[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626900":3},{"organization":4,"outcomesModule":7,"designInfo":51,"detailedDescription":60,"studyPopulation":50,"armGroups":61,"interventions":82,"overallOfficials":50,"centralContacts":91,"locations":99,"responsibleParty":696,"collaborators":50,"id":698,"slug":699,"hasResults":700,"nctId":701,"briefTitle":702,"officialTitle":703,"acronym":50,"eligibilityCriteria":704,"healthyVolunteers":700,"sex":705,"minAge":706,"maxAge":50,"enrollmentInfo":707,"targetDuration":50,"studyType":710,"phases":711,"briefSummary":713,"conditions":714,"keywords":716,"overallStatus":102,"whyStopped":50,"lastUpdateSubmitDate":720,"lastUpdatePostDateStruct":721,"startDateStruct":724,"completionDateStruct":726,"leadSponsor":728,"locationsCount":729},{"fullName":5,"class":6},"Novartis","INDUSTRY",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":50},[9],{"measure":10,"description":11,"timeFrame":12},"Change of geographic atrophy (GA) lesion area in the study eye","To evaluate the dose response relationship of FWY003 on GA lesion area in the study eye in participants with GA secondary to age-related macular degeneration (AMD).","From Baseline to Month 18",[14,18,22,25,28,31,34,37,40,43,46],{"measure":15,"description":16,"timeFrame":17},"Number of participants with adverse events (AEs) and serious adverse events (SAEs)","To assess the safety and tolerability of FWY003.","From first dose (Day 1) to Month 19",{"measure":19,"description":20,"timeFrame":21},"Change in visual function measure by ETDRS (Regular Luminance) Best Corrected Visual Acuity (BCVA) in the study eye","To assess the change in visual function over time by measuring Best Corrected Visual Acuity (BCVA) using the Early Treatment Diabetic Retinopathy Study (ETDRS) chart under normal lighting conditions. BCVA is the sharpest vision a person can achieve with optimal correction, such as glasses or contact lenses. The ETDRS eye chart is the standardized chart used in clinical trials.","Baseline through Month 18",{"measure":23,"description":24,"timeFrame":21},"Change in visual function measure by ETDRS Low Luminance Visual Acuity (LLVA) in the study eye","To assess the change in visual function using Early Treatment Diabetic Retinopathy Study (ETDRS) Low Luminance Visual Acuity (LLVA) vision test. This test measures how well a person can see under low-light conditions. It is performed using the standard ETDRS eye chart.",{"measure":26,"description":27,"timeFrame":21},"Change in visual function measure by Quantitative contrast sensitivity function (qCSF) under regular luminance in the study eye","To assess the change in visual function by using a test called the quantitative Contrast Sensitivity Function (qCSF). qCSF checks how faint a pattern a person can see, and how that changes for large vs. small details.",{"measure":29,"description":30,"timeFrame":21},"Change in visual function measure by Low Contrast quantitative Visual Acuity (LCqVA) under regular luminance in the study eye","To assess the change in visual function using a test called Low Contrast quantitative Visual Acuity (LCqVA). LCqVA is visual acuity test where letters on the chart are printed with reduced contrast. The test is performed in normal lighting conditions.",{"measure":32,"description":33,"timeFrame":21},"Change in visual