[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100205295":3},{"organization":4,"outcomesModule":7,"designInfo":45,"detailedDescription":52,"studyPopulation":48,"armGroups":53,"interventions":81,"overallOfficials":136,"centralContacts":149,"locations":160,"responsibleParty":1431,"collaborators":1433,"id":1449,"slug":1450,"hasResults":1451,"nctId":1452,"briefTitle":1453,"officialTitle":1453,"acronym":48,"eligibilityCriteria":1454,"healthyVolunteers":1451,"sex":1455,"minAge":1456,"maxAge":1457,"enrollmentInfo":1458,"targetDuration":48,"studyType":1461,"phases":1462,"briefSummary":1465,"conditions":1466,"keywords":1468,"overallStatus":163,"whyStopped":48,"lastUpdateSubmitDate":1472,"lastUpdatePostDateStruct":1473,"startDateStruct":1476,"completionDateStruct":1478,"leadSponsor":1480,"locationsCount":1481},{"fullName":5,"class":6},"St. Anna Kinderkrebsforschung","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":19,"otherOutcomes":35},[9,13,16],{"measure":10,"description":11,"timeFrame":12},"Overall Survival (OS) Stratum 1a (randomisation TBI+ chemo-conditioning vs. chemo-conditioning only)","Stratum 1 - randomisation related question was closed in December 2018; patients are in active follow-up: To show that a non total body irradiation (TBI) containing conditioning (Flu\u002FThio\u002FivBu or Flu\u002FThio\u002FTreo) results in a non-inferior survival as compared to conditioning with TBI\u002FEtoposide in children older than 4 years after HSCT from a Human leucocyte antigen (HLA) identical sibling donor (MSD) or a HLA matched donor (MD). The primary endpoint is the OS calculated from the date of the randomisation. Death from any cause will be considered an event.","first: 18 months after inclusion of first patient, afterwards annually up to 10 years",{"measure":14,"description":15,"timeFrame":12},"Event free survival (EFS) Stratum 2 (mismatched donor transplantation)","EFS after allogeneic HSCT. EFS calculated from date of recruitment to disease progression or relapse, secondary neoplasm and death from any cause.",{"measure":17,"description":18,"timeFrame":12},"Overall Survival (OS), Stratum 1b: MSD\u002FMD without randomisation","To explore the impact of risk factors on the incidence of adverse events of special interest (AESIs) and on overall survival and event free survival in the entire MSD\u002FMD cohort",[20,23,26,29,32],{"measure":21,"description":22,"timeFrame":12},"EFS (Stratum 1a and 1b)","EFS calculated from date of randomization (1a) or recruitment (1b) to disease progression or relapse, secondary neoplasm and death from any cause. Patients lost to follow-up without event will be censored at the date of their last follow-up evaluation.",{"measure":24,"description":25,"timeFrame":12},"TRM","Cumulative Incidence of Treatment-related mortality (TRM) for Stratum 1 and 2.",{"measure":27,"description":28,"timeFrame":12},"Relapse\u002Fprogression","Cumulative Incidence of Relapse for Stratum 1a, 1b and 2.",{"measure":30,"description":31,"timeFrame":12},"Acute and late toxicity for Stratum 1a, 1b and 2","according a preselection out of CTC3",{"measure":33,"description":34,"timeFrame":12},"OS (Stratum 2)","The primary endpoint is the OS calculated from the date of the recruitment . Death from any cause will be considered an event.",[36,39,42],{"measure":37,"description":38,"timeFrame":12},"Acute Graft versus Host Disease (aGVHD)","According to the modified Seattle Glucksberg criteria",{"measure":40,"description":41,"timeFrame":12},"Secondary malignancies","Incidence, type and timepoint of occurence",{"measure":43,"description":44,"timeFrame":12},"Chronic Graft-versus-host disease (cGvHD)","Chronic GVHD is diagnosed using criteria created through the NIH consensus development project",{"allocation":46,"interventionModel":47,"interventionModelDescription":48,"primaryPurpose":49,"observationalModel":48,"timePerspective":48,"maskingInfo":50},"NON_RANDOMIZED","PARALLEL",null,"TREATMENT",{"masking":51,"maskingDescription":48,"whoMasked":48},"NONE","Acute and late side effects of TBI in combination with other chemotherapeutic are manifold to the growing organism and include severe organ dysfunction\u002Ffailure due to toxicity. Although transplant associated mortality was reduced after HSCT in the last decade due to better HLA matching, infection prevention and control, the burden of late complications is still a matter of concern. Growth retardation, hormonal dysfunction, sterility and the risk of secondary cancer are the late consequences of TBI in children. However, so far no prospective study has demonstrated similar outcomes in paediatric ALL using chemo-conditioning regimen before HSCT. The reason for that is manifold: only a minority of children with ALL qualifies for allogeneic HSCT as most patients are cured with sole modern chemotherapy approaches. Those with dismal prognosis are treated in HSCT centres offering a care to patients with different diseases. Therefore it is nearly impossible to answer the complex outcome questions in single centres or even in single countries. International cooperation is essential to allow prospective investigation within comparable patient cohorts.\n\nThe trial was initiated as a prospective, randomised, global study to investigate whether chemotherapy based conditioning could replace TBI in pediatric patients with acute lymphoblastic leukemia (ALL) undergoing allogeneic hematopoietic stem cell transplantation (HSCT). It was registered and approved as a prospective, randomized, controlled, open-label, international, multicenter, phase III, non-inferiority trial. Pediatric patients with acute lymphoblastic leukemia (ALL) aged ≤18 years at diagnosis and 4-21 years at HSCT in complete remission pre-HSCT, and with an HLA-compatible related (MSD) or unrelated donor (MD) were randomly assigned to myeloablative conditioning with fractionated 12 Gy TBI and etoposide versus fludarabine (Flu), thiotepa (Thio), and either busulfan (Bu) or treosulfan (Treo). The decision to use the irradiation-free conditioning or Flu\u002FThio\u002FTreo or Flu\u002FThio\u002FivBu was country specific. Patients aged \\\u003C 4 years received irradiation-free conditioning. Patients with a mismatched donor (MMD) were stratified according to the donor's stem cell source (cord blood, haploidentical HSCT or bone marrow\u002Fperipheral blood stem cells).\n\nThe stopping rule was applied on March 31, 2019 following a suspension of random assignment in December 2018 after the chemoconditioning was proven to be significantly inferior to TBI. As a result, TBI\u002FVP16 conditioning remains the standard for patients older than 4 years with MSD\u002FMD. If TBI\u002FVP16 was not the conditioning regimen, participating centres\u002Ftreating physicians could choose either Flu\u002FThio\u002Fiv BU or Flu\u002FThio\u002FTreo based on individual patient assessment.