[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100560767":3},{"organization":4,"outcomesModule":7,"designInfo":33,"detailedDescription":25,"studyPopulation":25,"armGroups":39,"interventions":45,"overallOfficials":25,"centralContacts":52,"locations":57,"responsibleParty":1082,"collaborators":25,"id":1084,"slug":1085,"hasResults":1086,"nctId":1087,"briefTitle":1088,"officialTitle":1089,"acronym":25,"eligibilityCriteria":1090,"healthyVolunteers":1086,"sex":1091,"minAge":1092,"maxAge":25,"enrollmentInfo":1093,"targetDuration":25,"studyType":1096,"phases":1097,"briefSummary":1099,"conditions":1100,"keywords":25,"overallStatus":60,"whyStopped":25,"lastUpdateSubmitDate":1102,"lastUpdatePostDateStruct":1103,"startDateStruct":1106,"completionDateStruct":1108,"leadSponsor":1110,"locationsCount":1111},{"fullName":5,"class":6},"Boehringer Ingelheim","INDUSTRY",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":25},[9],{"measure":10,"description":11,"timeFrame":12},"Proportion of patients with objective response (OR)","according to Response Evaluation Criteria in Solid Tumours (RECIST) 1.1 by central independent review, and it will be summarised descriptively as absolute and relative frequencies","Up to 51 months",[14,17,20,23,26,30],{"measure":15,"description":16,"timeFrame":12},"Duration of objective response (DOR)","Duration of objective response (DOR) is defined as the time from first documented Objective response (OR) according to RECIST 1.1 until the earliest date of disease progression or death among patients with confirmed OR, assessed by central independent review.",{"measure":18,"description":19,"timeFrame":12},"Progression-Free Survival (PFS)","PFS is defined as the time from treatment start until the earliest date of tumour progression according to RECIST 1.1 assessed by central independent review, or death from any cause, whichever occurs first.",{"measure":21,"description":22,"timeFrame":12},"Disease control (DC)","Disease control (DC) is defined as best overall response (BOR) of complete response (CR) or partial response (PR) or stable disease (SD) where BOR is defined according to RECIST 1.1 from first treatment administration until the earliest of disease progression, death, or last evaluable tumour assessment before the start of subsequent anti-cancer therapy, or treatment discontinuation, as assessed by central independent review.",{"measure":24,"description":25,"timeFrame":12},"Occurrence of treatment-emergent Adverse Events (AEs)",null,{"measure":27,"description":28,"timeFrame":29},"Change from baseline to Week 48 or progressive disease (PD) by central independent review, if earlier, of the EORTC QLQ-C30, which includes IL-19, the physical functioning scale","QLQ-C30 incorporates both multi-items scales and single-item measures. These include 1 global health status\u002FQoL scale, 5 functional scales, 3 symptoms scales and 6 single items to assess dyspnoea, insomnia, appetite loss, constipation, diarrhoea, and financial difficulties. Each of the multi-item scales includes a different set of items - no item occurs in more than one scale. European Organisation for Research and Treatment of Cancer, quality-of-life questionnaire (EORTC QLQ-C30) does not produce a single overall summary score by default. Scores can be reported via domain-specific scores or summary score (since 2016) ranging from 0 to 100 with higher scores representing a better QoL.","At baseline and up to 48 weeks",{"measure":31,"description":32,"timeFrame":12},"Overall survival (OS)","OR is defined as the time from start of treatment to death from any cause",{"allocation":34,"interventionModel":35,"interventionModelDescription":25,"primaryPurpose":36,"observationalModel":25,"timePerspective":25,"maskingInfo":37},"NA","SINGLE_GROUP","TREATMENT",{"masking":38,"maskingDescription":25,"whoMasked":25},"NONE",[40],{"label":41,"type":42,"description":25,"interventionNames":43},"Zongertinib treatment","EXPERIMENTAL",[44],"Drug: Zongertinib",[46],{"type":47,"name":48,"description":48,"armGroupLabels":49,"otherNames":50},"DRUG","Zongertinib",[41],[51],"BI 1810631, Hernexeos®",[53],{"name":5,"role":54,"phone":55,"phoneExt":25,"email":56},"CONTACT","1-800-243-0127","clintriage.rdg@boehringer-ingelheim.com",[58,76,87,99,110,121,133,145,157,169,181,191,203,214,222,234,246,258,269,280,292,308,319,331,343,355,370,381,397,409,421,433,439,454,466,477,488,499,510,521,529,540,548,559,574,585,594,605,616,627,642,653,664,675,684,695,710,721,732,743,754,765,775,781,787,798,804,810,821,827,833,848,859,874,888,902,916,924,932,940,955,966,977,985,993,1004,1012,1023,1034,1045,1060,1071],{"facility":59,"status":60,"city":61,"state":62,"zip":63,"country":64,"countryCode":65,"cosmosGeoPoint":66,"geoPoint":71,"contacts":72},"Alaska Oncology and Hematology, LLC","RECRUITING","Anchorage","Alaska","99508","United