function measure by LCqVA under low luminance in the study eye","To assess the change in visual function in dim-light conditions using a test called Low Contrast quantitative Visual Acuity (LCqVA). This test measures how well a person can read low-contrast letters. The test is performed with reduced luminance (making the environment darker).",{"measure":35,"description":36,"timeFrame":21},"Proportion of participants with ≥15 letters loss","To measure how many participants in a study lose 15 or more letters on a visual test",{"measure":38,"description":39,"timeFrame":21},"Change in area of total and partial ellipsoid zone (EZ) attenuation in the macula in the study eye","To assess the effect of FWY003 on photoreceptor parameters in the study eye.",{"measure":41,"description":42,"timeFrame":21},"Plasma concentrations of FWY003","To assess the pharmacokinetic profile of FWY003.",{"measure":44,"description":45,"timeFrame":21},"Rate of change of GA lesion area (square-root transformed) in the study eye","To assess the rate of change in GA lesion area in the study eye.",{"measure":47,"description":48,"timeFrame":49},"Change of GA lesion area (square-root transformed)","To assess the effect of FWY003 on GA lesion area.","Baseline through Month 12",null,{"allocation":52,"interventionModel":53,"interventionModelDescription":50,"primaryPurpose":54,"observationalModel":50,"timePerspective":50,"maskingInfo":55},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":56,"maskingDescription":50,"whoMasked":57},"DOUBLE",[58,59],"PARTICIPANT","INVESTIGATOR","This study is designed as a randomized, multi-center, double-masked, prospective study to characterize the dose response relationship, efficacy and safety of FWY003.",[62,68,72,76],{"label":63,"type":64,"description":65,"interventionNames":66},"FWY003 dose level 1","EXPERIMENTAL","Participants will receive FWY003 dose level 1",[67],"Drug: FWY003",{"label":69,"type":64,"description":70,"interventionNames":71},"FWY003 dose level 2","Participants will receive FWY003 dose level 2",[67],{"label":73,"type":64,"description":74,"interventionNames":75},"FWY003 dose level 3","Participants will receive FWY003 dose level 3",[67],{"label":77,"type":78,"description":79,"interventionNames":80},"Placebo","PLACEBO_COMPARATOR","Participants will receive placebo",[81],"Drug: Placebo",[83,88],{"type":84,"name":85,"description":86,"armGroupLabels":87,"otherNames":50},"DRUG","FWY003","FWY003 arm participants will receive a specific dose of FWY003",[63,69,73],{"type":84,"name":77,"description":89,"armGroupLabels":90,"otherNames":50},"Placebo arm participants will receive placebo",[77],[92,97],{"name":93,"role":94,"phone":95,"phoneExt":50,"email":96},"Novartis Pharmaceuticals","CONTACT","1-888-669-6682","novartis.email@novartis.com",{"name":93,"role":94,"phone":98,"phoneExt":50,"email":50},"+41613241111",[100,122,138,154,170,185,201,218,235,251,264,280,296,313,328,343,355,363,371,380,390,401,409,420,429,434,445,453,461,469,479,487,495,503,514,523,531,542,551,556,565,576,580,591,599,617,628,636,642,646,655,663,673,680,688],{"facility":101,"status":102,"city":103,"state":104,"zip":105,"country":106,"countryCode":107,"cosmosGeoPoint":108,"geoPoint":113,"contacts":114},"Salehi Retina Institute","RECRUITING","Huntington Beach","California","92647","United