\n\nThe MSD\u002FMD randomised patients remain in a follow-up to explore the impact of risk factors on the incidence of Adverse Events of Special Interest (AESIs) and on overall survival and event free survival in the entire MSD\u002FMD cohort.\n\nIn MMD patients, event free survival (EFS) after HSCT from HLA mismatched donors using mismatched unrelated donors (MMD), mismatched cord blood or HLA haplo-identical family members is observed.\n\nDuring the trial, new questions arise, such as new chemotherapy options for no-irradiation conditioning, individualised drug dosing, influence of pharmacogenomics, immune reconstitution, influence of different levels of MRD negativity, donor factors such as MSD vs. MD, HSCT in patients younger than 4 years and in infants, differences in outcome in a non-randomised cohort, factors influencing the development of acute and chronic GvHD, and many other questions that could be analysed and investigated based on the data collected in the trial. In addition, relapse remains the major cause of treatment failure in infants and young children with high-risk ALL undergoing HSCT.\n\nTo address this, the protocol was amended (version 7.0\u002F29 October 2022) to allow a choice of conditioning between TBI\u002FVP16 and chemo-conditioning Flu\u002FThio\u002FTreo or Flu\u002FThio\u002FBu and optionally Bu\u002FVP16\u002FCy for patients aged 0-2 years.\n\n* TBI\u002FVP16 remains the standard of care for patients \\> 4 years.\n* Patients aged 2-4 years may optionally receive the TBI\u002FVP16 conditioning at the discretion of the treating physician to avoid acute and long-term side effects, which are more pronounced in this age group.\n* Patients \\\u003C2 years of age do not receive TBI.\n* For patients who are not eligible for TBI, treating physicians may choose either Flu\u002FThio\u002FivBu or Flu\u002FThio\u002FTreo as both chemo-conditioning regimens result in similar OS, EFS and NRM.\n* Patients aged 0-2 years may receive Bu\u002FVP16\u002FCy at the discretion of the treating physician.\n\nIn countries that have stopped enrolling patients prior to the approval of protocol version 7.0\u002F29 October 2022, or in countries where V7.0 was not approved at the time of the transition to the Clinical Trials Regulation, the choice of conditioning between TBI\u002FVP16 and chemo-conditioning according to international protocol version 6.0\u002F9 September 2019 is as follows:\n\n* TBI\u002FVP16 remains the standard of care for patients \\> 4 years.\n* Patients \\\u003C4 years of age do not receive TBI.\n* For patients aged \\\u003C4 years and those ineligible for TBI, treating physicians may choose either Flu\u002FThio\u002FivBu or Flu\u002FThio\u002FTreo as both chemo-conditioning regimens result in similar OS, EFS and NRM.\n\nIn EU\u002FEEA countries that have transitioned to the Clinical Trials Regulation, a consolidated version of the protocol (v8.0, effective 1 July 2024) is in use, reflecting the common core provisions of versions 6 and 7 that have been approved in the respective Member States.