States","US",{"type":67,"coordinates":68},"Point",[69,70],-149.90028,61.21806,{"lat":70,"lon":69},[73],{"name":5,"role":54,"phone":74,"phoneExt":25,"email":75},"833-602-2368","unitedstates@bitrialsupport.com",{"facility":77,"status":78,"city":79,"state":80,"zip":81,"country":64,"countryCode":65,"cosmosGeoPoint":82,"geoPoint":86,"contacts":25},"University of Arizona Comprehensive Cancer Center","COMPLETED","Tucson","Arizona","85719",{"type":67,"coordinates":83},[84,85],-110.92648,32.22174,{"lat":85,"lon":84},{"facility":88,"status":60,"city":89,"state":90,"zip":91,"country":64,"countryCode":65,"cosmosGeoPoint":92,"geoPoint":96,"contacts":97},"Precision NextGen Oncology","Beverly Hills","California","90212",{"type":67,"coordinates":93},[94,95],-118.40036,34.07362,{"lat":95,"lon":94},[98],{"name":5,"role":54,"phone":74,"phoneExt":25,"email":75},{"facility":100,"status":60,"city":101,"state":90,"zip":102,"country":64,"countryCode":65,"cosmosGeoPoint":103,"geoPoint":107,"contacts":108},"Scripps Cancer Center Torrey Pines","La Jolla","92037",{"type":67,"coordinates":104},[105,106],-117.2742,32.84727,{"lat":106,"lon":105},[109],{"name":5,"role":54,"phone":74,"phoneExt":25,"email":75},{"facility":111,"status":60,"city":112,"state":90,"zip":113,"country":64,"countryCode":65,"cosmosGeoPoint":114,"geoPoint":118,"contacts":119},"Valkyrie Clinical Trials","Los Angeles","90067",{"type":67,"coordinates":115},[116,117],-118.24368,34.05223,{"lat":117,"lon":116},[120],{"name":5,"role":54,"phone":74,"phoneExt":25,"email":75},{"facility":122,"status":60,"city":123,"state":124,"zip":125,"country":64,"countryCode":65,"cosmosGeoPoint":126,"geoPoint":130,"contacts":131},"Yale University School of Medicine","New Haven","Connecticut","06511",{"type":67,"coordinates":127},[128,129],-72.92816,41.30815,{"lat":129,"lon":128},[132],{"name":5,"role":54,"phone":74,"phoneExt":25,"email":75},{"facility":134,"status":60,"city":135,"state":136,"zip":137,"country":64,"countryCode":65,"cosmosGeoPoint":138,"geoPoint":142,"contacts":143},"BRCR Global - Tamarac","Tamarac","Florida","33321",{"type":67,"coordinates":139},[140,141],-80.24977,26.21286,{"lat":141,"lon":140},[144],{"name":5,"role":54,"phone":74,"phoneExt":25,"email":75},{"facility":146,"status":60,"city":147,"state":148,"zip":149,"country":64,"countryCode":65,"cosmosGeoPoint":150,"geoPoint":154,"contacts":155},"Illinois Cancer Specialists","Arlington Heights","Illinois","60005",{"type":67,"coordinates":151},[152,153],-87.98063,42.08836,{"lat":153,"lon":152},[156],{"name":5,"role":54,"phone":74,"phoneExt":25,"email":75},{"facility":158,"status":60,"city":159,"state":160,"zip":161,"country":64,"countryCode":65,"cosmosGeoPoint":162,"geoPoint":166,"contacts":167},"Community MD Anderson Cancer Center - East Medical Oncology","Indianapolis","Indiana","46219",{"type":67,"coordinates":163},[164,165],-86.15804,39.76838,{"lat":165,"lon":164},[168],{"name":5,"role":54,"phone":74,"phoneExt":25,"email":75},{"facility":170,"status":60,"city":171,"state":172,"zip":173,"country":64,"countryCode":65,"cosmosGeoPoint":174,"geoPoint":178,"contacts":179},"Maryland Oncology Hematology, Columbia","Columbia","Maryland","21044",{"type":67,"coordinates":175},[176,177],-76.83942,39.24038,{"lat":177,"lon":176},[180],{"name":5,"role":54,"phone":74,"phoneExt":25,"email":75},{"facility":182,"status":78,"city":183,"state":184,"zip":185,"country":64,"countryCode":65,"cosmosGeoPoint":186,"geoPoint":190,"contacts":25},"Karmanos Cancer Institute","Detroit","Michigan","48201",{"type":67,"coordinates":187},[188,189],-83.04575,42.33143,{"lat":189,"lon":188},{"facility":192,"status":60,"city":193,"state":194,"zip":195,"country":64,"countryCode":65,"cosmosGeoPoint":196,"geoPoint":200,"contacts":201},"Presbyterian Healthcare Services","Albuquerque","New Mexico","87110",{"type":67,"coordinates":197},[198,199],-106.65114,35.08449,{"lat":199,"lon":198},[202],{"name":5,"role":54,"phone":74,"phoneExt":25,"email":75},{"facility":204,"status":60,"city":205,"state":205,"zip":206,"country":64,"countryCode":65,"cosmosGeoPoint":207,"geoPoint":211,"contacts":212},"Icahn School of Medicine at Mount Sinai","New York","10029",{"type":67,"coordinates":208},[209,210],-74.00597,40.71427,{"lat":210,"lon":209},[213],{"name":5,"role":54,"phone":74,"phoneExt":25,"email":75},{"facility":215,"status":60,"city":205,"state":205,"zip":216,"country":64,"countryCode":65,"cosmosGeoPoint":217,"geoPoint":219,"contacts":220},"Memorial Sloan-Kettering Cancer Center","10065",{"type":67,"coordinates":218},[209,210],{"lat":210,"lon":209},[221],{"name":5,"role":54,"phone":74,"phoneExt":25,"email":75},{"facility":223,"status":60,"city":224,"state":225,"zip":226,"country":64,"countryCode":65,"cosmosGeoPoint":227,"geoPoint":231,"contacts":232},"Taylor Cancer Research Center","Maumee","Ohio","43537",{"type":67,"coordinates":228},[229,230],-83.65382,41.56283,{"lat":230,"lon":229},[233],{"name":5,"role":54,"phone":74,"phoneExt":25,"email":75},{"facility":235,"status":60,"city":236,"state":237,"zip":238,"country":64,"countryCode":65,"cosmosGeoPoint":239,"geoPoint":243,"contacts":244},"Alliance Cancer