States","US",{"type":109,"coordinates":110},"Point",[111,112],-117.99923,33.6603,{"lat":112,"lon":111},[115,119],{"name":116,"role":94,"phone":117,"phoneExt":50,"email":118},"Gillian Nguyen","+1 657 227 9496","g.nguyen@retinasocal.com",{"name":120,"role":121,"phone":50,"phoneExt":50,"email":50},"Hani Salehi-Had","PRINCIPAL_INVESTIGATOR",{"facility":123,"status":102,"city":124,"state":104,"zip":125,"country":106,"countryCode":107,"cosmosGeoPoint":126,"geoPoint":130,"contacts":131},"Retinal Consultants Medical Group Inc","Sacramento","95841",{"type":109,"coordinates":127},[128,129],-121.4944,38.58157,{"lat":129,"lon":128},[132,136],{"name":133,"role":94,"phone":134,"phoneExt":50,"email":135},"Daniel Ortiz","+1 916 339 3655","ortizd@retinalmd.com",{"name":137,"role":121,"phone":50,"phoneExt":50,"email":50},"Margaret Chang",{"facility":139,"status":102,"city":140,"state":104,"zip":141,"country":106,"countryCode":107,"cosmosGeoPoint":142,"geoPoint":146,"contacts":147},"California Retina Consultants","Santa Barbara","93103",{"type":109,"coordinates":143},[144,145],-119.69819,34.42083,{"lat":145,"lon":144},[148,152],{"name":149,"role":94,"phone":150,"phoneExt":50,"email":151},"Muskaan Kaur Bal","+1 805 963 1648","muskaanb@californiaretina.com",{"name":153,"role":121,"phone":50,"phoneExt":50,"email":50},"Dante Pieramici",{"facility":155,"status":102,"city":156,"state":157,"zip":158,"country":106,"countryCode":107,"cosmosGeoPoint":159,"geoPoint":163,"contacts":164},"Advanced Research LLC","Boynton Beach","Florida","33437",{"type":109,"coordinates":160},[161,162],-80.06643,26.52535,{"lat":162,"lon":161},[165,168],{"name":166,"role":94,"phone":50,"phoneExt":50,"email":167},"Alayka Reddy","areddy@advancedresearchfl.com",{"name":169,"role":121,"phone":50,"phoneExt":50,"email":50},"Drew Philip Bawcombe",{"facility":155,"status":102,"city":171,"state":157,"zip":172,"country":106,"countryCode":107,"cosmosGeoPoint":173,"geoPoint":177,"contacts":178},"Deerfield Beach","33064",{"type":109,"coordinates":174},[175,176],-80.09977,26.31841,{"lat":176,"lon":175},[179,183],{"name":180,"role":94,"phone":181,"phoneExt":50,"email":182},"Quacian Dennis","+1 954 204 0052","qdennis@advancedresearchfl.com",{"name":184,"role":121,"phone":50,"phoneExt":50,"email":50},"Shailesh Gupta",{"facility":186,"status":102,"city":187,"state":157,"zip":188,"country":106,"countryCode":107,"cosmosGeoPoint":189,"geoPoint":193,"contacts":194},"Retina Vitreous Associates of Florida","St. Petersburg","33711",{"type":109,"coordinates":190},[191,192],-82.67927,27.77086,{"lat":192,"lon":191},[195,199],{"name":196,"role":94,"phone":197,"phoneExt":50,"email":198},"Logan Wilson","+1 727 323 0077","lwilson@rvaf.com",{"name":200,"role":121,"phone":50,"phoneExt":50,"email":50},"David Eichenbaum",{"facility":202,"status":102,"city":203,"state":204,"zip":205,"country":106,"countryCode":107,"cosmosGeoPoint":206,"geoPoint":210,"contacts":211},"Opthamalic Consultants of Boston","Boston","Massachusetts","02114",{"type":109,"coordinates":207},[208,209],-71.05977,42.35843,{"lat":209,"lon":208},[212,216],{"name":213,"role":94,"phone":214,"phoneExt":50,"email":215},"Haylie Carlon","+1 617 314 2636","hcarlon@eyeboston.com",{"name":217,"role":121,"phone":50,"phoneExt":50,"email":50},"Jeffrey S Heier",{"facility":219,"status":102,"city":220,"state":221,"zip":222,"country":106,"countryCode":107,"cosmosGeoPoint":223,"geoPoint":227,"contacts":228},"NJ Retina","Toms River","New Jersey","08755",{"type":109,"coordinates":224},[225,226],-74.19792,39.95373,{"lat":226,"lon":225},[229,233],{"name":230,"role":94,"phone":231,"phoneExt":50,"email":232},"Andy Merino","+1 732 906 1887","amerino@njretina.com",{"name":234,"role":121,"phone":50,"phoneExt":50,"email":50},"Howard Fine",{"facility":236,"status":102,"city":237,"state":237,"zip":238,"country":106,"countryCode":107,"cosmosGeoPoint":239,"geoPoint":243,"contacts":244},"New York Eye and Ear Infirmary of Mount Sinai","New York","10003",{"type":109,"coordinates":240},[241,242],-74.00597,40.71427,{"lat":242,"lon":241},[245,249],{"name":246,"role":94,"phone":247,"phoneExt":50,"email":248},"Katy Tai","+1 212 979 4251","ktai@nyee.edu",{"name":250,"role":121,"phone":50,"phoneExt":50,"email":50},"Richard Rosen",{"facility":252,"status":102,"city":237,"state":237,"zip":253,"country":106,"countryCode":107,"cosmosGeoPoint":254,"geoPoint":256,"contacts":257},"Columbia University Medical Center","10032",{"type":109,"coordinates":255},[241,242],{"lat":242,"lon":241},[258,262],{"name":259,"role":94,"phone":260,"phoneExt":50,"email":261},"Sokleab Em","+1 212 305 6361","se2389@cumc.columbia.edu",{"name":263,"role":121,"phone":50,"phoneExt":50,"email":50},"Tongalp Tezel",{"facility":265,"status":102,"city":266,"state":267,"zip":268,"country":106,"countryCode":107,"cosmosGeoPoint":269,"geoPoint":273,"contacts":274},"Erie Retina Research LLC","Erie","Pennsylvania","16505",{"type":109,"coordinates":270},[271,272],-80.08506,42.12922,{"lat":272,"lon":271},[275,278],{"name":276,"role":94,"phone":50,"phoneExt":50,"email":277},"Jade Horn","jhorn@erieretinaresearch.com",{"name":279,"role":121,"phone":50,"phoneExt":50,"email":50},"David Almeida",{"facility":281,"status":102,"city":282,"state":267,"zip":283,"country":106,"countryCode":107,"cosmosGeoPoint":284,"geoPoint":288,"contacts":289},"Mid Atlantic Retina","Philadelphia","19107",{"type":109,"coordinates":285},[286,287],-75.16362,39.95238,{"lat":287,"lon":286},[290,294],{"name":291,"role":94,"phone":292,"phoneExt":50,"email":293},"Angelique Ortiz","+1 800 331 6634","asortiz@midatlanticretina.com",{"name":295,"role":121,"phone":50,"phoneExt":50,"email":50},"Carl Regillo",{"facility":297,"status":102,"city":298,"state":299,"zip":300,"country":106,"countryCode":107,"cosmosGeoPoint":301,"geoPoint":305,"contacts":306},"Retina Consultants TX Rsrch Ctr","Bellaire","Texas","77401",{"type":109,"coordinates":302},[303,304],-95.45883,29.70579,{"lat":304,"lon":303},[307,311],{"name":308,"role":94,"phone":309,"phoneExt":50,"email":310},"MaryGrace Powers","+1 713 524 3434","marygrace.powers@retinaconsultantstexas.com",{"name":312,"role":121,"phone":50,"phoneExt":50,"email":50},"David M Brown",{"facility":314,"status":102,"city":315,"state":299,"zip":316,"country":106,"countryCode":107,"cosmosGeoPoint":317,"geoPoint":321,"contacts":322},"Retina Consultants of Houston PA","Houston","77030",{"type":109,"coordinates":318},[319,320],-95.36327,29.76328,{"lat":320,"lon":319},[323,326],{"name":324,"role":94,"phone":50,"phoneExt":50,"email":325},"Erin Shelato","erin.shelato@retinaconsultantstexas.com",{"name":327,"role":121,"phone":50,"phoneExt":50,"email":50},"Charles C