-stimulatory antitumor agents, etc.)\n* Known active or uncontrolled central nervous system (CNS) or brain metastases (progressing or requiring anticonvulsants or corticosteroids for symptomatic control) and\u002For carcinomatous meningitis\n* Patients with active or history of autoimmune disease or immune deficiency that has required treatment in past 2 years\n* History of malignancy other than CRC, within 5 years prior to screening. Participants with Lynch syndrome are not excluded.\n* Participants requiring treatment with systemic immunosuppressive medication (such as corticosteroids) within 2 weeks prior to initiation of study treatment, or anticipation of need for systemic immunosuppressive medication during study treatment\n* Participants with active hepatitis B, hepatitis C or HIV\n* Participants with known Werner Syndrome (WRN)\n* Prior treatment with any WRN helicase inhibitor","ALL","18 Years",{"count":1170,"type":1171},140,"ESTIMATED","INTERVENTIONAL",[1174],"PHASE2","Researchers are looking for a better way to treat people with advanced colorectal cancer.\n\nColorectal cancer (cancer of the colon or rectum) is one of the most common cancers worldwide. Treatments include surgery, chemotherapy, radiotherapy, and immunotherapy; however, these treatments do not work for everyone, may cause serious adverse events or may stop working eventually. New treatments and treatment combinations are needed, especially for cancers that cannot be removed with surgery or that have spread to other parts of the body (called advanced or metastatic cancer).\n\nCells normally repair themselves when mistakes happen as they divide. But in some people with cancer, the repair system does not work properly because of a problem called dMMR (deficient mismatch repair). As a result, mistakes build up in the cell's DNA, leading to a condition called MSI (microsatellite instability). Over time, these changes can cause cells to grow and behave abnormally, contributing to the development and growth of cancer.\n\nTo survive, some cancer cells with dMMR or MSI rely on a protein called Werner helicase. This protein helps repair some of the DNA damage allowing them to keep growing. Because these cancer cells depend more on Werner helicase than healthy cells, blocking this protein may help stop cancer cells from surviving while having less effect on healthy cells.\n\nThe study drug, VVD-133214, is designed to block the Werner helicase protein. Blocking this protein may help stop cancer cells from growing, while causing less harm to healthy cells. VVD-133214 is being studied in combination with pembrolizumab, an approved immunotherapy that helps the immune system recognize and attack cancer cells.\n\nThis study will test the combination of VVD-133214 and pembrolizumab in people with advanced colorectal cancer with MSI and\u002For dMMR who have not yet received treatment for their advanced disease. The study aims to find the best dose of VVD-133214 in combination with pembrolizumab and to test whether the combination is more effective than pembrolizumab alone.\n\nParticipants will receive treatment with VVD-133214 for as long as it can help them and does not cause serious adverse events. Treatment with pembrolizumab will stop after two years. Participants can also stop treatment at any time.\n\nDuring the study, participants will have regular visits with the study doctor for tests, scans, and check-ups. These visits help check how well the cancer is responding to the treatment and monitor the participants' health.\n\nThe study will also monitor adverse events, which are any new or worsening medical problems that can happen during the study. Doctors record all adverse events, irrespective of whether the study doctor believes they are related to the study treatments, to help ensure participants' safety throughout the study.\n\nAfter stopping treatment, participants will return for follow-up visits: 30 days after their last dose of VVD-133214 and\u002For 100 days after their last dose of pembrolizumab. After that, participants will have long-term follow-up visits every 90 days for as long as they agree to continue participating in follow-up.",[1177],"Colorectal Adenocarcinoma",[1179,1180,55,1181,1182,1183],"dMMR","MSI CRC","Werner helicase","First line","Lynch Syndrome","2026-09-15",{"date":1186,"type":1187},"2026-09-16","ACTUAL",{"date":1189,"type":1187},"2026-09-11",{"date":1191,"type":1171},"2030-12-31",{"name":5,"class":6},122]