Specialists, PC, Wynnewood","Wynnewood","Pennsylvania","19096",{"type":67,"coordinates":240},[241,242],-75.27074,40.00289,{"lat":242,"lon":241},[245],{"name":5,"role":54,"phone":74,"phoneExt":25,"email":75},{"facility":247,"status":60,"city":248,"state":249,"zip":250,"country":64,"countryCode":65,"cosmosGeoPoint":251,"geoPoint":255,"contacts":256},"Sarah Cannon Research Institute at Mary Crowley","Dallas","Texas","75230",{"type":67,"coordinates":252},[253,254],-96.80667,32.78306,{"lat":254,"lon":253},[257],{"name":5,"role":54,"phone":74,"phoneExt":25,"email":75},{"facility":259,"status":60,"city":260,"state":249,"zip":261,"country":64,"countryCode":65,"cosmosGeoPoint":262,"geoPoint":266,"contacts":267},"The University of Texas MD Anderson Cancer Center","Houston","77030",{"type":67,"coordinates":263},[264,265],-95.36327,29.76328,{"lat":265,"lon":264},[268],{"name":5,"role":54,"phone":74,"phoneExt":25,"email":75},{"facility":270,"status":60,"city":271,"state":249,"zip":272,"country":64,"countryCode":65,"cosmosGeoPoint":273,"geoPoint":277,"contacts":278},"Texas Oncology - Plano West","Plano","75093",{"type":67,"coordinates":274},[275,276],-96.69889,33.01984,{"lat":276,"lon":275},[279],{"name":5,"role":54,"phone":74,"phoneExt":25,"email":75},{"facility":281,"status":60,"city":282,"state":283,"zip":284,"country":64,"countryCode":65,"cosmosGeoPoint":285,"geoPoint":289,"contacts":290},"Virginia Cancer Specialists, PC","Fairfax","Virginia","22031",{"type":67,"coordinates":286},[287,288],-77.30637,38.84622,{"lat":288,"lon":287},[291],{"name":5,"role":54,"phone":74,"phoneExt":25,"email":75},{"facility":293,"status":60,"city":294,"state":295,"zip":296,"country":297,"countryCode":298,"cosmosGeoPoint":299,"geoPoint":303,"contacts":304},"Macquarie University","Macquarie Park","New South Wales","2109","Australia","AU",{"type":67,"coordinates":300},[301,302],151.12757,-33.78105,{"lat":302,"lon":301},[305],{"name":5,"role":54,"phone":306,"phoneExt":25,"email":307},"1800271035","australia@bitrialsupport.com",{"facility":309,"status":60,"city":310,"state":295,"zip":311,"country":297,"countryCode":298,"cosmosGeoPoint":312,"geoPoint":316,"contacts":317},"GenesisCare North Shore","St Leonards","2065",{"type":67,"coordinates":313},[314,315],151.19836,-33.82344,{"lat":315,"lon":314},[318],{"name":5,"role":54,"phone":306,"phoneExt":25,"email":307},{"facility":320,"status":60,"city":321,"state":322,"zip":323,"country":297,"countryCode":298,"cosmosGeoPoint":324,"geoPoint":328,"contacts":329},"Princess Alexandra Hospital","Woolloongabba","Queensland","4102",{"type":67,"coordinates":325},[326,327],153.03655,-27.48855,{"lat":327,"lon":326},[330],{"name":5,"role":54,"phone":306,"phoneExt":25,"email":307},{"facility":332,"status":60,"city":333,"state":334,"zip":335,"country":297,"countryCode":298,"cosmosGeoPoint":336,"geoPoint":340,"contacts":341},"Cancer Research South Australia","Adelaide","South Australia","5000",{"type":67,"coordinates":337},[338,339],138.59863,-34.92866,{"lat":339,"lon":338},[342],{"name":5,"role":54,"phone":306,"phoneExt":25,"email":307},{"facility":344,"status":60,"city":345,"state":346,"zip":347,"country":297,"countryCode":298,"cosmosGeoPoint":348,"geoPoint":352,"contacts":353},"St John of God Subiaco Hospital","Subiaco","Western Australia","6008",{"type":67,"coordinates":349},[350,351],115.8268,-31.9485,{"lat":351,"lon":350},[354],{"name":5,"role":54,"phone":306,"phoneExt":25,"email":307},{"facility":356,"status":60,"city":357,"state":25,"zip":358,"country":359,"countryCode":360,"cosmosGeoPoint":361,"geoPoint":365,"contacts":366},"Cliniques Universitaires Saint-Luc","Brussels","1200","Belgium","BE",{"type":67,"coordinates":362},[363,364],4.34878,50.85045,{"lat":364,"lon":363},[367],{"name":5,"role":54,"phone":368,"phoneExt":25,"email":369},"080049616","belgique@bitrialsupport.com",{"facility":371,"status":60,"city":372,"state":25,"zip":373,"country":359,"countryCode":360,"cosmosGeoPoint":374,"geoPoint":378,"contacts":379},"Universitair Ziekenhuis Antwerpen","Edegem","2650",{"type":67,"coordinates":375},[376,377],4.44504,51.15662,{"lat":377,"lon":376},[380],{"name":5,"role":54,"phone":368,"phoneExt":25,"email":369},{"facility":382,"status":60,"city":383,"state":384,"zip":385,"country":386,"countryCode":387,"cosmosGeoPoint":388,"geoPoint":392,"contacts":393},"Cross Cancer Institute (University of Alberta)","Edmonton","Alberta","T6G 1Z2","Canada","CA",{"type":67,"coordinates":389},[390,391],-113.46871,53.55014,{"lat":391,"lon":390},[394],{"name":5,"role":54,"phone":395,"phoneExt":25,"email":396},"18336022346","canada@bitrialsupport.com",{"facility":398,"status":60,"city":399,"state":400,"zip":401,"country":386,"countryCode":387,"cosmosGeoPoint":402,"geoPoint":406,"contacts":407},"BC Cancer Agency - Vancouver","Vancouver","British Columbia","V5Z 4E6",{"type":67,"coordinates":403},[404,405],-123.11934,49.24966,{"lat":405,"lon":404},[408],{"name":5,"role":54,"phone":395,"phoneExt":25,"email":396},{"facility":410,"status":60,"city":411,"state":412,"zip":413,"country":386,"countryCode":387,"cosmosGeoPoint":414,"geoPoint":418,"contacts":419},"Princess