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Hospital","22332",{"type":74,"coordinates":1200},[1193,1194],{"lat":1194,"lon":1193},{"facility":1203,"status":67,"city":1204,"state":18,"zip":1205,"country":1190,"countryCode":18,"cosmosGeoPoint":1206,"geoPoint":1210,"contacts":18},"Korea University Anam Hospital","Seoul","02841",{"type":74,"coordinates":1207},[1208,1209],126.9784,37.566,{"lat":1209,"lon":1208},{"facility":1212,"status":119,"city":1204,"state":18,"zip":1213,"country":1190,"countryCode":18,"cosmosGeoPoint":1214,"geoPoint":1216,"contacts":18},"Eunpyeong St. Mary's Hospital","03312",{"type":74,"coordinates":1215},[1208,1209],{"lat":1209,"lon":1208},{"facility":1218,"status":119,"city":1204,"state":18,"zip":1219,"country":1190,"countryCode":18,"cosmosGeoPoint":1220,"geoPoint":1222,"contacts":18},"Hanyang University Seoul Hospital","04763",{"type":74,"coordinates":1221},[1208,1209],{"lat":1209,"lon":1208},{"facility":1224,"status":90,"city":1204,"state":18,"zip":1225,"country":1190,"countryCode":18,"cosmosGeoPoint":1226,"geoPoint":1228,"contacts":18},"Konkuk University Medical Center","05030",{"type":74,"coordinates":1227},[1208,1209],{"lat":1209,"lon":1208},{"facility":1230,"status":67,"city":1204,"state":18,"zip":1231,"country":1190,"countryCode":18,"cosmosGeoPoint":1232,"geoPoint":1234,"contacts":18},"Samsung Medical Center","06351",{"type":74,"coordinates":1233},[1208,1209],{"lat":1209,"lon":1208},{"facility":1236,"status":67,"city":1204,"state":18,"zip":1237,"country":1190,"countryCode":18,"cosmosGeoPoint":1238,"geoPoint":1240,"contacts":18},"SMG-SNU Boramae Medical Center","07061",{"type":74,"coordinates":1239},[1208,1209],{"lat":1209,"lon":1208},{"facility":1242,"status":606,"city":1243,"state":18,"zip":1244,"country":1245,"countryCode":1246,"cosmosGeoPoint":1247,"geoPoint":1251,"contacts":18},"Hospital Universitario Virgen Macarena","Seville","41009","Spain","ES",{"type":74,"coordinates":1248},[1249,1250],-5.97317,37.38283,{"lat":1250,"lon":1249},{"facility":1253,"status":606,"city":1254,"state":18,"zip":1255,"country":1245,"countryCode":1246,"cosmosGeoPoint":1256,"geoPoint":1260,"contacts":18},"Hospital Provincial de Zamora","Zamora","49021",{"type":74,"coordinates":1257},[1258,1259],-5.74456,41.50633,{"lat":1259,"lon":1258},{"facility":1262,"status":67,"city":1263,"state":18,"zip":1264,"country":1265,"countryCode":1266,"cosmosGeoPoint":1267,"geoPoint":1271,"contacts":18},"Kaohsiung Medical University Chung-Ho Memorial Hospital","Kaohsiung City","80756","Taiwan","TW",{"type":74,"coordinates":1268},[1269,1270],120.31333,22.61626,{"lat":1270,"lon":1269},{"facility":1273,"status":67,"city":1263,"state":18,"zip":18,"country":1265,"countryCode":1266,"cosmosGeoPoint":1274,"geoPoint":1276,"contacts":18},"E-DA Hospital",{"type":74,"coordinates":1275},[1269,1270],{"lat":1270,"lon":1269},{"facility":1278,"status":90,"city":1279,"state":18,"zip":1280,"country":1265,"countryCode":1266,"cosmosGeoPoint":1281,"geoPoint":1285,"contacts":18},"Taipei Medical University-Shuang Ho Hospital","New Taipei City","23561",{"type":74,"coordinates":1282},[1283,1284],121.45703,25.06199,{"lat":1284,"lon":1283},{"facility":1287,"status":90,"city":1288,"state":18,"zip":1289,"country":1265,"countryCode":1266,"cosmosGeoPoint":1290,"geoPoint":1294,"contacts":18},"National Cheng Kung University Hospital","Tainan","704",{"type":74,"coordinates":1291},[1292,1293],120.21333,22.99083,{"lat":1293,"lon":1292},{"facility":1296,"status":67,"city":1297,"state":18,"zip":1298,"country":1265,"countryCode":1266,"cosmosGeoPoint":1299,"geoPoint":1303,"contacts":18},"National Taiwan University Hospital","Taipei","10002",{"type":74,"coordinates":1300},[1301,1302],121.52639,25.05306,{"lat":1302,"lon":1301},{"type":1305,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100528354","phase-2-acp-204-in-adults-with-alzheimers-disease-psychosis-100528354",false,"NCT06159673","ACP-204 