Wykoff",{"facility":329,"status":102,"city":330,"state":299,"zip":331,"country":106,"countryCode":107,"cosmosGeoPoint":332,"geoPoint":336,"contacts":337},"Retina Consultants of Texas","Katy","77494",{"type":109,"coordinates":333},[334,335],-95.8244,29.78579,{"lat":335,"lon":334},[338,341],{"name":339,"role":94,"phone":50,"phoneExt":50,"email":340},"Kymmia Majedi","kymmia.majedi@retinaconsultantstexas.com",{"name":342,"role":121,"phone":50,"phoneExt":50,"email":50},"Kenneth Fan",{"facility":344,"status":102,"city":345,"state":346,"zip":347,"country":348,"countryCode":349,"cosmosGeoPoint":350,"geoPoint":354,"contacts":50},"Novartis Investigative Site","Albury","New South Wales","2640","Australia","AU",{"type":109,"coordinates":351},[352,353],146.92401,-36.07482,{"lat":353,"lon":352},{"facility":344,"status":102,"city":356,"state":346,"zip":357,"country":348,"countryCode":349,"cosmosGeoPoint":358,"geoPoint":362,"contacts":50},"Parramatta","2150",{"type":109,"coordinates":359},[360,361],151.00348,-33.8178,{"lat":361,"lon":360},{"facility":344,"status":102,"city":364,"state":346,"zip":365,"country":348,"countryCode":349,"cosmosGeoPoint":366,"geoPoint":370,"contacts":50},"Strathfield","2135",{"type":109,"coordinates":367},[368,369],151.07986,-33.88096,{"lat":369,"lon":368},{"facility":344,"status":102,"city":372,"state":373,"zip":374,"country":348,"countryCode":349,"cosmosGeoPoint":375,"geoPoint":379,"contacts":50},"East Melbourne","Victoria","3002",{"type":109,"coordinates":376},[377,378],144.9879,-37.81667,{"lat":378,"lon":377},{"facility":344,"status":102,"city":381,"state":50,"zip":382,"country":383,"countryCode":384,"cosmosGeoPoint":385,"geoPoint":389,"contacts":50},"Sofia","1618","Bulgaria","BG",{"type":109,"coordinates":386},[387,388],23.32415,42.69751,{"lat":388,"lon":387},{"facility":344,"status":102,"city":391,"state":392,"zip":393,"country":394,"countryCode":395,"cosmosGeoPoint":396,"geoPoint":400,"contacts":50},"London","Ontario","N6A 4L8","Canada","CA",{"type":109,"coordinates":397},[398,399],-81.23304,42.98339,{"lat":399,"lon":398},{"facility":344,"status":102,"city":402,"state":392,"zip":403,"country":394,"countryCode":395,"cosmosGeoPoint":404,"geoPoint":408,"contacts":50},"Ottawa","K2B 7E9",{"type":109,"coordinates":405},[406,407],-75.69812,45.41117,{"lat":407,"lon":406},{"facility":344,"status":102,"city":410,"state":411,"zip":412,"country":413,"countryCode":414,"cosmosGeoPoint":415,"geoPoint":419,"contacts":50},"Barranquilla","Atlántico","080001","Colombia","CO",{"type":109,"coordinates":416},[417,418],-74.78132,10.96854,{"lat":418,"lon":417},{"facility":344,"status":102,"city":421,"state":50,"zip":422,"country":423,"countryCode":50,"cosmosGeoPoint":424,"geoPoint":428,"contacts":50},"Prague","100 34","Czechia",{"type":109,"coordinates":425},[426,427],14.42076,50.08804,{"lat":427,"lon":426},{"facility":344,"status":102,"city":421,"state":50,"zip":430,"country":423,"countryCode":50,"cosmosGeoPoint":431,"geoPoint":433,"contacts":50},"128 