Margaret Cancer Centre","Toronto","Ontario","M5G 2M9",{"type":67,"coordinates":415},[416,417],-79.39864,43.70643,{"lat":417,"lon":416},[420],{"name":5,"role":54,"phone":395,"phoneExt":25,"email":396},{"facility":422,"status":60,"city":423,"state":424,"zip":425,"country":386,"countryCode":387,"cosmosGeoPoint":426,"geoPoint":430,"contacts":431},"Centre Hospitalier de l'Universite de Montreal (CHUM)","Montreal","Quebec","H2X 0A9",{"type":67,"coordinates":427},[428,429],-73.58781,45.50884,{"lat":429,"lon":428},[432],{"name":5,"role":54,"phone":395,"phoneExt":25,"email":396},{"facility":434,"status":78,"city":423,"state":424,"zip":435,"country":386,"countryCode":387,"cosmosGeoPoint":436,"geoPoint":438,"contacts":25},"McGill University Health Centre (MUHC)","H4A 3J1",{"type":67,"coordinates":437},[428,429],{"lat":429,"lon":428},{"facility":440,"status":60,"city":441,"state":25,"zip":442,"country":443,"countryCode":444,"cosmosGeoPoint":445,"geoPoint":449,"contacts":450},"Peking University First Hospital","Beijing","100034","China","CN",{"type":67,"coordinates":446},[447,448],116.39723,39.9075,{"lat":448,"lon":447},[451],{"name":5,"role":54,"phone":452,"phoneExt":25,"email":453},"4001200553","china@bitrialsupport.com",{"facility":455,"status":456,"city":457,"state":25,"zip":458,"country":443,"countryCode":444,"cosmosGeoPoint":459,"geoPoint":463,"contacts":464},"Hunan Province Tumor Hospital","NOT_YET_RECRUITING","Changsha","410013",{"type":67,"coordinates":460},[461,462],112.97087,28.19874,{"lat":462,"lon":461},[465],{"name":5,"role":54,"phone":452,"phoneExt":25,"email":453},{"facility":467,"status":60,"city":468,"state":25,"zip":469,"country":443,"countryCode":444,"cosmosGeoPoint":470,"geoPoint":474,"contacts":475},"Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine","Hangzhou","310016",{"type":67,"coordinates":471},[472,473],120.16142,30.29365,{"lat":473,"lon":472},[476],{"name":5,"role":54,"phone":452,"phoneExt":25,"email":453},{"facility":478,"status":60,"city":479,"state":25,"zip":480,"country":443,"countryCode":444,"cosmosGeoPoint":481,"geoPoint":485,"contacts":486},"Anhui Provincial Cancer Hospital","Hefei","230001",{"type":67,"coordinates":482},[483,484],117.28083,31.86389,{"lat":484,"lon":483},[487],{"name":5,"role":54,"phone":452,"phoneExt":25,"email":453},{"facility":489,"status":60,"city":490,"state":25,"zip":491,"country":443,"countryCode":444,"cosmosGeoPoint":492,"geoPoint":496,"contacts":497},"The First Affiliated Hospital of Nanchang University","Nanchang","330006",{"type":67,"coordinates":493},[494,495],115.85306,28.68396,{"lat":495,"lon":494},[498],{"name":5,"role":54,"phone":452,"phoneExt":25,"email":453},{"facility":500,"status":456,"city":501,"state":25,"zip":502,"country":443,"countryCode":444,"cosmosGeoPoint":503,"geoPoint":507,"contacts":508},"Nanjing Drum Tower Hospital","Nanjing","210008",{"type":67,"coordinates":504},[505,506],118.77778,32.06167,{"lat":506,"lon":505},[509],{"name":5,"role":54,"phone":452,"phoneExt":25,"email":453},{"facility":511,"status":60,"city":512,"state":25,"zip":513,"country":443,"countryCode":444,"cosmosGeoPoint":514,"geoPoint":518,"contacts":519},"Shanghai East Hospital","Shanghai","200120",{"type":67,"coordinates":515},[516,517],121.45806,31.22222,{"lat":517,"lon":516},[520],{"name":5,"role":54,"phone":452,"phoneExt":25,"email":453},{"facility":522,"status":60,"city":512,"state":25,"zip":523,"country":443,"countryCode":444,"cosmosGeoPoint":524,"geoPoint":526,"contacts":527},"Shanghai GoBroad Cancer Hospital","200131",{"type":67,"coordinates":525},[516,517],{"lat":517,"lon":516},[528],{"name":5,"role":54,"phone":452,"phoneExt":25,"email":453},{"facility":530,"status":60,"city":531,"state":25,"zip":532,"country":443,"countryCode":444,"cosmosGeoPoint":533,"geoPoint":537,"contacts":538},"Union Hospital Tongji Medical College Huazhong University of Science and Technology","Wuhan","430022",{"type":67,"coordinates":534},[535,536],114.26667,30.58333,{"lat":536,"lon":535},[539],{"name":5,"role":54,"phone":452,"phoneExt":25,"email":453},{"facility":541,"status":456,"city":531,"state":25,"zip":542,"country":443,"countryCode":444,"cosmosGeoPoint":543,"geoPoint":545,"contacts":546},"Tongji Hospital Affiliated Tongji Medical College Huazhong University of S & T","430030",{"type":67,"coordinates":544},[535,536],{"lat":536,"lon":535},[547],{"name":5,"role":54,"phone":452,"phoneExt":25,"email":453},{"facility":549,"status":60,"city":550,"state":25,"zip":551,"country":443,"countryCode":444,"cosmosGeoPoint":552,"geoPoint":556,"contacts":557},"Henan Cancer Hospital","Zhengzhou","450008",{"type":67,"coordinates":553},[554,555],113.64861,34.75778,{"lat":555,"lon":554},[558],{"name":5,"role":54,"phone":452,"phoneExt":25,"email":453},{"facility":560,"status":60,"city":561,"state":25,"zip":562,"country":563,"countryCode":564,"cosmosGeoPoint":565,"geoPoint":569,"contacts":570},"INS