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Hospital","04763",{"type":52,"coordinates":1164},[1151,1152],{"lat":1152,"lon":1151},{"facility":1167,"status":68,"city":1147,"state":28,"zip":1168,"country":1133,"countryCode":28,"cosmosGeoPoint":1169,"geoPoint":1171,"contacts":28},"Konkuk University Medical Center","05030",{"type":52,"coordinates":1170},[1151,1152],{"lat":1152,"lon":1151},{"facility":1173,"status":45,"city":1147,"state":28,"zip":1174,"country":1133,"countryCode":28,"cosmosGeoPoint":1175,"geoPoint":1177,"contacts":28},"Samsung Medical Center","06351",{"type":52,"coordinates":1176},[1151,1152],{"lat":1152,"lon":1151},{"facility":1179,"status":45,"city":1147,"state":28,"zip":1180,"country":1133,"countryCode":28,"cosmosGeoPoint":1181,"geoPoint":1183,"contacts":28},"SMG-SNU Boramae Medical Center","07061",{"type":52,"coordinates":1182},[1151,1152],{"lat":1152,"lon":1151},{"facility":1185,"status":549,"city":1186,"state":28,"zip":1187,"country":1188,"countryCode":1189,"cosmosGeoPoint":1190,"geoPoint":1194,"contacts":28},"Hospital Universitario Virgen Macarena","Seville","41009","Spain","ES",{"type":52,"coordinates":1191},[1192,1193],-5.97317,37.38283,{"lat":1193,"lon":1192},{"facility":1196,"status":549,"city":1197,"state":28,"zip":1198,"country":1188,"countryCode":1189,"cosmosGeoPoint":1199,"geoPoint":1203,"contacts":28},"Hospital Provincial de Zamora","Zamora","49021",{"type":52,"coordinates":1200},[1201,1202],-5.74456,41.50633,{"lat":1202,"lon":1201},{"facility":1205,"status":45,"city":1206,"state":28,"zip":1207,"country":1208,"countryCode":1209,"cosmosGeoPoint":1210,"geoPoint":1214,"contacts":28},"Kaohsiung Medical University Chung-Ho Memorial Hospital","Kaohsiung City","80756","Taiwan","TW",{"type":52,"coordinates":1211},[1212,1213],120.31333,22.61626,{"lat":1213,"lon":1212},{"facility":1216,"status":45,"city":1206,"state":28,"zip":28,"country":1208,"countryCode":1209,"cosmosGeoPoint":1217,"geoPoint":1219,"contacts":28},"E-DA Hospital",{"type":52,"coordinates":1218},[1212,1213],{"lat":1213,"lon":1212},{"facility":1221,"status":68,"city":1222,"state":28,"zip":1223,"country":1208,"countryCode":1209,"cosmosGeoPoint":1224,"geoPoint":1228,"contacts":28},"Taipei Medical University-Shuang Ho Hospital","New Taipei City","23561",{"type":52,"coordinates":1225},[1226,1227],121.45703,25.06199,{"lat":1227,"lon":1226},{"facility":1230,"status":68,"city":1231,"state":28,"zip":1232,"country":1208,"countryCode":1209,"cosmosGeoPoint":1233,"geoPoint":1237,"contacts":28},"National Cheng Kung University Hospital","Tainan","704",{"type":52,"coordinates":1234},[1235,1236],120.21333,22.99083,{"lat":1236,"lon":1235},{"facility":1239,"status":45,"city":1240,"state":28,"zip":1241,"country":1208,"countryCode":1209,"cosmosGeoPoint":1242,"geoPoint":1246,"contacts":28},"National Taiwan University Hospital","Taipei","10002",{"type":52,"coordinates":1243},[1244,1245],121.52639,25.05306,{"lat":1245,"lon":1244},{"type":1248,"investigatorFullName":28,"investigatorTitle":28,"investigatorAffiliation":28,"oldNameTitle":28,"oldOrganization":28},"SPONSOR","100528354","phase-2-acp-204-in-adults-with-alzheimers-disease-psychosis-100528354",false,"NCT06159673","ACP-204 in Adults With Alzheimer's Disease Psychosis","A Master Protocol for Three Independent, Seamlessly Enrolling, Double-blind, Placebo-controlled Efficacy and Safety Studies of ACP-204 in Adults With Alzheimer's Disease Psychosis","Inclusion Criteria:\n\n* Is male or female and ≥55 and ≤95 years of age living in the community or in an institutionalized setting\n* Meets clinical criteria for possible or probable AD based on the 2011 National Institute on Aging-Alzheimer Association (NIA-AA) criteria\n* Meets the revised criteria for psychosis in major or mild neurocognitive disorder established by the International Psychogeriatrics Association (IPA)\n* Has either blood-based biomarker or documented evidence (e.g. positron emission tomography, cerebrospinal fluid biomarker) indicating amyloid plaque deposition and neuropathologic change consistent with AD\n* Has a prior magnetic resonance imaging or computed tomography scan of the brain that is consistent with the diagnosis of AD\n* Meets revised criteria for psychosis in major or mild neurocognitive disorder as per International Psychogeriatrics Association\n* MMSE score ≥6 and ≤24\n* Psychotic symptoms for at least 2 months\n* Lives in a stable place of residence and there are no plans to change living arrangements\n* Has a designated study partner\u002Fcaregiver\n* Able to complete all study visits with a study partner\u002Fcaregiver\n* Must be on a stable dose of cholinesterase inhibitor or memantine, if applicable\n\nExclusion Criteria:\n\n* Requires treatment with a medication prohibited by the protocol\n* Is in hospice and receiving end-of-life palliative care, or has become bedridden\n* Requires skilled nursing care\n* Psychotic symptoms that are primarily attributable to delirium, substance abuse, or a medical or psychiatric condition other than dementia\n* Known history of cerebral amyloid angiopathy, epilepsy, central nervous system neoplasm, or unexplained syncope\n* Atrial fibrillation\n* Symptomatic orthostatic hypotension\n* Protocol-defined exclusionary clinical laboratory findings\n* Treatment with anti-tau therapy or donanemab within 2 months prior to Screening\n\nAdditional inclusion\u002Fexclusion criteria apply. Subjects will be evaluated at screening to ensure that all criteria for study participation are met.","ALL","55 Years","95 Years",{"count":1260,"type":1261},1074,"ESTIMATED","INTERVENTIONAL",[1264,1265],"PHASE2","PHASE3","This is a master protocol for 3 independent, seamlessly enrolling, multicenter, randomized, double-blind, placebo-controlled, parallel-group studies in patients with ADP\n\n* Substudy 1 (Phase 2) will evaluate efficacy and dose response of ACP-204 30 and 60 mg vs placebo. This substudy will be initiated first.\n* Substudies 2A and 2B (both: Phase 3) will be confirmatory studies of either both doses (ACP-204 30 and 60 mg, respectively) or a single dose from Part 1 vs placebo. Substudies 2A and 2B will be performed independently of each other and will commence after enrollment of Part 1.\n\nAll 3 substudies will be analyzed independently of each other.\n\nEach substudy individually will consist of a screening period (up to 49 days); a double-blind treatment period (6 weeks); a safety follow-up period (30 days) for patients not rolling over into an open-label extension study; and vital status follow-up (for patients who terminated their substudy early).",[1268],"Alzheimer's Disease Psychosis",[1270,1271,1272],"Alzheimer's disease psychosis","Hallucinations","Delusions","2026-07-23",{"date":1275,"type":1276},"2026-07-24","ACTUAL",{"date":1278,"type":1276},"2023-11-14",{"date":1280,"type":1261},"2028-02",{"name":5,"class":6},148]