\n\nCountries that are not subject to the CTR use versions that have been approved in their respective countries.",[54,64,71,77],{"label":55,"type":56,"description":57,"interventionNames":58},"Flu\u002FThio\u002FTreo","EXPERIMENTAL","Fludarabine\u002FThiotepa\u002FTreosulfan is used as conditioning regimen for haematopoietic stem cell transplantation (HSCT) in patients with:\n\n* MSD (matched sibling donors) or MD (matched related or unrelated donors). In addition, patients undergoing MD HSCT will receive ATG Thymo- or Grafalon.\n* MMD (mismatched donors) with CB (Cord blood) or TCD (T-Cell depletion) or CD34+ selection. In addition, these patients will receive ATG Thymo- or Grafalon.\n* MMD (mismatched donors) patients receiving Post TX-Cyclophosphamide",[59,60,61,62,63],"Drug: Thiotepa","Drug: Treosulfan","Drug: Fludarabine","Drug: ATG Thymoglobulin","Drug: Grafalon",{"label":65,"type":66,"description":67,"interventionNames":68},"TBI\u002FVP16","ACTIVE_COMPARATOR","TBI (Total Body Irradiation) \u002F VP16 is used as conditioning regimen for haematopoietic stem cell transplantation (HSCT) in patients older than 48 months with:\n\n* MSD (matched sibling donors) or MD (matched related or unrelated donors). In addition, patients undergoing MD HSCT will receive ATG Thymo- or Grafalon.\n* MMD (mismatched donors) with CB (Cord blood) or TCD (T-Cell depletion) or CD34+ selection. In addition, these patients will receive ATG Thymo- or Grafalon.\n* MMD (mismatched donors) patients receiving Post TX-Cyclophosphamide.\n\nPatients aged 24-48 months may optionally receive Total Body Irradiation (TBI).",[69,70,62,63],"Drug: VP16","Radiation: TBI",{"label":72,"type":56,"description":73,"interventionNames":74},"Flu\u002FThio\u002FivBu","Fludarabine\u002FThiotepa\u002FiV Busulfan is used as conditioning regimen for haematopoietic stem cell transplantation (HSCT) in patients with:\n\n* MSD (matched sibling donors) or MD (matched related or unrelated donors). In addition, patients undergoing MD HSCT will receive ATG Thymo- or Grafalon.\n* MMD (mismatched donors) with CB (Cord blood) or TCD (T-Cell depletion) or CD34+ selection. In addition, these patients will receive ATG Thymo- or Grafalon.\n* MMD (mismatched donors) patients receiving Post TX-Cyclophosphamide",[59,61,75,62,76,63],"Drug: Busulfan","Drug: Cyclophosphamide",{"label":78,"type":56,"description":79,"interventionNames":80},"Bu\u002FVP16\u002FCy","Busulfan\u002FVP16\u002FCyclophosphamide is an alternative conditioning arm that may optionally be used for HSCT with MSD\u002FMD and MMD graft in patients aged 0-24 months. Patients undergoing MD HSCT will also receive ATG Thymo- or Grafalon.",[69,75,76],[82,89,94,100,106,112,118,124,130],{"type":83,"name":84,"description":85,"armGroupLabels":86,"otherNames":87},"DRUG","VP16","60 mg\u002Fkg BW,1 day in TBI\u002FVP16 conditioning; 40 mg\u002Fkg BW in Bu\u002FVP16\u002FCy conditioning",[78,65],[88],"Etoposide",{"type":90,"name":91,"description":92,"armGroupLabels":93,"otherNames":48},"RADIATION","TBI","2 x 2Gy\u002Fday , 3 days (total 12Gy)",[65],{"type":83,"name":95,"description":96,"armGroupLabels":97,"otherNames":98},"Thiotepa","2x5 mg\u002Fkg BW, 1 day",[55,72],[99],"Thio",{"type":83,"name":101,"description":102,"armGroupLabels":103,"otherNames":104},"Treosulfan","14g\u002Fm² BS, 3 days",[55],[105],"Treo",{"type":83,"name":107,"description":108,"armGroupLabels":109,"otherNames":110},"Fludarabine","30 mg\u002Fm² BS, 5 days",[55,72],[111],"Flu",{"type":83,"name":113,"description":114,"armGroupLabels":115,"otherNames":116},"Busulfan","iV, dosage according therapeutic drug monitoring, 4 