Bergonie","Bordeaux","33000","France","FR",{"type":67,"coordinates":566},[567,568],-0.58046,44.84124,{"lat":568,"lon":567},[571],{"name":5,"role":54,"phone":572,"phoneExt":25,"email":573},"0805102354","france@bitrialsupport.com",{"facility":575,"status":60,"city":576,"state":25,"zip":577,"country":563,"countryCode":564,"cosmosGeoPoint":578,"geoPoint":582,"contacts":583},"CTR Georges-François Leclerc","Dijon","21079",{"type":67,"coordinates":579},[580,581],5.01391,47.31344,{"lat":581,"lon":580},[584],{"name":5,"role":54,"phone":572,"phoneExt":25,"email":573},{"facility":586,"status":78,"city":587,"state":25,"zip":588,"country":563,"countryCode":564,"cosmosGeoPoint":589,"geoPoint":593,"contacts":25},"CTR Leon Berard","Lyon","69373",{"type":67,"coordinates":590},[591,592],4.84789,45.74906,{"lat":592,"lon":591},{"facility":595,"status":60,"city":596,"state":25,"zip":597,"country":563,"countryCode":564,"cosmosGeoPoint":598,"geoPoint":602,"contacts":603},"HOP Timone","Marseille","13385",{"type":67,"coordinates":599},[600,601],5.38107,43.29695,{"lat":601,"lon":600},[604],{"name":5,"role":54,"phone":572,"phoneExt":25,"email":573},{"facility":606,"status":60,"city":607,"state":25,"zip":608,"country":563,"countryCode":564,"cosmosGeoPoint":609,"geoPoint":613,"contacts":614},"HOP la Milétrie","Poitiers","86000",{"type":67,"coordinates":610},[611,612],0.34348,46.58261,{"lat":612,"lon":611},[615],{"name":5,"role":54,"phone":572,"phoneExt":25,"email":573},{"facility":617,"status":60,"city":618,"state":25,"zip":619,"country":563,"countryCode":564,"cosmosGeoPoint":620,"geoPoint":624,"contacts":625},"Institut Gustave Roussy","Villejuif","94805",{"type":67,"coordinates":621},[622,623],2.35992,48.7939,{"lat":623,"lon":622},[626],{"name":5,"role":54,"phone":572,"phoneExt":25,"email":573},{"facility":628,"status":60,"city":629,"state":25,"zip":630,"country":631,"countryCode":632,"cosmosGeoPoint":633,"geoPoint":637,"contacts":638},"Charité - Universitätsmedizin Berlin","Berlin","12203","Germany","DE",{"type":67,"coordinates":634},[635,636],13.41053,52.52437,{"lat":636,"lon":635},[639],{"name":5,"role":54,"phone":640,"phoneExt":25,"email":641},"08007234742","deutschland@bitrialsupport.com",{"facility":643,"status":60,"city":644,"state":25,"zip":645,"country":631,"countryCode":632,"cosmosGeoPoint":646,"geoPoint":650,"contacts":651},"Justus-Liebig Universität Gießen","Giessen","35392",{"type":67,"coordinates":647},[648,649],8.67554,50.58727,{"lat":649,"lon":648},[652],{"name":5,"role":54,"phone":640,"phoneExt":25,"email":641},{"facility":654,"status":60,"city":655,"state":25,"zip":656,"country":631,"countryCode":632,"cosmosGeoPoint":657,"geoPoint":661,"contacts":662},"Asklepios Kliniken GmbH & Co. KGaA","Hamburg","22763",{"type":67,"coordinates":658},[659,660],9.99302,53.55073,{"lat":660,"lon":659},[663],{"name":5,"role":54,"phone":640,"phoneExt":25,"email":641},{"facility":665,"status":60,"city":666,"state":25,"zip":667,"country":631,"countryCode":632,"cosmosGeoPoint":668,"geoPoint":672,"contacts":673},"Universität Leipzig","Leipzig","04103",{"type":67,"coordinates":669},[670,671],12.37129,51.33962,{"lat":671,"lon":670},[674],{"name":5,"role":54,"phone":640,"phoneExt":25,"email":641},{"facility":676,"status":78,"city":677,"state":25,"zip":678,"country":631,"countryCode":632,"cosmosGeoPoint":679,"geoPoint":683,"contacts":25},"Universitätsklinikum Mannheim GmbH","Mannheim","68167",{"type":67,"coordinates":680},[681,682],8.46694,49.4891,{"lat":682,"lon":681},{"facility":685,"status":60,"city":686,"state":25,"zip":687,"country":631,"countryCode":632,"cosmosGeoPoint":688,"geoPoint":692,"contacts":693},"Klinikum rechts der Isar der Technischen Universität München","München","81675",{"type":67,"coordinates":689},[690,691],13.31243,51.60698,{"lat":691,"lon":690},[694],{"name":5,"role":54,"phone":640,"phoneExt":25,"email":641},{"facility":696,"status":60,"city":697,"state":25,"zip":698,"country":699,"countryCode":700,"cosmosGeoPoint":701,"geoPoint":705,"contacts":706},"Az. Ospedaliere Umberto I di Ancona","Ancona","60020","Italy","IT",{"type":67,"coordinates":702},[703,704],13.5103,43.60717,{"lat":704,"lon":703},[707],{"name":5,"role":54,"phone":708,"phoneExt":25,"email":709},"800977373","italia@bitrialsupport.com",{"facility":711,"status":456,"city":712,"state":25,"zip":713,"country":699,"countryCode":700,"cosmosGeoPoint":714,"geoPoint":718,"contacts":719},"Centro di riferimento Oncologico","Aviano (PN)","33081",{"type":67,"coordinates":715},[716,717],12.59472,46.07056,{"lat":717,"lon":716},[720],{"name":5,"role":54,"phone":708,"phoneExt":25,"email":709},{"facility":722,"status":60,"city":723,"state":25,"zip":724,"country":699,"countryCode":700,"cosmosGeoPoint":725,"geoPoint":729,"contacts":730},"Istituto Scientifico Romagnolo","Meldola (FC)","47014",{"type":67,"coordinates":726},[727,728],12.0626,44.12775,{"lat":728,"lon":727},[731],{"name":5,"role":54,"phone":708,"phoneExt":25,"email":709},{"facility":733,"status":60,"city":734,"state":25,"zip":735,"country":699,"countryCode":700,"cosmosGeoPoint":736,"geoPoint":740,"contacts":741},"ASST