08",{"type":109,"coordinates":432},[426,427],{"lat":427,"lon":426},{"facility":344,"status":102,"city":435,"state":436,"zip":437,"country":438,"countryCode":439,"cosmosGeoPoint":440,"geoPoint":444,"contacts":50},"Lyon","Rhone","69004","France","FR",{"type":109,"coordinates":441},[442,443],4.84789,45.74906,{"lat":443,"lon":442},{"facility":344,"status":102,"city":446,"state":50,"zip":447,"country":438,"countryCode":439,"cosmosGeoPoint":448,"geoPoint":452,"contacts":50},"Créteil","94000",{"type":109,"coordinates":449},[450,451],2.46569,48.79266,{"lat":451,"lon":450},{"facility":344,"status":102,"city":454,"state":50,"zip":455,"country":438,"countryCode":439,"cosmosGeoPoint":456,"geoPoint":460,"contacts":50},"Dijon","21000",{"type":109,"coordinates":457},[458,459],5.01391,47.31344,{"lat":459,"lon":458},{"facility":344,"status":102,"city":462,"state":50,"zip":463,"country":438,"countryCode":439,"cosmosGeoPoint":464,"geoPoint":468,"contacts":50},"Paris","75940",{"type":109,"coordinates":465},[466,467],2.3488,48.85341,{"lat":467,"lon":466},{"facility":344,"status":102,"city":470,"state":471,"zip":472,"country":471,"countryCode":473,"cosmosGeoPoint":474,"geoPoint":478,"contacts":50},"Ludwigshafen","Germany","67063","DE",{"type":109,"coordinates":475},[476,477],9.06138,47.81663,{"lat":477,"lon":476},{"facility":344,"status":102,"city":480,"state":50,"zip":481,"country":471,"countryCode":473,"cosmosGeoPoint":482,"geoPoint":486,"contacts":50},"Bonn","53105",{"type":109,"coordinates":483},[484,485],7.09549,50.73438,{"lat":485,"lon":484},{"facility":344,"status":102,"city":488,"state":50,"zip":489,"country":471,"countryCode":473,"cosmosGeoPoint":490,"geoPoint":494,"contacts":50},"Münster","48145",{"type":109,"coordinates":491},[492,493],7.62571,51.96236,{"lat":493,"lon":492},{"facility":344,"status":102,"city":496,"state":50,"zip":497,"country":471,"countryCode":473,"cosmosGeoPoint":498,"geoPoint":502,"contacts":50},"Tübingen","72076",{"type":109,"coordinates":499},[500,501],9.05222,48.52266,{"lat":501,"lon":500},{"facility":344,"status":102,"city":504,"state":505,"zip":506,"country":507,"countryCode":508,"cosmosGeoPoint":509,"geoPoint":513,"contacts":50},"Pécs","Baranya","7621","Hungary","HU",{"type":109,"coordinates":510},[511,512],18.22814,46.07617,{"lat":512,"lon":511},{"facility":344,"status":102,"city":515,"state":516,"zip":517,"country":507,"countryCode":508,"cosmosGeoPoint":518,"geoPoint":522,"contacts":50},"Debrecen","Hajdu Bihar Megye","4032",{"type":109,"coordinates":519},[520,521],21.62444,47.53167,{"lat":521,"lon":520},{"facility":344,"status":102,"city":524,"state":50,"zip":525,"country":507,"countryCode":508,"cosmosGeoPoint":526,"geoPoint":530,"contacts":50},"Budapest","1083",{"type":109,"coordinates":527},[528,529],19.04045,47.49835,{"lat":529,"lon":528},{"facility":344,"status":102,"city":532,"state":533,"zip":534,"country":535,"countryCode":536,"cosmosGeoPoint":537,"geoPoint":541,"contacts":50},"Florence","FI","50134","Italy","IT",{"type":109,"coordinates":538},[539,540],11.24626,43.77925,{"lat":540,"lon":539},{"facility":344,"status":102,"city":543,"state":544,"zip":545,"country":535,"countryCode":536,"cosmosGeoPoint":546,"geoPoint":550,"contacts":50},"Milan","MI","20122",{"type":109,"coordinates":547},[548,549],12.59836,42.78235,{"lat":549,"lon":548},{"facility":344,"status":102,"city":543,"state":544,"zip":552,"country":535,"countryCode":536,"cosmosGeoPoint":553,"geoPoint":555,"contacts":50},"20132",{"type":109,"coordinates":554},[548,549],{"lat":549,"lon":548},{"facility":344,"status":102,"city":557,"state":558,"zip":559,"country":535,"countryCode":536,"cosmosGeoPoint":560,"geoPoint":564,"contacts":50},"Roma","RM","00184",{"type":109,"coordinates":561},[562,563],11.10642,44.99364,{"lat":563,"lon":562},{"facility":344,"status":102,"city":566,"state":567,"zip":568,"country":569,"countryCode":570,"cosmosGeoPoint":571,"geoPoint":575,"contacts":50},"Kobe","Hyōgo","6500047","Japan","JP",{"type":109,"coordinates":572},[573,574],135.183,34.6913,{"lat":574,"lon":573},{"facility":344,"status":102,"city":577,"state":578,"zip":579,"country":569,"countryCode":570,"cosmosGeoPoint":50,"geoPoint":50,"contacts":50},"Bunkyo