days",[78,72],[117],"Bu",{"type":83,"name":119,"description":120,"armGroupLabels":121,"otherNames":122},"ATG Thymoglobulin","MD: ATG Thymo: 2,5mg\u002Fkg BW\u002Fd 3 days.",[55,72,65],[123],"ATG Thymo",{"type":83,"name":125,"description":126,"armGroupLabels":127,"otherNames":128},"Cyclophosphamide","as part of conditioning 60 mg\u002Fkg BW 2 days or as GvHD Prophylaxis 50mg\u002Fkg BW\u002Fd 2 days with Mesna",[78,72],[129],"Cy",{"type":83,"name":131,"description":132,"armGroupLabels":133,"otherNames":134},"Grafalon","MD: 15mg\u002Fkg BW\u002Fd 3 days MMD: 10mg\u002Fkg BW\u002Fd 3 days",[55,72,65],[135],"Anti-human T-lymphocyte immunoglobulin",[137,141,144,147],{"name":138,"affiliation":139,"role":140},"Christina Peters, Prof. MD PhD","St. Anna Kinderspital, Vienna, Austria","STUDY_CHAIR",{"name":142,"affiliation":143,"role":140},"Peter Bader, Prof. MD PhD","Goethe University",{"name":145,"affiliation":146,"role":140},"Franco Locatelli, Prof. MD PhD","Ospedale Pediatrico Bambino Gesù, Rome, Italy",{"name":148,"affiliation":139,"role":140},"Anita Lawitschka, Assoc. Prof. MD",[150,155],{"name":138,"role":151,"phone":152,"phoneExt":153,"email":154},"CONTACT","+43140170","3106","christina.peters@stanna.at",{"name":156,"role":151,"phone":157,"phoneExt":158,"email":159},"Tijana Frank, MD, MScEng","+43140470","4755","tijana.frank@ccri.at",[161,179,197,209,218,227,236,245,263,279,298,308,323,334,348,362,375,385,388,396,405,413,422,437,456,476,493,504,515,524,533,542,551,560,569,578,587,596,605,614,623,635,644,653,662,671,680,689,698,707,716,725,734,743,752,761,770,779,788,794,803,812,821,830,839,864,882,893,902,911,922,931,940,949,958,967,976,985,994,1004,1019,1034,1045,1059,1070,1086,1096,1104,1112,1120,1128,1138,1146,1161,1179,1194,1209,1219,1227,1240,1253,1269,1283,1297,1311,1327,1341,1355,1365,1370,1375,1383,1388,1396,1401,1405,1410,1418,1423],{"facility":162,"status":163,"city":164,"state":48,"zip":48,"country":165,"countryCode":166,"cosmosGeoPoint":167,"geoPoint":172,"contacts":173},"Hospital de Pediatria \"Juan P. Garrahan\" Combate de Los Pozos N°1800 CABA","RECRUITING","Buenos Aires","Argentina","AR",{"type":168,"coordinates":169},"Point",[170,171],-58.37723,-34.61315,{"lat":171,"lon":170},[174,177],{"name":175,"role":151,"phone":48,"phoneExt":48,"email":176},"Raquel Staciuk, MD PhD","rstaciuk@gmail.com",{"name":175,"role":178,"phone":48,"phoneExt":48,"email":48},"PRINCIPAL_INVESTIGATOR",{"facility":180,"status":163,"city":181,"state":48,"zip":182,"country":165,"countryCode":166,"cosmosGeoPoint":183,"geoPoint":187,"contacts":188},"Hospital Sor Maria Ludovica, Department Hematology Stem Cell Transplant Unit","La Plata","1651",{"type":168,"coordinates":184},[185,186],-57.95442,-34.92126,{"lat":186,"lon":185},[189,192,194],{"name":190,"role":151,"phone":48,"phoneExt":48,"email":191},"Sandra Formisano, MD","sandraformisano@yahoo.com.ar",{"name":193,"role":178,"phone":48,"phoneExt":48,"email":48},"Sandra Formisano, MD PhD",{"name":195,"role":196,"phone":48,"phoneExt":48,"email":48},"Daniela Iglesias, MD PhD","SUB_INVESTIGATOR",{"facility":198,"status":199,"city":200,"state":48,"zip":201,"country":202,"countryCode":203,"cosmosGeoPoint":204,"geoPoint":208,"contacts":48},"Children's Cancer Centre The Royal Children's Hospital","ACTIVE_NOT_RECRUITING","Melbourne","3052","Australia","AU",{"type":168,"coordinates":205},[206,207],144.96332,-37.814,{"lat":207,"lon":206},{"facility":210,"status":199,"city":211,"state":48,"zip":212,"country":202,"countryCode":203,"cosmosGeoPoint":213,"geoPoint":217,"contacts":48},"Princess