Grande Ospedale Metropolitano Niguarda","Milan","20162",{"type":67,"coordinates":737},[738,739],12.59836,42.78235,{"lat":739,"lon":738},[742],{"name":5,"role":54,"phone":708,"phoneExt":25,"email":709},{"facility":744,"status":60,"city":745,"state":25,"zip":746,"country":699,"countryCode":700,"cosmosGeoPoint":747,"geoPoint":751,"contacts":752},"AOU Università degli Studi della Campania Luigi Vanvitelli","Naples","80131",{"type":67,"coordinates":748},[749,750],14.26811,40.85216,{"lat":750,"lon":749},[753],{"name":5,"role":54,"phone":708,"phoneExt":25,"email":709},{"facility":755,"status":60,"city":756,"state":25,"zip":757,"country":699,"countryCode":700,"cosmosGeoPoint":758,"geoPoint":762,"contacts":763},"Fondazione Policlinico Universitario Campus Bio-medico","Rome","00128",{"type":67,"coordinates":759},[760,761],12.51133,41.89193,{"lat":761,"lon":760},[764],{"name":5,"role":54,"phone":708,"phoneExt":25,"email":709},{"facility":766,"status":60,"city":767,"state":25,"zip":768,"country":769,"countryCode":770,"cosmosGeoPoint":25,"geoPoint":25,"contacts":771},"Aichi Cancer Center Hospital","Aichi, Nagoya","464-8681","Japan","JP",[772],{"name":5,"role":54,"phone":773,"phoneExt":25,"email":774},"05050508862","nippon@bitrialsupport.com",{"facility":776,"status":60,"city":777,"state":25,"zip":778,"country":769,"countryCode":770,"cosmosGeoPoint":25,"geoPoint":25,"contacts":779},"National Cancer Center Hospital East","Chiba, Kashiwa","277-8577",[780],{"name":5,"role":54,"phone":773,"phoneExt":25,"email":774},{"facility":782,"status":60,"city":783,"state":25,"zip":784,"country":769,"countryCode":770,"cosmosGeoPoint":25,"geoPoint":25,"contacts":785},"Kyushu University Hospital","Fukuoka, Fukuoka","812-8582",[786],{"name":5,"role":54,"phone":773,"phoneExt":25,"email":774},{"facility":788,"status":60,"city":789,"state":25,"zip":790,"country":769,"countryCode":770,"cosmosGeoPoint":791,"geoPoint":795,"contacts":796},"Hokkaido University Hospital","Hokkaido, Sapporo","060-8648",{"type":67,"coordinates":792},[793,794],141.35,43.06667,{"lat":794,"lon":793},[797],{"name":5,"role":54,"phone":773,"phoneExt":25,"email":774},{"facility":799,"status":60,"city":800,"state":25,"zip":801,"country":769,"countryCode":770,"cosmosGeoPoint":25,"geoPoint":25,"contacts":802},"Okayama University Hospital","Okayama, Okayama","700-8558",[803],{"name":5,"role":54,"phone":773,"phoneExt":25,"email":774},{"facility":805,"status":60,"city":806,"state":25,"zip":807,"country":769,"countryCode":770,"cosmosGeoPoint":25,"geoPoint":25,"contacts":808},"Osaka International Cancer Institute","Osaka, Osaka","541-8567",[809],{"name":5,"role":54,"phone":773,"phoneExt":25,"email":774},{"facility":811,"status":60,"city":812,"state":25,"zip":813,"country":769,"countryCode":770,"cosmosGeoPoint":814,"geoPoint":818,"contacts":819},"Shizuoka Cancer Center","Shizuoka, Sunto-gun","411-8777",{"type":67,"coordinates":815},[816,817],138.38333,34.98333,{"lat":817,"lon":816},[820],{"name":5,"role":54,"phone":773,"phoneExt":25,"email":774},{"facility":822,"status":60,"city":823,"state":25,"zip":824,"country":769,"countryCode":770,"cosmosGeoPoint":25,"geoPoint":25,"contacts":825},"National Cancer Center Hospital","Tokyo, Chuo-ku","104-0045",[826],{"name":5,"role":54,"phone":773,"phoneExt":25,"email":774},{"facility":828,"status":60,"city":829,"state":25,"zip":830,"country":769,"countryCode":770,"cosmosGeoPoint":25,"geoPoint":25,"contacts":831},"Japanese Foundation for Cancer Research","Tokyo, Koto-ku","135-8550",[832],{"name":5,"role":54,"phone":773,"phoneExt":25,"email":774},{"facility":834,"status":60,"city":835,"state":25,"zip":836,"country":837,"countryCode":838,"cosmosGeoPoint":839,"geoPoint":843,"contacts":844},"Nederlands Kanker Instituut","Amsterdam","1066 CX","Netherlands","NL",{"type":67,"coordinates":840},[841,842],4.88969,52.37403,{"lat":842,"lon":841},[845],{"name":5,"role":54,"phone":846,"phoneExt":25,"email":847},"08000204613","nederland@bitrialsupport.com",{"facility":849,"status":60,"city":850,"state":25,"zip":851,"country":837,"countryCode":838,"cosmosGeoPoint":852,"geoPoint":856,"contacts":857},"Radboud Universitair Medisch Centrum","Nijmegen","6525 GL",{"type":67,"coordinates":853},[854,855],5.85278,51.8425,{"lat":855,"lon":854},[858],{"name":5,"role":54,"phone":846,"phoneExt":25,"email":847},{"facility":860,"status":60,"city":861,"state":25,"zip":862,"country":863,"countryCode":864,"cosmosGeoPoint":865,"geoPoint":869,"contacts":870},"Oslo Universitetssykehus HF, Radiumhospitalet","Oslo","N-0379","Norway","NO",{"type":67,"coordinates":866},[867,868],10.74609,59.91273,{"lat":868,"lon":867},[871],{"name":5,"role":54,"phone":872,"phoneExt":25,"email":873},"80058261","norge@bitrialsupport.com",{"facility":875,"status":60,"city":876,"state":25,"zip":877,"country":878,"countryCode":879,"cosmosGeoPoint":880,"geoPoint":884,"contacts":885},"Pan American Center for Oncology Trials, LLC","Rio Piedras","00935","Puerto