Ku","Tokyo","1138655",{"facility":344,"status":102,"city":581,"state":582,"zip":583,"country":584,"countryCode":585,"cosmosGeoPoint":586,"geoPoint":590,"contacts":50},"Bydgoszcz","Kuyavian-Pomeranian Voivodeship","85-631","Poland","PL",{"type":109,"coordinates":587},[588,589],18.00762,53.1235,{"lat":589,"lon":588},{"facility":344,"status":102,"city":592,"state":50,"zip":593,"country":584,"countryCode":585,"cosmosGeoPoint":594,"geoPoint":598,"contacts":50},"Krakow","31-070",{"type":109,"coordinates":595},[596,597],19.93658,50.06143,{"lat":597,"lon":596},{"facility":600,"status":102,"city":601,"state":50,"zip":602,"country":603,"countryCode":604,"cosmosGeoPoint":605,"geoPoint":609,"contacts":610},"Emanuelli Research and Development Center LLC","Arecibo","00612","Puerto Rico","PR",{"type":109,"coordinates":606},[607,608],-66.71573,18.47245,{"lat":608,"lon":607},[611,615],{"name":612,"role":94,"phone":613,"phoneExt":50,"email":614},"Diane Perez Perez","+1 787 879 7722","dperez@erdpr.com",{"name":616,"role":121,"phone":50,"phoneExt":50,"email":50},"Andres Emanuelli Anzalotta",{"facility":344,"status":102,"city":618,"state":619,"zip":620,"country":621,"countryCode":622,"cosmosGeoPoint":623,"geoPoint":627,"contacts":50},"Cluj-Napoca","Cluj","400006","Romania","RO",{"type":109,"coordinates":624},[625,626],23.6,46.76667,{"lat":626,"lon":625},{"facility":344,"status":102,"city":629,"state":50,"zip":630,"country":621,"countryCode":622,"cosmosGeoPoint":631,"geoPoint":635,"contacts":50},"Bucharest","011658",{"type":109,"coordinates":632},[633,634],26.10626,44.43225,{"lat":634,"lon":633},{"facility":344,"status":102,"city":637,"state":638,"zip":639,"country":640,"countryCode":641,"cosmosGeoPoint":50,"geoPoint":50,"contacts":50},"Santiago Compostela","A Coruna","15706","Spain","ES",{"facility":344,"status":102,"city":643,"state":644,"zip":645,"country":640,"countryCode":641,"cosmosGeoPoint":50,"geoPoint":50,"contacts":50},"Sant Cugat Del V","Barcelona","08190",{"facility":344,"status":102,"city":647,"state":648,"zip":649,"country":640,"countryCode":641,"cosmosGeoPoint":650,"geoPoint":654,"contacts":50},"Burjassot","Valencia","46100",{"type":109,"coordinates":651},[652,653],-0.41327,39.50984,{"lat":653,"lon":652},{"facility":344,"status":102,"city":656,"state":50,"zip":657,"country":640,"countryCode":641,"cosmosGeoPoint":658,"geoPoint":662,"contacts":50},"Córdoba","14012",{"type":109,"coordinates":659},[660,661],-4.77275,37.89155,{"lat":661,"lon":660},{"facility":344,"status":102,"city":664,"state":50,"zip":665,"country":666,"countryCode":667,"cosmosGeoPoint":668,"geoPoint":672,"contacts":50},"Bristol","BS1 2LX","United Kingdom","UK",{"type":109,"coordinates":669},[670,671],-2.59665,51.45523,{"lat":671,"lon":670},{"facility":344,"status":102,"city":391,"state":50,"zip":674,"country":666,"countryCode":667,"cosmosGeoPoint":675,"geoPoint":679,"contacts":50},"NW10 