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There is no evidence for a competing aetiology.\n  * Historical biopsy (≤ 5 years prior to randomisation) showed steatohepatitis with F1 to F3 fibrosis, but now with cirrhosis either by NITs or biopsy. There is no evidence of competing aetiology. If there is a current biopsy (≤ 6 months prior to randomisation), and it does not show evidence of steatosis or steatohepatitis, there is at least 1 coexisting or history of metabolic comorbidity.\n  * The most recent liver biopsy (≤ 5 years prior to randomisation) showing cirrhosis with steatosis. There are at least 2 coexisting metabolic comorbidities or history of metabolic comorbidities, including obesity and\u002For type 2 diabetes mellitus (T2DM). There is no evidence for a competing aetiology.\n  * Historical biopsy (≤ 5 years prior to randomisation) showed steatosis, but now with cirrhosis, either by NITs or biopsy. If there is a current biopsy (≤ 6 months prior to randomisation), and it does not show evidence of steatosis or steatohepatitis, there are at least 2 coexisting or history of metabolic comorbidities including obesity and\u002For T2DM. There is no evidence of competing aetiology.\n  * Trial participant with cirrhosis with current or previous imaging showing evidence of steatosis (by liver ultrasound or CT scan or FibroScan® with CAP ≥288 dB\u002Fm or MRI-PDFF ≥5%). There is no liver histology available. There are at least 2 coexisting or history of metabolic comorbidities, including obesity and\u002For T2DM. There is no evidence of competing aetiology.\n  * Cryptogenic cirrhosis' (either by NITs or biopsy; not to exceed 20% of trial participants) without current or previous evidence of steatosis by imaging or steatosis\u002Fsteatohepatitis by histology. There are at least 2 coexisting or history of metabolic comorbidities, including obesity and\u002For T2DM. There is no evidence of competing aetiology.\n\nFurther inclusion criteria apply.\n\nExclusion Criteria:\n\n* Patients with clinically significant signs of advanced portal hypertension defined by any of the following:\n\n  * VCTE ≥30 kPa\n  * VCTE ≥25 kPa if the platelets are ≥150,000\u002FμL\n  * History of esophageal or gastric varices (Grade ≥1) on endoscopy\n  * Hepatic venous pressure gradient (HVPG) ≥10 mmHg\n* Other causes of liver disease based on medical history and\u002For centralized review of liver histology, including but not limited to alcoholic liver disease, autoimmune disorders (e.g., primary biliary cholangitis \\[PBC\\], primary sclerosing cholangitis \\[PSC\\], autoimmune hepatitis), drug-induced hepatotoxicity, Wilson disease, clinically significant iron overload, or alpha-1- antitryspin deficiency\n* Chronic viral hepatitis parameters that would be considered exclusionary for the participation in this trial are (hepatitis B and C testing will be done at screening visit):\n\n  * Hepatitis B virus (HBV): Past or present hepatitis B infection, including a positive hepatitis B surface antigen (HBsAg) and\u002For detectable HBV Deoxyribonucleic Acid (DNA).\n  * Hepatitis C virus (HCV): Past or present hepatitis C infection, including positive hepatitis C antibodies and\u002For detectable HCV ribonucleic acid (RNA).\n* History of liver transplantation or patients listed for liver transplantation\n* Suspicion, confirmed diagnosis, or history of Hepatocellular Carcinoma (HCC)\n* Present or past evidence of decompensating events of liver cirrhosis\n* Model for End-Stage Liver Disease (MELD) score \\> 12, unless due to therapeutic anti-coagulation\n* History of significant alcohol consumption (defined as intake of \\> 210 g\u002Fweek in males and \\> 140 g\u002Fweek in females on average over a consecutive period of more than 3 months) within 1 year prior to screening\n* International Normalized Ratio (INR) \\>1.3 unless due to therapeutic anticoagulants or laboratory error Further exclusion criteria apply.","ALL","18 Years","75 Years",{"count":368,"type":369},29,"ESTIMATED","INTERVENTIONAL",[372],"PHASE2","This study is open to adults with a type of confirmed liver condition called compensated cirrhosis due to Metabolic Dysfunction-Associated Steatohepatitis (MASH). The purpose of this study is to find out how well a study medicine called BI 3802876 is tolerated in people with this condition. The study looks at how different doses of BI 3802876 are handled by the body. BI 3802876 is being developed to improve liver health in people living with this liver condition.\n\nParticipants are put in 3 different dose groups randomly, which means by chance. Participants within a group get BI 3802876 or placebo. Placebo looks like BI 3802876 but does not contain any medicine. Participants have more than twice the chance of receiving BI 3802876 than placebo. The study medicine is given as an infusion into a vein.\n\nParticipants are in the study for about half a year. During this time, they visit the study site 12 times. At 2 visits, participants get the study medicine. Doctors collect information on any health problems and take blood samples to check how BI 3802876 is handled by the body. They compare results between the groups.",[375],"Liver Cirrhosis","2026-08-18",{"date":378,"type":379},"2026-08-19","ACTUAL",{"date":381,"type":379},"2026-02-27",{"date":383,"type":369},"2027-08-05",{"name":5,"class":6},27]