Rico","PR",{"type":67,"coordinates":881},[882,883],-66.04989,18.39745,{"lat":883,"lon":882},[886],{"name":5,"role":54,"phone":887,"phoneExt":25,"email":75},"18336022368",{"facility":889,"status":60,"city":890,"state":25,"zip":891,"country":890,"countryCode":892,"cosmosGeoPoint":893,"geoPoint":897,"contacts":898},"National Cancer Centre Singapore","Singapore","168583","SG",{"type":67,"coordinates":894},[895,896],103.85007,1.28967,{"lat":896,"lon":895},[899],{"name":5,"role":54,"phone":900,"phoneExt":25,"email":901},"8001207344","singapore@bitrialsupport.com",{"facility":903,"status":60,"city":904,"state":25,"zip":905,"country":906,"countryCode":25,"cosmosGeoPoint":907,"geoPoint":911,"contacts":912},"Seoul National University Hospital","Seoul","03080","South Korea",{"type":67,"coordinates":908},[909,910],126.9784,37.566,{"lat":910,"lon":909},[913],{"name":5,"role":54,"phone":914,"phoneExt":25,"email":915},"0808802084","namhan@bitrialsupport.com",{"facility":917,"status":60,"city":904,"state":25,"zip":918,"country":906,"countryCode":25,"cosmosGeoPoint":919,"geoPoint":921,"contacts":922},"Severance Hospital","03722",{"type":67,"coordinates":920},[909,910],{"lat":910,"lon":909},[923],{"name":5,"role":54,"phone":914,"phoneExt":25,"email":915},{"facility":925,"status":60,"city":904,"state":25,"zip":926,"country":906,"countryCode":25,"cosmosGeoPoint":927,"geoPoint":929,"contacts":930},"Asan Medical Center","05505",{"type":67,"coordinates":928},[909,910],{"lat":910,"lon":909},[931],{"name":5,"role":54,"phone":914,"phoneExt":25,"email":915},{"facility":933,"status":60,"city":904,"state":25,"zip":934,"country":906,"countryCode":25,"cosmosGeoPoint":935,"geoPoint":937,"contacts":938},"Samsung Medical Center","135-710",{"type":67,"coordinates":936},[909,910],{"lat":910,"lon":909},[939],{"name":5,"role":54,"phone":914,"phoneExt":25,"email":915},{"facility":941,"status":60,"city":942,"state":25,"zip":943,"country":944,"countryCode":945,"cosmosGeoPoint":946,"geoPoint":950,"contacts":951},"Complejo Hospitalario Universitario A Coruña","A Coruña","15006","Spain","ES",{"type":67,"coordinates":947},[948,949],-8.396,43.37135,{"lat":949,"lon":948},[952],{"name":5,"role":54,"phone":953,"phoneExt":25,"email":954},"900876092","espana@bitrialsupport.com",{"facility":956,"status":456,"city":957,"state":25,"zip":958,"country":944,"countryCode":945,"cosmosGeoPoint":959,"geoPoint":963,"contacts":964},"Hospital Germans Trias i Pujol","Badalona","08916",{"type":67,"coordinates":960},[961,962],2.24741,41.45004,{"lat":962,"lon":961},[965],{"name":5,"role":54,"phone":953,"phoneExt":25,"email":954},{"facility":967,"status":60,"city":968,"state":25,"zip":969,"country":944,"countryCode":945,"cosmosGeoPoint":970,"geoPoint":974,"contacts":975},"Hospital del Mar","Barcelona","08003",{"type":67,"coordinates":971},[972,973],2.15899,41.38879,{"lat":973,"lon":972},[976],{"name":5,"role":54,"phone":953,"phoneExt":25,"email":954},{"facility":978,"status":60,"city":968,"state":25,"zip":979,"country":944,"countryCode":945,"cosmosGeoPoint":980,"geoPoint":982,"contacts":983},"Hospital Universitari Vall d'Hebron","08035",{"type":67,"coordinates":981},[972,973],{"lat":973,"lon":972},[984],{"name":5,"role":54,"phone":953,"phoneExt":25,"email":954},{"facility":986,"status":456,"city":968,"state":25,"zip":987,"country":944,"countryCode":945,"cosmosGeoPoint":988,"geoPoint":990,"contacts":991},"Hospital Duran i Reynals","08908",{"type":67,"coordinates":989},[972,973],{"lat":973,"lon":972},[992],{"name":5,"role":54,"phone":953,"phoneExt":25,"email":954},{"facility":994,"status":60,"city":995,"state":25,"zip":996,"country":944,"countryCode":945,"cosmosGeoPoint":997,"geoPoint":1001,"contacts":1002},"Clínica Universidad de Navarra - Madrid","Madrid","28027",{"type":67,"coordinates":998},[999,1000],-3.70256,40.4165,{"lat":1000,"lon":999},[1003],{"name":5,"role":54,"phone":953,"phoneExt":25,"email":954},{"facility":1005,"status":60,"city":995,"state":25,"zip":1006,"country":944,"countryCode":945,"cosmosGeoPoint":1007,"geoPoint":1009,"contacts":1010},"Hospital Clínico San Carlos","28040",{"type":67,"coordinates":1008},[999,1000],{"lat":1000,"lon":999},[1011],{"name":5,"role":54,"phone":953,"phoneExt":25,"email":954},{"facility":1013,"status":60,"city":1014,"state":25,"zip":1015,"country":944,"countryCode":945,"cosmosGeoPoint":1016,"geoPoint":1020,"contacts":1021},"Clínica Universidad de Navarra","Pamplona","31008",{"type":67,"coordinates":1017},[1018,1019],-1.64323,42.81687,{"lat":1019,"lon":1018},[1022],{"name":5,"role":54,"phone":953,"phoneExt":25,"email":954},{"facility":1024,"status":60,"city":1025,"state":25,"zip":1026,"country":944,"countryCode":945,"cosmosGeoPoint":1027,"geoPoint":1031,"contacts":1032},"Hospital Virgen del Rocio","Seville","41013",{"type":67,"coordinates":1028},[1029,1030],-5.97317,37.38283,{"lat":1030,"lon":1029},[1033],{"name":5,"role":54,"phone":953,"phoneExt":25,"email":954},{"facility":1035,"status":456,"city":1036,"state":25,"zip":1037,"country":944,"countryCode":945,"cosmosGeoPoint":1038,"geoPoint":1042,"contacts":1043},"Hospital