7NS",{"type":109,"coordinates":676},[677,678],-0.12574,51.50853,{"lat":678,"lon":677},{"facility":344,"status":102,"city":681,"state":50,"zip":682,"country":666,"countryCode":667,"cosmosGeoPoint":683,"geoPoint":687,"contacts":50},"Newcastle upon Tyne","NE1 4LP",{"type":109,"coordinates":684},[685,686],-1.61396,54.97328,{"lat":686,"lon":685},{"facility":344,"status":102,"city":689,"state":50,"zip":690,"country":666,"countryCode":667,"cosmosGeoPoint":691,"geoPoint":695,"contacts":50},"Southampton","SO16 6YD",{"type":109,"coordinates":692},[693,694],-1.40428,50.90395,{"lat":694,"lon":693},{"type":697,"investigatorFullName":50,"investigatorTitle":50,"investigatorAffiliation":50,"oldNameTitle":50,"oldOrganization":50},"SPONSOR","100626900","phase-2-a-study-to-investigate-efficacy-and-safety-of-fwy003-compared-with-placebo-in-participants-with-geographic-atrophy-secondary-to-age-related-macular-degeneration-100626900",false,"NCT07441642","A Study to Investigate Efficacy and Safety of FWY003 Compared With Placebo in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration","A Randomized, Double Masked, Placebo-controlled, Multicenter, Dose-range Finding Study to Assess the Efficacy and Safety of FWY003 in Patients With Geographic Atrophy Secondary to Age-related Macular Degeneration","Inclusion Criteria:\n\nMale or female participants ≥ 50 years of age.\n\n* A diagnosis of GA secondary to AMD in at least one eye (study eye). If both eyes qualify, then the eye with the better BCVA would be assigned as study eye.\n\n  1. Total GA area must be ≥2.5 and ≤17.5 mm2 (1 and 7 disk areas (DA), respectively)\n  2. If GA lesion is multifocal, then the total lesion area must be between 2.5-17.5 mm2 and at least one lesion should have an area of at least 1.25 mm2\n  3. Entire GA lesion must be visualized on the macula centered image and not contiguous with peripapillary atrophy\n* ETDRS BCVA ≥ 35 letters (20\u002F200) in the study eye.\n\nExclusion Criteria:\n\n* A history of, or current evidence of, choroidal neovascularization (exudative MNV) in the study eye.\n* Previous cell or gene therapy in either eye.\n* Macular atrophy in either eye due to a cause other than AMD, such as Stargardt disease, cone rod dystrophy, toxic maculopathies, etc.\n* Intraocular surgery, including cataract and vitreoretinal surgery, in the study eye within 3 months prior to Baseline.\n* Presence of significant media opacity, eye movement disorder (nystagmus), severe ptosis, extraocular motility restriction or head tremor, which in the opinion of the investigator, would prevent adequate fundus visualization or which in the opinion of the Reading Center could interfere with the assessment of study images.\n\nOther protocol-defined inclusion\u002Fexclusion criteria may apply.","ALL","50 Years",{"count":708,"type":709},272,"ESTIMATED","INTERVENTIONAL",[712],"PHASE2","To characterize the dose response relationship of FWY003 in participants with geographic atrophy (GA) secondary to age-related macular degeneration (AMD).",[715],"Geographic Atrophy Secondary to Age-related Macular Degeneration",[85,717,718,719],"safety","tolerability","geographical atrophy","2026-09-07",{"date":722,"type":723},"2026-09-09","ACTUAL",{"date":725,"type":723},"2026-03-09",{"date":727,"type":709},"2029-08-22",{"name":93,"class":6},55]