in Adults With Alzheimer's Disease Psychosis","A Master Protocol for Three Independent, Seamlessly Enrolling, Double-blind, Placebo-controlled Efficacy and Safety Studies of ACP-204 in Adults With Alzheimer's Disease Psychosis","Inclusion Criteria:\n\n* Is male or female and ≥55 and ≤95 years of age living in the community or in an institutionalized setting\n* Meets clinical criteria for possible or probable AD based on the 2011 National Institute on Aging-Alzheimer Association (NIA-AA) criteria\n* Meets the revised criteria for psychosis in major or mild neurocognitive disorder established by the International Psychogeriatrics Association (IPA)\n* Has either blood-based biomarker or documented evidence (e.g. positron emission tomography, cerebrospinal fluid biomarker) indicating amyloid plaque deposition and neuropathologic change consistent with AD\n* Has a prior magnetic resonance imaging or computed tomography scan of the brain that is consistent with the diagnosis of AD\n* Meets revised criteria for psychosis in major or mild neurocognitive disorder as per International Psychogeriatrics Association\n* MMSE score ≥6 and ≤24\n* Psychotic symptoms for at least 2 months\n* Lives in a stable place of residence and there are no plans to change living arrangements\n* Has a designated study partner\u002Fcaregiver\n* Able to complete all study visits with a study partner\u002Fcaregiver\n* Must be on a stable dose of cholinesterase inhibitor or memantine, if applicable\n\nExclusion Criteria:\n\n* Requires treatment with a medication prohibited by the protocol\n* Is in hospice and receiving end-of-life palliative care, or has become bedridden\n* Requires skilled nursing care\n* Psychotic symptoms that are primarily attributable to delirium, substance abuse, or a medical or psychiatric condition other than dementia\n* Known history of cerebral amyloid angiopathy, epilepsy, central nervous system neoplasm, or unexplained syncope\n* Atrial fibrillation\n* Symptomatic orthostatic hypotension\n* Protocol-defined exclusionary clinical laboratory findings\n* Treatment with anti-tau therapy or donanemab within 2 months prior to Screening\n\nAdditional inclusion\u002Fexclusion criteria apply. Subjects will be evaluated at screening to ensure that all criteria for study participation are met.","ALL","55 Years","95 Years",{"count":1317,"type":1318},1074,"ESTIMATED","INTERVENTIONAL",[1321,1322],"PHASE2","PHASE3","This is a master protocol for 3 independent, seamlessly enrolling, multicenter, randomized, double-blind, placebo-controlled, parallel-group studies in patients with ADP\n\n* Substudy 1 (Phase 2) will evaluate efficacy and dose response of ACP-204 30 and 60 mg vs placebo. This substudy will be initiated first.\n* Substudies 2A and 2B (both: Phase 3) will be confirmatory studies of either both doses (ACP-204 30 and 60 mg, respectively) or a single dose from Part 1 vs placebo. Substudies 2A and 2B will be performed independently of each other and will commence after enrollment of Part 1.\n\nAll 3 substudies will be analyzed independently of each other.\n\nEach substudy individually will consist of a screening period (up to 49 days); a double-blind treatment period (6 weeks); a safety follow-up period (30 days) for patients not rolling over into an open-label extension study; and vital status follow-up (for patients who terminated their substudy early).",[1325],"Alzheimer's Disease Psychosis",[1327,1328,1329],"Alzheimer's disease psychosis","Hallucinations","Delusions","2026-10-02",{"date":1332,"type":1333},"2026-10-05","ACTUAL",{"date":1335,"type":1333},"2023-11-14",{"date":1337,"type":1318},"2028-02",{"name":5,"class":6},152]