Margaret Hospital for Children","Perth","6008",{"type":168,"coordinates":214},[215,216],115.8614,-31.95224,{"lat":216,"lon":215},{"facility":219,"status":199,"city":220,"state":48,"zip":221,"country":202,"countryCode":203,"cosmosGeoPoint":222,"geoPoint":226,"contacts":48},"Sydney Children's Hospital","Randwick","2031",{"type":168,"coordinates":223},[224,225],151.24895,-33.91439,{"lat":225,"lon":224},{"facility":228,"status":199,"city":229,"state":48,"zip":230,"country":202,"countryCode":203,"cosmosGeoPoint":231,"geoPoint":235,"contacts":48},"Lady Cilento Children's Hospital","South Brisbane","4101",{"type":168,"coordinates":232},[233,234],153.02049,-27.48034,{"lat":234,"lon":233},{"facility":237,"status":199,"city":238,"state":48,"zip":239,"country":202,"countryCode":203,"cosmosGeoPoint":240,"geoPoint":244,"contacts":48},"The Children's Hospital at Westmead Oncology Unit","Sydney","2145",{"type":168,"coordinates":241},[242,243],151.20732,-33.86785,{"lat":243,"lon":242},{"facility":246,"status":163,"city":247,"state":48,"zip":248,"country":249,"countryCode":250,"cosmosGeoPoint":251,"geoPoint":255,"contacts":256},"Universitätsklinik für Kinder- und Jugendheilkunde, Abt. f. Hämato-Onkologie","Graz","8036","Austria","AT",{"type":168,"coordinates":252},[253,254],15.44197,47.06733,{"lat":254,"lon":253},[257,260,261],{"name":258,"role":151,"phone":48,"phoneExt":48,"email":259},"Wolfgang Schwinger, MD PhD","wolfgang.schwinger@medunigraz.at",{"name":258,"role":178,"phone":48,"phoneExt":48,"email":48},{"name":262,"role":196,"phone":48,"phoneExt":48,"email":48},"Daniela Sperl, MD",{"facility":264,"status":163,"city":265,"state":48,"zip":266,"country":249,"countryCode":250,"cosmosGeoPoint":267,"geoPoint":271,"contacts":272},"Universitätsklinik für Kinder- und Jugendheilkunde","Innsbruck","6020",{"type":168,"coordinates":268},[269,270],11.39454,47.26266,{"lat":270,"lon":269},[273,276,277],{"name":274,"role":151,"phone":48,"phoneExt":48,"email":275},"Gabriele Kropshofer, MD PhD","gabriele.kropshofer@tirol-kliniken.at",{"name":274,"role":178,"phone":48,"phoneExt":48,"email":48},{"name":278,"role":196,"phone":48,"phoneExt":48,"email":48},"Bernhard Meister, MD",{"facility":280,"status":163,"city":281,"state":48,"zip":282,"country":249,"countryCode":250,"cosmosGeoPoint":283,"geoPoint":287,"contacts":288},"St. Anna Children's Hospital, Vienna, Austria","Vienna","1090",{"type":168,"coordinates":284},[285,286],16.37208,48.20849,{"lat":286,"lon":285},[289,292,293,294,296],{"name":290,"role":151,"phone":48,"phoneExt":48,"email":291},"Herbert Pichler, MD","herbert.pichler@stanna.at",{"name":291,"role":151,"phone":48,"phoneExt":48,"email":48},{"name":290,"role":178,"phone":48,"phoneExt":48,"email":48},{"name":295,"role":196,"phone":48,"phoneExt":48,"email":48},"Roswitha Lüftinger, MD",{"name":297,"role":196,"phone":48,"phoneExt":48,"email":48},"Elisabeth Salzer, MD",{"facility":299,"status":199,"city":300,"state":48,"zip":48,"country":301,"countryCode":302,"cosmosGeoPoint":303,"geoPoint":307,"contacts":48},"Belarusian Research Center for Pediatric Oncology, Hematology and Immunology","Minsk","Belarus","BY",{"type":168,"coordinates":304},[305,306],27.56653,53.90019,{"lat":306,"lon":305},{"facility":309,"status":163,"city":310,"state":48,"zip":311,"country":312,"countryCode":313,"cosmosGeoPoint":314,"geoPoint":318,"contacts":319},"Hôpital