Clinico De Valencia (INCLIVA)","Valencia","46010",{"type":67,"coordinates":1039},[1040,1041],-0.37966,39.47391,{"lat":1041,"lon":1040},[1044],{"name":5,"role":54,"phone":953,"phoneExt":25,"email":954},{"facility":1046,"status":60,"city":1047,"state":25,"zip":1048,"country":1049,"countryCode":1050,"cosmosGeoPoint":1051,"geoPoint":1055,"contacts":1056},"Ninewells Hospital & Medical School","Dundee","DD1 9SY","United Kingdom","UK",{"type":67,"coordinates":1052},[1053,1054],-2.97489,56.46913,{"lat":1054,"lon":1053},[1057],{"name":5,"role":54,"phone":1058,"phoneExt":25,"email":1059},"08000514022","unitedkingdom@bitrialsupport.com",{"facility":1061,"status":456,"city":1062,"state":25,"zip":1063,"country":1049,"countryCode":1050,"cosmosGeoPoint":1064,"geoPoint":1068,"contacts":1069},"Hammersmith Hospital","London","W12 0HS",{"type":67,"coordinates":1065},[1066,1067],-0.12574,51.50853,{"lat":1067,"lon":1066},[1070],{"name":5,"role":54,"phone":1058,"phoneExt":25,"email":1059},{"facility":1072,"status":60,"city":1073,"state":25,"zip":1074,"country":1049,"countryCode":1050,"cosmosGeoPoint":1075,"geoPoint":1079,"contacts":1080},"The Christie Hospital","Manchester","M20 4BX",{"type":67,"coordinates":1076},[1077,1078],-2.23743,53.48095,{"lat":1078,"lon":1077},[1081],{"name":5,"role":54,"phone":1058,"phoneExt":25,"email":1059},{"type":1083,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100560767","phase-2-beamion-pantumor-1-a-study-to-test-whether-zongertinib-helps-people-with-advanced-cancers-with-her2-alterations-100560767",false,"NCT06581432","Beamion PANTUMOR-1: A Study to Test Whether Zongertinib Helps People With Advanced Cancers With HER2 Alterations","Beamion PANTUMOR-1: A Phase II, Multicentre, Multicohort, Open-label Trial to Evaluate the Efficacy and Safety of Oral Zongertinib (BI 1810631) for the Treatment of Selected HER2-mutated or Overexpressed\u002FAmplified Solid Tumours","Inclusion criteria:\n\n* Patients aged ≥18 years\n* Documented Human epidermal growth factor receptor 2 (HER2)-positive status or known activating HER2 mutations (by local testing)\n* Histologically or cytologically confirmed locally advanced, unresectable, or metastatic solid tumours\n* Disease progression following prior treatment in the metastatic setting (including treatment with antibody-drug conjugates (ADCs)) and no suitable standard of care treatment options\n* Availability of archival tumour tissue sample to confirm HER2 status\n* Presence of ≥1 measurable lesion outside the central nervous system (CNS) according to Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 (investigator assessed)\n* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 Further inclusion criteria apply.\n\nExclusion criteria:\n\n* Diagnosis of HER2-positive (overexpressed\u002Famplified) metastatic breast cancer or metastatic gastroesophageal adenocarcinoma\n* Diagnosis of HER2-mutant non-small cell lung cancer (NSCLC)\n* Previous treatment with any HER2 tyrosine kinase inhibitors (TKIs)\n* Previous or concomitant malignancies other than the one treated in this trial within the previous 3 years except the following effectively treated cancers: nonmelanoma skin cancers, carcinoma in situ of the cervix, ductal carcinoma in situ of the breast, localized prostate cancer on watchful waiting or active surveillance, and other effectively treated malignancies that are considered cured by local treatment\n* Uncontrolled or symptomatic brain or subdural metastases during screening\n* Known diagnosis of leptomeningeal disease\n* Intake of restricted medications or any drug considered likely to interfere with the trial being conducted in a safe mannerFurther exclusion criteria apply.","ALL","18 Years",{"count":1094,"type":1095},588,"ESTIMATED","INTERVENTIONAL",[1098],"PHASE2","This is a study for people with advanced cancer for whom previous treatment was not successful. Adults aged 18 and over with advanced cancer with HER2 alterations can join the study. The purpose of this study is to find out whether a medicine called zongertinib helps people with advanced cancers with HER2 alterations. HER2 alterations can cause cancer. Zongertinib inhibits HER2.\n\nParticipants are put into groups based on the type of advanced cancer they have, the type of HER2 alterations they have, and the dose of zongertinib they receive. Depending on the group they are in, participants take 1 of 2 different doses of zongertinib each day. Participants can continue the treatment as long as they benefit from it and can tolerate it.\n\nParticipants visit the study site regularly. During many of the visits, the doctors check the size of the tumour and whether it has spread to other parts of the body. During all the visits, the doctors check participants' health and take note of any unwanted effects.",[1101],"Solid Tumours","2026-10-12",{"date":1104,"type":1105},"2026-10-13","ACTUAL",{"date":1107,"type":1105},"2024-10-11",{"date":1109,"type":1095},"2028-12-29",{"name":5,"class":6},92]