Universitaire des Enfants Reine Fabiola (HUDERF)","Brussels","1020","Belgium","BE",{"type":168,"coordinates":315},[316,317],4.34878,50.85045,{"lat":317,"lon":316},[320,322],{"name":321,"role":151,"phone":48,"phoneExt":48,"email":48},"Pauline Mazilier, MD",{"name":321,"role":178,"phone":48,"phoneExt":48,"email":48},{"facility":324,"status":163,"city":310,"state":48,"zip":325,"country":312,"countryCode":313,"cosmosGeoPoint":326,"geoPoint":328,"contacts":329},"Cliniques Universitaires Saint-Luc (UCL) Hématologie et oncologie pédiatrique","1200",{"type":168,"coordinates":327},[316,317],{"lat":317,"lon":316},[330,333],{"name":331,"role":151,"phone":48,"phoneExt":48,"email":332},"Benedicte Brichard, MD PhD","benedicte.brichard@uclouvain.be",{"name":331,"role":178,"phone":48,"phoneExt":48,"email":48},{"facility":335,"status":163,"city":336,"state":48,"zip":337,"country":312,"countryCode":313,"cosmosGeoPoint":338,"geoPoint":342,"contacts":343},"University Hospital Gent Pediatrische hemato-oncologie","Ghent","9000",{"type":168,"coordinates":339},[340,341],3.71667,51.05,{"lat":341,"lon":340},[344,347],{"name":345,"role":151,"phone":48,"phoneExt":48,"email":346},"Viktoria Bourdon, MD, PhD","vicotria.bordon@uzgent.be",{"name":345,"role":178,"phone":48,"phoneExt":48,"email":48},{"facility":349,"status":163,"city":350,"state":48,"zip":351,"country":312,"countryCode":313,"cosmosGeoPoint":352,"geoPoint":356,"contacts":357},"University Hospitals Leuven Kinderhemato-oncologie","Leuven","3000",{"type":168,"coordinates":353},[354,355],4.70093,50.87959,{"lat":355,"lon":354},[358,361],{"name":359,"role":151,"phone":48,"phoneExt":48,"email":360},"Marleen Renard, MD PhD","marleen.renard@uzleuven.be",{"name":359,"role":178,"phone":48,"phoneExt":48,"email":48},{"facility":363,"status":163,"city":364,"state":48,"zip":48,"country":312,"countryCode":313,"cosmosGeoPoint":365,"geoPoint":369,"contacts":370},"Centre Hospitalier Universitaire de Liège Domaine Universitaire du Sart Tilman","Liège",{"type":168,"coordinates":366},[367,368],5.56749,50.63373,{"lat":368,"lon":367},[371,374],{"name":372,"role":151,"phone":48,"phoneExt":48,"email":373},"Marie Françoise Dresse, MD PhD","marie.francoise.dresse@chrcitadelle.be",{"name":372,"role":178,"phone":48,"phoneExt":48,"email":48},{"facility":376,"status":199,"city":377,"state":48,"zip":48,"country":378,"countryCode":379,"cosmosGeoPoint":380,"geoPoint":384,"contacts":48},"Alberta Children's Hospital Division of Pediatric Oncology","Calgary","Canada","CA",{"type":168,"coordinates":381},[382,383],-114.08529,51.05011,{"lat":383,"lon":382},{"facility":386,"status":199,"city":387,"state":48,"zip":48,"country":378,"countryCode":379,"cosmosGeoPoint":48,"geoPoint":48,"contacts":48},"Montreal Children's Hospital","Montral",{"facility":389,"status":199,"city":390,"state":48,"zip":48,"country":378,"countryCode":379,"cosmosGeoPoint":391,"geoPoint":395,"contacts":48},"CHU Sainte-Justine Hematology-Oncology Division","Montreal",{"type":168,"coordinates":392},[393,394],-73.58781,45.50884,{"lat":394,"lon":393},{"facility":397,"status":398,"city":399,"state":48,"zip":48,"country":378,"countryCode":379,"cosmosGeoPoint":400,"geoPoint":404,"contacts":48},"Hospital for Sick Children University of Toronto Division of 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